Cited by 389PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

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Nutrient acquisition strategies of mammalian cells

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Palm, Wilhelm, Thompson, Craig B.·2017·Nature

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Abstract

Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.

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Self-citation
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Authors: Palm, W., & Thompson, C. B.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Thompson, Craig B.
ORCID: Palm, Wilhelm
Thompson, Craig B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2017-06
Volume: 546
Issue: 7657
Pages: 234-242
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature22379
PMC: PMC5541675
OpenAlex: W2624068238
Cited by: 388
References: 111
Citations by year: 2026: 25 · 2025: 37 · 2024: 34 · 2023: 36 · 2022: 58 · 2021: 53 · 2020: 55 · 2019: 39 · 2018: 40 · 2017: 11
FWCI: 3.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Genentech Foundation
Hope Funds for Cancer Research
Foundation of Hope for Research and Treatment of Mental Illness
National Cancer Institute (P01CA104838, R01CA201318, P30CA008748)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: nutrient acquisition, nutrient sensing, transmembrane transporters, growth factors, oncogenes, tumour suppressor, cancer metabolism, metabolic flexibility, starvation survival, cell proliferation, nutrient homeostasis
MeSH terms: Animals, Cells, Endocytosis, Glucose, Glutamine, Lysosomes, Neoplasms, Pinocytosis, Proteins, Intercellular Signaling Peptides and Proteins, Cell Proliferation, Tumor Microenvironment

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Nutrient acquisition strategies of mammalian cells

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