The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Integrated genomic characterization of oesophageal carcinoma
Open accessAbstract
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.
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Comprehensive molecular characterization of human colon and rectal cancer
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Comprehensive molecular characterization of gastric adenocarcinoma
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Mutational heterogeneity in cancer and the search for new cancer-associated genes
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Self-citationmiRBase: annotating high confidence microRNAs using deep sequencing data
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Comprehensive genomic characterization of squamous cell lung cancers
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Pan-cancer analysis of whole genomes
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Conserved pan-cancer microenvironment subtypes predict response to immunotherapy
Bagaev, A., Kotlov, N., Nomie, K., Svekolkin, V., Gafurov, A., Isaeva, O., Osokin, N., Kozlov, I., Frenkel, F., Gancharova, O., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.04.014 · Cited by 1,302
Metadata
- Authors
- The Cancer Genome Atlas Research Network
- Venue
- Nature
- Published
- 2017-01
- Volume
- 541
- Issue
- 7636
- Pages
- 169-175
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2570401594
- Cited by
- 1,821
- References
- 10
- FWCI
- 191.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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