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Hippocampal–prefrontal input supports spatial encoding in working memory
Open accessAbstract
Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and hippocampus are known to contribute jointly to successful spatial working memory, the anatomical pathway and temporal window for the interaction of these structures critical to spatial working memory has not yet been established. Here we find that direct hippocampal-prefrontal afferents are critical for encoding, but not for maintenance or retrieval, of spatial cues in mice. These cues are represented by the activity of individual prefrontal units in a manner that is dependent on hippocampal input only during the cue-encoding phase of a spatial working memory task. Successful encoding of these cues appears to be mediated by gamma-frequency synchrony between the two structures. These findings indicate a critical role for the direct hippocampal-prefrontal afferent pathway in the continuous updating of task-related spatial information during spatial working memory.
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“The direct hippocampal to prefrontal afferents in mice are found to be critical for encoding of spatial cues during working memory, and successful encoding of task-related information is mediated by gamma-frequency synchrony between hippocampus and PFC 21.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [21]
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Metadata
- Authors
- Spellman, T., Rigotti, M., Ahmari, S. E., Fusi, S., Gogos, J. A., & Gordon, J. A.
- Affiliations
- Columbia University (US)
- IBM Research - Thomas J. Watson Research Center (US)
- University of Pittsburgh (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Gordon, Joshua A.
- ORCID
- Venue
- Nature
- Published
- 2015-06-08
- Volume
- 522
- Issue
- 7556
- Pages
- 309-314
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4505751
- OpenAlex
- W1576349452
- Cited by
- 693
- References
- 51
- Citations by year
- 2026: 48 · 2025: 71 · 2024: 49 · 2023: 59 · 2022: 57 · 2021: 103 · 2020: 67 · 2019: 59 · 2018: 58 · 2017: 67 · 2016: 44 · 2015: 11
- FWCI
- 36.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (5r01mh096274-06)
- National Institute of Mental Health (R01-MH096274, MH081968, K08MH087718, MH096274, R01MH081968)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- spatial working memory, hippocampus, prefrontal cortex, memory maintenance, memory retrieval, single-unit activity, mice
- MeSH terms
- Action Potentials, Afferent Pathways, Animals, Cues, Hippocampus, Male, Memory, Short-Term, Models, Neurological, Space Perception, Prefrontal Cortex, Mice, Optogenetics, Spatial Memory
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