Biopharmaceutical benchmarks 2018

Walsh, Gary·2018·Nature Biotechnology

DOI 10.1038/nbt.4305

Cited by (849)

Items 101–200 of 849

Hydration-Induced Structural Changes in the Solid State of Protein: A SAXS/WAXS Study on Lysozyme
Tuan Phan-Xuan, Ekaterina Bogdanova, A. Millqvist-Fureby, Jonas Fransson, A. Terry, V. Kocherbitov · 2020 · Molecular Pharmaceutics
Electrically responsive release of proteins from conducting polymer hydrogels
Ernest Cheah, Mahima Bansal, Linh Nguyen, Anaïs E. Chalard, Jenny Malmström, Simon J. O’Carroll, Bronwen J. Connor, Zimei Wu, Darren M. Svirskis · 2023 · Acta Biomaterialia
Monitoring of amino acids and antibody N-glycosylation in high cell density perfusion culture based on Raman spectroscopy
Hubert Schwarz, Meeri Mäkinen, Andreas Castan, Véronique Chotteau · 2022 · Biochemical Engineering Journal
A synthetic transcription platform for programmable gene expression in mammalian cells
William C. W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C.G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wróblewska et al. · 2022 · Nature Communications
Systematic use of synthetic 5′-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories
Eisenhut, Peter, Mebrahtu, Aman, Moradi Barzadd, Mona, Thalén, Niklas, Klanert, Gerald, Weinguny, Marcus, Sandegren, Anna, Su, Chao, Hatton, Diane, Borth, Nicole et al. · 2020 · Nucleic Acids Research
Antibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions
Kenichi Nagase, Saki Ishii, K. Ikeda, Sota Yamada, D. Ichikawa, A. Akimoto, Yutaka Hattori, H. Kanazawa · 2020 · Scientific Reports
Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges
Simone Schadt, Simon Hauri, Filipe Lopes, Martin R. Edelmann, Roland F. Staack, Roberto Villaseñor, Hubert Kettenberger, Adrian B. Roth, Franz Schuler, Wolfgang F. Richter et al. · 2019 · Drug Metabolism and Disposition
Scaled-Up Production and Tableting of Grindable Electrospun Fibers Containing a Protein-Type Drug
Panna Vass, Edit Hirsch, Rita Kóczián, B. Démuth, A. Farkas, C. Fehér, Edina Szabó, Á. Németh, S. K. Andersen, T. Vigh et al. · 2019 · Pharmaceutics
Increase recombinant antibody yields through optimizing vector design and production process in CHO cells
Yong Xiao Yang, Zhengmei Li, Qin Li, Kai Ma, Yan Lin, Huigen Feng, Tianyun Wang · 2022 · Applied Microbiology and Biotechnology
Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable pool
Valerie Schmieder, Juergen Fieder, Raphael Drerup, Erik Arango Gutierrez, Carina Guelch, Jessica Stolzenberger, Mihaela Stumbaum, Volker Steffen Mueller, Fabian Higel, Martin Bergbauer et al. · 2022 · Journal of Biotechnology
Systematic assessment of process analytical technologies for biologics
Christopher M. Gillespie, Dhanuka P. Wasalathanthri, Diana B. Ritz, George Zhou, Keith A. Davis, Thomas Wucherpfennig, Nadine Hazelwood · 2021 · Biotechnology and Bioengineering
Plant-Based Vaccines: The Way Ahead?
Zacharie LeBlanc, Peter M. Waterhouse, Julia Bally · 2020 · Viruses
Truly continuous low pH viral inactivation for biopharmaceutical process integration
Duarte L. Martins, Jure Senčar, N. Hammerschmidt, Andreas Flicker, J. Kindermann, T. Kreil, Alois Jungbauer · 2020 · Biotechnology and Bioengineering
Current challenges and recent advances on the path towards continuous biomanufacturing
Miloš Drobnjaković, Roger Hart, Boonserm Kulvatunyou, Nenad Ivezic, Vijay Srinivasan · 2023 · Biotechnology Progress
Cancer Nanomedicines Based on Synthetic Polypeptides
Huanli Sun, Xiaolei Gu, Qiang Zhang, Hao Xu, Zhiyuan Zhong, Chao Deng · 2019 · Biomacromolecules
Glycoengineering Chinese hamster ovary cells: a short history
Donini, Roberto, Haslam, Stuart M., Kontoravdi, Cleo · 2021 · Biochemical Society Transactions
A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes
K. J. la Cour Karottki, Hooman Hefzi, Song-Yuan Li, L. E. Pedersen, Philipp N. Spahn, C. Joshi, David E. Ruckerbauer, Juan Hernández Bort, Alex Thomas, Jae Seong Lee et al. · 2020 · bioRxiv
Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans
Ngan Nguyen, Jian'er Lin, Shi Jie Tay, Mariati, Jessna H. M. Yeo, Terry Nguyen‐Khuong, Yuansheng Yang · 2021 · Scientific Reports
Treatment challenges and delivery systems in immunomodulation and probiotic therapies for periodontitis
Anže Zidar, Julijana Kristl, Petra Kocbek, Špela Zupančič · 2021 · Expert Opinion on Drug Delivery
Build a Sustainable Vaccines Industry with Synthetic Biology
R. Kitney, Jennifer Bell, J. Philp · 2021 · Trends in Biotechnology
Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE
Liang Zhang, Hubert Schwarz, Mingliang Wang, Andreas Castan, Håkan Hjalmarsson, Véronique Chotteau · 2020 · Metabolic Engineering
Expression vector cassette engineering for recombinant therapeutic production in mammalian cell systems
Tianyun Wang, Xiao han Guo · 2020 · Applied Microbiology and Biotechnology
Regulation of Metabolic Homeostasis in Cell Culture Bioprocesses
Conor M. O’Brien, Bhanu Chandra Mulukutla, Douglas G. Mashek, Wei‐Shou Hu · 2020 · Trends in biotechnology
Direct characterization of overproduced proteins by native mass spectrometry
Shay Vimer, Gili Ben‐Nissan, Michal Sharon · 2020 · Nature Protocols
Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells
Lisa Strasser, Stefano Boi, Felipe Guapo, Nicholas Donohue, Niall Barron, Alana Rainbow-Fletcher, Jonathan Bones · 2021 · International Journal of Molecular Sciences
Interferon-Based Biopharmaceuticals: Overview on the Production, Purification, and Formulation
Leonor S. Castro, Guilherme S. Lobo, Patrícia Pereira, Mara G. Freire, Márcia C. Neves, Augusto Quaresma Pedro · 2021 · Vaccines
Real‐Time Monitoring of Quality Attributes by In‐Line Fourier Transform Infrared Spectroscopic Sensors at Ultrafiltration and Diafiltration of Bioprocess
Wasalathanthri, Dhanuka P., Feroz, Hasin, Puri, Neha, Hung, Jessica, Lane, Gregory, Holstein, Melissa, Chemmalil, Letha, Both, Douglas, Ghose, Sanchayita, Ding, Julia et al. · 2020 · Biotechnology and Bioengineering
Exposing the molecular heterogeneity of glycosylated biotherapeutics
Schachner, Luis F., Mullen, Christopher, Phung, Wilson, Hinkle, Joshua D., Beardsley, Michelle Irwin, Bentley, Tracy, Day, Peter, Tsai, Christina, Sukumaran, Siddharth, Baginski, Tomasz et al. · 2024 · Nature Communications
Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products
Alexander Armstrong, Kieran Horry, Tingting Cui, Martyn E. Hulley, Richard C Turner, Suzanne S. Farid, Stephen Goldrick, Daniel G. Bracewell · 2021 · Journal of Chromatography A
Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations
Heena Dhiman, Marguerite Campbell, Michael Melcher, Kevin D. Smith, Nicole Borth · 2020 · Computational and Structural Biotechnology Journal
An in vivo platform to select and evolve aggregation-resistant proteins
Jessica S. Ebo, Janet C. Saunders, P. W. A. Devine, A. Gordon, Amy S. Warwick, B. Schiffrin, Stacey E. Chin, Elizabeth England, James D. Button, C. Lloyd et al. · 2020 · Nature Communications
Immobilized enzyme cascade for targeted glycosylation
Elli Makrydaki, Roberto Donini, Anja Krueger, Kate E. Royle, Ignacio Moya‐Ramírez, D.A. Kuntz, David R. Rose, Stuart M. Haslam, Karen Marie Polizzi, Cleo Kontoravdi · 2024 · Nature Chemical Biology
Systematic identification of safe harbor regions in the CHO genome through a comprehensive epigenome analysis
William Hilliard, Kelvin H. Lee · 2020 · Biotechnology and Bioengineering
Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies
Fengfei Ma, Fahimeh Raoufi, Marc Andre Bailly, Laurence Fayadat‐Dilman, Daniela M. Tomazela · 2020 · mAbs
Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion
Daniel Ley, Sara Pereira, Lasse Ebdrup Pedersen, Johnny Arnsdorf, Hooman Hefzi, Anne Mathilde Davy, Tae Kwang Ha, Tune Wulff, Helene Faustrup Kildegaard, Mikael Rørdam Andersen · 2019 · Metabolic Engineering
Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells
Pérez-Rodriguez, Saumel, Ramírez-Lira, María de Jesús, Trujillo-Roldán, Mauricio A., Valdez-Cruz, Norma A. · 2020 · Bioengineered
Advances and applications of capillary electromigration methods in the analysis of therapeutic and diagnostic recombinant proteins – A Review
Hanno Stutz · 2022 · Journal of Pharmaceutical and Biomedical Analysis
Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells
Noelia Blanco, Ambrose J. Williams, Danming Tang, Dejin Zhan, Shahram Misaghi, Robert F. Kelley, Laura C. Simmons · 2020 · Biotechnology and Bioengineering
Reinventing the Wheel: Synthetic Circular RNAs for Mammalian Cell Engineering
Alan Costello, Nga Thi Lao, Niall Barron, MARTIN M. CLYNES · 2019 · Trends in biotechnology
Mixed polymer brush as a functional ligand of silica beads for temperature-modulated hydrophobic and electrostatic interactions.
Kenichi Nagase, Sakiko Kitazawa, Sota Yamada, A. Akimoto, H. Kanazawa · 2020 · Analytica Chimica Acta
Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cells
Cristina Parola, Daniel Neumeier, Simon Friedensohn, Lucia Csepregi, Mariangela Di Tacchio, Derek M. Mason, Sai T. Reddy · 2019 · mAbs
Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix resulting in a directly compressible powder for tableting.
Panna Vass, Z. Nagy, Rita Kóczián, C. Fehér, B. Démuth, Edina Szabó, S. K. Andersen, T. Vigh, G. Verreck, I. Csontos et al. · 2019 · European Journal of Pharmaceutical Sciences
How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines
Nicolas Marx, Peter Eisenhut, Marcus Weinguny, Gerald Klanert, Nicole Borth · 2022 · Biotechnology Advances
Cell-Free Synthetic Glycobiology: Designing and Engineering Glycomolecules Outside of Living Cells
Thapakorn Jaroentomeechai, May N. Taw, Mingji Li, Alicia K. Aquino, Ninad Agashe, Sean S. Chung, Michael C. Jewett, Matthew P. DeLisa · 2020 · Frontiers in Chemistry
Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells
Marcus Weinguny, Gerald Klanert, Peter Eisenhut, Andreas Jonsson, Daniel Ivansson, Ann Lövgren, Nicole Borth · 2020 · Computational and Structural Biotechnology Journal
Integrated Design of Biopharmaceutical Manufacturing Processes: Operation Modes and Process Configurations for Monoclonal Antibody Production
Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama · 2020 · Computer-aided chemical engineering/Computer aided chemical engineering
Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody
Hiroaki Oyama, Hiroki Koga, Takashi Tadokoro, Katsumi Maenaka, Akira Shiota, Masami Yokoyama, Masanori Noda, Tetsuo Torisu, Susumu Uchiyama · 2019 · Journal of Pharmaceutical Sciences
Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery
Mai Bay Stie, Heidi Öblom, Anders Christian Nørgaard Hansen, Jette Bredahl Jacobsen, Ioannis S. Chronakis, Jukka Rantanen, Hanne Mørck Nielsen, Natalja Genina · 2022 · Carbohydrate Polymers
Modeling the Gibbs-Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model
Till Briskot, Nils Hillebrandt, Simon Kluters, Gang Wang, J. Studts, Tobias Hahn, Thiemo C Huuk, J. Hubbuch · 2022 · Journal of Membrane Science
Thermoinducible expression system for producing recombinant proteins in Escherichia coli: advances and insights
Sara Restrepo-Pineda, Néstor O. Pérez, Norma A. Valdez‐Cruz, Mauricio A. Trujillo‐Roldán · 2021 · FEMS Microbiology Reviews
Model-based process development and evaluation of twin-column continuous capture processes with Protein A affinity resin.
Yan-Na Sun, Ce Shi, Qi-Lei Zhang, Shan-Jing Yao, N. Slater, Dong-Qiang Lin · 2020 · Journal of Chromatography A
Computational fluid dynamics (CFD) as a tool for industrial UF/DF tank optimization
J. Wutz, B. Waterkotte, K. Heitmann, T. Wucherpfennig · 2020
Design space and robustness analysis of batch and counter-current frontal chromatography processes for the removal of antibody aggregates.
Sebastian Vogg, Thomas Müller-Späth, M. Morbidelli · 2020 · Journal of Chromatography A
How can monoclonal antibodies be harnessed against neglected tropical diseases and other infectious diseases?
Andreas H. Laustsen · 2019 · Expert Opinion on Drug Discovery
Harnessing Transient Expression Systems with Plant Viral Vectors for the Production of Biopharmaceuticals in Nicotiana benthamiana
Sayed Abdul Akher, K. Wang, Kylie Hall, Oluwaseyi Setonji Hunpatin, Muhammad Shan, Zeng-Lin Zhang, Yongfeng Guo · 2025 · International Journal of Molecular Sciences
CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells
Pavlos Kotidis, Roberto Donini, Johnny Arnsdorf, Anders Holmgaard Hansen, Bjørn Gunnar Rude Voldborg, Austin W.T. Chiang, Stuart M. Haslam, Michael J. Betenbaugh, Ioscani Jiménez del Val, Nathan E. Lewis et al. · 2023 · Metabolic Engineering
Optimising expression and extraction of recombinant proteins in plants
Ryan J. Coates, M. Young, S. Scofield · 2022 · Frontiers in Plant Science
Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin
Mai Bay Stie, Johan Ring Gätke, Ioannis S. Chronakis, Jette Bredahl Jacobsen, Hanne Mørck Nielsen · 2022 · International Journal of Molecular Sciences
Protein A-based ligands for affinity chromatography of antibodies
Qing-Hong Shi, Y. Sun · 2020
Generation and use of recombinant gonadotropins in fish.
G. Molés, Krist Hausken, M. Carrillo, S. Zanuy, B. Levavi-Sivan, A. Gomez · 2020 · General and Comparative Endocrinology
Choice of host cell line is essential for the functional glycosylation of the Fc region of human IgG1 inhibitors of influenza B viruses
Blundell, Patricia A, Lu, Dongli, Dell, Anne, Haslam, Stuart, Pleass, Richard J · 2020 · The Journal of Immunology
Progress of Transposon Vector System for Production of Recombinant Therapeutic Proteins in Mammalian Cells
Mian Wei, Chunliu Mi, Changqin Jing, Tianyun Wang · 2022 · Frontiers in Bioengineering and Biotechnology
Building a Versatile Protein Production Platform Using Engineered Trichoderma reesei.
Shunxing Chai, Zhi-Hua Zhu, Er-Nuo Tian, Meili Xiao, Yan Wang, Gen Zou, Zhi-Hua Zhou · 2021 · ACS Synthetic Biology
Exploring the molecular content of CHO exosomes during bioprocessing
Christoph Keysberg, Oliver Hertel, Louise Schelletter, Tobias Busche, Chiara Sochart, Jörn Kalinowski, Raimund Hoffrogge, Kerstin Otte, Thomas Noll · 2021 · Applied Microbiology and Biotechnology
Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies
Marcus Weinguny, Gerald Klanert, Peter Eisenhut, Isac Lee, Winston Timp, Nicole Borth · 2021 · Biotechnology Journal
Tracing production instability in a clonally derived CHO cell line using single‐cell transcriptomics
Ioanna Tzani, Nicholas Herrmann, Sara Carillo, Cathy A. Spargo, Ryan Hagan, Niall Barron, Jonathan Bones, W. Shannon Dillmore, Colin Clarke · 2021 · Biotechnology and Bioengineering
Strategies for Setting Patient-Centric Commercial Specifications for Biotherapeutic Products.
M. Ruesch, L. Benetti, Eileen Berkay, David Cirelli, Neha Frantz, Martin H Gastens, Wayne P Kelley, Juliana K Kretsinger, Mike Lewis, Shawn Novick et al. · 2020 · Journal of Pharmacy and Science
Polysaccharide-Based Biomaterials for Protein Delivery
Kaili Wang, Mingqi Liu, Ran Mo · 2020 · Medicine in Drug Discovery
Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches
Sebastián Sosa-Carrillo, Henri Galez, Sara Napolitano, F. Bertaux, Gregory Batt · 2022 · bioRxiv
Data-driven and model-guided systematic framework for media development in CHO cell culture
Jong Kwang Hong, Dong‐Hyuk Choi, Seo‐Young Park, Yaron R. Silberberg, Fumi Shozui, E. Nakamura, Takashi Kayahara, Dong‐Yup Lee · 2022 · Metabolic Engineering
Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications
Antiopi Vardaxi, Martha Kafetzi, Stergios Pispas · 2022 · Polymers
Transgenic eukaryotic microalgae as green factories: providing new ideas for the production of biologically active substances
Qianwen Shi, Cheng Chen, Wei Zhang, Ping Wu, Meng Sun, Hui Chen Wu, Haizhen Wu, Pengcheng Fu, Jianhua Fan · 2021 · Journal of Applied Phycology
High-Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads.
Marta Napiórkowska, Luzius Pestalozzi, S. Panke, M. Held, S. Schmitt · 2020 · Small
Conformational Ensembles of Antibodies Determine Their Hydrophobicity
Franz Waibl, Monica L. Fernández‐Quintero, Anna Sophia Kamenik, Johannes Kraml, Florian Hofer, Hubert Kettenberger, Guy J. Georges, Klaus Roman Liedl · 2020 · Biophysical Journal
Development of a generic reversed-phase liquid chromatography method for protein quantification using analytical quality-by-design principles.
J. Kopp, Florian B. Zauner, A. Pell, Johanna Hausjell, Diana Humer, Julian Jakob Ebner, C. Herwig, O. Spadiut, C. Slouka, Reinhard Pell · 2020 · Journal of Pharmaceutical and Biomedical Analysis
Strategies for enhancing gene expression in Escherichia coli
Tomo Kondo, Shigehiko Yumura · 2020 · Applied Microbiology and Biotechnology
A PSE perspective for the efficient production of monoclonal antibodies: integration of process, cell, and product design aspects
Sara Badr, Hirokazu Sugiyama · 2020 · Current Opinion in Chemical Engineering
Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance
Louis J. Wilson, Will Lewis, Richard Kucia-Tran, D. Bracewell · 2019 · Biotechnology progress (Print)
Manipulating gene expression levels in mammalian cell factories: An outline of synthetic molecular toolboxes to achieve multiplexed control
Peter Eisenhut, Nicolas Marx, Giulia Borsi, Maja Papež, Caterina Ruggeri, Martina Baumann, Nicole Borth · 2023 · New Biotechnology
CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering
Katja Glinšek, Krištof Bozovičar, Tomaž Bratkovič · 2023 · International Journal of Molecular Sciences
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation
Catarina Almeida, Augusto Quaresma Pedro, Ana P. M. Tavares, Márcia C. Neves, Mara G. Freire · 2023 · Frontiers in Bioengineering and Biotechnology
A model-based approach towards accelerated process development: A case study on chromatography
Steven Sachio, Cleo Kontoravdi, Maria M. Papathanasiou · 2023 · Process Safety and Environmental Protection
Forms and Methods for Interferon’s Encapsulation
Thelvia I. Ramos, Carlos A. Villacis-Aguirre, Nelson Santiago Vispo, Leandro Santiago Padilla, Seidy Pedroso‐Santana, Natalie C. Parra, Jorge Roberto Toledo · 2021 · Pharmaceutics
Building better biobetters: From fundamentals to industrial application
Karin Mariana Torres‐Obreque, Giovanna Pastore Meneguetti, Jorge Javier Muso Cachumba, Valker Araujo Feitosa, João H. P. M. Santos, Sónia P. M. Ventura, Carlota de Oliveira Rangel‐Yagui · 2021 · Drug Discovery Today
Anticalin® proteins: from bench to bedside
Friedrich‐Christian Deuschle, Elena Ilyukhina, Arne Skerra · 2020 · Expert Opinion on Biological Therapy
Stable Protein Sialylation in Physcomitrella
Lennard L. Bohlender, Juliana Parsons, Sebastian N. W. Hoernstein, Christine Rempfer, Natalia Ruiz-Molina, Timo Lorenz, Fernando Rodríguez-Jahnke, Rudolf Figl, Benjamin Fode, Friedrich Altmann et al. · 2020 · Frontiers in Plant Science
Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2
Jeffrey Victor Leyton · 2020 · Antibodies
The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directions
Kajan Srirangan, Martin Loignon, Yves Durocher · 2020 · Critical Reviews in Biotechnology
Polymeric Nanocarrier Formulations of Biologics Using Inverse Flash NanoPrecipitation
Chester E. Markwalter, Robert F. Pagels, Ava N. Hejazi, Akiva G. R. Gordon, Alexandra Skowron, Robert K. Prud’homme · 2020 · The AAPS Journal
How reliable are Chinese hamster ovary (CHO) cell genome‐scale metabolic models?
Benjamin Strain, James Morrissey, Athanasios Antonakoudis, Cleo Kontoravdi · 2023 · Biotechnology and Bioengineering
Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Jing Yang Wang, Alena Khmelinskaia, William Sheffler, Marcos C. Miranda, Aleksandar Antanasijevic, Andrew J. Borst, Susana Vázquez Torres, Chelsea Shu, Yang Hsia, Una Nattermann et al. · 2023 · Proceedings of the National Academy of Sciences
Best Practices for Aggregate Quantitation of Antibody Therapeutics by Sedimentation Velocity Analytical Ultracentrifugation
George M. Bou-Assaf, Ivan L. Budyak, Michael D. Brenowitz, Eric S. Day, David Hayes, John J. Hill, Ranajoy Majumdar, Paola Ringhieri, Peter Schuck, Jasper C. Lin · 2022 · Journal of Pharmaceutical Sciences
Charge variant analysis of protein-based biopharmaceuticals using two-dimensional liquid chromatography hyphenated to mass spectrometry
Simon Jaag, Marina Shirokikh, Michael Lämmerhofer · 2020 · Journal of Chromatography A
Novel human Ab against vascular endothelial growth factor receptor 2 shows therapeutic potential for leukemia and prostate cancer
Ruei‐Min Lu, Chiung‐Yi Chiu, I.-Ju Liu, Yu‐Ling Chang, Yaw‐Jen Liu, Han‐Chung Wu · 2019 · Cancer Science
Artificial Intelligence Assisted Pharmaceutical Crystallization
Zuoxuan Zhu, Yuan Zhang, Zhixuan Wang, Weiwei Tang, Jingkang Wang, Junbo Gong · 2024 · Crystal Growth & Design
Convolutional Neural Networks Guided Raman Spectroscopy as a Process Analytical Technology (PAT) Tool for Monitoring and Simultaneous Prediction of Monoclonal Antibody Charge Variants
Nitika, Nitika, Keerthiveena, B., Thakur, Garima, Rathore, Anurag S. · 2024 · Pharmaceutical Research
Visible Light Induces Site-Specific Oxidative Heavy Chain Fragmentation of a Monoclonal Antibody (IgG1) Mediated by an Iron(III)-Containing Histidine Buffer.
Yilue Zhang, C. Schöneich · 2022 · Molecular Pharmaceutics
Bioprocessing of recombinant proteins from Escherichia coli inclusion bodies: insights from structure-function relationship for novel applications
Kajal Kachhawaha, Santanu Singh, Khyati Joshi, Priyanka Nain, Sumit K. Singh · 2022 · Preparative Biochemistry & Biotechnology
Use of ubiquitous chromatin opening elements (UCOE) as tools to maintain transgene expression in biotechnology
Rebecca E. Sizer, Robert J. White · 2022 · Computational and Structural Biotechnology Journal
Near-infrared spectroscopy based monitoring of all 20 amino acids in mammalian cell culture broth
Geetanjali Basavaraj Hubli, Shantanu Banerjee, Anurag Singh Rathore · 2022 · Talanta