Cited by 389PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

Nutrient acquisition strategies of mammalian cells

Open access

Palm, Wilhelm, Thompson, Craig B.·2017·Nature

Open this paper in CoChat — free account

Abstract

Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature22379

Cites

111 of 111 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Self-citation
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Self-citation
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
Fundamentals of Cancer Metabolism
DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances · doi:10.1126/sciadv.1600200 · Cited by 3,013
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Self-citation

Flagged first, then by citations

Show all 111 references

Research works printed but not linked: 1

Lewis, W. H. Pinocytosis. Bull. Johns Hopkins Hosp. 49, 17–26 (1931)

Sorted by citations

Items 301–389 of 389

A lysosomal lipid transport pathway that enables cell survival under choline limitationPreprint
Scharenberg, S. G., Dong, W., Nyame, K., Levin‐Konigsberg, R., Krishnan, A. R., Rawat, E. S., Spees, K. K., Bassik, M. C., & Abu-Remaileh, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.27.517422 · Cited by 3
TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescencePreprint
Kahlhofer, J., Marchet, N., Seifert, B., Zubak, K., Hotze, M., Egger, A.-S., Manzl, C., Weyer, Y., Weys, S., Offterdinger, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.29.620655 · Cited by 3
Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stressPreprint
Scaglione, M., Knight, M., Trihemasava, K., Rome, K., Archambault, A., Oh, J., Tanaka, E., Hall, E., Le, T. N. V., Lines, C. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.632829 · Cited by 3
Identification of the Regulatory Elements and Protein Substrates of Lysine AcetoacetylationPreprint
Fu, Q., Nguyen, T., Kumar, B., Azadi, P., & Zheng, Y. G. (2025) · eLife · doi:10.7554/elife.104123.1 · Cited by 2
IgG Fc-binding protein positively regulates the assembly of pore-forming protein complex βγ-CAT evolved to drive cell vesicular delivery and transport
Bian, X., Si, Z.-R., Wang, Q., Liu, L., Shi, Z., Tian, C., Lee, W., & Zhang, Y. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104717 · Cited by 2
Arf1 promotes porcine intestinal epithelial cell proliferation via the mTORC1 signaling pathway
Fang, Y.-X., Lu, E.-Q., Xu, H. E., Zhang, Y., & Zhu, M. (2024) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-024-00942-y · Cited by 2
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency
Cendrowski, J., Wróbel, M., Mazur, M., Jary, B., Maurya, R., Wang, S., Korostyński, M., Dziewulska, A., Rohm, M., Kuropka, P., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05490-y · Cited by 2
Scalable robot collective resilience by sharing resources
Holdcroft, K., Bolotnikova, A., Monforte, A. J., & Paik, J. K. (2026) · Science Robotics · doi:10.1126/scirobotics.ady6304 · Cited by 2
Everything in moderation or moderating everything? Nutrient balancing in the context of evolution and cancer metabolism
Sholl, J. (2022) · Biology & Philosophy · doi:10.1007/s10539-022-09845-2 · Cited by 2
Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells
Xu, N., Lin, H., Ding, X., Wang, P., & Lin, J. (2025) · Talanta · doi:10.1016/j.talanta.2025.127754 · Cited by 2
Radiation-Induced Rescue Effect: Insights from Microbeam Experiments
Yu, K. N. (2022) · Biology · doi:10.3390/biology11111548 · Cited by 2
Critical factors affecting cells behavior in microfluidic chips
Attarilar, S., Ebrahimi, M., & Wang, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823536-2.00004-3 · Cited by 2
Amphibian pore-forming protein βγ-CAT drives extracellular nutrient scavenging under cell nutrient deficiency
Liu, L., Liu, L., Shi, Z., Bian, X., Si, Z.-R., Wang, Q., Xiang, Y., & Zhang, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106598 · Cited by 6
Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastomaPreprint
Cormerais, Y., Pagnuzzi-Boncompagni, M., Schrötter, S., Giuliano, S., Tambutté, É., Endou, H., Wempe, M. F., Pagès, G., Pouysségur, J., & Picco, V. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/428722 · Cited by 2
Pore-forming protein βγ-CAT drives extracellular nutrient scavenging under cell starvationPreprint
Liu, L., Liu, L., Shi, Z., Bian, X., Wang, Q., Xiang, Y., & Zhang, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.20.500773 · Cited by 2
A multiprotein signaling complex sustains AKT and mTOR/S6K activity necessary for the survival of cancer cells undergoing stressPreprint
Pumar, O. T., Zanotelli, M. R., Lin, M.-C. J., Schmitt, R. R., Green, K. S., Rojas, K. S., Hwang, I. Y., Cerione, R. A., & Wilson, K. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.03.522657 · Cited by 5
A chromosome-level genome assembly of an avivorous bat species (Nyctalus aviator)
Yang, G., Liu, Y., Zhang, Y., Gong, L., Han, Y., Huang, Z., Ke, C., Wu, H., Lin, A., Feng, J., et al. (2024) · Scientific Data · doi:10.1038/s41597-024-03322-z · Cited by 2
The posttranslational regulation of amino acid transporters is critical for their function in the tumor microenvironment
Koe, J. C., & Parker, S. J. (2023) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2023.103022 · Cited by 2
Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia
Sun, J. K., Hart, R. P., Herrup, K., Peng, A. Z., Wong, G. C., Wu, D., Kwan, K. M., & Chow, H. (2025) · Nature Communications · doi:10.1038/s41467-025-64360-8 · Cited by 1
Comparative analysis of metabolome and transcriptomes to explore the inhibited influence of sonodynamic therapy combined with lonidamine on hepatocellular carcinoma
Tan, H., Tian, H., Chen, Y., Wu, B., Cheng, W., & Shang, H. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2593600 · Cited by 1
Targeting obesity and adipokine signaling in the breast cancer microenvironment for enhanced tumor therapy
Li, W., Qu, J., Li, W., Cao, Y., Xu, R., & Xu, L. (2026) · Nanoscale · doi:10.1039/d5nr05009j · Cited by 2
Lactate dehydrogenase is associated with PTTH-stimulated ecdysteroidogenesis in Bombyx mori
Gu, S. (2026) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2026.104999 · Cited by 1
Bidirectional Feedback Between Metabolic Reprogramming and Epithelial–Mesenchymal Transition: From Mechanisms to Therapeutic Interventions
Liu, Y., Wang, M., Liu, D., Lyu, H., Zhang, D., & Sun, Y. (2026) · Molecules · doi:10.3390/molecules31122060 · Cited by 1
Pediatric posterior fossa ependymoma and metabolism
Halligan, K. E., Michealraj, K. A., Cruz, A. F., Felker, J. T., Daniels, C. E., Taylor, M. D., & Agnihotri, S. (2021) · Glioma · doi:10.4103/glioma.glioma_17_21 · Cited by 1
TIPRL, a Potential Double-edge Molecule to be Targeted and Re-targeted Toward Cancer
Gao, J., You, T., Liu, J., Yang, L., Liu, Y., & Wang, Y. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01334-5 · Cited by 1
Coordinated transcriptional networks program organelle expansion and metabolic flows for high endothelial morphology and function
Bi, Y., Brulois, K., Ayesha, A., Xiang, M., Ballet, R., Ocón, B., Dinh, T. T., Lazarus, N. H., Kunte, M., Ramos, G., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.014 · Cited by 1
Exocytotic vesicle fusion classification for early disease diagnosis using a mobile GPU microsystem
Szczęsny, S., & Pietrzak, P. (2021) · Neural Computing and Applications · doi:10.1007/s00521-021-06676-2 · Cited by 1
CMOS Perceptron for Vesicle Fusion Classification
Naumowicz, M., Pietrzak, P., Szczęsny, S., & Huderek, D. (2022) · Electronics · doi:10.3390/electronics11060843 · Cited by 1
Novel 'Housekeeping' Genes and an Unusually Heterogeneous Distribution of Transporter Expression Profiles in Human Tissues and Cell Lines, Assessed Using the Gini CoefficientPreprint
O’Hagan, S., Muelas, M. W., Day, P. J., Lundberg, E. K., & Kell, D. B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/155697 · Cited by 1
Significant antitumour effect of an antibody against TMEM180, a new cancer-specific moleculePreprint
Yasunaga, M., Saijou, S., Hanaoka, S., Anzai, T., Tsumura, R., & Matsumura, Y. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/397844 · Cited by 1
Beyond Computational Genomics towards Systems Metabolomics for Precision OncologyPreprint
Alberghina, L. (2018) · Preprints.org · doi:10.20944/preprints201808.0127.v1
Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotypePreprint
Khatib, A., Solaimuthu, B., Yosef, M. B., Oren, G., Rmaileh, A. A., Frisch, M. S., Axelrod, J. H., Lichtenstein, M., & Shaul, Y. D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/818245 · Cited by 1
Loss of p32 triggers energy deficiency and impairs goblet cell differentiation in ulcerative colitisPreprint
Sünderhauf, A., Hicken, M., Schlichting, H., Skibbe, K., Ragab, M., Raschdorf, A., Hirose, M., Schäffler, H., Bokemeyer, A., Bettenworth, D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.09.417915 · Cited by 1
Tumor landscape of epithelial ovarian cancer highlights that EGR1 drives tumor invasion at single-cell resolutionPreprint
Zhang, Y.-F., Sun, S., Qi, Y., Dai, Y., Hao, Y., Xin, M., Xu, R., Chen, H., Wu, X., Liu, Q., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.26.501637 · Cited by 1
Autophagy regulator ATG7 links lipid metabolism to cell-fate decisions in kidney tubule health and diseasePreprint
Nieri, D., Keller, S. A., Pierre, L., Carloni, F., Pili, R., Chen, Z., Ouellette, A. M., Berquez, M., Krohn, P., Raimondi, A., et al. (2025) · medRxiv · doi:10.1101/2025.03.26.25324675 · Cited by 1
The Epithelial To Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
Ramirez‐Peña, E. (2018) · Digital Commons-TMC (Texas Medical Center)
Papers of note in Nature 546 (7657)
VanHook, A. M. (2017) · Science Signaling · doi:10.1126/scisignal.aao0451
Influência do meio condicionado por células de carcinoma epidermoide de língua sobre linfoblastos e células mononucleares do sangue periférico
Castro, S. B. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.23.2019.tde-13032019-151348
PHD3 controls energy homeostasis and exercise capacityPreprint
Yoon, H., Spinelli, J. B., Zaganjor, E., Wong, S. J., German, N. J., Randall, E. C., Dean, A., Clermont, A. C., Paulo, J. A., Garcia, D., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/781765 · Cited by 1
Investigating the role of amino acid transporter LAT3/SLC43A1 in prostate cancer
Zhang, K. (2019) · The Sydney eScholarship Repository (The University of Sydney)
CHANGES IN ULTRASTRUCTURE OF CALF MUSCLE AND MYOCARDIUM UNDER PHYSICAL LODADING IN EXPERIMENT
Voitenko, V., & Гунина, Л. (2020) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.20.2.114
Acquired deficiency of the peroxisomal enzyme enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is a metabolic vulnerability in hepatoblastomaPreprint
Wang, H., Chen, X., Schwalbe, M., Gorka, J. E., Mandel, J. A., Wang, J., Lu, J. L., Goetzman, E. S., Dobrowolski, S. F., & Prochownik, E. V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.24.265421
Experimental research of garden spinach extract as a potential anabolic medicinal product
Nykyforuk, A., Степанівна, Ф. Л., Lykhatskyі, P. H., & Пида, В. П. (2020) · Pharmacia · doi:10.3897/pharmacia.67.e56880
Die Rolle von mTORC1 in der Verstoffwechslung extrazellulärer Proteine
Hermann, J., & Palm, W. (2020) · BIOspektrum · doi:10.1007/s12268-020-1481-4
Self-citation
Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in ratsPreprint
Trott, A. J., Greenwell, B. J., Karhadkar, T. R., Guerrero‐Vargas, N. N., Escobar, C., Buijs, R. M., & Menet, J. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.13.444001
A bispecific aptamer sensor towards T-cell leukemia detection in the tumor microenvironmentPreprint
Boykoff, N., Mallikaratchy, P. R., Lenn, J., & Freage, L. (2021) · doi:10.33774/chemrxiv-2021-2hztc
Quantitative phase velocimetry measures bulk intracellular transport of cell mass during the cell cyclePreprint
Pradeep, S., & Zangle, T. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.04.452408
Microenvironmental factors in cell segregation and heterogeneity in breast cancer developmentPreprint
Romero-Arias, J. R., González-Castro, C. A., & Ramı́rez-Santiago, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.01.470838
Measuring Endocytosis and Endosomal Uptake at Single Cell Resolution
Sangokoya, C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2281-0_6
Targeting T-cell immunometabolism during transplantationPreprint
Kazmi, S., Khan, M. A., Shamma, T., Altuhami, A., Assiri, A. M., & Broering, D. (2020) · doi:10.22541/au.160407370.05004270/v1
The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells
Chintaluri, K. (2021) · doi:10.32920/ryerson.14661819.v1
The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells
Chintaluri, K. (2021) · doi:10.32920/ryerson.14661819
Application of nuclear magnetic resonance spectroscopy for the detection of metabolic changes in blood cells with defective DNA repair
Vanderstichelen, G. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.68013
Glutamine synthetase : a potential therapeutic target in acute myeloid leukemia
Kreitz, J. (2022) · doi:10.21248/gups.68562
Laboratory Protocols in Medical Biotechnology II (Contemporary Principles and Practices of Bacterial and Human Cell Culture)
Rather, S. A., Sharma, S., Pervaiz, N., & Rather, R. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-98554-7_13
Tumor microenvironment landscape of epithelial ovarian carcinoma highlights EGR1-driven mechanisms of tumor invasion at single-cell resolutionPreprint
Guo, Q., Zhang, Y., Sun, S., Qi, Y., Dai, Y., Hao, Y., Xin, M., Xu, R., Chen, H., Wu, X., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1966592/v1
WITHDRAWN: Elevated glucose promotes DNA replication and cancer cell growth through pRB-E2F1Preprint
Liu, X., Zhou, Q., Bai, D., & Schrier, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3126261/v1
Identification of the regulatory elements and protein substrates of lysine acetoacetylation
Fu, Q., Nguyen, T., Kumar, B., Azadi, P., & Zheng, Y. G. (2026) · eLife · doi:10.1101/2024.10.31.621296 · Cited by 1
Uncovering the Heterogeneity of Signaling Pathways in Skin Cutaneous Melanoma: Insights into Prognostic Values and Immune Interactions
Liu, Y., Li, C., & Deng, W. (2025) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s500654
Understanding cellular proliferation activity in breast cancer using multi-compartment model of transverse relaxation time mapping on 3T MRI
Nkonde, K. A., Cheung, S. M., Senn, N., & He, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1482112 · Cited by 1
Identification of the regulatory elements and protein substrates of lysine acetoacetylationPreprint
Fu, Q., Nguyen, T., Kumar, B., Azadi, P., & Zheng, Y. G. (2025) · eLife · doi:10.7554/elife.104123
Comparison of 2D and 3D culture methods on morphology, viability, surface markers, and pluripotency gene of umbilical cord mesenchymal stem cells
Septiana, W. L., Azzahra, R., Ahmad, A., Nurvianto, D., Utomo, M. F. B., Junaidi, H., & Astuti, S. W. (2025) · Journal of Cellular Biotechnology · doi:10.1177/23523689251359483
Adaptation to the Environment
Carter, O. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-24031-7.00007-6
Emulsion interfacial nanoarchitectonics with a biomimetic channel‐architected polymer for enhanced biocatalysis
Sun, Z., Wang, M., Shen, N., Ren, L., Chen, X., & Yu, J. (2025) · AIChE Journal · doi:10.1002/aic.70092
Identification of the Regulatory Elements and Protein Substrates of Lysine AcetoacetylationPreprint
Fu, Q., Nguyen, T., Kumar, B., Azadi, P., & Zheng, Y. G. (2025) · eLife · doi:10.7554/elife.104123.2
The role of diet and nutraceuticals in the amelioration of multidrug resistance amongst cancer patients
Banerjee, S., Banerjee, A., Singhvi, G., Taliyan, R., & Dhar, P. (2025) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-025-00706-x
Identification of the Regulatory Elements and Protein Substrates of Lysine AcetoacetylationPreprint
Fu, Q., Nguyen, T., Kumar, B., Azadi, P., & Zheng, Y. G. (2025) · eLife · doi:10.7554/elife.104123.3
Plasma membrane-to-lysosome FGR signaling regulates endocytosis-associated lysosome homeostasis
Yin, Q., Qian, J., Ding, X., Ren, X., Li, S., Zhang, Z., Li, M., Xiao, L., Zhang, Z., Lai, F., et al. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202506139
Glucose availability tunes latent CD8+ T cell expansion potential through a mitogen-independent, mTOR-dependent regulatory switchPreprint
Le, T. N. V., Trihemasava, K., Turner, L. H., Rome, K., Wu, A., & Bailis, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.16.699963
Resting energy expenditure measured by indirect calorimetry in children with cancer: A systematic literature review
Froon-Torenstra, D., Renting, L., Takken, T., Vermeij, W. P., Kok, D. E. G., & Tissing, W. J. E. (2026) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2026.102932
Signaling pathway underlying autocrine activation of ecdysteroidogenesis in prothoracic glands of Bombyx mori
Gu, S. (2026) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2026.104515
Elevated endocytic trafficking mediated by GPRASP2 maintains HSC fidelityPreprint
Huizen, A. V. V., Zhai, M., Totani, H., Rathnayake, D., Kooienga, E., Sharma, I., Kelley, Z., Rodgers, M., Zanotti, F., Palmer, L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704594
Les macrophages recyclent les bactéries pour alimenter leurs défenses antimicrobiennes
Torres, C., Lhuissier, C., & Garaude, J. (2026) · médecine/sciences · doi:10.1051/medsci/2026011
Etude de la reprogrammation des voies métaboliques des acides aminés au cours de la carcinogenèse pancréatique
Gouirand, V. (2018) · theses.fr (ABES) · doi:10.70675/fff49f3ezaf3bz4eaaz80f7z7dd647ad95a1
Rôle de l'autophagie dans l'émergence des cellules souches cancéreuses : implication du métabolisme
El-Hout, M. (2019) · theses.fr (ABES) · doi:10.70675/881cf980z01caz4a56z8a81zdcebe1247536
Induction de la mort ferroptotique dans les cellules de cancer pancréatique : rôle essentiel de la cystéine et du transporteur xCT
Daher, B. (2020) · theses.fr (ABES) · doi:10.70675/191d800aza1c8z4fefzab1ezf7b410fe80d0
Role of lysosome positioning in bladder cancer progression
Mathur, P. (2022) · theses.fr (ABES) · doi:10.70675/c0ae8691z03b0z41dcz9d39ze3270db6d1e1
Control of the invadopodia/MT1-MMP axis by mTORC1/TFEB signaling pathway in breast cancer cells
Remy, D. (2022) · theses.fr (ABES) · doi:10.70675/849dc96dz8e18z4428zbf6fz67c9b1d98114
Role of natural killer cells in cancer immunology
Manwatkar, S., Kumar, S., Chandak, G., Kumar, B., Baghel, D. S., & Pandey, N. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-41551-7.00006-0
An explainable prognostic prediction panel for sepsis based on serum amino acid profiles
Liu, Y., Zhao, L., Sun, M., Zhang, J., Gu, C., Hu, N., Gu, S., & Shi, Y. X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1757924
Comparative Genomics Reveals Convergent Evolution Between Avivorous Bats ( Ia io and Nyctalus aviator )
Geng, Y., Liu, Y., Gong, L., Huang, Z., Lin, A., Feng, J., Zhang, Y., & Jiang, T. (2026) · Integrative Zoology · doi:10.1111/1749-4877.70146
Mitochondrial transfer-mediated metabolic reprogramming and drug resistance in bone metastasis: mechanisms and therapeutic strategies
Deng, W., Liu, B. Q., & Xiang, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1863593 · Cited by 1
In situ white-to-brown reprogramming to induce adipocyte thermogenesis by engineered bacteria for breast cancer immunotherapy
An, L., Yang, Z., Li, R., Cheng, J., Cai, Y., Dong, H., Liu, Y., Li, Y., & Li, Y. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.180379
Lysosome-targeted nanomaterials for advanced cancer therapy: Overcoming resistance, activating immunity and amplifying therapeutic synergy
Zheng, H., Cheng, H., Li, N., & Cai, J. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.08.005
Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells
Wang, J., Ni, Z., Zhang, X., He, L., Zhang, X., Cheng, X., Wang, H., Sun, G., Lu, Z., Liu, C., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2601318123
Iron‐Deprivation Liposomes for Cancer Therapy
Jia, J., Li, Y., Zhou, H., Zhu, F., Rong, G., Yu, W., Sun, Z., & Cheng, Y. (2026) · Angewandte Chemie · doi:10.1002/ange.5926794
Iron‐Deprivation Liposomes for Cancer Therapy
Jia, J., Li, Y., Zhou, H., Zhu, F., Rong, G., Yu, W., Sun, Z., & Cheng, Y. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.5926794
Non-Canonical HIF2 Accumulation in Breast Cancer Cells
Kozal, K., Opitz, A., Jarosiewicz, M., Juszczak, M., & Krześlak, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209306
BindingDB Entry 50011244: Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.
BindingDB (2022) · UC San Diego · doi:10.7270/q2zs314k

Authors: Palm, W., & Thompson, C. B.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Thompson, Craig B.
ORCID: Palm, Wilhelm
Thompson, Craig B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2017-06
Volume: 546
Issue: 7657
Pages: 234-242
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature22379
PMC: PMC5541675
OpenAlex: W2624068238
Cited by: 388
References: 111
Citations by year: 2026: 25 · 2025: 37 · 2024: 34 · 2023: 36 · 2022: 58 · 2021: 53 · 2020: 55 · 2019: 39 · 2018: 40 · 2017: 11
FWCI: 3.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Genentech Foundation
Hope Funds for Cancer Research
Foundation of Hope for Research and Treatment of Mental Illness
National Cancer Institute (P01CA104838, R01CA201318, P30CA008748)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: nutrient acquisition, nutrient sensing, transmembrane transporters, growth factors, oncogenes, tumour suppressor, cancer metabolism, metabolic flexibility, starvation survival, cell proliferation, nutrient homeostasis
MeSH terms: Animals, Cells, Endocytosis, Glucose, Glutamine, Lysosomes, Neoplasms, Pinocytosis, Proteins, Intercellular Signaling Peptides and Proteins, Cell Proliferation, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nutrient acquisition strategies of mammalian cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks