The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
Open accessAbstract
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
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Cites
Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicity
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Self-citationSurvival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure
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Cited by
A swarm of slippery micropropellers penetrates the vitreous body of the eye
Wu, Z., Troll, J., Jeong, H.-H., Wei, Q., Stang, M., Ziemssen, F., Wang, Z., Dong, M., Schnichels, S., Qiu, T., et al. (2018) · Science Advances · doi:10.1126/sciadv.aat4388 · Cited by 567
Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes
Yu, Y., Yuk, H., Parada, G. A., Wu, Y., Liu, X., Nabzdyk, C. S., Youcef‐Toumi, K., Zang, J., & Zhao, X. (2019) · Advanced Materials · doi:10.1002/adma.201807101 · Cited by 482
Liquid-Infused Surfaces: A Review of Theory, Design, and Applications
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Self-citationDesigning Bioinspired Anti‐Biofouling Surfaces based on a Superwettability Strategy
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Metadata
- Authors
- Leslie, D. C., Waterhouse, A., Berthet, J. B., Valentin, T. M., Watters, A. L., Jain, A., Kim, P., Hatton, B. D., Nedder, A., Donovan, K., Super, E. H., Howell, C., Johnson, C. P., Vu, T. L., Bolgen, D. E., Rifai, S., Hansen, A. R., Aizenberg, M., Super, M., Aizenberg, J., & Ingber, D. E.
- Venue
- Nature Biotechnology
- Published
- 2014-10-12
- Volume
- 32
- Issue
- 11
- Pages
- 1134-1140
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2059148563
- Cited by
- 758
- References
- 30
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Leslie, D. C., Waterhouse, A., Berthet, J. B., Valentin, T. M., Watters, A. L., Jain, A., Kim, P., Hatton, B. D., Nedder, A., Donovan, K., Super, E. H., Howell, C., Johnson, C. P., Vu, T. L., Bolgen, D. E., Rifai, S., Hansen, A. R., Aizenberg, M., Super, M., . . . Ingber, D. E. (2014). A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nature Biotechnology. https://doi.org/10.1038/nbt.3020
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