Macropinocytosis in cancer-associated fibroblasts is dependent on CaMKK2/ARHGEF2 signaling and functions to support tumor and stromal cell fitness

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,651 · see citing works

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590 · see citing works

Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241 · see citing works

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

Garcia, D., & Shaw, R. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.032 · Cited by 1,997 · see citing works

Glucose feeds the TCA cycle via circulating lactate

Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Zhan, L., Yanxiang Guo, J., et al. (2017) · Nature · doi:10.1038/nature24057 · Cited by 1,721 · see citing works

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works

Pancreatic cancers require autophagy for tumor growth

Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J. M., Dell'Antonio, G., et al. (2011) · Genes & Development · doi:10.1101/gad.2016111 · Cited by 1,498 · see citing works

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Sousa, C. M., Biancur, D. E., Wang, X., Halbrook, C. J., Sherman, M. H., Zhang, L., Kremer, D., Hwang, R. F., Witkiewicz, A. K., Ying, H., et al. (2016) · Nature · doi:10.1038/nature19084 · Cited by 1,122 · see citing works

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

Hwang, R. F., Moore, T. T., Arumugam, T., Ramachandran, V., Amos, K. D., Rivera, A. M., Ji, B., Evans, D. B., & Logsdon, C. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5714 · Cited by 1,093 · see citing works

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science · doi:10.1126/science.aab4138 · Cited by 1,085 · see citing works

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer

Bayne, L. J., Beatty, G. L., Jhala, N., Clark, C. E., Rhim, A. D., Stanger, B. Z., & Vonderheide, R. H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.025 · Cited by 947 · cited 1× · see citing works

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2211 · Cited by 893 · see citing works

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Cluntun, A. A., Lukey, M. J., Cerione, R. A., & Locasale, J. W. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.01.005 · Cited by 796 · see citing works

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Trends in Cell Biology · doi:10.1016/0962-8924(92)90174-l · Cited by 756 · see citing works

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by <i>ras</i> Proteins

Bar-Sagi, D., & Feramisco, J. R. (1986) · Science · doi:10.1126/science.3090687 · Cited by 734 · see citing works

Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

Hosios, A. M., Hecht, V. C., Danai, L. V., Johnson, M. O., Rathmell, J. C., Steinhauser, M. L., Manalis, S. R., & Vander Heiden, M. G. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.012 · Cited by 641 · see citing works

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

Erdogan, B., Ao, M., White, L. M., Means, A. L., Brewer, B. M., Yang, L., Washington, M. K., Shi, C., Franco, O. E., Weaver, A. M., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201704053 · Cited by 552 · see citing works

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

Lee, J. J., Perera, R. M., Wang, H., Wu, D.-C., Liu, X. S., Han, S., Fitamant, J., Jones, P. D., Ghanta, K. S., Kawano, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411679111 · Cited by 502 · see citing works

The utilization of extracellular proteins as nutrients is suppressed by mTORC1

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell · doi:10.1016/j.cell.2015.06.017 · Cited by 457 · see citing works

A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1212 · Cited by 332 · see citing works

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Davidson, S. M., Jonas, O., Keibler, M. A., Hou, H. W., Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., et al. (2017) · Nature Medicine · doi:10.1038/nm.4256 · Cited by 331 · see citing works

Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment

Helms, E. J., Oñate, M. K., & Sherman, M. H. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1353 · Cited by 283 · see citing works

Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

Racioppi, L., & Means, A. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.356485 · Cited by 282 · see citing works

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.11.002 · Cited by 245 · see citing works

Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

Kania, E., Pająk, B., & Orzechowski, A. (2015) · BioMed Research International · doi:10.1155/2015/352794 · Cited by 228 · see citing works

Determining the macropinocytic index of cells through a quantitative image-based assay

Commisso, C., Flinn, R. J., & Bar‐Sagi, D. (2014) · Nature Protocols · doi:10.1038/nprot.2014.004 · Cited by 222 · see citing works

Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells

Levine, Y. C., Li, G. K., & Michel, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702182200 · Cited by 207 · see citing works

PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells

Kim, S. M., Nguyen, T. T., Ravi, A., Kubiniok, P., Finicle, B. T., Jayashankar, V., Malacrida, L., Hou, J., Robertson, J., Gao, D., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1215 · Cited by 199 · see citing works

Analysis of Activated GAPs and GEFs in Cell Lysates

García‐Mata, R., Wennerberg, K., Arthur, W. T., Hooten, N. N., Ellerbroek, S. M., & Burridge, K. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)06031-9 · Cited by 194 · see citing works

Collagen VI in cancer and its biological mechanisms

Chen, P., Cescon, M., & Bonaldo, P. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.001 · Cited by 186 · see citing works

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer

Recouvreux, M. V., Moldenhauer, M. R., Galenkamp, K. M. O., Jung, M., James, B., Zhang, Y., Lowy, A., Bagchi, A., & Commisso, C. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200388 · Cited by 181 · see citing works

A comparison of fluorescent Ca2+ indicators for imaging local Ca2+ signals in cultured cells

Lock, J. T., Parker, I., & Smith, I. F. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.10.003 · Cited by 176 · see citing works

EGFR-Pak signaling selectively regulates glutamine deprivation-induced macropinocytosis

Lee, S.-W., Zhang, Y., Jung, M., Cruz, N., Alas, B., & Commisso, C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.05.043 · Cited by 172 · see citing works

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

Mishra, R., Haldar, S., Placencio, V. R., Madhav, A., Rohena-Rivera, K., Agarwal, P., Duong, F. L., Angara, B., Tripathi, M., Liu, Z., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99397 · Cited by 164 · see citing works

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K., & Wennerberg, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207401200 · Cited by 137 · see citing works

Integrated Proteomic Profiling of Cell Line Conditioned Media and Pancreatic Juice for the Identification of Pancreatic Cancer Biomarkers

Makawita, S., Smith, C. R., Batruch, I., Zheng, Y., Rückert, F., Grützmann, R., Pilarsky, C. P., Gallinger, S., & Diamandis, E. P. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008599 · Cited by 113 · see citing works

GPR68, a proton‐sensing GPCR, mediates interaction of cancer‐associated fibroblasts and cancer cells

Wiley, S. Z., Sriram, K., Liang, W., Chang, S. E., French, R. P., McCann, T., Sicklick, J. K., Nishihara, H., Lowy, A. M., & Insel, P. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700834r · Cited by 109 · see citing works

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

Nofal, M., Zhang, K., Han, S., & Rabinowitz, J. D. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.011 · Cited by 94 · see citing works

Hexosamine pathway and (ER) protein quality control

Denzel, M. S., & Antebi, A. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.10.001 · Cited by 89 · see citing works

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion

Shanware, N. P., Bray, K., Eng, C. H., Wang, F., Follettie, M. T., Myers, J. S., Fantin, V. R., & Abraham, R. T. (2014) · Nature Communications · doi:10.1038/ncomms5900 · Cited by 86 · see citing works

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

Ratnikov, B. I., Aza‐Blanc, P., Ronai, Z. A., Smith, J. W., Osterman, A. L., & Scott, D. A. (2015) · Oncotarget · doi:10.18632/oncotarget.3132 · Cited by 80 · see citing works

SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion

Fritz, R. D., Menshykau, D., Martin, K., Reimann, A., Pontelli, V., & Pertz, O. C. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.09.002 · Cited by 76 · see citing works

Clinical Significance of Serum COL6A3 in Pancreatic Ductal Adenocarcinoma

Kang, C. Y., Wang, J., Axell‐House, D. B., Soni, P., Chu, M., Chipitsyna, G. I., Sarosiek, K., Sendecki, J. A., Hyslop, T., Zoubi, M. S. A., et al. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2326-y · Cited by 67 · see citing works

COL6A1 promotes metastasis and predicts poor prognosis in patients with pancreatic cancer

Owusu-Ansah, K. G., Song, G., Chen, R., Edoo, M. I. A., Li, J., Chen, B., Wu, J., Zhou, L., Xie, H., Jiang, D., et al. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4825 · Cited by 62 · see citing works

Macropinosome formation, maturation and membrane recycling: lessons from clathrin-independent endosomal membrane systems

Donaldson, J. G. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0148 · Cited by 43 · see citing works

Prognostic value of COL6A3 in pancreatic adenocarcinoma

Svoronos, C., Tsoulfas, G., Souvatzi, M., & Chatzitheoklitos, E. (2020) · Annals of Hepato-Biliary-Pancreatic Surgery · doi:10.14701/ahbps.2020.24.1.52 · Cited by 22 · see citing works

ER stress and hexosamine pathway during tumourigenesis: A pas de deux?

Vasseur, S., & Manié, S. N. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.04.001 · Cited by 17 · see citing works

Detection and Quantification of Macropinosomes in Pancreatic Tumors

Lee, S.-W., Alas, B. F., & Commisso, C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8879-2_16 · Cited by 17 · see citing works

Quantitation of Macropinocytosis in Cancer Cells

Galenkamp, K. M. O., Alas, B. F., & Commisso, C. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9027-6_8 · Cited by 17 · see citing works

The hallmarks of cancer metabolism: still emerging

Pavlova, N. N., Zhu, J., & Thompson, C. B. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.007 · Cited by 1,418 · see citing works

Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works

Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance

Sherman, M. H., & Beatty, G. L. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031621-024600 · Cited by 481 · see citing works

Ferroptosis: principles and significance in health and disease

Chen, F., Kang, R., Tang, D., & Liu, J. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01564-3 · Cited by 313 · see citing works

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics

Liu, Y., Sinjab, A. F., Min, J., Han, G., Paradiso, F., Zhang, Y., Wang, R., Pei, G., Dai, Y., Liu, Y., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.004 · Cited by 249 · see citing works

Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer-associated fibroblasts

Helms, E. J., Berry, M. W., Chaw, R. C., DuFort, C. C., Sun, D., Onate, M. K., Oon, C., Bhattacharyya, S., Sanford-Crane, H., Horton, W., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0601 · Cited by 238 · see citing works

Endocytosis in cancer and cancer therapy

Banushi, B., Joseph, S. R., Lum, B., Lee, J. J., & Simpson, F. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00574-6 · Cited by 245 · see citing works

Current and future immunotherapeutic approaches in pancreatic cancer treatment

Farhangnia, P., Khorramdelazad, H., Nickho, H., & Delbandi, A. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01561-6 · Cited by 247 · see citing works

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

Rimal, R., Desai, P. B., Daware, R., Hosseinnejad, A., Prakash, J., Lammers, T., & Singh, S. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114504 · Cited by 201 · see citing works

Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly

Ratto, E., Chowdhury, S., Siefert, N. S., Schneider, M., Wittmann, M., Helm, D., & Palm, W. (2022) · Nature Communications · doi:10.1038/s41467-022-32515-6 · Cited by 167 · see citing works

Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution

Zhang, F., Ma, Y., Li, D., Wei, J., Chen, K., Zhang, E., Liu, G., Chu, X., Liu, X., Liu, W., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01600-2 · Cited by 158 · see citing works

Regulation of antioxidants in cancer

Hecht, F., Zocchi, M., Alimohammadi, F., & Harris, I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.001 · Cited by 135 · see citing works

The V-ATPases in cancer and cell death

Chen, F., Kang, R., Liu, J., & Tang, D. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00477-y · Cited by 131 · see citing works

Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer

Pei, G., Min, J., Rajapakshe, K., Branchi, V., Liu, Y., Selvanesan, B. C., Thege, F. I., Sadeghian, D., Zhang, D., Cho, K. S., et al. (2025) · Nature · doi:10.1038/s41586-025-08927-x · Cited by 114 · see citing works

Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma

Byun, J., Lee, S., Kang, G. W., Lee, Y. R., Park, S. Y., Song, I., Yun, J. W., Lee, J., Choi, Y., & Park, K. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02296-3 · Cited by 112 · see citing works

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting

Vaish, U., Jain, T., Are, A. C., & Dudeja, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413408 · Cited by 94 · see citing works

Macropinocytosis: mechanisms and regulation

Salloum, G., Bresnick, A. R., & Backer, J. (2023) · Biochemical Journal · doi:10.1042/bcj20210584 · Cited by 90 · see citing works

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling

Shen, R., Liu, D., Wang, X., Guo, Z., Sun, H., Song, Y., & Wang, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.828657 · Cited by 76 · see citing works

Tumor microenvironmental nutrients, cellular responses, and cancer

Lobel, G. P., Jiang, Y., & Simon, M. C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.011 · Cited by 74 · see citing works

Exploiting cancer’s drinking problem: regulation and therapeutic potential of macropinocytosis

Puccini, J., Badgley, M. A., & Bar‐Sagi, D. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.09.004 · Cited by 67 · see citing works

The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities

Kung, H., Zheng, K., Zimmerman, J. W., & Zheng, L. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01077-z · Cited by 69 · see citing works

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

Zhong, C., Yang, J., Zhang, Y., Fan, X., Fan, Y., Hua, N., Li, D., Jin, S., Li, Y., Chen, P., et al. (2023) · Research · doi:10.34133/research.0159 · Cited by 58 · see citing works

The Role and Therapeutic Potential of Macropinocytosis in Cancer

Qiu, Z., Liu, W., Zhu, Q., Ke, K., Zhu, Q., Jin, W., Yu, S., Yang, Z., Li, L., Sun, X., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.919819 · Cited by 52 · see citing works

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Zhang, Y., Li, L., Murad, R., Maganti, S., Manceau, A., Faso, H. A., Neff, M., Galapate, C. M., Grenier, S. F., Carrette, F., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.021 · Cited by 49 · see citing works

Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis

Bae, E., Huang, P., Muller-Greven, G. M., Hambardzumyan, D., Sloan, A. E., Nowacki, A. S., Marko, N. F., Carlin, C. R., & Gladson, C. L. (2022) · Nature Communications · doi:10.1038/s41467-022-31981-2 · Cited by 48 · see citing works

Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment

Yamamoto, K., Iwadate, D., Kato, H., Nakai, Y., Tateishi, K., & Fujishiro, M. (2022) · Cancers · doi:10.3390/cancers14184351 · Cited by 48 · see citing works

Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma

Tomaszewski, W. H., Polania, J. W., Chakraborty, M. A., Perera, J., Ratiu, J. J., Hoyt-Miggelbrink, A. M., McDonnell, D. P., Khasraw, M., Ashley, D. M., Fecci, P. E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34175-y · Cited by 46 · see citing works

Exploiting macropinocytosis for drug delivery into KRAS mutant cancer

Liu, H., & Qian, F. (2022) · Theranostics · doi:10.7150/thno.67889 · Cited by 46 · see citing works

Systematic interaction of plasma albumin with the efficacy of chemotherapeutic drugs

Yu, L., Hua, Z., Luo, X., Zhao, T., & Liu, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188655 · Cited by 43 · see citing works

Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways

Lambies, G., & Commisso, C. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-94004-1_2 · Cited by 41 · see citing works

Regulation and role of CAMKK2 in prostate cancer

Pulliam, T. L., Goli, P., Awad, D., Lin, C., Wilkenfeld, S. R., & Frigo, D. E. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00588-z · Cited by 36 · see citing works

Cancer-Associated Fibroblasts: Lessons from Pancreatic Cancer

Sherman, M. H., & di Magliano, M. P. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061421-035400 · Cited by 37 · see citing works

Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment

Tanaka, H. Y., Nakazawa, T., Enomoto, A., Masamune, A., & Kano, M. R. (2023) · Cancers · doi:10.3390/cancers15030724 · Cited by 40 · see citing works

Metabolic intervention liposome for targeting glutamine-addiction of breast cancer

Wu, M., Wang, Q., Chen, S., Zhou, Z., Li, J., Sun, H., Liu, J., Wang, G., Zhou, F., & Sun, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.07.034 · Cited by 34 · see citing works

CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Chen, A., Sun, X. Y., Xiao, S., Guo, L., Shang, M., Shi, D., Meng, D., Zhao, Y., Wang, X., & Li, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01979-z · Cited by 34 · see citing works

Tumor–stromal metabolic crosstalk in pancreatic cancer

Thakur, R. K., Mullen, N. J., Mehla, K., & Singh, P. K. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2025.04.007 · Cited by 33 · see citing works

Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment

Li, X., Zhou, J., Wang, X., Li, C., Ma, Z., Wan, Q., & Fu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1152312 · Cited by 33 · see citing works

CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues

Guan, Y., Zhang, M., Song, J., Negrete, M., Adcock, T., Kandel, R., Racioppi, L., & Gerecht, S. (2025) · Advanced Science · doi:10.1002/advs.202417778 · Cited by 28 · see citing works

Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention

Muranaka, H., Akinsola, R., Billet, S., Pandol, S. J., Hendifar, A. E., Bhowmick, N. A., & Gong, J. (2024) · Cancers · doi:10.3390/cancers16051057 · Cited by 26 · see citing works

Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

Ammar, N., Hildebrandt, M., Geismann, C., Röder, C., Gemoll, T., Sebens, S., Trauzold, A., & Schäfer, H. (2023) · Antioxidants · doi:10.3390/antiox12101818 · Cited by 27 · see citing works

Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets

Chen, X., Chen, F., Jia, S., Lu, Q., & Zhao, M. F. (2025) · Theranostics · doi:10.7150/thno.104900 · Cited by 23 · see citing works

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis

Mukherjee, D., Previs, R. A., Haines, C. N., Abo, M. A., Juras, P. K., Strickland, K. C., Chakraborty, B., Artham, S., Whitaker, R. S., Hebert, K. L., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-1622 · Cited by 23 · see citing works

Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis

Puccini, J., Jia, W., Tong, L., & Bar‐Sagi, D. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213272120 · Cited by 20 · see citing works

CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy

Yamashita, K., & Kumamoto, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116003 · Cited by 20 · see citing works

Targeting macropinocytosis for cancer therapy

Tang, D., Wang, J., Kroemer, G., & Kang, R. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00892-x · Cited by 19 · see citing works

Biodistribution and therapeutic efficacy of a gold nanoparticle-based targeted drug delivery system against pancreatic cancer

Elechalawar, C. K., Gulla, S. K., Roy, R. V., Means, N., Zhang, Y., Asifa, S., Robertson, D. J., Xu, C., Bhattacharya, R., & Mukherjee, P. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216810 · Cited by 19 · see citing works

Cell polarity proteins promote macropinocytosis in response to metabolic stress

Lambies, G., Lee, S.-W., Duong‐Polk, K., Aza‐Blanc, P., Maganti, S., Galapate, C. M., Deshpande, A. J., Deshpande, A. J., Scott, D. A., Dawson, D. W., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54788-9 · Cited by 18 · see citing works

The Role of Stroma in Cancer MetabolismPreprint

Kimmelman, A. C., & Sherman, M. H. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041540 · Cited by 18 · see citing works

A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A–PPAR Axis in Pancreatic Ductal Adenocarcinoma

Pan, H., Sun, Y., Qian, L.-H., Liao, Y.-N., Gai, Y.-Z., Huo, Y., Li, Z., & Nie, H. (2023) · Research · doi:10.34133/research.0300 · Cited by 17 · see citing works

Targeting glutamine metabolism crosstalk with tumor immune response

Dong, C., Zhao, Y., Han, Y., Li, M., & Wang, G. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189257 · Cited by 20 · see citing works

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

Zhang, Y., Zou, W., Dou, W., Luo, H., & Ouyang, X. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1377329 · Cited by 16 · see citing works

The Effect of Substrate Properties on Cellular Behavior and Nanoparticle Uptake in Human Fibroblasts and Epithelial Cells

de Almeida, M. S., Lee, A., Itel, F., Maniura‐Weber, K., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2024) · Nanomaterials · doi:10.3390/nano14040342 · Cited by 16 · see citing works

Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts

Miyazaki, Y., Mori, N., Akagi, Y., Oda, T., & Kida, Y. S. (2022) · Cancers · doi:10.3390/cancers14061375 · Cited by 15 · see citing works

Signaling Pathways that Regulate Macropinocytosis in Mammalian Cells

Palm, W. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-94004-1_8 · Cited by 16 · see citing works

Macropinocytosis: Molecular mechanisms and regulation

Tu, H., Wang, H., & Cai, H. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102563 · Cited by 14 · see citing works

Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment

Rogers, L. C., Kremer, J. C., Brashears, C. B., Lin, Z., Hu, Z. S., Bastos, A. C. S., Baker, A., Fettig, N. M., Zhou, D., Shoghi, K. I., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2642 · Cited by 14 · see citing works

HOXB4 Mis-Regulation Induced by Microcystin-LR and Correlated With Immune Infiltration Is Unfavorable to Colorectal Cancer Prognosis

Wang, L., Jin, H., Zeng, Y., Tan, Y., Wang, J., Fu, W., Chen, W., Cui, K., Qiu, Z., & Zhou, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.803493 · Cited by 13 · see citing works

Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment

Arnold, F., Vecchio, A. D., Hussain, Z., & Sherman, M. H. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-025-00905-9 · Cited by 14 · see citing works

KRASG12R-Independent Macropinocytosis in Pancreatic Cancer

Hobbs, G. A., & Der, C. J. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-94004-1_11 · Cited by 12 · see citing works

SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer

Kang, H. W., Kim, J. H., Jeong, J. W., Fang, S., Yun, W., Hye-Sol, J. U. N. G., Kwon, W., Jang, J. S., Kim, H. J., & Park, J. S. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01596-w · Cited by 11 · see citing works

Pancreatic ductal adenocarcinoma cells regulated the gemcitabine‐resistance function of CAFs by LINC00460

Zhu, X., Li, J., Ni, X., Wu, X. F., Hou, X., Li, Y.-X., Li, S., Zhao, W., & Yin, X. (2022) · Cancer Science · doi:10.1111/cas.15547 · Cited by 11 · see citing works

SGC-CAMKK2-1: A Chemical Probe for CAMKK2

Wells, C. I., Liang, Y., Pulliam, T. L., Lin, C., Awad, D., Eduful, B. J., O’Byrne, S. N., Hossain, M. A., Catta‐Preta, C. M. C., Ramos, P. Z., et al. (2023) · Cells · doi:10.3390/cells12020287 · Cited by 11 · see citing works

Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation

Elechalawar, C. K., Rao, G., Gulla, S. K., Patel, M. M., Frickenstein, A. N., Means, N., Roy, R. V., Tsiokas, L., Asfa, S., Panja, P., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c00920 · Cited by 12 · see citing works

PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity

Ye, Z., Ng, C. P., Liu, H., Bao, Q., Xu, S., Zu, D., He, Y., Huang, Y., Al-Aidaroos, A. Q., Guo, K., et al. (2024) · Theranostics · doi:10.7150/thno.93127 · Cited by 10 · see citing works

Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives

Hashimoto, A., & Hashimoto, S. (2024) · Cancers · doi:10.3390/cancers16234094 · Cited by 10 · see citing works

CARMIL1-AA selectively inhibits macropinocytosis while sparing autophagy

Lim, R. M., Lu, A., Chuang, B. M., Anaraki, C., Chu, B., Halbrook, C. J., & Edinger, A. L. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-09-0434 · Cited by 9 · see citing works

Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease

Shen, Y., & Gleghorn, J. P. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10581-z · Cited by 9 · see citing works

Targeting and exploiting macropinocytosis in cancer therapy

Moon, H., Cho, B. K., Kang, S. H., Ryu, J. H., & Kwon, I. C. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113962 · Cited by 9 · see citing works

Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment

Ma, J., Bhardwaj, V., Lobie, P. E., & Pandey, V. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02620-x · Cited by 10 · see citing works

The aging tumor metabolic microenvironment

Pilley, S. E., Esparza, E., & Mullen, P. J. (2023) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2023.102995 · Cited by 9 · see citing works

Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma

Brambillasca, S., Cera, M. R., Andronache, A., Dey, S. K., Fagà, G., Fancelli, D., Frittoli, E., Pasi, M., Robusto, M., Varasi, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116991 · Cited by 12 · see citing works

Pancreatic cancer: genetics, disease progression, therapeutic resistance and treatment strategies

Singh, K., Shishodia, G., & Koul, H. K. (2021) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2021.96 · Cited by 9 · see citing works

Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth

Vieira, R. F. L., Sanchez, S. R., Arumugam, M., Mower, P. D., Curtin, M. C., Jackson, A. E., Gallop, M. R., Wright, J., Bowles, A., Ducker, G. S., et al. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00407-0 · Cited by 8 · see citing works

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

Lin, Z., Ni, C., Jiang, H., Yang, H., Deng, L., Liu, P., Li, X., Yu, Y., Li, W., Wang, R., et al. (2025) · MedComm · doi:10.1002/mco2.70362 · Cited by 8 · see citing works

Stress-adapted cancer-associated fibroblasts as mediators of immunosuppression and therapy resistance

Hu, Y., Ge, J., Xin, M., Guo, R., Wu, C., & Ma, W. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218706 · Cited by 12 · see citing works

Alcohol-induced C/EBP β-driven VIRMA decreases oxidative stress and promotes pancreatic ductal adenocarcinoma growth and metastasis via the m6A/YTHDF2/SLC43A2 pathway

Gao, L., Lv, G., Liu, Z., Tian, Y., Han, F., Li, L., Wang, G., & Zhang, Y. (2025) · Oncogene · doi:10.1038/s41388-025-03283-6 · Cited by 8 · see citing works

Inhibition of Macropinocytosis Enhances the Sensitivity of Osteosarcoma Cells to Benzethonium Chloride

Xia, H., Huang, Y., Zhang, L., Luo, L., Wang, X., Lu, Q., Xu, J., Yang, C., Jiwa, H., Liang, S., et al. (2023) · Cancers · doi:10.3390/cancers15030961 · Cited by 8 · see citing works

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Liu, R., Su, L., Gao, S., Liu, W., & Wang, H. (2026) · Advanced Science · doi:10.1002/advs.202510043 · Cited by 8 · see citing works

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

Galenkamp, K. M. O., Galapate, C. M., Zhang, Y., & Commisso, C. (2021) · Journal of Visualized Experiments · doi:10.3791/62828 · Cited by 7 · see citing works

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

Burge, R. A., Bialousow, L., Linke, A. J., Coalson, H. S., Adair, S. J., Sundararaj, K. P., Smith, M., Bumbleburg, C., Bauer, T. W., Kashatus, D. F., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4501 · Cited by 6 · see citing works

Transgelin defines pro-tumorigenic cancer-associated fibroblasts in pancreatic cancer

Wang, X., Shinjo, K., Kumegawa, K., Maruyama, R., Mii, S., Shiraki, Y., Nishimura, T., Murofushi, Y., Suzuki, M., Kabasawa, T., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03299-5 · Cited by 7 · see citing works

High antigen-presenting CAF levels correlate with reduced glycosaminoglycan biosynthesis-heparan sulfate/heparin metabolism in immune cells and poor prognosis in esophageal squamous cell carcinoma: Insights from bulk and single-cell transcriptome profiling

Wang, S., Van, K. V., Zheng, M., Chen, W., & Ma, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140418 · Cited by 5 · see citing works

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancerPreprint

Zhang, Y., Li, L., Maganti, S., Hope, J. L., Galapate, C. M., Carrette, F., Duong‐Polk, K., Bagchi, A., Scott, D. A., Lowy, A. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.625709 · Cited by 5 · see citing works

A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populationsPreprint

Bernard, V., Ku, L.-T., Wang, T., Acevedo-Diaz, A., Rajapakshe, K., Jacobson, G., Tovar, D., Min, J., Pei, G., Tat, C. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.20.660757 · Cited by 5 · see citing works

Catabolic rewiring in cancer impacts dietary interventions

Chinopoulos, C. (2025) · Communications Biology · doi:10.1038/s42003-025-09333-9 · Cited by 5 · see citing works

Spatiotemporal Blockade of Autophagy and Macropinocytosis in Pancreatic Cancer via Lysosomal‐Activated Nanoreactors

Lu, Y., Zu, Z., Zhong, N., Li, Y., Sha, X., Lu, S.-F., Zhang, J., Sun, H., Luo, X., Xu, Z., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202502220 · Cited by 3 · see citing works

Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies

Li, Z., Deng, J., Wang, H., Liu, T., Zhou, Y., Ouyang, P., Liang, X., Zhang, X., Qi, S., & Li, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101834 · Cited by 3 · see citing works

p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis

Nishiyama, T., Tazawa, H., Nagai, Y., Shoji, R., Kajiwara, Y., Hashimoto, N., Takahashi, Y., Kikuchi, S., Kuroda, S., Ohara, T., et al. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00989-3 · Cited by 3 · see citing works

Kinome state is predictive of cell viability in pancreatic cancer tumor and cancer-associated fibroblast cell lines

Berginski, M. E., Jenner, M. R., Joisa, C. U., Loeza, G. H., Golitz, B. T., Lipner, M. B., Leary, J. R., Rashid, N., Johnson, G. L., Yeh, J. J., et al. (2024) · PeerJ · doi:10.7717/peerj.17797 · Cited by 3 · see citing works

Ca 2+ /Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasisPreprint

Mukherjee, D., Previs, R. A., Haines, C. N., Abo, M. A., Juras, P. K., Strickland, K. C., Chakraborty, B., Artham, S., Whitaker, R. S., Hebert, K. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.17.536051 · Cited by 3 · see citing works

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Curvello, R., Hauser, S., Seifert, M., Barlow, C. K., Steele, J. R., Salisbury, E., Croagh, D. G., Stok, K. S., Taubenberger, A. V., Schittenhelm, R. B., et al. (2026) · Advanced Science · doi:10.1002/advs.202516578 · Cited by 4 · see citing works

Metabolic reprogramming in tumor-associated cells of hematologic malignancies: mechanisms, crosstalk networks, and therapeutic implications in the tumor microenvironment

Hong, Z., Wu, Y., Liu, W., Li, D., & Xu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1773233 · Cited by 2 · see citing works

Targeting aberrant amino acid metabolism for pancreatic cancer therapy: Opportunities for nanoparticles

Zang, X., Lei, K., Wang, J., Gong, R., Gao, C., Jing, Z., Song, J., & Ren, H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155071 · Cited by 2 · see citing works

Nutrient Scavenging From Muscle Cells: A Survival Strategy of Pancreatic Cancer Cells Ends in Cachexia

Regel, I., & Mayerle, J. V. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.07.069 · Cited by 2 · see citing works

Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities

Ballarò, R., Penna, F., & Beltrà, M. (2025) · International review of cytology · doi:10.1016/bs.ircmb.2025.08.008 · Cited by 1 · see citing works

Macropinocytosis inhibition attenuates profibrotic responses in lung fibroblasts and pulmonary fibrosis models

Rosas, I. O., McDowell-Sanchez, A. K., Sanchez, S., Cala-García, J., Cohen, A. R. W., Ruiz-Echartea, E., Ochsner, S. A., Kraushaar, D. C., Celada, L. J., Sun, D., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci197651 · Cited by 1 · see citing works

The CAMK protein family: Pivotal roles in calcium-dependent disease pathways and emerging therapeutic strategies

Fu, R., Wang, Y., Wang, W., Song, Q., Zhang, H., & Yang, L. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112557 · Cited by 1 · see citing works

Copper-driven nanoadjuvant reverses immunosuppression in colorectal cancer by orchestrating metabolic dysfunction and innate immune activation

Zhang, Y., Huang, Y., Liu, S., Tian, H., Chang, Q., Zhang, T., Yan, F., Ye, Q., Huang, C., & Xie, N. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.177486 · Cited by 1 · see citing works

Size switchable nanomodulator achieving ratio-precise dual-drug codelivery for synergistic glutamine metabolism modulation in pancreatic cancer

Fan, H., Li, X., Song, H., Zhang, S., Tian, Z., Chen, Y., Zhou, J., Geng, S., Liu, H., Wang, Y., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124406 · Cited by 1 · see citing works

Insights into the molecular regulatory mechanisms of tumor macropinocytosis

Wang, C., Yuan, Z., Lin, B., Meng, Z., Jin, Z., Yang, F., & Su, H. (2025) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-1391 · Cited by 1 · see citing works

Abstract PO-130: Macropinocytosis at the nexus of crosstalk in the pancreatic tumor microenvironment

Zhang, Y., Recouvreux, M. V., Jung, M., Galencamp, K., Li, Y., Zagnitko, O. P., Scott, D. A., Lowy, A. M., & Commisso, C. (2021) · Cancer Research · doi:10.1158/1538-7445.panca21-po-130

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Zhang, Y., Li, L., Murad, R., Maganti, S., Manceau, A., Faso, H. A., Neff, M., Galapate, C. M., Grenier, S. F., Carrette, F., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.021 · Cited by 49 · see citing works

Abstract 3155: Metabolic stress induces an intrinsic inflammatory CAF phenotype that regulates stromal architecture in pancreatic cancer

Zhang, Y., Maganti, S., Hope, J. L., Li, L., Galapate, C. M., Carrette, F., Bradley, L. M., & Commisso, C. (2024) · Cancer Research · doi:10.1158/1538-7445.am2024-3155

EGFR-Pak signaling selectively regulates glutamine deprivation-induced macropinocytosis

Lee, S.-W., Zhang, Y., Jung, M., Cruz, N., Alas, B., & Commisso, C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.05.043 · Cited by 172 · see citing works

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancerPreprint

Zhang, Y., Li, L., Maganti, S., Hope, J. L., Galapate, C. M., Carrette, F., Duong‐Polk, K., Bagchi, A., Scott, D. A., Lowy, A. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.625709 · Cited by 5 · see citing works