The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
Abstract
T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of individualized mutanome vaccines and implemented an RNA-based poly-neo-epitope approach to mobilize immunity against a spectrum of cancer mutations. Here we report the first-in-human application of this concept in melanoma. We set up a process comprising comprehensive identification of individual mutations, computational prediction of neo-epitopes, and design and manufacturing of a vaccine unique for each patient. All patients developed T cell responses against multiple vaccine neo-epitopes at up to high single-digit percentages. Vaccine-induced T cell infiltration and neo-epitope-specific killing of autologous tumour cells were shown in post-vaccination resected metastases from two patients. The cumulative rate of metastatic events was highly significantly reduced after the start of vaccination, resulting in a sustained progression-free survival. Two of the five patients with metastatic disease experienced vaccine-related objective responses. One of these patients had a late relapse owing to outgrowth of β2-microglobulin-deficient melanoma cells as an acquired resistance mechanism. A third patient developed a complete response to vaccination in combination with PD-1 blockade therapy. Our study demonstrates that individual mutations can be exploited, thereby opening a path to personalized immunotherapy for patients with cancer.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, intranodal vaccination with free mRNA encoding ten neoepitopes of 13 patients with metastatic melanoma generated T cell immunity against multiple neoepitopes in all patients209.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [209]
In the citing paper
“A first-in-human trial demonstrated the clinical feasibility and safety of this approach for advanced melanoma cancers: all vaccinated patients developed CD4 + and CD8 + T cell responses against the selected antigens, with some patients showing objective antitumor responses [15].”
From Three decades of messenger RNA vaccine development (2019) · cites this paper as [15]
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
Primer3—new capabilities and interfaces
Untergasser, A., Cutcutache, I., Kõressaar, T., Ye, J., Faircloth, B., Remm, M., & Rozen, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks596 · Cited by 9,165
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802
Self-citationPD-1 blockade induces responses by inhibiting adaptive immune resistance
Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609
Pembrolizumab versus Ipilimumab in Advanced Melanoma
Robert, C., Schachter, J., Long, G. V., Arance, A., Grob, J. J., Mortier, L., Daud, A., Carlino, M. S., McNeil, C., Lotem, M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503093 · Cited by 5,887
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 1,002
The perfect personalized cancer therapy: cancer vaccines against neoantigens
Aurisicchio, L., Pallocca, M., Ciliberto, G., & Palombo, F. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0751-1 · Cited by 93
Nam, J., Son, S., Park, K. S., & Moon, J. J. (2021) · Advanced Science · doi:10.1002/advs.202002577 · Cited by 92
The MHC Motif Atlas: a database of MHC binding specificities and ligands
Tadros, D. M., Eggenschwiler, S., Racle, J., & Gfeller, D. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac965 · Cited by 90
Müller, M., Gfeller, D., Coukos, G., & Bassani‐Sternberg, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01367 · Cited by 87
Horrevorts, S. K., Stolk, D. A., van de Ven, R., Hulst, M., Hof, B. V. H., Duinkerken, S., Heineke, M. H., Ma, W., Dusoswa, S. A., Nieuwland, R., et al. (2019) · Cancers · doi:10.3390/cancers11091266 · Cited by 91
Veatch, J. R., Jesernig, B. L., Kargl, J., Fitzgibbon, M., Lee, S. M., Baik, C., Martins, R., Houghton, A. M., & Riddell, S. R. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0402 · Cited by 89
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
Siewert, C. D., Haas, H., Cornet, V., Nogueira, S. S., Nawroth, T., Uebbing, L., Ziller, A., Al-Gousous, J., Rădulescu, A., Schroer, M. A., et al. (2020) · Cells · doi:10.3390/cells9092034 · Cited by 92
HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
Witzleben, A. V., Wang, C., Laban, S. A., Savelyeva, N., & Ottensmeier, C. H. H. (2020) · Cells · doi:10.3390/cells9092103 · Cited by 93
Gartner, J. J., Parkhurst, M. R., Gros, A., Tran, E., Jafferji, M. S., Copeland, A. R., Hanada, K., Zacharakis, N., Lalani, A., Krishna, S., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00197-6 · Cited by 90
Goddard, E. T., Linde, M. H., Srivastava, S., Klug, G., Shabaneh, T. B., Iannone, S., Grzelak, C. A., Marsh, S. A., Riggio, A. I., Shor, R. E., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2023.12.011 · Cited by 96
Zhang, X., Goedegebuure, S. P., Chen, M. Y., Mishra, R., Zhang, F., Yu, Y. Y., Singhal, K., Li, L., Gao, F., Myers, N. B., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01388-3 · Cited by 89
Tumour and microenvironment crosstalk in NSCLC progression and response to therapy
Rahal, Z., Darzi, R. E., Moghaddam, S. J., Cascone, T., & Kadara, H. N. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01021-1 · Cited by 105
Balta, E., Wabnitz, G. H., & Samstag, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115736 · Cited by 88
Nucleic Acid Drugs—Current Status, Issues, and Expectations for Exosomes
Yamada, Y. (2021) · Cancers · doi:10.3390/cancers13195002 · Cited by 92
Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
Jacquemin, V., Antoine, M., Dom, G., Detours, V., Maenhaut, C., & Dumont, J. E. (2022) · Cancers · doi:10.3390/cancers14020280 · Cited by 92
Precision medicine in diabetes: an opportunity for clinical translation
Merino, J., & Florez, J. C. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13588 · Cited by 90
Zeng, B., Middelberg, A. P. J., Gemiarto, A. T., MacDonald, K. P. A., Baxter, A. G., Talekar, M., Moi, D., Tullett, K. M., Caminschi, I., Lahoud, M. H., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96791 · Cited by 87
mRNA nanodelivery systems: targeting strategies and administration routes
Yuan, M., Han, Z., Liang, Y., Sun, Y., He, B., Chen, W., & Fan, L. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00425-3 · Cited by 98
Recent progress in mRNA cancer vaccines
Yao, R., Xie, C., & Xia, X. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2307187 · Cited by 91
Small circular RNAs as vaccines for cancer immunotherapy
Zhang, Y., Liu, X., Shen, T., Wang, Q., Zhou, S., Yang, S., Liao, S., Su, T., Mei, L., Zhang, B., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01344-5 · Cited by 94
Qiu, F. X., Becker, K. W., Knight, F. C., Baljon, J. J., Sevimli, S., Shae, D., Gilchuk, P., Joyce, S., & Wilson, J. T. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.052 · Cited by 87
The current clinical landscape of personalized cancer vaccines
Fritah, H., Rovelli, R., Chiang, C. L.-L., & Kandalaft, L. E. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102383 · Cited by 87
Arieta, C. M., Xie, Y. J., Rothenberg, D., Diao, H., Harjanto, D., Meda, S., Marquart, K., Koenitzer, B., Sciuto, T. E., Lobo, A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.04.007 · Cited by 88
Self-citationGálvez‐Cancino, F., López, E., Menares, E., Díaz, X., Flores, C., Cáceres, P., Hidalgo, S., Chovar, O., Alcántara‐Hernández, M., Borgna, V., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1442163 · Cited by 91
Systems Immunology: Learning the Rules of the Immune System
Villani, A., Sarkizova, S., & Hacohen, N. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053035 · Cited by 89
Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer
Liu, S., Matsuzaki, J., Wei, L., Tsuji, T., Battaglia, S., Hu, Q., Cortes, E., Wong, L.-P., Yan, L., Long, M. D., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0629-6 · Cited by 85
Millar, D. G., Ramjiawan, R. R., Kawaguchi, K., Gupta, N., Jiang, C., Zhang, S., Nojiri, T., Ho, W. W., Aoki, S., Jung, K., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0404-8 · Cited by 85
Engelhard, V. H., Obeng, R. C., Cummings, K. L., Petroni, G. R., Ambakhutwala, A. L., Chianese‐Bullock, K. A., Smith, K. T., Lulu, A. M., Varhegyi, N., Smolkin, M. E., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000262 · Cited by 87
Cancer Vaccines: Antigen Selection Strategy
Zhao, Y., Baldin, A. V., Isayev, O., Werner, J., Zamyatnin, A. A., & Bazhin, A. V. (2021) · Vaccines · doi:10.3390/vaccines9020085 · Cited by 87
Personalized cancer vaccine design using AI-powered technologies
Kumar, A., Dixit, S., Srinivasan, K., Dinakaran, M., & Vincent, P. M. D. R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1357217 · Cited by 94
Moynihan, K. D., Holden, R. L., Mehta, N. K., Wang, C., Karver, M. R., Dinter, J., Liang, S., Abraham, W. D., Melo, M. B., Zhang, A. Q., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0607 · Cited by 81
Therapeutic cancer vaccine: building the future from lessons of the past
Tran, T., Blanc, C., Granier, C., Saldmann, A., Tanchot, C., & Tartour, É. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0691-z · Cited by 85
Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy
Johnson, D. T., Zhou, J., Kroll, A. V., Fang, R. H., Yan, M., Xiao, C., Chen, X., Kline, J. P., Zhang, L., & Zhang, D. (2021) · Leukemia · doi:10.1038/s41375-021-01432-w · Cited by 87
Recent progress of dendritic cell-derived exosomes (Dex) as an anti-cancer nanovaccine
Xia, J., Miao, Y., Wang, X., Huang, X., & Dai, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113250 · Cited by 89
Metal‐Organic Frameworks for Gene Therapy and Detection
He, Y., Li, D., Wu, L., Yin, X., Zhang, X., Patterson, L. H., & Zhang, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202212277 · Cited by 85
The 2018 Nobel Prize in medicine goes to cancer immunotherapy
Guo, Z. S. (2018) · BMC Cancer · doi:10.1186/s12885-018-5020-3 · Cited by 88
Testing thousands of nanoparticles in vivo using DNA barcodes
Lokugamage, M. P., Sago, C. D., & Dahlman, J. E. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.08.001 · Cited by 84
Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors
Kisielow, J., Obermair, F.-J., & Köpf, M. (2019) · Nature Immunology · doi:10.1038/s41590-019-0335-z · Cited by 83
Vaccines for immunoprevention of cancer
Enokida, T., Moreira, A., & Bhardwaj, N. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146956 · Cited by 85
Chen, H., Li, Z., Qiu, L., Dong, X., Chen, G., Shi, Y., Cai, L., Liu, W., Ye, H., Zhou, Y., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004389 · Cited by 85
Vaccines as treatments for prostate cancer
Rastogi, I., Muralidhar, A., & McNeel, D. G. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00739-w · Cited by 86
Eliciting antitumor immunity via therapeutic cancer vaccines
Peng, K., Zhao, X., Fu, Y., & Liang, Y. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01316-4 · Cited by 104
Steatohepatitis Impairs T-cell–Directed Immunotherapies Against Liver Tumors in Mice
Heinrich, B., Brown, Z. J., Diggs, L. P., Vormehr, M., Ma, C., Subramanyam, V., Rosato, U., Ruf, B., Walz, J. S., McVey, J. C., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.031 · Cited by 81
Self-citationBonsack, M., Hoppe, S., Winter, J., Tichy, D., Zeller, C. M., Kupper, M. D., Schitter, E. C., Blatnik, R., & Riemer, A. B. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0584 · Cited by 83
Zhao, J., Chen, Y., Ding, Z., & Liu, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01184 · Cited by 80
Liu, C. J., Schaettler, M. O., Blaha, D. T., Bowman-Kirigin, J. A., Kobayashi, D. K., Livingstone, A. J., Bender, D. E., Miller, C. A., Kranz, D. M., Johanns, T. M., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa050 · Cited by 86
Architects of immunity: How dendritic cells shape CD8 + T cell fate in cancer
Bhandarkar, V., Dinter, T., & Spranger, S. (2025) · Science Immunology · doi:10.1126/sciimmunol.adf4726 · Cited by 88
mRNA in cancer immunotherapy: beyond a source of antigen
Hoecke, L. V., Verbeke, R., Dewitte, H., Lentacker, I., Vermaelen, K. Y., Breckpot, K., & Lint, S. V. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01329-3 · Cited by 85
Peng, S., Chen, S., Hu, W., Mei, J., Zeng, X., Su, T., Wang, W., Chen, Z., Xiao, H., Zhou, Q., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0931 · Cited by 79
Ni, J., Zhang, Z., Ge, M.-J., Chen, J., & Zhuo, W. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00953-z · Cited by 85
Development of therapeutic vaccines for the treatment of diseases
Tian, Y., Hu, D., Li, Y., & Li, Y. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00098-9 · Cited by 89
Sittplangkoon, C., Alameh, M.-G., Weissman, D., Lin, P. J. C., Tam, Y. K., Prompetchara, E., & Palaga, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.983000 · Cited by 79
“Prior to the widely use of mRNA vaccine for COVID-19, the mRNA-based cancer vaccines have been tested in clinical trials (9) such as personalized RNA mutanome vaccine (10) that is highly effective in inducing anti-tumor immunity.”
MethodCOVID-19 in Human, Animal, and Environment: A Review
Swelum, A. A., Shafi, M. E., Albaqami, N. M., El‐Saadony, M. T., Elsify, A. M., Abdo, M., Taha, A. E.-S., Abdel‐Moneim, A. E., Al-Gabri, N. A., Almaiman, A. A., et al. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00578 · Cited by 83
Maximizing the Translational Yield of mRNA Therapeutics by Minimizing 5′-UTRs
Trepotec, Z., Aneja, M. K., Geiger, J., Hasenpusch, G., Plank, C., & Rudolph, C. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0485 · Cited by 77
Wang, C., Shi, X., Song, H., Zhang, C., Wang, X., Huang, P., Dong, A., Zhang, Y., Kong, D., & Wang, W. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120579 · Cited by 77
Targeting neoantigens for cancer immunotherapy
Zhao, X., Pan, X., Wang, Y., & Zhang, Y. (2021) · Biomarker Research · doi:10.1186/s40364-021-00315-7 · Cited by 78
Cancer Neoantigens: Challenges and Future Directions for Prediction, Prioritization, and Validation
Borden, E. S., Buetow, K. H., Wilson, M. A., & Hastings, K. T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.836821 · Cited by 86
Bauer, J., Köhler, N., Maringer, Y., Bucher, P., Bilich, T., Zwick, M., Dicks, S., Nelde, A., Dubbelaar, M. L., Scheid, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33746-3 · Cited by 77
Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
Moussion, C., & Delamarre, L. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101848 · Cited by 82
Schischlik, F., Jäger, R., Rosebrock, F., Hug, E., Schuster, M. K., Holly, R., Fuchs, E., Feenstra, J. D. M., Bogner, E., Gisslinger, B., et al. (2019) · Blood · doi:10.1182/blood.2019000519 · Cited by 77
Direct Detection and Quantification of Neoantigens
Wang, Q., Douglass, J., Hwang, M. S., Hsiue, E. H.-C., Mog, B. J., Zhang, M., Papadopoulos, N., Kinzler, K. W., Zhou, S., & Vogelstein, B. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0107 · Cited by 81
Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells—An Update
Dörrie, J., Schaft, N., Schuler, G., & Schuler‐Thurner, B. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020092 · Cited by 79
Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process
Feola, S., Chiaro, J., Martins, B., & Cerullo, V. (2020) · Cancers · doi:10.3390/cancers12061660 · Cited by 86
Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach
Kim, C.-G., Sang, Y. B., Lee, J. H., & Chon, H. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158035 · Cited by 78
Chen, Z., Zhang, S., Han, N., Jiang, J., Xu, Y., Ma, D., Lu, L., Guo, X., Qiu, M. R., Huang, Q., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.691605 · Cited by 79
mRNA Cancer Vaccines: Construction and Boosting Strategies
Liu, X., Huang, P., Yang, R., & Deng, H. (2023) · ACS Nano · doi:10.1021/acsnano.3c05635 · Cited by 79
Multi-Omics Profiling of the Tumor Microenvironment: Paving the Way to Precision Immuno-Oncology
Finotello, F., & Eduati, F. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00430 · Cited by 77
Evolution of Cancer Vaccines—Challenges, Achievements, and Future Directions
Tay, B. Q., Wright, Q., Ladwa, R., Perry, C., Leggatt, G., Simpson, F., Wells, J. W., Panizza, B. J., Frazer, I. H., & Cruz, J. L. G. (2021) · Vaccines · doi:10.3390/vaccines9050535 · Cited by 76
Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and Vaccines
Fernández‐Delgado, I., Calzada‐Fraile, D., & Sánchez‐Madrid, F. (2020) · Cancers · doi:10.3390/cancers12123558 · Cited by 79
Therapeutic strategies to remodel immunologically cold tumors
Wang, M., Wang, S., Desai, J., Trapani, J. A., & Neeson, P. J. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1226 · Cited by 79
Structural dissimilarity from self drives neoepitope escape from immune tolerance
Devlin, J. R., Alonso, J. A., Ayres, C. M., Keller, G. L. J., Bobisse, S., Kooi, C. W. V., Coukos, G., Gfeller, D., Harari, A., & Baker, B. M. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0610-1 · Cited by 70
Bassani‐Sternberg, M., Digklia, A., Huber, F., Wagner, D., Sempoux, C. L., Stevenson, B. J., Thierry, A., Michaux, J., Pak, H., Racle, J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01832 · Cited by 75
Schmidt, M., Weyer‐Elberich, V., Hengstler, J. G., Heimes, A.-S., Almstedt, K., Gerhold‐Ay, A., Lebrecht, A., Battista, M. J., Hasenburg, A., Şahin, U., et al. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0942-x · Cited by 78
Nanocarriers for cancer nano-immunotherapy
Rana, I., Oh, J., Baig, J., Moon, J. H., Son, S., & Nam, J. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01241-3 · Cited by 76
Correlates of immune and clinical activity of novel cancer vaccines
van der Burg, S. H. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.04.001 · Cited by 76
Johanns, T. M., Miller, C. A., Liu, C. J., Perrin, R. J., Bender, D. E., Kobayashi, D. K., Campian, J. L., Chicoine, M. R., Dacey, R. G., Huang, J., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2018.1561106 · Cited by 75
Computational Pipeline for the PGV-001 Neoantigen Vaccine Trial
Rubinsteyn, A., Kodysh, J., Hodes, I., Mondet, S., Aksoy, B. A., Finnigan, J. P., Bhardwaj, N., & Hammerbacher, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01807 · Cited by 74
Charles, J., Chaperot, L., Hannani, D., Costa, J. B., Templier, I., Trabelsi, S., Gil, H., Moisan, A., Persoons, V., Hegelhofer, H., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1738812 · Cited by 75
Cell and tissue engineering in lymph nodes for cancer immunotherapy
Najibi, A. J., & Mooney, D. J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.023 · Cited by 73
Cancer Vaccines: Promising Therapeutics or an Unattainable Dream
Donninger, H., Li, C., Eaton, J. W., & Yaddanapudi, K. (2021) · Vaccines · doi:10.3390/vaccines9060668 · Cited by 74
Li, F., Deng, L., Jackson, K. R., Talukder, A. H., Katailiha, A. S., Bradley, S. D., Zou, Q., Chen, C., Huo, C., Chiu, Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002531 · Cited by 74
Recent Advances and Next Breakthrough in Immunotherapy for Cancer Treatment
Yang, L., Ning, Q., & Tang, S. (2022) · Journal of Immunology Research · doi:10.1155/2022/8052212 · Cited by 78
Synergistic potential of immune checkpoint inhibitors and therapeutic cancer vaccines
Oladejo, M., Paulishak, W., & Wood, L. M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.003 · Cited by 75
Nucleic Acid-Based Approaches for Tumor Therapy
Hager, S., Fittler, F. J., Wagner, E., & Bros, M. (2020) · Cells · doi:10.3390/cells9092061 · Cited by 78
Wang, J., Meng, J., Wei, R., Lee, R. J., Teng, L., Zhang, P., & Li, Y. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01717 · Cited by 72
Liu, M., Cao, Z., Zhang, R., Chen, Y., & Yang, X. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c08285 · Cited by 71
Cancer vaccines: past, present and future; a review article
Grimmett, E., Al-Share, B. A., Alkassab, M. B., Zhou, R. W., Desai, A., Rahim, M. M. A., & Woldie, I. (2022) · Discover Oncology · doi:10.1007/s12672-022-00491-4 · Cited by 77
The future of cancer immunotherapy: DNA vaccines leading the way
Pandya, A. J., Shah, Y. B., Kothari, N. R., Postwala, H. I., Shah, A. C., Parekh, P. S., & Chorawala, M. R. (2023) · Medical Oncology · doi:10.1007/s12032-023-02060-3 · Cited by 80
Tumor Vaccines: Unleashing the Power of the Immune System to Fight Cancer
Liu, D., Che, X., Wang, X., Ma, C., & Wu, G. (2023) · Pharmaceuticals · doi:10.3390/ph16101384 · Cited by 84
Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines
Rinoldi, C., Zargarian, S. S., Nakielski, P., Li, X., Liguori, A., Petronella, F., Presutti, D., Wang, Q., Costantini, M., Sio, L. D., et al. (2021) · Small Methods · doi:10.1002/smtd.202100402 · Cited by 78
Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors
Ye, T., Li, F., Ma, G., & Wei, W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113927 · Cited by 73
Computational immunogenomic approaches to predict response to cancer immunotherapies
Addala, V., Newell, F., Pearson, J. V., Redwood, A., Robinson, B. W. S., Creaney, J., & Waddell, N. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00830-6 · Cited by 79
Beck, J. D., Diken, M., Suchan, M., Streuber, M., Diken, E., KOLB, L. D., Allnoch, L., Vascotto, F., Peters, D., Beißert, T., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.013 · Cited by 72
Self-citationdbPepNeo: a manually curated database for human tumor neoantigen peptides
Tan, X., Li, D., Huang, P., Jian, X., Wan, H., Wang, G., Li, Y., Ouyang, J., Lin, Y., & Xie, L. (2020) · Database · doi:10.1093/database/baaa004 · Cited by 71
Stickdorn, J., Stein, L., Arnold-Schild, D., Hahlbrock, J., Medina‐Montano, C., Bartneck, J., Ziß, T., Montermann, E., Kappel, C., Hobernik, D., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c10709 · Cited by 70
Self-citationMucosal immunity and vaccination strategies: current insights and future perspectives
Zhang, Z., Hong, W., Zhang, Y., Li, X., Que, H., & Wei, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00301-7 · Cited by 81
Uebbing, L., Ziller, A., Siewert, C., Schroer, M. A., Blanchet, C. E., Svergun, D. I., Ramishetti, S., Peer, D., Şahin, U., Haas, H., et al. (2020) · Langmuir · doi:10.1021/acs.langmuir.0c02446 · Cited by 68
Chyuan, I., Chu, C., & Hsu, P. (2021) · Cancers · doi:10.3390/cancers13061188 · Cited by 68
Cancer/testis antigens: from serology to mRNA cancer vaccine
Fan, C., Qu, H., Wang, X., Sobhani, N., Wang, L., Liu, S., Xiong, W., Zeng, Z., & Li, Y. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.016 · Cited by 72
Dolina, J. S., Lee, J., Brightman, S. E., McArdle, S., Hall, S. M., Thota, R. R., Zavala, K. S., Lanka, M., Premlal, A. L. R., Greenbaum, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci164258 · Cited by 68
Metadata
- Authors
- Sahin, U., Derhovanessian, E., Miller, M., Kloke, B.-P., Simon, P., Löwer, M., Bukur, V., Tadmor, A. D., Luxemburger, U., Schrörs, B., Omokoko, T., Vormehr, M., Albrecht, C., Paruzynski, A., Kuhn, A. N., Buck, J., Heesch, S., Schreeb, K. H., Müller, F., Ortseifer, I., Vogler, I., Godehardt, E., Attig, S., Rae, R., Breitkreuz, A., Tolliver, C., Suchan, M., Martic, G., Hohberger, A., Sorn, P., Diekmann, J., Ciesla, J., Waksmann, O., Brück, A.-K., Witt, M., Zillgen, M., Rothermel, A., Kasemann, B., Langer, D., Bolte, S., Diken, M., Kreiter, S., Nemecek, R., Gebhardt, C., Grabbe, S., Höller, C., Utikal, J., Huber, C., Loquai, C., & Türeci, Ö.
- Affiliations
- BioNTech (Germany) (DE)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Medical University of Vienna (AT)
- German Cancer Research Center (DE)
- ORCID
- Venue
- Nature
- Published
- 2017-07-05
- Volume
- 547
- Issue
- 7662
- Pages
- 222-226
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2724264513
- Cited by
- 2,488
- References
- 43
- Citations by year
- 2026: 228 · 2025: 255 · 2024: 259 · 2023: 299 · 2022: 277 · 2021: 317 · 2020: 290 · 2019: 262 · 2018: 239 · 2017: 58
- FWCI
- 105.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- neoantigens, melanoma, cancer immunotherapy, T cell response, metastasis prevention, anti-PD-1 therapy, acquired resistance, beta2-microglobulin deficiency, vaccine safety and tolerability, tumor cell killing, tumor-infiltrating T cells
- MeSH terms
- Nivolumab, Antibodies, Monoclonal, Epitopes, beta 2-Microglobulin, Humans, Immunotherapy, Melanoma, Mutation, Neoplasm Metastasis, Neoplasm Recurrence, Local, RNA, T-Lymphocytes, Vaccination, CD8 Antigens, Cancer Vaccines, Precision Medicine, B7-H1 Antigen, Programmed Cell Death 1 Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review