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The Atlantic salmon genome provides insights into rediploidization
Open accessAbstract
The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (Salmo salar), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial for the post-Ss4R rediploidization process. Comparisons of duplicate gene expression patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly demonstrate far more instances of neofunctionalization than subfunctionalization. Surprisingly, we find that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products. Finally, we demonstrate that the Atlantic salmon assembly can serve as a reference sequence for the study of other salmonids for a range of purposes.
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Metadata
- Authors
- Lien, S., Koop, B. F., Sandve, S. R., Miller, J. R., Kent, M. P., Nome, T., Hvidsten, T. R., Leong, J. S., Minkley, D. R., Zimin, A., Grammes, F., Grove, H., Gjuvsland, A., Walenz, B., Hermansen, R. A., von Schalburg, K., Rondeau, E. B., Di Genova, A., Samy, J. K. A., Olav Vik, J., Vigeland, M. D., Caler, L., Grimholt, U., Jentoft, S., Inge Våge, D., de Jong, P., Moen, T., Baranski, M., Palti, Y., Smith, D. R., Yorke, J. A., Nederbragt, A. J., Tooming-Klunderud, A., Jakobsen, K. S., Jiang, X., Fan, D., Hu, Y., Liberles, D. A., Vidal, R., Iturra, P., Jones, S. J. M., Jonassen, I., Maass, A., Omholt, S. W., & Davidson, W. S.
- Venue
- Nature
- Published
- 2016-04-18
- Volume
- 533
- Issue
- 7602
- Pages
- 200-205
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2337283254
- Cited by
- 1,047
- References
- 18
- FWCI
- 128.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lien, S., Koop, B. F., Sandve, S. R., Miller, J. R., Kent, M. P., Nome, T., Hvidsten, T. R., Leong, J. S., Minkley, D. R., Zimin, A., Grammes, F., Grove, H., Gjuvsland, A., Walenz, B., Hermansen, R. A., von Schalburg, K., Rondeau, E. B., Di Genova, A., Samy, J. K. A., . . . Davidson, W. S. (2016). The Atlantic salmon genome provides insights into rediploidization. Nature. https://doi.org/10.1038/nature17164
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
