Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

Lee, Sangwon, Choi, Jungyuen, Mohanty, Jyotidarsini, Sousa, Leiliane P., Tome, Francisco, Pardon, Els, Steyaert, Jan, Lemmon, Mark A., Lax, Irit, Schlessinger, Joseph·2018·Nature
DOI 10.1038/nature25010

Cited by (234)

Items 201–234 of 234

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  13. The FGF metabolic axis
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  15. Additional file 1 of A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
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  16. Additional file 2 of FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
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  17. Additional file 2 of A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
    Rameswara Reddy Segireddy, Hugo Belda, Annie Yang, Kirsten Dundas, Julia Knöckel, Francis Galaway, Wood, Laura, Doris Quinkert, Ellen Knuepfer, Moritz Treeck et al. · 2024 · Figshare
  18. Additional file 3 of A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
    Rameswara Reddy Segireddy, Hugo Belda, Annie Yang, Kirsten Dundas, Julia Knöckel, Francis Galaway, Wood, Laura, Doris Quinkert, Ellen Knuepfer, Moritz Treeck et al. · 2024 · Figshare
  19. Additional file 6 of A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
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  20. Additional file 5 of A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
    Rameswara Reddy Segireddy, Hugo Belda, Annie Yang, Kirsten Dundas, Julia Knöckel, Francis Galaway, Wood, Laura, Doris Quinkert, Ellen Knuepfer, Moritz Treeck et al. · 2024 · Figshare
  21. Additional file 4 of A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
    Rameswara Reddy Segireddy, Hugo Belda, Annie Yang, Kirsten Dundas, Julia Knöckel, Francis Galaway, Wood, Laura, Doris Quinkert, Ellen Knuepfer, Moritz Treeck et al. · 2024 · Figshare
  22. The fibroblast growth factor-Klotho endocrine system in health and disease
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  23. Causes et conséquences de la variabilité interindividuelle des altérations lymphocytaires T dans la maladie rénale chronique
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  24. Hepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion
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  25. Prediction-Guided Design of a More Developable FGF21 Construct
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  26. Discovery of a covalent FGFR2-selective inhibitor overcoming clinically-acquired resistance mutations
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  27. Multi-tissue transcriptomic atlas reveals systemic effects of FGF19 on metabolism and immunity
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  28. Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
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  29. Allosteric β-Klotho Modulation to Restore FGF21 Sensitivity in Type 2 Diabetes
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  30. Lactobacillus helveticus R0052 Ameliorates Cholestasis with FXR-Related Pathways and Modulation of Gut Microbiota
    Xueyang Chen, Li Jiang, Ailing Li, Jian Shen · 2026 · Microorganisms
  31. “Klotho as a Tumor Suppressor in Gynecological and Breast Malignancies: From Mechanisms to Therapeutic Potential- A Narrative Review”
    Naina Kumar · 2026 · Indian Journal of Gynecologic Oncology
  32. The gastrointestinal KATP-ERK signaling axis: Molecular mechanisms, pharmacological opportunities, and emerging translational technologies
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  33. Liver-derived FGF21 contributes to protection against Alzheimer’s disease pathogenesis
    Rabab Al‐Lahham, Qaiss Dweik, Sravan G.S. Sreenivasa Murthy, Satkarjeet Kaur Gill, Balaji Krishnan, Silvana Valdebenito, Eliseo A. Eugenín, Cornelis J. Elferink · 2026 · NeuroImmune Pharmacology and Therapeutics
  34. BindingDB Entry 50021965: Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor.
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