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Nutrient acquisition strategies of mammalian cells
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Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
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“However, there is evidence in rapidly proliferating cells in cancer that serum albumin can be transported into cells and cell organelles, where it can be degraded to its component amino acids acting as building blocks.84, 85, 86, 87, 88”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [87]
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Metadata
- Authors
- Palm, W., & Thompson, C. B.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Thompson, Craig B.
- Venue
- Nature
- Published
- 2017-06
- Volume
- 546
- Issue
- 7657
- Pages
- 234-242
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5541675
- OpenAlex
- W2624068238
- Cited by
- 388
- References
- 111
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 34 · 2023: 36 · 2022: 58 · 2021: 53 · 2020: 55 · 2019: 39 · 2018: 40 · 2017: 11
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Genentech Foundation
- Hope Funds for Cancer Research
- Foundation of Hope for Research and Treatment of Mental Illness
- National Cancer Institute (P01CA104838, R01CA201318, P30CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- nutrient acquisition, nutrient sensing, transmembrane transporters, growth factors, oncogenes, tumour suppressor, cancer metabolism, metabolic flexibility, starvation survival, cell proliferation, nutrient homeostasis
- MeSH terms
- Animals, Cells, Endocytosis, Glucose, Glutamine, Lysosomes, Neoplasms, Pinocytosis, Proteins, Intercellular Signaling Peptides and Proteins, Cell Proliferation, Tumor Microenvironment
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