IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

The structure of the nervous system of the nematode <i>Caenorhabditis elegans</i>

White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · see citing works

Structure and signalling in the IL-17 receptor family

Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475 · see citing works

Functional Specialization of Interleukin-17 Family Members

Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.012 · Cited by 1,289 · see citing works

The neural circuit for touch sensitivity in Caenorhabditis elegans

Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093 · see citing works

Expanded dynamic range of fluorescent indicators for Ca ²⁺ by circularly permuted yellow fluorescent proteins

Nagai, T., Yamada, S., Tominaga, T., Ichikawa, M., & Miyawaki, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400417101 · Cited by 1,030 · see citing works

Neuromodulation of neuronal circuits: back to the future

Marder, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.010 · Cited by 904 · see citing works

Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. elegans

de Bono, M., & Bargmann, C. I. (1998) · Cell · doi:10.1016/s0092-8674(00)81609-8 · Cited by 819 · see citing works

Neuromodulation of Brain States

Lee, S., & Dan, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.012 · Cited by 666 · see citing works

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease

Qian, Y., Liu, C., Hartupee, J., Altuntas, C. Z., Gulen, M. F., Jane-wit, D., Xiao, J., Lu, Y., Giltiay, N., Liu, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1439 · Cited by 614 · see citing works

Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans

Chronis, N., Zimmer, M., & Bargmann, C. I. (2007) · Nature Methods · doi:10.1038/nmeth1075 · Cited by 596 · see citing works

Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue

Gray, J. M., Karow, D. S., Lu, H., Chang, A. J., Chang, J. S., Ellis, R. E., Marletta, M. A., & Bargmann, C. I. (2004) · Nature · doi:10.1038/nature02714 · Cited by 591 · see citing works

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding

Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548 · see citing works

Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search

Root, C. M., Ko, K. I., Jafari, A., & Wang, J. W. (2011) · Cell · doi:10.1016/j.cell.2011.02.008 · Cited by 526 · see citing works

A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans

Macosko, E. Z., Pokala, N., Feinberg, E. H., Chalasani, S. H., Butcher, R. A., Clardy, J., & Bargmann, C. I. (2009) · Nature · doi:10.1038/nature07886 · Cited by 475 · see citing works

A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans.

Pujol, N., Link, E. M., Liu, L. X., Kurz, C., Alloing, G., Tan, M.-W., Ray, K. P., Solari, R. C. E., Johnson, C. D., & Ewbank, J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00241-x · Cited by 455 · see citing works

Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila

Cohn, R., Morantte, I., & Ruta, V. (2015) · Cell · doi:10.1016/j.cell.2015.11.019 · Cited by 430 · see citing works

Identification of a Targeting Factor for Posttranslational Membrane Protein Insertion into the ER

Stefanovic, S., & Hegde, R. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.036 · Cited by 406 · see citing works

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon

Frøkjær‐Jensen, C., Davis, M. W., Sarov, M., Taylor, J. C., Flibotte, S., LaBella, M. L., Pozniakovsky, A., Moerman, D. G., & Jørgensen, E. M. (2014) · Nature Methods · doi:10.1038/nmeth.2889 · Cited by 357 · see citing works

Small-molecule pheromones that control dauer development in Caenorhabditis elegans

Butcher, R. A., Fujita, M., Schroeder, F. C., & Clardy, J. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.3 · Cited by 346 · see citing works

Expression and regulation of an FMRFamide‐related neuropeptide gene family in Caenorhabditis elegans

Kim, K., & Li, C. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20189 · Cited by 294 · see citing works

Genetic Analysis of Endocytosis in Caenorhabditis elegans: Coelomocyte Uptake Defective Mutants

Fares, H., & Greenwald, I. (2001) · Genetics · doi:10.1093/genetics/159.1.133 · Cited by 285 · see citing works

Recent advances in the IL-17 cytokine family

Gaffen, S. L. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.006 · Cited by 283 · see citing works

Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli

de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002) · Nature · doi:10.1038/nature01169 · Cited by 279 · see citing works

A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei

Yamazaki, S., Muta, T., & Takeshige, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103426200 · Cited by 277 · see citing works

The STIR-domain superfamily in signal transduction, development and immunity

Novatchkova, M., Leibbrandt, A., Werzowa, J., Neubüser, A., & Eisenhaber, F. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00067-7 · Cited by 255 · see citing works

Olfactory learning skews mushroom body output pathways to steer behavioral choice in Drosophila

Owald, D., & Waddell, S. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.10.002 · Cited by 251 · see citing works

Experience-Dependent Modulation of C. elegans Behavior by Ambient Oxygen

Cheung, B. H. H., Cohen, M., Rogers, C. M., Albayram, Ö., & de Bono, M. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.017 · Cited by 216 · see citing works

Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans

Coates, J. C., & de Bono, M. (2002) · Nature · doi:10.1038/nature01170 · Cited by 198 · see citing works

Structural basis of receptor sharing by interleukin 17 cytokines

Ely, L. K., Fischer, S., & Garcia, K. C. (2009) · Nature Immunology · doi:10.1038/ni.1813 · Cited by 195 · see citing works

Behavioral avoidance of pathogenic bacteria by Caenorhabditis elegans

Meisel, J. D., & Kim, D. H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.08.008 · Cited by 181 · see citing works

A Toolkit and Robust Pipeline for the Generation of Fosmid-Based Reporter Genes in C. elegans

Tursun, B., Cochella, L., Carrera, I., & Hobert, O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004625 · Cited by 166 · see citing works

A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components

Butcher, R. A., Ragains, J. R., Kim, E., & Clardy, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806676105 · Cited by 156 · see citing works

MAIL, a novel nuclear IκB protein that potentiates LPS‐induced IL‐6 production

Kitamura, H., Kanehira, K., Okita, K., Morimatsu, M., & Saito, M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02185-2 · Cited by 153 · see citing works

Induction of Neutrophil Gelatinase-associated Lipocalin Expression by Co-stimulation with Interleukin-17 and Tumor Necrosis Factor-α Is Controlled by IκB-ζ but neither by C/EBP-β nor C/EBP-δ

Karlsen, J. R., Borregaard, N., & Cowland, J. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017129 · Cited by 146 · see citing works

Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination

Chen, C., Fenk, L. A., & de Bono, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt805 · Cited by 141 · see citing works

Neuromodulatory State and Sex Specify Alternative Behaviors through Antagonistic Synaptic Pathways in C. elegans

Jang, H., Kim, K., Neal, S. J., Macosko, E. Z., Kim, D., Butcher, R. A., Zeiger, D. M., Bargmann, C. I., & Sengupta, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.034 · Cited by 140 · see citing works

Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

Persson, A., Gross, E., Laurent, P., Busch, K. E., Bretes, H., & de Bono, M. (2009) · Nature · doi:10.1038/nature07820 · Cited by 136 · see citing works

Behavioral Motifs and Neural Pathways Coordinating O2 Responses and Aggregation in C. elegans

Rogers, C. M., Persson, A., Cheung, B. H. H., & de Bono, M. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.023 · Cited by 129 · see citing works

Tonic signaling from O2 sensors sets neural circuit activity and behavioral state

Busch, K. E., Laurent, P., Soltész, Z., Murphy, R. J., Faivre, O., Hedwig, B., Thomas, M. V., Smith, H., & de Bono, M. (2012) · Nature Neuroscience · doi:10.1038/nn.3061 · Cited by 120 · see citing works

Isolation of a Novel Interleukin-1-inducible Nuclear Protein Bearing Ankyrin-repeat Motifs

Haruta, H., Kato, A., & Todokoro, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100075200 · Cited by 108 · see citing works

Requirements for Two Proximal NF-κB Binding Sites and IκB-ζ in IL-17A-induced Human β-Defensin 2 Expression by Conducting Airway Epithelium

Kao, C., Kim, C., Huang, F., & Wu, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708289200 · Cited by 80 · see citing works

Decoding a neural circuit controlling global animal state in C. elegans

Laurent, P., Soltész, Z., Nelson, G. M., Chen, C., Arellano‐Carbajal, F., Levy, E. D., & de Bono, M. (2015) · eLife · doi:10.7554/elife.04241 · Cited by 75 · see citing works

An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism

Chen, C., Itakura, E., Weber, K. P., Hegde, R. S., & de Bono, M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004082 · Cited by 58 · see citing works

Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila

Su, C.-Y., & Wang, J. W. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.04.008 · Cited by 47 · see citing works

Evolution of Vertebrate Immunity: Sequence and Functional Analysis of the SEFIR Domain Family Member Act1

Ryzhakov, G., Blazek, K. D., & Udalova, I. A. (2011) · Journal of Molecular Evolution · doi:10.1007/s00239-011-9450-7 · Cited by 22 · see citing works

Editorial overview: Neuromodulation: Tuning the properties of neurons, networks and behavior

McCormick, D. A., & Nusbaum, M. P. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.10.010 · Cited by 18 · see citing works

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

Schneider, C., O’Leary, C. E., von Moltke, J., Liang, H.-E., Ang, Q. Y., Turnbaugh, P. J., Radhakrishnan, S., Pellizzon, M., Ma, A., & Locksley, R. M. (2018) · Cell · doi:10.1016/j.cell.2018.05.014 · Cited by 478 · see citing works

The Meningeal Lymphatic System: A New Player in Neurophysiology

Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479 · see citing works

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0776-4 · Cited by 416 · see citing works

Neuromodulation by the immune system: a focus on cytokines

Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348 · see citing works

Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory

Ribeiro, M., Brigas, H. C., Temido-Ferreira, M., Pousinha, P. A., Regen, T., Santa, C., Coelho, J. E., Marques-Morgado, I., Valente, C. A., Omenetti, S., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aay5199 · Cited by 335 · see citing works

Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

Leonardi, I., Gao, I. H., Lin, W.-Y., Allen, M., Li, X. V., Fiers, W. D., De Celie, M. B., Putzel, G. G., Yantiss, R. K., Johncilla, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.017 · Cited by 307 · see citing works

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

Reed, M. D., Yim, Y. S., Wimmer, R. D., Kim, H., Ryu, C., Welch, G. M., Andina, M., King, H. O., Waisman, A., Halassa, M. M., et al. (2020) · Nature · doi:10.1038/s41586-019-1843-6 · Cited by 274 · see citing works

Immune cells and CNS physiology: Microglia and beyond

Norris, G. T., & Kipnis, J. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180199 · Cited by 274 · see citing works

IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease

Brigas, H. C., Ribeiro, M. A., Coelho, J. E., Gomes, R., Gómez‐Murcia, V., Carvalho, K., Faivre, É., Costa-Pereira, S., Darrigues, J., de Almeida, A. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109574 · Cited by 232 · see citing works

Neuroimmune circuits in inter-organ communication

Huh, J. R., & Veiga‐Fernandes, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0247-z · Cited by 216 · see citing works

Th17 cells in depression

Beurel, E., & Lowell, J. A. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.08.001 · Cited by 187 · see citing works

Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy

Luo, H., Liu, H.-Z., Zhang, W., Matsuda, M., Lü, N., Chen, G., Xu, Z., & Zhang, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.085 · Cited by 163 · see citing works

Beyond the gut: decoding the gut–immune–brain axis in health and disease

Park, J. C., Chang, L., Kwon, H.-K., & Im, S.-H. (2025) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-025-01333-3 · Cited by 149 · see citing works

Immunity to the microbiota promotes sensory neuron regeneration

Enamorado, M., Kulalert, W., Han, S., Rao, I., Delaleu, J., Link, V. M., Yong, D., Smelkinson, M. G., Gil, L., Nakajima, S., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.037 · Cited by 142 · see citing works

The immune system and psychiatric disease: a basic science perspective

Bennett, F. C., & Molofsky, A. V. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13334 · Cited by 133 · see citing works

General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems

Svensson, E., Apergis‐Schoute, J., Burnstock, G., Nusbaum, M. P., Parker, D., & Schiöth, H. B. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00117 · Cited by 128 · see citing works

Why Innate Lymphoid Cells?

Kotas, M. E., & Locksley, R. M. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.002 · Cited by 116 · see citing works

GABAergic neuronal IL-4R mediates T cell effect on memory

Herz, J., Fu, Z., Kim, K., Dykstra, T., Wall, M. K., Li, H., Salvador, A. F., Zou, B., Yan, N., Blackburn, S. M., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.10.022 · Cited by 109 · see citing works

The long and the short of it – a perspective on peptidergic regulation of circuits and behaviour

Jékely, G., Melzer, S., Beets, I., Kadow, I. C. G., Koene, J. M., Haddad, S., & Holden-Dye, L. M. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.166710 · Cited by 102 · see citing works

Cutting Edge: Critical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of Autism

Lammert, C. R., Frost, E. L., Bolte, A. C., Paysour, M. J., Shaw, M. E., Bellinger, C. E., Weigel, T. K., Zunder, E. R., & Lukens, J. R. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701755 · Cited by 105 · see citing works

Innate immunity in C. elegans

Martineau, C. N., Kirienko, N. V., & Pujol, N. (2021) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.12.007 · Cited by 101 · see citing works

A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

Imambocus, B. N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F. M., Hu, C., Sauter, K., Varela, E. M., Herédia, F., Casimiro, A. P., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.10.069 · Cited by 94 · see citing works

Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

Filippo, M. D., Mancini, A., Bellingacci, L., Gaetani, L., Mazzocchetti, P., Zelante, T., Barbera, L. L., LUCA, A. D., Tantucci, M., Tozzi, A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110094 · Cited by 93 · see citing works

Social anxiety disorder-associated gut microbiota increases social fear

Ritz, N. L., Brocka, M., Butler, M., Cowan, C. S. M., Barrera-Bugueño, C., Turkington, C. J. R., Draper, L. A., Bastiaanssen, T. F. S., Turpin, V., Morales, L., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2308706120 · Cited by 72 · see citing works

Antimicrobial peptides modulate long-term memory

Barajas-Azpeleta, R., Wu, J., Gill, J. S., Welte, R., Seidel, C. W., McKinney, S., Dissel, S., & Si, K. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007440 · Cited by 69 · see citing works

IL-17 induces macrophages to M2-like phenotype via NF-κB

Shen, J., Sun, X., Pan, B., Cao, S., Cao, J., Che, D., Liu, F., Zhang, S., & Yu, Y. (2018) · Cancer Management and Research · doi:10.2147/cmar.s174899 · Cited by 67 · see citing works

Type 2 immunity in the brain and brain borders

Mamuladze, T., & Kipnis, J. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01043-8 · Cited by 65 · see citing works

Immune system: The “seventh sense”

Kipnis, J. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172295 · Cited by 63 · see citing works

Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation

Peng, T., Chanthaphavong, R. S., Sun, S., Trigilio, J. A., Phasouk, K., Jin, L., Layton, E. D., Li, A. Z., Correnti, C. E., De van der Schueren, W., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20160581 · Cited by 60 · see citing works

Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?

Kunz, N., & Kemper, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629986 · Cited by 61 · see citing works

Multimodal sensory processing in Caenorhabditis elegans

Metaxakis, A., Petratou, D., & Tavernarakis, N. (2018) · Open Biology · doi:10.1098/rsob.180049 · Cited by 58 · see citing works

Interleukin 17A in atherosclerosis – Regulation and pathophysiologic effector function

Nordlohne, J., & von Vietinghoff, S. (2017) · Cytokine · doi:10.1016/j.cyto.2017.06.016 · Cited by 55 · see citing works

Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit

Watteyne, J., Peymen, K., der Auwera, P. V., Borghgraef, C., Vandewyer, E., Damme, S. V., Rutten, I., Lammertyn, J., Jelier, R., Schoofs, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15964-9 · Cited by 52 · see citing works

Interleukin-17 as a key player in neuroimmunometabolism

Douglas, A., Stevens, B., & Lynch, L. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00846-3 · Cited by 49 · see citing works

The central nervous system: privileged by immune connections

Kipnis, J., & Filiano, A. J. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.152 · Cited by 48 · see citing works

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

Flynn, S. M., Chen, C., Artan, M., Barratt, S., Crisp, A., Nelson, G. M., Peak‐Chew, S., Begum, F., Skehel, M. J., & de Bono, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15872-y · Cited by 47 · see citing works

Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior

McLachlan, I. G., Kramer, T. S., Dua, M., DiLoreto, E. M., Gomes, M. A., Dag, U., Srinivasan, J., & Flavell, S. W. (2022) · eLife · doi:10.7554/elife.79557 · Cited by 47 · see citing works

Immunosurveillance of Candida albicans commensalism by the adaptive immune system

Swidergall, M., & LeibundGut‐Landmann, S. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00536-5 · Cited by 47 · see citing works

The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology

Amoriello, R., Memo, C., Ballerini, L., & Ballerini, C. (2024) · Molecular Brain · doi:10.1186/s13041-024-01077-7 · Cited by 45 · see citing works

Memory of recent oxygen experience switches pheromone valence in Caenorhabditis elegans

Fenk, L. A., & de Bono, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618934114 · Cited by 41 · see citing works

Dynamic functional connectivity in the static connectome of Caenorhabditis elegans

Flavell, S. W., & Gordus, A. G. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.12.002 · Cited by 34 · see citing works

Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB

Lee, Y., Ishikawa, T., Lee, H., Lee, B., Ryu, C., Mejia, I. D., Kim, M., Lu, G., Hong, Y., Feng, M., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.006 · Cited by 38 · see citing works

Cytokines, synaptic plasticity and network dynamics: a matter of balance

Bellingacci, L., Canonichesi, J., Mancini, A., Parnetti, L., & Filippo, M. D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371344 · Cited by 37 · see citing works

Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis Induces Bone Loss-Correlated Alzheimer’s Disease-Like Pathologies in Middle-Aged Mice

Gu, Y., Wu, Z., Zeng, F., Jiang, M., Teeling, J. L., Ni, J., & Takahashi, I. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200689 · Cited by 35 · see citing works

How Bacteria Impact Host Nervous System and Behaviors: Lessons from Flies and Worms

Masuzzo, A., Montanari, M., Kurz, C. L., & Royet, J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.007 · Cited by 35 · see citing works

Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction

Mancini, A., Ghiglieri, V., Parnetti, L., Calabresi, P., & Filippo, M. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.644294 · Cited by 37 · see citing works

Why inflammation and the activities of the immune system matter for social and personality psychology (and not only for those who study health)

Gassen, J., & Hill, S. E. (2019) · Social and Personality Psychology Compass · doi:10.1111/spc3.12471 · Cited by 30 · see citing works

Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling

Pande, S., Yang, X., & Friesel, R. E. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-020-00695-7 · Cited by 30 · see citing works

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity

Cortez, V. S., Viragova, S., Koga, S., Liu, M., O’Leary, C. E., Ricardo-González, R. R., Schroeder, A., Kochhar, N. P., Vaka, D., Boffelli, D., et al. (2025) · Cell · doi:10.1016/j.cell.2025.08.017 · Cited by 29 · see citing works

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

Steel, N., Faniyi, A. A., Rahman, S., Swietlik, S., Czajkowska, B. I., Chan, B. T., Hardgrave, A., Steel, A., Sparwasser, T. D., Assas, M. B., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007657 · Cited by 29 · see citing works

Exploring the Association between Monoclonal Antibodies and Depression and Suicidal Ideation and Behavior: A VigiBase Study

Minnema, L. A., Giezen, T. J., Souverein, P. C., Egberts, T. C. G., Leufkens, H. G. M., & Gardarsdóttir, H. (2019) · Drug Safety · doi:10.1007/s40264-018-00789-9 · Cited by 28 · see citing works

Lead (Pb) exposure exacerbates behavioral and immune abnormalities by upregulating Th17 and NF-κB-related signaling in BTBR T+ Itpr3tf/J autistic mouse model

Almutairi, M. M., Nadeem, A., Ansari, M. A., Bakheet, S. A., Attia, S. M., Albekairi, T. H., Alhosaini, K. A., Algahtani, M., Alsaad, A. M. S., Al‐Mazroua, H. A., et al. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.06.007 · Cited by 26 · see citing works

Granulocyte Colony Stimulating Factor Enhances Reward Learning through Potentiation of Mesolimbic Dopamine System Function

Kutlu, M. G., Brady, L. J., Peck, E. G., Hofford, R. S., Yorgason, J., Siciliano, C. A., Kiraly, D. D., & Calipari, E. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1116-18.2018 · Cited by 23 · see citing works

Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19

Mancini, M., Natoli, S., Gardoni, F., Luca, M. D., & Pisani, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065618 · Cited by 24 · see citing works

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Williams, P., Zahratka, J. A., Rodenbeck, M., Wanamaker, J., Linzie, H., & Bamber, B. A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1908-17.2018 · Cited by 24 · see citing works

Microbial adaptive pathogenicity strategies to the host inflammatory environment

Hitzler, S. U. J., Fernández-Fernández, C., Montaño, D. E., Dietschmann, A., & Gresnigt, M. S. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae032 · Cited by 23 · see citing works

Neuromodulators: an essential part of survival

Alcedo, J., & Prahlad, V. (2020) · Journal of Neurogenetics · doi:10.1080/01677063.2020.1839066 · Cited by 22 · see citing works

One messenger shared by two systems: How cytokines directly modulate neurons

Yang, L., Huh, J. R., & Choi, G. B. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102708 · Cited by 22 · see citing works

IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway

Sun, D., Li, W., Ding, D., Tan, K., Ding, W., Wang, Z., Fu, S., Hou, G., Zhou, W., & Gu, F. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01995-4 · Cited by 20 · see citing works

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

Brena, D., Bertran, J., Porta-de-la-Riva, M., Guillén, Y., Cornes, E., Kukhtar, D., Campos-Vicens, L., Fernández, L., Pecharromán, I., López, A. G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73146-5 · Cited by 19 · see citing works

Brain interleukins and Alzheimer’s disease

Abdelhamed, H. G., Hassan, A. A., Sakraan, A., Al-Deeb, R. T., Mousa, D. M., Ezz, H. S. A., Noor, N. A., Khadrawy, Y. A., & Radwan, N. M. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01538-5 · Cited by 20 · see citing works

Maternal and Adult Interleukin-17A Exposure and Autism Spectrum Disorder

Fujitani, M., Miyajima, H., Otani, Y., & Liu, X. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.836181 · Cited by 20 · see citing works

Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation

Wu, Y., Zhu, J., Liu, H., & Liu, H. (2021) · Aging · doi:10.18632/aging.202704 · Cited by 17 · see citing works

Effects on peripheral and central nervous system of key inflammatory intercellular signalling peptides and proteins in psoriasis

Tang, J., Zhao, S., Shi, H., Li, X., Ran, L., Cao, J., & He, Y. (2024) · Experimental Dermatology · doi:10.1111/exd.15104 · Cited by 17 · see citing works

Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice

Liu, H., Lv, X., Zhao, X., Yi, L., Lü, N., Xu, W., & Zhang, Y. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.09.016 · Cited by 15 · see citing works

The histamine-4 receptor antagonist JNJ7777120 prevents immune abnormalities by inhibiting RORγt/T-bet transcription factor signaling pathways in BTBR T+ Itpr3tf/J mice exposed to gamma rays

Ahmad, S. F., Nadeem, A., Ansari, M. A., Bakheet, S. A., Al‐Mazroua, H. A., Khan, M. R., Alasmari, A. F., Alanazi, W. A., Sobeai, H. M. A., & Attia, S. M. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.09.007 · Cited by 15 · see citing works

Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response

Sinnige, T., Ciryam, P. S., Casford, S., Dobson, C. M., de Bono, M., & Vendruscolo, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217746 · Cited by 14 · see citing works

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Alvero, A. B., Fox, A. L., Madina, B. R., Krady, M. M., Gogoi, R. P., Chehade, H., Nakaar, V., Almassian, B., Yarovinsky, T. O., Rutherford, T., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0127 · Cited by 13 · see citing works

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Dou, Y., You, J., Wang, J., Li, X., Lin, Y., Liu, B., & Ma, L. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.70092 · Cited by 12 · see citing works

Philosophy of Immunology

Pradeu, T. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108616706 · Cited by 73 · see citing works

Interleukin-17: A Social Cytokine

Hoogenraad, C. C., & Riol‐Blanco, L. (2020) · Cell · doi:10.1016/j.cell.2020.03.060 · Cited by 12 · see citing works

Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53

Godthi, A., Min, S., Das, S., Cruz-Corchado, J., Deonarine, A., Misel‐Wuchter, K., Issuree, P. D. A., & Prahlad, V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315248121 · Cited by 11 · see citing works

Discrete escape responses are generated by neuropeptide-mediated circuit logicPreprint

Imambocus, B. N., Wittich, A., Tenedini, F. M., Zhou, F., Hu, C., Sauter, K., Varela, E. M., Herédia, F., Casimiro, A. P., Macedo, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.22.307033 · Cited by 12 · see citing works

The IL-17 pathway intertwines with neurotrophin and TLR/IL-1R pathways since its domain shuffling origin

Chen, S., Fan, H., Ran, C., Hong, Y., Feng, H., Yue, Z., Zhang, H., Pontarotti, P., Xu, A., & Huang, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400903121 · Cited by 11 · see citing works

Neuronal calmodulin levels are controlled by CAMTA transcription factors

Vuong-Brender, T. T. K., Flynn, S. M., Vallis, Y., Sönmez, S. E., & de Bono, M. (2021) · eLife · doi:10.7554/elife.68238 · Cited by 11 · see citing works

Role of interleukin 17 (IL-17) in the inflammatory hypothesis of depression

Bliźniewska-Kowalska, K. M., Halaris, A. E., Gałecki, P., & Gałecka, M. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100610 · Cited by 11 · see citing works

Kunkel Lecture: Fundamental immunodeficiency and its correction

Nathan, C. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170637 · Cited by 11 · see citing works

An Interleukin-17 Isoform from Thick Shell Mussel Mytilus coruscus Serves as a Mediator of Inflammatory Response

Zhao, J., Dong, Z., Zhu, L. X., Song, W., & Qi, P. (2023) · Molecules · doi:10.3390/molecules28041806 · Cited by 9 · see citing works

Molecular characterization and expression of twenty interleukin-17 transcripts in the common Chinese cuttlefish (Sepiella japonica) in response to Vibrio harveyi infection

Zhou, X., Fang, P.-X., Cao, H., Xie, J., Li, S., & Chi, C. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108903 · Cited by 9 · see citing works

The role of interleukin-17 in neurological disorders

Park, S. E., Ferreira, A. F. F., Kwon, H., Yu, J., Diniz, L., Ulrich, H., Britto, L. R. G., & Kim, E. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2510994 · Cited by 8 · see citing works

Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A

Delaleu, J., Burstein, V. L., Ansaldo, E., Beccacece, I., Nagai, M., Bouladoux, N. J., Corral, D., Zamora, A. M., Ayash, A., Smelkinson, M. G., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2525146122 · Cited by 7 · see citing works

Approaches to studying the developmental switch of Strongyloides – Moving beyond the dauer hypothesis

Viney, M., & Morris, R. (2022) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2022.111477 · Cited by 7 · see citing works

A new age for (mucosal) NeuroImmunology

Eberl, G. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00573-0 · Cited by 7 · see citing works

Cytokines of Invertebrate Immunity

DeFilippo, J., & Beck, G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.90751-9 · Cited by 7 · see citing works

Proteomic analysis of Fasciola gigantica excretory and secretory products (FgESPs) co-immunoprecipitated using a time course of infected buffalo sera

Zheng, M., Jiang, X., Kong, X., Guo, Y., Zhang, W., & Di, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1089394 · Cited by 6 · see citing works

IL-17: good fear no tears

Rua, R., & Pujol, N. (2020) · Nature Immunology · doi:10.1038/s41590-020-0792-4 · Cited by 5 · see citing works

The URX oxygen-sensing neurons in C. elegans are ciliated

Kazatskaya, A., Yuan, L., Amin-Wetzel, N., Philbrook, A., de Bono, M., & Sengupta, P. (2020) · PubMed Central · doi:10.17912/micropub.biology.000303 · Cited by 5 · see citing works

Immune-Mediated Bidirectional Causality Between Inflammatory Bowel Disease and Chronic Periodontitis: Evidence from Mendelian Randomization and Integrative Bioinformatics Analysis

Feng, Z., Chen, Z., Wang, X., Zhou, M., & Liu, S. (2025) · Biomedicines · doi:10.3390/biomedicines13020476 · Cited by 4 · see citing works

Immune control of the basal ganglia network: Interleukin-17 as a key modulator of striatal synaptic plasticity

Andrea, M., Bellingacci, L., Canonichesi, J., Sciaccaluga, M., Megaro, A., Zianni, E., Carluccio, M. D., Pariano, M., Emiliano, E., Tozzi, A., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106994 · Cited by 4 · see citing works

Fungus packs a punch in the gut

Cho, D. H., & Choi, G. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.012 · Cited by 4 · see citing works

Data‐driven dissection of the fever effect in autism spectrum disorder

Muller, E., Shalev, I., Bachmat, E., & Eran, A. (2023) · Autism Research · doi:10.1002/aur.2935 · Cited by 4 · see citing works

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Ringstad, N. (2017) · Current Biology · doi:10.1016/j.cub.2017.03.005 · Cited by 4 · see citing works

Nematicidal effects of silencing arginine kinase in the pine wood nematode, Bursaphelenchus xylophilus, determined using a dsRNA-like siRNA assembly

Guo, K., Huang, Z., Wang, C., Liu, X., Chen, Y., Fang, J., Jin, W., Xu, J., Wu, F., & Zhou, X. D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135401 · Cited by 3 · see citing works

unc-119 mutants have an increased fungal spore adhesion that is not rescued by Cb-unc-119

Omi, S., & Pujol, N. (2020) · Europe PMC (PubMed Central) · doi:10.17912/micropub.biology.000344 · Cited by 3 · see citing works

CgIκB2 negatively regulates the expression of interferon-like protein by Rel/NF-κB signal in Crassostrea gigas

Niu, J., Wang, S., Qiao, X., Yu, S., Yu, Z. Y., Jin, Y., Huang, M., Wang, L., & Wang, L. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109853 · Cited by 3 · see citing works

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Ding, W., Moattari, C. R., Stohl, L. L., Wagner, J. A., Zhou, X. K., & Granstein, R. D. (2025) · Immunology · doi:10.1111/imm.13892 · Cited by 2 · see citing works

M cell–dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer’s patches

Komiyama, S., Kodaira, Y., Maeda, R., Sugiura, Y., Suzuki, K., Saeki, A., Kinashi, Y., Oguchi, H., Takano, K., Onawa, S., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2506550123 · Cited by 3 · see citing works

Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism

Zhou, L., & Liu, Y. (2026) · Cell Research · doi:10.1038/s41422-026-01223-x · Cited by 2 · see citing works

The many roads to C. elegans dauer arrest: A review and perspective

Selvarasu, K., Godthi, A., & Prahlad, V. (2025) · Journal of Biosciences · doi:10.1007/s12038-025-00517-3 · Cited by 2 · see citing works

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Silverstein, N. J., & Huh, J. R. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.007 · Cited by 2 · see citing works

A circuit modulator

Whalley, K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.23

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

Flynn, S. M., Chen, C., Artan, M., Barratt, S., Crisp, A., Nelson, G. M., Peak‐Chew, S., Begum, F., Skehel, M. J., & de Bono, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15872-y · Cited by 47 · see citing works

Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans

Flynn, S. M. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.20805

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Ringstad, N. (2017) · Current Biology · doi:10.1016/j.cub.2017.03.005 · Cited by 4 · see citing works