Interleukin-17 as a key player in neuroimmunometabolism

Douglas, Aaron; Stevens, Brenneth; Lynch, Lydia

doi:10.1038/s42255-023-00846-3

Cited by 49Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityNeuroinflammation and Neurodegeneration Mechanisms

Interleukin-17 as a key player in neuroimmunometabolism

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Douglas, Aaron, Stevens, Brenneth, Lynch, Lydia·2023·Nature Metabolism

DOI 10.1038/s42255-023-00846-3PMC PMC10440016

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Abstract

In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression throughout evolution, dating as far back as cnidaria, molluscs and worms, which predate lymphocytes. The evolutionary conservation of IL-17 suggests that it is involved in innate defence strategies, but also that this cytokine family has a fundamental role beyond typical host defence. Throughout evolution, IL-17 seems to have a major function in homeostatic maintenance at barrier sites. Most recently, a pivotal role has been identified for IL-17 in regulating cellular metabolism, neuroimmunology and tissue physiology, particularly in adipose tissue. Here we review the emerging role of IL-17 signalling in regulating metabolic processes, which may shine a light on the evolutionary role of IL-17 beyond typical immune responses. We propose that IL-17 helps to coordinate the cross-talk among the nervous, endocrine and immune systems for whole-body energy homeostasis as a key player in neuroimmunometabolism.

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“Emerging evidence has underscored the neuroimmune role of Treg cells and TH17 cells in the gut–brain axis, extending to neuropathological conditions such as AD, suggesting potential areas for future research.621,622”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [621]

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Issue Information
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IL-17 Triggers the Onset of Cognitive and Synaptic Deficits In Early Stages Of Alzheimer's DiseasePreprint
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Immunity to the Microbiota Promotes Sensory Neuron RegenerationPreprint
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Authors: Douglas, A., Stevens, B., & Lynch, L.
Affiliations: Trinity College Dublin (IE)
Brigham and Women's Hospital (US)
Corresponding author: Lynch, Lydia
ORCID: Douglas, Aaron
Lynch, Lydia
Venue: Nature Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2023-07-20
Volume: 5
Issue: 7
Pages: 1088-1100
ISSN: 2522-5812 (ISSN-L)
DOI: 10.1038/s42255-023-00846-3
PMC: PMC10440016
OpenAlex: W4384934670
Cited by: 49
References: 156
Citations by year: 2026: 13 · 2025: 14 · 2024: 20 · 2023: 2
FWCI: 1.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Diabetes Association (1-16-JDF-061)
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (R01AI134861)
Irish Research Council
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: IL-17, energy homeostasis, IL-17 signaling, evolutionary conservation, innate immunity, adipose tissue metabolism, host defense
MeSH terms: Adipose Tissue, Animals, Immunity, Innate, Lymphocytes, Mammals, Cytokines, Interleukin-17

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Interleukin-17 as a key player in neuroimmunometabolism

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