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A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder

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βKlotho is identified as a target for theranostics in non-small cell lung cancer

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Exploring endocrine FGFs - structures, functions and biomedical applications

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Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor

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Soluble α-klotho anchors TRPV5 to the distal tubular cell membrane independent of FGFR1 by binding TRPV5 and galectin-1 simultaneously

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Exerkines: Potential regulators of diabetic cardiomyopathy

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βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline

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Resources and Methods for Engineering “Designer” Glycan-Binding Proteins

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Liver‐derived FGF21 is required for the effect of time‐restricted feeding on high‐fat diet‐induced fatty liver in mice

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The fibroblast growth factor–Klotho axis at molecular level

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β-Klotho as novel therapeutic target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A narrative review

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Differential roles of individual bile acid in physiology and disease

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Serum β-klotho is a potential biomarker in the prediction of clinical outcomes among patients with NSCLC

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Next-generation isoform-selective fibroblast growth factor receptor inhibitors

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Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly

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Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs

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The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population

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Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer

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Characterization of FGF21 Sites of Production and Signaling in Mice

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Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

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Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression

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FGF21 Analogues and MASLD: A Summary of Preclinical and Clinical Data

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Research progress on the role of FGF21 in insulin resistance

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Association Between the Anti-Aging Protein Klotho and Sleep Duration in General Population

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Development of Zalfermin, a Long-Acting Proteolytically Stabilized FGF21 Analog

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The Pituitary Is a Candidate Organ That Modulates Circulating Klotho Levels

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Fibroblast Growth Factors: Roles and Emerging Therapeutic Applications

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Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21

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Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

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Novel Abs targeting the N‐terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile‐acid‐related side‐effects

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Emerging Trends in the Use of Therapeutic Hypothermia as a Method for Neuroprotection in Brain Damage (Review)

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The Role of Fibroblast Growth Factor 19 Subfamily in Different Populations Suffering From Osteoporosis

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Klotho promotes AMPK activity and maintains renal vascular integrity by regulating the YAP signaling pathway

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Unraveling Endocrine FGF Signaling Complex to Combat Metabolic Diseases

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Aberrant acetylated modification of FGF21‑KLB signaling contributes to hepatocellular carcinoma metastasis through the β‑catenin pathway

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A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions

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A primer on the pleiotropic endocrine fibroblast growth factor FGF19/FGF15

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In search of alternatively spliced alpha‐Klotho Kl1 protein in mouse brain

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Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling

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Treating metabolic dysfunction‐associated steatohepatitis: The fat‐trimming FGF21 approach

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βKlotho, a direct target of miR-206, contributes to the growth of hepatoblastoma through augmenting PI3K/Akt/mTOR signaling.

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Early Investigational and Experimental Therapeutics for the Treatment of Hypertriglyceridemia

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An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease

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Efimosfermin for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH): Mechanism of Action, Clinical Development and Emerging Therapeutic Potential

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Adipocyte FGF21 Signaling Defect Aggravated Adipose Tissue Inflammation in Gestational Diabetes Mellitus

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Nanobodies as solubilization chaperones for the expression and purification of inclusion-body prone proteins

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The role of alpha-Klotho protein in male and female reproduction. A systematic review

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Therapeutic Strategies for MASH: An Update on Drug Candidates Under Investigation in Late-Phase Clinical Trials

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FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction

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BRAIDing receptors for cell-specific targeting

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Computer-aided engineering of stabilized fibroblast growth factor 21

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FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell CarcinomaPreprint

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Enhanced bioactivity and stability of a long-acting FGF21: A novel variant for the treatment of NASH

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Muscle cells affect the promoting effect of FGF21 on lipid accumulation in porcine adipocytes through AhR/FGFR1 signaling pathway

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Белок клото и сердечно-сосудистая система

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Multi-trait genome-wide association meta-analysis of dietary intake identifies new loci and genetic and functional links with metabolic traitsPreprint

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Site-specific analysis and functional characterization of N-linked glycosylation for β-Klotho protein

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Serum β-klotho is a potential biomarker for diagnosing alcoholic liver disease and differentiating from nonalcoholic fatty liver disease

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Klotho protein and insulin resistance

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FGF21 reduces ER stress by enhancing the unfolded protein and integrated stress responses through increased sulfide signaling

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Overexpression and Purification of Mitogenic and Metabolic Fibroblast Growth Factors

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