Cited by 1,324Protist diversity and phylogenyOrigins and Evolution of LifeGenomics and Phylogenetic Studies

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Complex archaea that bridge the gap between prokaryotes and eukaryotes

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Spang, Anja, Saw, Jimmy H., Jørgensen, Steffen L., Zaremba-Niedzwiedzka, Katarzyna, Martijn, Joran, Lind, Anders E., van Eijk, Roel, Schleper, Christa, Guy, Lionel, Ettema, Thijs J. G.·2015·Nature

DOI 10.1038/nature14447PMC PMC4444528

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Abstract

The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided support for the emergence of the eukaryotic host cell from within the archaeal domain of life, but the identity and nature of the putative archaeal ancestor remain a subject of debate. Here we describe the discovery of 'Lokiarchaeota', a novel candidate archaeal phylum, which forms a monophyletic group with eukaryotes in phylogenomic analyses, and whose genomes encode an expanded repertoire of eukaryotic signature proteins that are suggestive of sophisticated membrane remodelling capabilities. Our results provide strong support for hypotheses in which the eukaryotic host evolved from a bona fide archaeon, and demonstrate that many components that underpin eukaryote-specific features were already present in that ancestor. This provided the host with a rich genomic 'starter-kit' to support the increase in the cellular and genomic complexity that is characteristic of eukaryotes.

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Authors: Spang, A., Saw, J. H., Jørgensen, S. L., Zaremba-Niedzwiedzka, K., Martijn, J., Lind, A. E., van Eijk, R., Schleper, C., Guy, L., & Ettema, T. J. G.
Affiliations: Uppsala University (SE)
University of Bergen (NO)
University of Vienna (AT)
Corresponding author: Guy, Lionel
Ettema, Thijs J. G.
ORCID: Spang, Anja
Saw, Jimmy H.
Jørgensen, Steffen L.
Martijn, Joran
Schleper, Christa
Guy, Lionel
Ettema, Thijs J. G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2015-05
Volume: 521
Issue: 7551
Pages: 173-179
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature14447
PMC: PMC4444528
OpenAlex: W1939911045
Cited by: 1,324
References: 98
Citations by year: 2026: 85 · 2025: 88 · 2024: 118 · 2023: 127 · 2022: 116 · 2021: 125 · 2020: 136 · 2019: 117 · 2018: 118 · 2017: 118 · 2016: 118 · 2015: 54
FWCI: 58.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: Lokiarchaeota, eukaryotic origin, archaea, membrane remodeling, phylogenomics, cellular complexity
MeSH terms: Actins, Archaea, Arctic Regions, Eukaryotic Cells, Actin Cytoskeleton, Molecular Sequence Data, Phylogeny, Prokaryotic Cells, Evolution, Molecular, Proteome, Monomeric GTP-Binding Proteins, Metagenome, Endosomal Sorting Complexes Required for Transport, Eukaryota, Hydrothermal Vents

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Complex archaea that bridge the gap between prokaryotes and eukaryotes

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