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The temporal scaling of Caenorhabditis elegans ageing

Stroustrup, Nicholas, Anthony, Winston E., Nash, Zachary M., Gowda, Vivek, Gomez, Adam, López-Moyado, Isaac F., Apfeld, Javier, Fontana, Walter·2016·Nature
DOI 10.1038/nature16550PMC PMC4828198
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  • A one-dimensional representation of the complex biochemistry and phenotypes of aging is supported by analyses of aging data.

    “The possibility of such a one-dimensional representation of the complex biochemistry and phenotypes of aging21–25 is supported by analyses of aging data26–30.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [30]

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Research works printed but not linked: 29

  1. Pincus, Z., Smith-Vikos, T. & Slack, F. J. MicroRNA predictors of longevity in Caenorhabditis elegans . PLoS Genet. 7, e1002306 (2011) · DOI
  2. Shaw, R. F. & Bercaw, B. L. Temperature and life-span in poikilothermous animals. Nature 196, 454–457 (1962) · DOI
  3. Mair, W., Goymer, P., Pletcher, S. D. & Partridge, L. Demography of dietary restriction and death in Drosophila . Science 301, 1731–1733 (2003) · DOI
  4. Wu, D., Rea, S. L., Cypser, J. R. & Johnson, T. E. Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell 8, 666–675 (2009) · DOI
  5. Lithgow, G. J., White, T. M., Melov, S. & Johnson, T. E. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl Acad. Sci. USA 92, 7540–7544 (1995) · DOI · Paper page
  6. Stroustrup, N. et al. The Caenorhabditis elegans lifespan machine. Nature Methods 10, 665–670 (2013) · DOI
  7. Johnson, T. E., Wu, D., Tedesco, P., Dames, S. & Vaupel, J. W. Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. J. Gerontol. A 56, B331–B339 (2001) · DOI
  8. Swindell, W. R. Accelerated failure time models provide a useful statistical framework for aging research. Exp. Gerontol. 44, 190–200 (2009) · DOI
  9. Vaupel, J. W., Manton, K. G. & Stallard, E. The impact of heterogeneity in individual frailty on the dynamics of mortality. Demography 16, 439–454 (1979) · DOI · Paper page
  10. Martin, G. M., Austad, S. N. & Johnson, T. E. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nature Genet. 13, 25–34 (1996) · DOI
  11. Tullet, J. M. et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans . Cell 132, 1025–1038 (2008) · DOI · Paper page
  12. Landis, J. N. & Murphy, C. T. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev. Dyn. 239, 1405–1412 (2010) · DOI
  13. Leiser, S. F., Begun, A. & Kaeberlein, M. HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10, 318–326 (2011) · DOI
  14. Kirkwood, T. B. & Shanley, D. P. Food restriction, evolution and ageing. Mech. Ageing Dev. 126, 1011–1016 (2005) · DOI
  15. Garigan, D. et al. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101–1112 (2002) · DOI · Paper page
  16. Lakowski, B. & Hekimi, S. The genetics of caloric restriction in Caenorhabditis elegans . Proc. Natl Acad. Sc. USA 95, 13091–13096 (1998) · DOI
  17. Suda, H., Sato, K. & Yanase, S. Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans . Mech. Ageing Dev. 133, 600–610 (2012) · DOI
  18. Atlan, H., Miquel, J., Helmle, L. C. & Dolkas, C. B. Thermodynamics of aging in Drosophila melanogaster . Mech. Ageing Dev. 5, 371–387 (1976) · DOI
  19. Murphy, C. T. et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans . Nature 424, 277–283 (2003) · DOI · Paper page
  20. Walker, G., Houthoofd, K., Vanfleteren, J. R. & Gems, D. Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech. Ageing Dev. 126, 929–937 (2005) · DOI
  21. McColl, G. et al. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans . Cell Metab. 12, 260–272 (2010) · DOI
  22. Oliveira, R. P. et al. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8, 524–541 (2009) · DOI
  23. Aalen, O. O. & Gjessing, H. K. Understanding the shape of the hazard rate: a process point of view. Stat. Sci. 16, 1–14 (2001) · DOI
  24. Gladyshev, V. N. The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 29, 506–512 (2013) · DOI
  25. Samuelson, A. V., Carr, C. E. & Ruvkun, G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 21, 2976–2994 (2007) · DOI
  26. Stiernagle, T. in WormBook (ed. The C. elegans Research Community) http://dx.doi.org/10.1895/wormbook.1.101.1 (February 11, 2006) · DOI
  27. Baeriswyl, S. et al. Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates. Biogerontology 11, 53–65 (2010) · DOI
  28. Wilkinson, D. S., Taylor, R. C. & Dillin, A. Analysis of aging in Caenorhabditis elegans . Methods Cell Biol. 107, 353–381 (2012) · DOI
  29. Rebora, P., Salim, A. & Reilly, M. bshazard: a flexible tool for nonparametric smoothing of the hazard function. R J . 6, 114–122 (2014) · DOI

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Metadata

Authors
Stroustrup, N., Anthony, W. E., Nash, Z. M., Gowda, V., Gomez, A., López-Moyado, I. F., Apfeld, J., & Fontana, W.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2016-01-27
Volume
530
Issue
7588
Pages
103-107
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature16550
PMC
PMC4828198
Cited by
196
References
4
Language
en
Licence

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