The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
The effects of Δ9-tetrahydrocannabinol on the dopamine system
Open accessAbstract
The effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health. Patterns of cannabis use are changing drastically owing to legalization, the availability of synthetic analogues (commonly termed spice), cannavaping and an emphasis on the purported therapeutic effects of cannabis. Many of the reinforcing effects of THC are mediated by the dopamine system. Owing to the complexity of the cannabinoid–dopamine interactions that take place, there is conflicting evidence from human and animal studies concerning the effects of THC on the dopamine system. Acute THC administration causes increased dopamine release and neuron activity, whereas long-term use is associated with blunting of the dopamine system. Future research must examine the long-term and developmental dopaminergic effects of THC.
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Cites
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D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
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Apathy and the Functional Anatomy of the Prefrontal Cortex–Basal Ganglia Circuits
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Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
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Self-citationEffects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
Volkow, N. D., Swanson, J. M., Evins, A. E., DeLisi, L. E., Meier, M. H., Gonzalez, R., Bloomfield, M. A. P., Curran, H. V., & Baler, R. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.3278 · Cited by 867
Self-citationRegional and cellular fractionation of working memory
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Cited by
The Neuroscience of Drug Reward and Addiction
Volkow, N. D., Michaelides, M., & Baler, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00014.2018 · Cited by 863
Self-citationCannabis use and cannabis use disorder
Connor, J. P., Stjepanović, D., Le Foll, B., Hoch, E., Budney, A. J., & Hall, W. D. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00247-4 · Cited by 552
One Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351
Metadata
- Authors
- Bloomfield, M. A. P., Ashok, A. H., Volkow, N. D., & Howes, O. D.
- Venue
- Nature
- Published
- 2016-11
- Volume
- 539
- Issue
- 7629
- Pages
- 369-377
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2554987321
- Cited by
- 373
- References
- 124
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
