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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
Abstract
T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of individualized mutanome vaccines and implemented an RNA-based poly-neo-epitope approach to mobilize immunity against a spectrum of cancer mutations. Here we report the first-in-human application of this concept in melanoma. We set up a process comprising comprehensive identification of individual mutations, computational prediction of neo-epitopes, and design and manufacturing of a vaccine unique for each patient. All patients developed T cell responses against multiple vaccine neo-epitopes at up to high single-digit percentages. Vaccine-induced T cell infiltration and neo-epitope-specific killing of autologous tumour cells were shown in post-vaccination resected metastases from two patients. The cumulative rate of metastatic events was highly significantly reduced after the start of vaccination, resulting in a sustained progression-free survival. Two of the five patients with metastatic disease experienced vaccine-related objective responses. One of these patients had a late relapse owing to outgrowth of β2-microglobulin-deficient melanoma cells as an acquired resistance mechanism. A third patient developed a complete response to vaccination in combination with PD-1 blockade therapy. Our study demonstrates that individual mutations can be exploited, thereby opening a path to personalized immunotherapy for patients with cancer.
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“For example, intranodal vaccination with free mRNA encoding ten neoepitopes of 13 patients with metastatic melanoma generated T cell immunity against multiple neoepitopes in all patients209.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [209]
In the citing paper
“A first-in-human trial demonstrated the clinical feasibility and safety of this approach for advanced melanoma cancers: all vaccinated patients developed CD4 + and CD8 + T cell responses against the selected antigens, with some patients showing objective antitumor responses [15].”
From Three decades of messenger RNA vaccine development (2019) · cites this paper as [15]
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
Primer3—new capabilities and interfaces
Untergasser, A., Cutcutache, I., Kõressaar, T., Ye, J., Faircloth, B., Remm, M., & Rozen, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks596 · Cited by 9,165
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802
Self-citationPD-1 blockade induces responses by inhibiting adaptive immune resistance
Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609
Pembrolizumab versus Ipilimumab in Advanced Melanoma
Robert, C., Schachter, J., Long, G. V., Arance, A., Grob, J. J., Mortier, L., Daud, A., Carlino, M. S., McNeil, C., Lotem, M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503093 · Cited by 5,887
Cited by
Sorted by citations
Items 601–700 of 1,002
Messenger RNA vaccines for cancer immunotherapy: progress promotes promise
Huff, A. L., Jaffee, E. M., & Zaidi, N. (2022) · Journal of Clinical Investigation · doi:10.1172/jci156211 · Cited by 60
Luo, Z., Cheng, X., Feng, B., Fan, D., Liu, X., Xie, R., Luo, T., Wegner, S. V., Ma, D., Chen, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202400049 · Cited by 55
Effern, M., Glodde, N., Braun, M., Liebing, J., Boll, H. N., Yong, M. C. R., Bawden, E., Hinze, D., Konijnenberg, D., Daoud, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.007 · Cited by 55
Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence
Zhou, X., Qu, M., Tebon, P. J., Jiang, X., Wang, C., Xue, Y., Zhu, J., Zhang, S., Öklü, R., Sengupta, S., et al. (2020) · Advanced Science · doi:10.1002/advs.202001447 · Cited by 55
Vaccination with Messenger RNA: A Promising Alternative to DNA Vaccination
Tombácz, I., Weissman, D., & Pardi, N. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0872-2_2 · Cited by 55
Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA
Vlatkovic, I., Ludwig, J., Boros, G., Szabó, G. T., Reichert, J., Buff, M. C. R., Baiersdörfer, M., Reinholz, J., Mahiny, A. J., Şahin, U., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020328 · Cited by 53
mRNA vaccine designs for optimal adjuvanticity and delivery
Mochida, Y., & Uchida, S. (2024) · RNA Biology · doi:10.1080/15476286.2024.2333123 · Cited by 57
Li, Y., Tian, Y., Li, C., Fang, W., Li, X., Jing, Z., Yang, Z., Zhang, X., Huang, Y., Gong, J., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102518 · Cited by 57
Neoantigen Vaccines Pass the Immunogenicity Test
Linette, G. P., & Carreno, B. M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.007 · Cited by 54
Wu, J., Li, W., Chen, P., Zhang, B., Hu, H., Li, Q., Zhao, L., Chen, Y., Zhao, Y., & Li, Y. (2018) · Chemical Communications · doi:10.1039/c8cc04860f · Cited by 56
New Hope for Therapeutic Cancer Vaccines in the Era of Immune Checkpoint Modulation
Curran, M. A., & Glisson, B. S. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-050217-121900 · Cited by 56
Tumor-Specific T Cell Activation in Malignant Brain Tumors
Mohme, M., & Neidert, M. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00205 · Cited by 55
Emerging Strategies in TCR-Engineered T Cells
Fang, W., Cheng, X., Xue, J. Z., & Xue, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.850358 · Cited by 58
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade
Miyai, Y., Sugiyama, D., Hase, T., Asai, N., Taki, T., Nishida, K., Fukui, T., Chen-Yoshikawa, T. F., Kobayashi, H., Mii, S., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202101230 · Cited by 55
Targeting strategies for mRNA delivery
Meyer, R. A., Neshat, S. Y., Green, J. J., Santos, J. L., & Tuesca, A. D. (2022) · Materials Today Advances · doi:10.1016/j.mtadv.2022.100240 · Cited by 55
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
Gurung, H. R., Heidersbach, A. J., Darwish, M., Chan, P. P. F., Li, J., Beresini, M. H., Zill, O. A., Wallace, A., Tong, A.-J., Hascall, D., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01945-y · Cited by 59
Recent Advances in Pharmaceutical Design: Unleashing the Potential of Novel Therapeutics
Prajapati, R. N., Bhushan, B., Singh, K., Chopra, H., Kumar, S., Agrawal, M., Pathak, D., Chanchal, D. K., & Kant, L. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010275850240102105033 · Cited by 62
Recent advances in lung cancer research: unravelling the future of treatment
Bertolaccini, L., Casiraghi, M., Uslenghi, C., Maiorca, S., & Spaggiari, L. (2024) · Updates in Surgery · doi:10.1007/s13304-024-01841-3 · Cited by 55
Accounting for proximal variants improves neoantigen prediction
Hundal, J., Kiwala, S., Feng, Y.-Y., Liu, C. J., Govindan, R., Chapman, W. C., Uppaluri, R., Swamidass, S. J., Griffith, O. L., Mardis, E. R., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0283-9 · Cited by 55
The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice
Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. Μ., & Celis, E. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-02294-5 · Cited by 53
Design of in vitro Transcribed mRNA Vectors for Research and Therapy
Tusup, M., French, L. E., Matos, M. D., Gatfield, D., Kündig, T. M., & Pascolo, S. (2019) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2019.391 · Cited by 55
Zhang, R., Tang, L., Tian, Y., Xiao, J., Hu, Q., Zhou, B., Zhenyu, D., Xu, H., & Yang, L. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119852 · Cited by 53
Personalized cancer vaccination in head and neck cancer
Shibata, H., Zhou, L., Xu, N., Egloff, A. M., & Uppaluri, R. (2020) · Cancer Science · doi:10.1111/cas.14784 · Cited by 54
mRNA vaccines: a new era in vaccine development
Chandra, S., Wilson, J. C., Good, D. M., & Wei, M. Q. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.043987 · Cited by 58
COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy
Novelli, G., Biancolella, M., Mehrian‐Shai, R., Colona, V. L., Brito, A. F., Grubaugh, N. D., Vasiliou, V., Luzzatto, L., & Reichardt, J. K. V. (2021) · Human Genomics · doi:10.1186/s40246-021-00326-3 · Cited by 51
Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges
Choucair, K., Imtiaz, H., Uddin, M. H., Nagasaka, M., Al-Hallak, M. N., Philip, P. A., El-Rayes, B., Pasche, B., & Azmi, A. S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02473-8 · Cited by 67
Acquired resistance to cancer immunotherapy
Draghi, A., Chamberlain, C. A., Furness, A. J. S., & Donia, M. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0692-y · Cited by 51
Venkatesh, G. S., Grover, A., Srinivasaraghavan, G., & Rao, S. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa479 · Cited by 55
Lu, L., Jiang, J., Zhan, M., Zhang, H., Wang, Q., Sun, S., Guo, X., Yin, H., Wei, Y., Li, S., et al. (2020) · Hepatology · doi:10.1002/hep.31502 · Cited by 52
The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
Machado, B. A. S., Hodel, K. V. S., Fonseca, L. M. D. S., Mascarenhas, L. A. B., Andrade, L. P. C. D. S., Rocha, V. P. C., Soares, M. B. P., Berglund, P., Duthie, M. S., Reed, S. G., et al. (2021) · Vaccines · doi:10.3390/vaccines9111345 · Cited by 55
Breaking Bottlenecks for the TCR Therapy of Cancer
Gaissmaier, L., Elshiaty, M., & Christopoulos, P. (2020) · Cells · doi:10.3390/cells9092095 · Cited by 52
Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development
Liang, J., & Zhao, X. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2021.0004 · Cited by 53
Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics
de Vyver, T. V., Smedt, S. C. D., & Raemdonck, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114041 · Cited by 51
Considerations for personalized neoantigen vaccination in Malignant glioma
Dunn, G. P., Sherpa, N. D., Manyanga, J., & Johanns, T. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114312 · Cited by 51
Engineering neoantigen vaccines to improve cancer personalized immunotherapy
Liu, Z., Lv, J., Dang, Q., Liu, L., Weng, S., Wang, L., Zhou, Z., Kong, Y., Li, H., Han, Y., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.76281 · Cited by 52
Phulphagar, K. M., Ctortecka, C., Jácome, A. S. V., Klaeger, S., Verzani, E. K., Hernandez, G. M., Udeshi, N. D., Clauser, K. R., Abelin, J. G., & Carr, S. A. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100563 · Cited by 49
IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
Pan, Y., Phillips, J. W., Zhang, B. D., Noguchi, M., Kutschera, E., McLaughlin, J., Nesterenko, P. A., Mao, Z., Bangayan, N. J., Wang, R., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221116120 · Cited by 50
Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy
Wilhelmy, C., Keil, I. S., Uebbing, L., Schroer, M. A., Franke, D., Nawroth, T., Barz, M., Şahin, U., Haas, H., Diken, M., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082068 · Cited by 51
Self-citationProteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
Tretter, C., Krätzig, N. D. A., Pecoraro, M., Lange, S., Seifert, P., von Frankenberg, C., Untch, J., Zuleger, G., Wilhelm, M., Zolg, D. P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39570-7 · Cited by 49
High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions
Blaha, D. T., Anderson, S. D., Yoakum, D. M., Hager, M. V., Zha, Y., Gajewski, T. F., & Kranz, D. M. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0395 · Cited by 49
Vitiello, M., Evangelista, M., Lascio, N. D., Kusmic, C., Massa, A., Orso, F., Sarti, S., Marranci, A., Rodzik, K., Germelli, L., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0681-1 · Cited by 53
Liu, G., Gao, N., Zhou, Y., Nie, J., Cheng, W., Luo, M., Mei, L., Zeng, X., & Deng, W. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11100507 · Cited by 51
TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes
Zhang, G., Chitkushev, L. T., Olsen, L. R., Keskin, D. B., & Brusić, V. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-03962-7 · Cited by 56
mRNA vaccines in the prevention and treatment of diseases
Gu, Y., Duan, J., Yang, N., Yang, Y., & Zhao, X. (2022) · MedComm · doi:10.1002/mco2.167 · Cited by 54
Huber, F., & Bassani‐Sternberg, M. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01208-8 · Cited by 57
Ruzicka, M., König, L. M., Formisano, S., Boehmer, D. F. R., Vick, B., Heuer, E.-M., Meinl, H., Kocheise, L., Zeitlhoefler, M., Ahlfeld, J., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0639-x · Cited by 50
T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies
Janelle, V., Rulleau, C., Testa, S. D., Carli, C., & Delisle, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00276 · Cited by 52
Immune Therapy Opportunities in Ovarian Cancer
Kandalaft, L. E., Odunsi, K. O., & Coukos, G. (2020) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_280539 · Cited by 52
Wu, Y., Kelly, S. H., Sanchez-Perez, L. A., Sampson, J. H., & Collier, J. H. (2020) · Biomaterials Science · doi:10.1039/d0bm00521e · Cited by 54
Therapeutic Liposomal Vaccines for Dendritic Cell Activation or Tolerance
Nagy, N. A., de Haas, A. M., Geijtenbeek, T. B. H., van Ree, R., Tas, S. W., van Kooyk, Y., & de Jong, E. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674048 · Cited by 49
Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer
Kanvinde, S., Kulkarni, T. A., Deodhar, S., Bhattacharya, D. S., & Dasgupta, A. (2022) · BioTech · doi:10.3390/biotech11010006 · Cited by 55
Ravindran, S., Rasool, S., & Maccalli, C. (2019) · Cancer Microenvironment · doi:10.1007/s12307-019-00233-1 · Cited by 49
Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapy
Richard, G., Princiotta, M. F., Bridon, D. P., Martin, W. D., Steinberg, G. D., & Groot, A. S. D. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2022.2012456 · Cited by 49
Oyama, R., Ishigame, H., Tanaka, H., Tateshita, N., Itazawa, M., Imai, R., Nishiumi, N., Kishikawa, J.-I., Kato, T., Anindita, J., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c02251 · Cited by 49
TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification
Gravel, N. H., Nelde, A., Bauer, J., Mühlenbruch, L., Schroeder, S. M., Neidert, M. C., Scheid, J., Lemke, S., Dubbelaar, M. L., Wacker, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42692-7 · Cited by 51
Recent advances and perspectives on the development of circular RNA cancer vaccines
Gong, Z., Hu, W., Zhou, C., Guo, J., Yang, L., & Wang, B. (2025) · npj Vaccines · doi:10.1038/s41541-025-01097-x · Cited by 55
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
Kärpänen, T., & Olweus, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01718 · Cited by 50
Targeting Head and Neck Cancer by Vaccination
Wang, C., Dickie, J., Sutavani, R. V., Pointer, C., Thomas, G. J., & Savelyeva, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00830 · Cited by 51
Hazama, S., Tamada, K., Yamaguchi, Y., Kawakami, Y., & Nagano, H. (2018) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12180 · Cited by 50
Novel Biomarkers for Personalized Cancer Immunotherapy
Shindo, Y., Hazama, S., Tsunedomi, R., Suzuki, N., & Nagano, H. (2019) · Cancers · doi:10.3390/cancers11091223 · Cited by 49
Salomon, N., Vascotto, F., Selmi, A., Vormehr, M., Quinkhardt, J., Bukur, T., Schrörs, B., Löewer, M., Diken, M., Türeci, Ö., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771925 · Cited by 49
Self-citationMorisaki, T., Hikichi, T., Onishi, H., Morisaki, T., Kubo, M., Hirano, T., Yoshimura, S., Kiyotani, K., & Nakamura, Y. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1778721 · Cited by 48
N 6 ‐methyladenosine Steers RNA Metabolism and Regulation in Cancer
Dong, S., Wu, Y., Liu, Y., Weng, H., & Huang, H. (2021) · 癌症:英文版 · doi:10.1002/cac2.12161 · Cited by 48
Liu, G., Carter, B., & Gifford, D. K. (2020) · Cell Systems · doi:10.1016/j.cels.2020.11.010 · Cited by 48
Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors
Çuburu, N., Bialkowski, L., Pontejo, S. M., Sethi, S. K., Bell, A. T. F., Kim, R., Thompson, C. D., Lowy, D. R., & Schiller, J. T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116738119 · Cited by 48
The immune-related role of beta-2-microglobulin in melanoma
Wang, C., Wang, Z., Yao, T., Zhou, J., & Wang, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.944722 · Cited by 52
The role of CD4+ T cells in tumor and chronic viral immune responses
Xie, L., Fang, J., Yu, J., Zhang, W., He, Z., Ye, L., & Wang, H. (2023) · MedComm · doi:10.1002/mco2.390 · Cited by 54
mRNA vaccines in the context of cancer treatment: from concept to application
Fu, Q., Zhao, X., Hu, J., Jiao, Y., Yan, Y., Pan, X., Wang, X., & Jiao, F. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06033-6 · Cited by 59
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC
Şahin, U., Schmidt, M., Derhovanessian, E., Cortini, A., Vogler, I., Omokoko, T., Godehardt, E., Attig, S., Newrzela, S., GRUTZNER, J., et al. (2026) · Nature · doi:10.1038/s41586-025-10004-2 · Cited by 50
Self-citationShared Neoantigens: Ideal Targets for Off-The-Shelf Cancer Immunotherapy
Zhao, W., Wu, J., Chen, S., & Zhou, Z. M. (2020) · Pharmacogenomics · doi:10.2217/pgs-2019-0184 · Cited by 49
Progress in Neoantigen Targeted Cancer Immunotherapies
Han, X., Ma, X., Li, Y., Wei, Y.-Q., Peng, Y., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00728 · Cited by 49
Newton, Y., Sedgewick, A. J., Cisneros, L. H., Golovato, J., Johnson, M., Szeto, C. W., Rabizadeh, S., Sanborn, Z., Benz, S. C., & Vaske, C. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-74483-1 · Cited by 48
Rawding, P. A., Bu, J., Wang, J., Kim, D., Drelich, A. J., Kim, Y. S., & Hong, S. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1752 · Cited by 50
Messenger RNA-Based Therapeutics and Vaccines: What’s beyond COVID-19?
Li, D., Liu, C., Li, Y., Tenchov, R., Sasso, J. M., Zhang, D., Li, D., Zou, L., Wang, X., & Zhou, Q. A. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00047 · Cited by 50
Challenges towards the realization of individualized cancer vaccines
Türeci, Ö., Löwer, M., Schrörs, B., Lang, M., Tadmor, A. D., & Şahin, U. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0266-2 · Cited by 49
Self-citationCai, W., Zhou, D., Wu, W., Tan, W. L., Wang, J., Zhou, C., & Lou, Y. (2018) · BMC Genomics · doi:10.1186/s12864-018-4958-5 · Cited by 47
Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor
Fontana, F., Fusciello, M., Groeneveldt, C., Capasso, C., Chiaro, J., Feola, S., Liu, Z., Mäkilä, E. M., Salonen, J., Hirvonen, J. J., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b09613 · Cited by 47
An Update on Adoptive T-Cell Therapy and Neoantigen Vaccines
Ott, P. A., Dotti, G., Yee, C., & Goff, S. L. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_238001 · Cited by 48
Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines
Zeng, L., Liao, Z., Li, W., Yuan, Q., Wu, P., Gu, Z., Liu, Z., & Liao, G. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.10.015 · Cited by 47
Bouzid, R., Peppelenbosch, M. P., & Buschow, S. I. (2020) · Cancers · doi:10.3390/cancers12051121 · Cited by 46
Prognostic Value of Neoantigen Load in Immune Checkpoint Inhibitor Therapy for Cancer
Zou, X.-L., Li, X., Ke, H., Zhang, G., Tang, Q., Yuan, J., Zhou, C.-J., Zhang, J., Zhang, R., & Chen, W.-Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689076 · Cited by 48
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Neoantigen cancer vaccines: a new star on the horizon
Li, X., You, J., Hong, L., Liu, W., Guo, P., & Hao, X. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0395 · Cited by 53
Ingels, J., Cock, L. D., Stevens, D., Mayer, R. L., Théry, F., Sanchez, G. S., Vermijlen, D., Weening, K., Smet, S. D., Lootens, N., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101516 · Cited by 49
Wang, X., Wang, W., Zou, S., Xu, Z., Cao, D., Zhang, S., Wei, M., Zhan, Q., Wen, C., Li, F., et al. (2024) · Cell Research · doi:10.1038/s41422-024-00990-9 · Cited by 46
Baharom, F., Hermans, D., Delamarre, L., & Seder, R. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01091-9 · Cited by 47
Park, W., Choi, J., Hwang, J., Kim, S. H., Kim, Y., Shim, M. K., Park, W., Yu, S., Jung, S., Yang, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c16562 · Cited by 47
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Song, K.-W., Lim, M. K., & Monje, M. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.017 · Cited by 50
Liu, H., Jia, Z., Yang, C., Song, M. L., Jing, Z., Zhao, Y., Wu, Z., Zhao, L., Wei, D., Yin, Z., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.014 · Cited by 45
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Lybaert, L., Vermaelen, K. Y., Geest, B. G. D., & Nuhn, L. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.09.009 · Cited by 46
Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients
Petrizzo, A., Tagliamonte, M., Mauriello, A., Costa, V., Aprile, M., Esposito, R., Caporale, A., Luciano, A., Arra, C., Tornesello, M. L., et al. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1662-9 · Cited by 46
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Yang, B., Liu, T., Qu, Y., Liu, H., Zheng, S. G., Cheng, B., & Sun, J. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00563 · Cited by 47
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Mauriello, A., Zeuli, R., Cavalluzzo, B., Petrizzo, A., Tornesello, M. L., Buonaguro, L., Ceccarelli, M., Tagliamonte, M., & Buonaguro, L. (2019) · Cancers · doi:10.3390/cancers11121824 · Cited by 50
Wang, G., Wan, H., Jian, X., Li, Y., Ouyang, J., Tan, X., Zhao, Y., Lin, Y., & Xie, L. (2020) · BioMed Research International · doi:10.1155/2020/5798356 · Cited by 47
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Bao, R., Spranger, S., Hernandez, K. M., Zha, Y., Pytel, P., Luke, J. J., Gajewski, T. F., Volchenboum, S. L., Cohn, S. L., & Desai, A. V. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002417 · Cited by 45
Wu, Y., Wen, H., Bernstein, Z. J., Hainline, K. M., Blakney, T. S., Congdon, K. L., Snyder, D. J., Sampson, J. H., Sanchez-Perez, L. A., & Collier, J. H. (2022) · Science Advances · doi:10.1126/sciadv.abm7833 · Cited by 48
Metadata
- Authors
- Sahin, U., Derhovanessian, E., Miller, M., Kloke, B.-P., Simon, P., Löwer, M., Bukur, V., Tadmor, A. D., Luxemburger, U., Schrörs, B., Omokoko, T., Vormehr, M., Albrecht, C., Paruzynski, A., Kuhn, A. N., Buck, J., Heesch, S., Schreeb, K. H., Müller, F., Ortseifer, I., Vogler, I., Godehardt, E., Attig, S., Rae, R., Breitkreuz, A., Tolliver, C., Suchan, M., Martic, G., Hohberger, A., Sorn, P., Diekmann, J., Ciesla, J., Waksmann, O., Brück, A.-K., Witt, M., Zillgen, M., Rothermel, A., Kasemann, B., Langer, D., Bolte, S., Diken, M., Kreiter, S., Nemecek, R., Gebhardt, C., Grabbe, S., Höller, C., Utikal, J., Huber, C., Loquai, C., & Türeci, Ö.
- Affiliations
- BioNTech (Germany) (DE)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Medical University of Vienna (AT)
- German Cancer Research Center (DE)
- ORCID
- Venue
- Nature
- Published
- 2017-07-05
- Volume
- 547
- Issue
- 7662
- Pages
- 222-226
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2724264513
- Cited by
- 2,488
- References
- 43
- Citations by year
- 2026: 228 · 2025: 255 · 2024: 259 · 2023: 299 · 2022: 277 · 2021: 317 · 2020: 290 · 2019: 262 · 2018: 239 · 2017: 58
- FWCI
- 105.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- neoantigens, melanoma, cancer immunotherapy, T cell response, metastasis prevention, anti-PD-1 therapy, acquired resistance, beta2-microglobulin deficiency, vaccine safety and tolerability, tumor cell killing, tumor-infiltrating T cells
- MeSH terms
- Nivolumab, Antibodies, Monoclonal, Epitopes, beta 2-Microglobulin, Humans, Immunotherapy, Melanoma, Mutation, Neoplasm Metastasis, Neoplasm Recurrence, Local, RNA, T-Lymphocytes, Vaccination, CD8 Antigens, Cancer Vaccines, Precision Medicine, B7-H1 Antigen, Programmed Cell Death 1 Receptor
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