Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Sousa, Cristovão M., Biancur, Douglas E., Wang, Xiaoxu, Halbrook, Christopher J., Sherman, Mara H., Zhang, Li, Kremer, Daniel, Hwang, Rosa F., Witkiewicz, Agnes K., Ying, Haoqiang, Asara, John M., Evans, Ronald M., Cantley, Lewis C., Lyssiotis, Costas A., Kimmelman, Alec C.·2016·Nature

DOI 10.1038/nature19084

Cited by (1,000)

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Metabolic interplays between the tumour and the host shape the tumour macroenvironment
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Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
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Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting
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Anna Hupfer, Anna I. Brichkina, Anke Koeniger, Corinna Ulrike Keber, Carsten Denkert, Petra Ina Pfefferle, Frederik Helmprobst, Axel Pagenstecher, Alexander Visekruna, Matthias Lauth · 2021 · Proceedings of the National Academy of Sciences
Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis
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Autophagy in the crosstalk between tumor and microenvironment
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Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis
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Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF 1‐dependent pathway
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Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism
Robert B. Hamanaka, Gökhan M. Mutlu · 2021 · FEBS Journal
Autophagy and liver cancer
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Role of autophagy in IL-1β export and release from cells
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Metabolism in the Tumor Microenvironment
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Metabolic Dependencies in Pancreatic Cancer
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Amino acid transporters as emerging therapeutic targets in cancer
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