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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
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Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide. Hence, it has been ranked by the World Health Organization as a top disorder of morbidity and lost productivity. Previous neuropathological studies have revealed a series of alterations in the brains of patients with bipolar disorder or animal models, such as reduced glial cell number in the prefrontal cortex of patients, upregulated activities of the protein kinase A and C pathways and changes in neurotransmission. However, the roles and causation of these changes in bipolar disorder have been too complex to exactly determine the pathology of the disease. Furthermore, although some patients show remarkable improvement with lithium treatment for yet unknown reasons, others are refractory to lithium treatment. Therefore, developing an accurate and powerful biological model for bipolar disorder has been a challenge. The introduction of induced pluripotent stem-cell (iPSC) technology has provided a new approach. Here we have developed an iPSC model for human bipolar disorder and investigated the cellular phenotypes of hippocampal dentate gyrus-like neurons derived from iPSCs of patients with bipolar disorder. Guided by RNA sequencing expression profiling, we have detected mitochondrial abnormalities in young neurons from patients with bipolar disorder by using mitochondrial assays; in addition, using both patch-clamp recording and somatic Ca(2+) imaging, we have observed hyperactive action-potential firing. This hyperexcitability phenotype of young neurons in bipolar disorder was selectively reversed by lithium treatment only in neurons derived from patients who also responded to lithium treatment. Therefore, hyperexcitability is one early endophenotype of bipolar disorder, and our model of iPSCs in this disease might be useful in developing new therapies and drugs aimed at its clinical treatment.
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“The neurons from people with BD were hyperexcitable and their activity was selectively modified by in vitro lithium in accordance with clinical response.419”
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Cites
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,508
Modelling schizophrenia using human induced pluripotent stem cells
Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375
Self-citationMarchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., & Muotri, A. R. (2010) · Cell · doi:10.1016/j.cell.2010.10.016 · Cited by 1,329
Self-citationHigh-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision
Grewe, B. F., Langer, D., Kasper, H., Kampa, B. M., & Helmchen, F. (2010) · Nature Methods · doi:10.1038/nmeth.1453 · Cited by 525
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Berk, M., Dodd, S., Kauer‐Sant’Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F., & Norman, T. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01058.x · Cited by 396
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand, K., Savas, J. N., Kim, Y., Tran, N., Simone, A., Hashimoto-Torii, K., Beaumont, K. G., Kim, H. J., Topol, A., Ladran, I., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.22 · Cited by 369
Self-citationYuan, L., Adams, J. P., Swank, M. W., Sweatt, J. D., & Johnston, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04860.2002 · Cited by 314
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells
Yu, D. X., Giorgio, F. P. D., Yao, J., Marchetto, M. C., Brennand, K., Wright, R., Mei, A., McHenry, L. K., Lisuk, D., Grasmick, J. M., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.01.009 · Cited by 269
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Panchision, D. M. (2016) · Stem Cells · doi:10.1002/stem.2295 · Cited by 27
Murano, T., Hagihara, H., Tajinda, K., Matsumoto, M., & Miyakawa, T. (2019) · Communications Biology · doi:10.1038/s42003-018-0277-2 · Cited by 26
Diverse pathophysiological processes converge on network disruption in mania
Lee, I., Nielsen, K., Nawaz, U., Hall, M., Öngür, D., Keshavan, M. S., & Brady, R. O. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.087 · Cited by 27
van den Hurk, M., & Bardy, C. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108350 · Cited by 28
Hosoya, M., & Czysz, K. (2016) · Cells · doi:10.3390/cells5040046 · Cited by 27
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von Schantz, M., Leocádio-Miguel, M. A., McCarthy, M. J., Papiol, S., & Landgraf, D. (2020) · Advances in genetics · doi:10.1016/bs.adgen.2020.11.005 · Cited by 25
Self-citationPinna, A., & Colasanti, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.689473 · Cited by 28
Niemsiri, V., Rosenthal, S. B., Nievergelt, C. M., Maihofer, A. X., Marchetto, M. C., Santos, R., Shekhtman, T., Alliey‐Rodriguez, N., Anand, A., Balaraman, Y., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01909-9 · Cited by 28
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RYBAKOWSKI, J. K. (2020) · Drug Development Research · doi:10.1002/ddr.21660 · Cited by 28
Wang, Q.-W., Lu, S., Liu, Y., Chen, Y., Wei, H., Shen, W., Chen, Y., Fu, C.-L., Wang, Y.-H., Dai, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016416117 · Cited by 26
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Kelsoe, J., Ou, A., Rosenthal, S., Adli, M., Akiyama, K., Akula, N., Alda, M., Amare, A. T., Ardau, R., Arias, B., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02811-4 · Cited by 25
Self-citationXiong, T.-W., Liu, B., Wu, Q., Xu, Y., Liu, P., Wang, Y., Liu, J., & Jing-shan, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147647 · Cited by 24
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Kaas, G. A., Kasuya, J., Lansdon, P., Ueda, A., Iyengar, A. S. R., Wu, C., & Kitamoto, T. (2016) · eNeuro · doi:10.1523/eneuro.0221-16.2016 · Cited by 27
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Khayachi, A., Abuzgaya, M., Liu, Y., Jiao, C., Dejgaard, K., Schorova, L., Kamesh, A., He, Q., Cousineau, Y., Pietrantonio, A., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105161 · Cited by 23
Self-citationMilanesi, E., Voinsky, I., Hadar, A., Srouji, A., Maj, C., Shekhtman, T., Gershovits, M., Gilad, S., Chillotti, C., Squassina, A., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1372629 · Cited by 24
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Zhang, S., Hu, S., Dong, W., Huang, S., Jiao, Z., Hu, Z., Dai, S., Yi, Y., Gong, X., Li, K., et al. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09621-0 · Cited by 23
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Rao, C. M., Bojja, S. L., Singh, N., & Kolathur, K. K. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220411081728 · Cited by 23
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Alciati, A., Reggiani, A. M., Caldirola, D., & Perna, G. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081340 · Cited by 22
Genomics of Lithium Action and Response
Pickard, B. S. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0554-7 · Cited by 24
Fries, G. R., Colpo, G. D., Monroy‐Jaramillo, N., Zhao, J., Zhao, Z., Arnold, J. G., Bowden, C. L., & Walss‐Bass, C. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.09.003 · Cited by 23
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Ryu, E., Nassan, M. M., Jenkins, G. D., Armasu, S. M., Andreazza, A. C., McElroy, S. L., Vawter, M. P., Frye, M. A., & Biernacka, J. M. (2017) · Complex Psychiatry · doi:10.1159/000464444 · Cited by 24
Fink, J. J., & Levine, E. S. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00237 · Cited by 26
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Case, K. C., Salsaa, M., Yu, W., & Greenberg, M. L. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_181 · Cited by 22
Watmuff, B., Liu, B., & Karmacharya, R. (2017) · Pharmacogenomics · doi:10.2217/pgs-2016-0187 · Cited by 22
The gene expression patterns as surrogate indices of pH in the brain
Hagihara, H., Murano, T., & Miyakawa, T. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1151480 · Cited by 19
Williams, L. A., Joshi, V., Murphy, M., Ferrante, J., Werley, C. A., Brookings, T., McManus, O. B., Grosse, J., Davies, C. H., & Dempsey, G. T. (2019) · Neurochemical Research · doi:10.1007/s11064-018-2694-5 · Cited by 20
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Li, S., Wang, M., & Zhou, J. (2020) · Biopreservation and Biobanking · doi:10.1089/bio.2019.0111 · Cited by 23
Vošahlíková, M., Roubalová, L., Cechová, K., Kaufman, J., Musil, S., Mikšı́k, I., Alda, M., & Svoboda, P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109953 · Cited by 22
Self-citationScott, M. R., & McClung, C. A. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102801 · Cited by 21
Examining FKBP5 mRNA expression in human iPSC-derived neural cells
Lieberman, R., Kranzler, H. R., Levine, E. S., & Covault, J. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.11.027 · Cited by 19
Liu, Y., Lu, S., & Yao, J. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12528 · Cited by 22
Self-citationNudell, V., Wei, H., Nievergelt, C. M., Maihofer, A. X., Shilling, P. D., Alda, M., Berrettini, W. H., Brennand, K., Calabrese, J. R., Coryell, W. H., et al. (2019) · Complex Psychiatry · doi:10.1159/000497354 · Cited by 21
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Rehbach, K., Fernando, M. B., & Brennand, K. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0518-19.2019 · Cited by 22
Self-citationFu, C.-L., Dong, B.-C., Jiang, X., Li, D., & Yao, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24234 · Cited by 20
Self-citationMcLean, C. K., Narayan, S., Lin, S. Y., Rai, N., Chung, Y., Hipolito, M. S., Cascella, N. G., Nürnberger, J. I., Ishizuka, K., Sawa, A., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0126-6 · Cited by 21
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Sabbagh, D. E. S. E., Machado, A. K., Pappis, L., Beroncal, E. L., Ji, D., Nader, G., Chander, P. R., Choi, J., Duong, A., Jeong, H., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03529-7 · Cited by 19
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Kaiser, J., Nay, K., Horne, C. R., McAloon, L. M., Fuller, O. K., Muller, A. G., Whyte, D. G., Means, A. R., Walder, K. R., Berk, M., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02260-3 · Cited by 19
Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
Adegbola, A. A., Bury, L. A. D., Fu, C. S., Zhang, M., & Wynshaw-Boris, A. J. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0150 · Cited by 21
Floruta, C. M., Du, R., Kang, H., Stein, J. L., & Weick, J. P. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.09.023 · Cited by 19
Xie, Y., Schutte, R. J., Ng, N. N., Ess, K. C., Schwartz, P. H., & O’Dowd, D. K. (2017) · Stem Cell Research · doi:10.1016/j.scr.2017.12.003 · Cited by 21
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Hoffmann, A., Sportelli, V., Ziller, M. J., & Spengler, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030770 · Cited by 18
Barboza, A. B. C., McElroy, S. L., Veldić, M., Singh, B., Kung, S., Romo‐Nava, F., Núñez, N. A., Cabello-Arreola, A., Coombes, B. J., Prieto, M. L., et al. (2020) · International Journal of Bipolar Disorders · doi:10.1186/s40345-020-00184-3 · Cited by 19
Pilarzyk, K., Porcher, L., Capell, W. R., Burbano, S. D., Davis, J., Fisher, J. L., Gorny, N., Petrolle, S., & Kelly, M. P. (2022) · Aging Cell · doi:10.1111/acel.13687 · Cited by 17
Transcriptomic Imputation of Bipolar Disorder and Bipolar subtypes reveals 29 novel associated genesPreprint
Huckins, L. M., Dobbyn, A. L., McFadden, W. C., Wang, W., Ruderfer, D. M., Hoffman, G. E., Rajagopal, V. M., Nguyen, H. T., Roussos, P., Fromer, M., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/222786 · Cited by 19
Miranda, A., Shekhtman, T., McCarthy, M., DeModena, A., Leckband, S. G., & Kelsoe, J. R. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.01.010 · Cited by 18
Self-citationCan lithium salts prevent depressive episodes in the real world?
González-Pinto, A. M., López-Peña, P., Ampudia, C. B., Vieta, E., & Martínez‐Cengotitabengoa, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.09.008 · Cited by 18
Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response
Avior, Y., Ron, S., Kroitorou, D., Albeldas, C., Lerner, V., Corneo, B., Nitzan, E., Laifenfeld, D., & Solal, T. C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01319-5 · Cited by 18
Gao, K., Ayati, M., Koyutürk, M., Calabrese, J. R., Ganocy, S. J., Kaye, N. M., Lazarus, H. M., Christian, E., & Kaplan, D. R. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4424 · Cited by 18
Self-citationWolter, J. M., Le, B. D., Matoba, N., Lafferty, M. J., Aygün, N., Liang, D., Courtney, K. P., Song, J., Piven, J., Zylka, M. J., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.08.014 · Cited by 18
Hagihara, H., Shoji, H., Hattori, S., Sala, G., Takamiya, Y., Tanaka, M., Ihara, M., Shibutani, M., Hatada, I., Hori, K., et al. (2023) · eLife · doi:10.7554/elife.89376 · Cited by 53
Genetics of Lithium Response in Bipolar Disorder
Papiol, S., Schulze, T. G., & Alda, M. (2018) · Pharmacopsychiatry · doi:10.1055/a-0590-4992 · Cited by 18
Self-citationAlten, B., Yeşiltepe, M., Bayraktar, E., Taş, S. T., Göçmen, A. Y., Kurşungöz, C., Martı́nez, A., & Sara, Y. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14500 · Cited by 18
HOOK, V. Y. H., Kind, T., Podvin, S., Palazoglu, M., Tran, C., Toneff, T., Samra, S., Lietz, C. B., & Fiehn, O. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00432 · Cited by 18
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Nakazawa, T., Hashimoto, R., Takuma, K., & Hashimoto, H. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.06.002 · Cited by 18
Izsák, J., Seth, H., Iljin, M., Theiss, S., Ågren, H., Funa, K., Aigner, L., Hanse, E., & Illes, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01399-3 · Cited by 18
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Parker, K. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01532-8 · Cited by 19
Nassan, M. M., Li, Q. S., Croarkin, P. E., Chen, W., Colby, C. L., Veldić, M., McElroy, S. L., Jenkins, G. D., Ryu, E., Cunningham, J. M., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.049 · Cited by 19
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Jones, G. H., Rong, C., Shariq, A. S., Mishra, A. P., & Machado‐Vieira, R. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_157 · Cited by 18
Perrottelli, A., Marzocchi, F. F., Caporusso, E., Giordano, G. M., Giuliani, L., Melillo, A., Pezzella, P., Bucci, P., Mucci, A., & Galderisi, S. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230112 · Cited by 17
Recent advances in the understanding and management of bipolar disorder in adults
RYBAKOWSKI, J. K. (2017) · F1000Research · doi:10.12688/f1000research.12329.1 · Cited by 17
Naujock, M., Speidel, A., Fischer, S. E., Kizner, V., Dorner‐Ciossek, C., & Gillardon, F. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0082 · Cited by 18
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Liang, N., Trujillo, C. A., Negraes, P. D., Muotri, A. R., Lameu, C., & Ulrich, H. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.025 · Cited by 18
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Mérida, I., Arranz‐Nicolás, J., Torres‐Ayuso, P., & Ávila‐Flores, A. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_221 · Cited by 17
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Harrison, P. J., Geddes, J. R., & Tunbridge, E. M. (2019) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.17309 · Cited by 18
Maloney, B., Balaraman, Y., Liu, Y., Chopra, N., Edenberg, H. J., Kelsoe, J. R., Nürnberger, J. I., & Lahiri, D. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-54076-3 · Cited by 17
Self-citationKhayachi, A., Schorova, L., Alda, M., Rouleau, G. A., & Milnerwood, A. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.002 · Cited by 15
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Coradduzza, D., Garroni, G., Congiargiu, A., Balzano, F., Cruciani, S., Sedda, S., Nivoli, A., & Maioli, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810489 · Cited by 19
Freyberg, Z., Andreazza, A. C., McClung, C. A., & Phillips, M. L. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.07.011 · Cited by 20
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Xu, C.-X., Huang, W., Shi, X., Du, Y., Liang, J., Fang, X., Chen, H.-Y., & Cheng, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04477-x · Cited by 16
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Lago, S. G., Tomasik, J., & Bahn, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01243-8 · Cited by 16
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Wen, Z. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24031 · Cited by 15
Schork, N. J., & Nazor, K. L. (2017) · Advances in genetics · doi:10.1016/bs.adgen.2017.06.001 · Cited by 16
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Puppo, F., Sadegh, S., Trujillo, C. A., Thunemann, M., Campbell, E. P., Vandenberghe, M., Shan, X., Akkouh, I. A., Miller, E. W., Bloodgood, B. L., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.671549 · Cited by 15
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Masui, A., Hirai, T., & Gotoh, S. (2022) · Archives of Toxicology · doi:10.1007/s00204-021-03188-9 · Cited by 16
Pisanu, C., Severino, G., Toma, I. D., Dierssen, M., Fusar‐Poli, P., Gennarelli, M., Lió, P., Maffioletti, E., Maron, E., Mehta, D., et al. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.12.005 · Cited by 15
Brennand, K. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20220235 · Cited by 16
Self-citationDrug discovery in psychopharmacology: from 2D models to cerebral organoids
Rossetti, A. C., Koch, P., & Ladewig, J. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.2/jladewig · Cited by 15
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Marques, A. P., Resende, R., Silva, D. F., Batista, M., Pereira, D., Wildenberg, B., Morais, S., Macedo, A., Pais, C., Melo, J. B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9050522 · Cited by 19
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Gonzalez, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.636294 · Cited by 19
Murano, T., Nakajima, R., Nakao, A., Hirata, N., Amemori, S., Murakami, A., Kamitani, Y., Yamamoto, J., & Miyakawa, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106830119 · Cited by 13
Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer’s Disease
Gherardelli, C., Cisternas, P., & Inestrosa, N. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158733 · Cited by 15
Santos, P. M., Campos, G. P., & Nascimento, C. F. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s376380 · Cited by 15
Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders
Seah, C., Huckins, L. M., & Brennand, K. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.033 · Cited by 12
Self-citationUnraveling the biology of bipolar disorder using induced pluripotent stem‐derived neurons
Miller, N. D., & Kelsoe, J. R. (2017) · Bipolar Disorders · doi:10.1111/bdi.12535 · Cited by 13
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Increased hippocampal excitability in miR-324-null mice
Hayman, D. J., Modebadze, T., Charlton, S. H., Cheung, K., Soul, J., Lin, H., Yao, H., Miles, C. G., Tsompani, D., Jackson, R. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89874-1 · Cited by 12
Marcatili, M., Sala, C., Dakanalis, A., Colmegna, F., D’Agostino, A., Gambini, O., Dell’Osso, B. M., Benatti, B., Conti, L., & Clerici, M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320968331 · Cited by 13
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Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?
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Benchoua, A., Lasbareilles, M., & Tournois, J. (2021) · Cells · doi:10.3390/cells10123290 · Cited by 14
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Yu, X., Hu, X., Wan, X., Zhang, Z., Wan, X., Cai, M., Yu, T., & Xiao, J. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.12.018 · Cited by 12
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Self-citation
Metadata
- Authors
- Study, T. P. O. B. D., Mertens, J., Wang, Q.-W., Kim, Y., Yu, D. X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K. E., Zhang, J., Soltani, S., Eames, T., Schafer, S. T., Boyer, L., Marchetto, M. C., Nurnberger, J. I., Calabrese, J. R., Oedegaard, K. J., McCarthy, M. J., Zandi, P. P., Alda, M., Nievergelt, C. M., Mi, S., Brennand, K. J., Kelsoe, J. R., Gage, F. H., & Yao, J.
- Affiliations
- Center for Life Sciences (CN)
- Salk Institute for Biological Studies (US)
- Chinese Academy of Sciences (CN)
- Case Western Reserve University (US)
- Haukeland University Hospital (NO)
- University of California San Diego (US)
- Johns Hopkins University (US)
- Dalhousie University (CA)
- Icahn School of Medicine at Mount Sinai (US)
- Jiangsu Normal University (CN)
- Corresponding author
- Kelsoe, John R.
- Gage, Fred H.
- Yao, Jun
- ORCID
- Venue
- Nature
- Published
- 2015-10-28
- Volume
- 527
- Issue
- 7576
- Pages
- 95-99
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4742055
- OpenAlex
- W2139372806
- Cited by
- 562
- References
- 30
- Citations by year
- 2026: 20 · 2025: 50 · 2024: 45 · 2023: 37 · 2022: 54 · 2021: 60 · 2020: 58 · 2019: 68 · 2018: 50 · 2017: 54 · 2016: 58 · 2015: 5
- FWCI
- 45.23
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-11-25)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- PMC
- Funders
- U.S. Department of Veterans Affairs (I01CX000363)
- National Institute of Mental Health (R01MH106056, U01 MH92758, R01MH101454, MH106056, U01MH092758)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- bipolar disorder, lithium response, lithium resistance, neuronal hyperexcitability, iPSC-derived neurons, mitochondrial abnormalities, action potential firing, endophenotypes, iPSC disease models, mood stabilizers, calcium imaging, patch-clamp electrophysiology, drug response prediction, personalized medicine, mania
- MeSH terms
- Action Potentials, Bipolar Disorder, Humans, Male, Mitochondria, Neurons, Antipsychotic Agents, Lithium Compounds, Patch-Clamp Techniques, Dentate Gyrus, Calcium Signaling, Induced Pluripotent Stem Cells, Endophenotypes
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