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A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue
Abstract
A new method for the covalent binding of heparin to artificial surfaces has been developed. The heparinized surface releases insignificant amounts of heparin and can be regarded as stable. The blood contact properties as studied in vitro revealed that the surface was highly thromboresistant in terms of reduced platelet adhesion, surface catalyzed adsorption and inhibition of thrombin and capacity to prevent clotting of nonanticoagulated blood.
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Citations
Cited by
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
Leslie, D. C., Waterhouse, A., Berthet, J. B., Valentin, T. M., Watters, A. L., Jain, A., Kim, P., Hatton, B. D., Nedder, A., Donovan, K., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3020 · Cited by 758
The blood and vascular cell compatibility of heparin-modified ePTFE vascular grafts
Hoshi, R. A., Van Lith, R., Jen, M. C., Allen, J. B., Lapidos, K. A., & Ameer, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.046 · Cited by 272
Incorporation of heparin into biomaterials
Sakiyama-Elbert, S. E. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.08.045 · Cited by 222
Kidane, A. G., Salacinski, H., Tiwari, A., Bruckdorfer, K. R., & Seifalian, A. M. (2004) · Biomacromolecules · doi:10.1021/bm0344553 · Cited by 166
Balakrishnan, B., Kumar, D. S., Yoshida, Y., & Jayakrishnan, A. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.032 · Cited by 157
Metadata
- Authors
- Larm, O., Larsson, R., & Olsson, P.
- Venue
- Biomaterials, Medical Devices, and Artificial Organs
- Publisher
- Informa UK Limited
- Published
- 1983-01
- Volume
- 11
- Issue
- 2-3
- Pages
- 161-173
- ISSN
- 0090-5488 (ISSN-L)
- OpenAlex
- W2142076308
- Cited by
- 437
- References
- 0
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue. https://app.cochat.ai/papers/10.3109/10731198309118804
- The paper
- Larm, O., Larsson, R., & Olsson, P. (1983). A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue. Biomaterials, Medical Devices, and Artificial Organs. https://doi.org/10.3109/10731198309118804
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
