Steyaert, Jan

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 3,009

Conformational biosensors reveal GPCR signalling from endosomes

Irannejad, R., Tomshine, J. C., Tomshine, J. R., Chevalier, M., Mahoney, J. P., Steyaert, J., Rasmussen, S. G. F., Sunahara, R. K., El-Samad, H., Huang, B., et al. (2013) · Nature

Receptor Mechanisms and SignalingCellular transport and secretion

Cited by 819

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., et al. (2016) · Nature

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 330

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

Laverty, D., Desai, R., Uchański, T., Masiulis, S., Stec, W. J., Malinauskas, T., Zivanov, J., Pardon, E., Steyaert, J., Miller, K. W., et al. (2019) · Nature

Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

Cited by 316

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

Lee, S., Choi, J., Mohanty, J., Sousa, L. P., Tome, F., Pardon, E., Steyaert, J., Lemmon, M. A., Lax, I., & Schlessinger, J. (2018) · Nature

Fibroblast Growth Factor ResearchParathyroid Disorders and Treatments

Cited by 236

Nanobody stabilization of G protein-coupled receptor conformational states

Steyaert, J., & Kobilka, B. K. (2011) · Current Opinion in Structural Biology

Receptor Mechanisms and SignalingEnzyme Structure and Function

Cited by 234

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Masureel, M., Zou, Y., Picard, L.-P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., et al. (2018) · Nature Chemical Biology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 194

Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins

Bloch, J. S., Mukherjee, S., Kowal, J., Filippova, E. V., Niederer, M., Pardon, E., Steyaert, J., Kossiakoff, A. A., & Locher, K. P. (2021) · Proceedings of the National Academy of Sciences

Advanced Electron Microscopy Techniques and ApplicationsEnzyme Structure and Function

Cited by 114

Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition

Sander, C. L., Sears, A. E., Pinto, A. F. M., Choi, E. H., Kahremany, S., Gao, F., Salom, D., Jin, H., Pardon, E., Suh, S., et al. (2021) · Journal of Cell Biology

Lipid Membrane Structure and BehaviorLipid metabolism and biosynthesis

Cited by 36

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

Kotov, V., Killer, M., Jungnickel, K. E. J., Lei, J., Finocchio, G., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.-S., et al. (2023) · Cell Reports

Drug Transport and Resistance MechanismsEnzyme Structure and Function

Cited by 20

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

Nunes-Silva, S., Gangnard, S., Vidal, M., Vuchelen, A., Dechavanne, S., Chan, S., Pardon, E., Steyaert, J., Ramboarina, S., Chêne, A., et al. (2014) · Scientific Reports

Malaria Research and ControlMonoclonal and Polyclonal Antibodies Research

Cited by 15

Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

Hariharan, P., Shi, Y., Katsube, S., Willibal, K., Burrows, N. D., Mitchell, P., Bakhtiiari, A., Stanfield, S., Pardon, E., Kaback, H. R., et al. (2024) · eLife

Drug Transport and Resistance MechanismsProtein Structure and Dynamics

Cited by 15

Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

Hariharan, P., Shi, Y., Katsube, S., Willibal, K., Burrows, N. D., Mitchell, P., Bakhtiiari, A., Stanfield, S., Pardon, E., Kaback, H. R., et al. (2024) · eLife

Drug Transport and Resistance MechanismsProtein Structure and Dynamics

Cited by 12

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams

Schenck, S., Laeremans, T., Steyaert, J., & Brunner, J. D. (2024) · Nature Communications

Botulinum Toxin and Related Neurological DisordersNeuroscience and Neuropharmacology Research

Cited by 9

Design principles of a membrane-spanning ubiquitin ligase

Williams, C., Nocka, L. M., Hedger, G., Parashara, P., Pardon, E., Latorraca, N. R., Pusapati, G. V., Sarkar, P., Lartey, D., Gao, L., et al. (2026) · Molecular Cell

Ubiquitin and proteasome pathwaysHedgehog Signaling Pathway Studies

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Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

Hariharan, P., Shi, Y., Katsube, S., Willibal, K., Burrows, N. D., Mitchell, P., Bakhtiiari, A., Stanfield, S., Pardon, E., Kaback, H. R., et al. (2024) · eLife

Drug Transport and Resistance MechanismsProtein Structure and Dynamics

Cited by 0