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Decoding global gene expression programs in liver cancer by noninvasive imaging
Abstract
Paralleling the diversity of genetic and protein activities, pathologic human tissues also exhibit diverse radiographic features. Here we show that dynamic imaging traits in non-invasive computed tomography (CT) systematically correlate with the global gene expression programs of primary human liver cancer. Combinations of twenty-eight imaging traits can reconstruct 78% of the global gene expression profiles, revealing cell proliferation, liver synthetic function, and patient prognosis. Thus, genomic activity of human liver cancers can be decoded by noninvasive imaging, thereby enabling noninvasive, serial and frequent molecular profiling for personalized medicine.
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“Because radiological phenotypes are fundamentally driven by the underlying pathophysiology, quantitative imaging analysis may reveal subtle relations between the two.22”
From Non-invasive tumor microenvironment evaluation and treatment response prediction in gastric cancer using deep learning radiomics (2023) · cites this paper as [22]
In the citing paper
“A watershed article in this regard came from Segal et al, who, in an early example of radiogenomics, used a finite series of radiologist-scored quantitative features to predict gene expression patterns in hepatocellular carcinoma (40).”
From Radiomics: Images Are More than Pictures, They Are Data (2016) · cites this paper as [40]
In the citing paper
“Seminal radiogenomic studies were the first to show a relationship between quantitative image features and gene expression patterns in patients with cancer (40,54,55).”
From Radiomics: Images Are More than Pictures, They Are Data (2016) · cites this paper as [40]
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Metadata
- Authors
- Segal, E., Sirlin, C. B., Ooi, C., Adler, A. S., Gollub, J., Chen, X., Chan, B. K., Matcuk, G. R., Barry, C. T., Chang, H. Y., & Kuo, M. D.
- Affiliations
- Weizmann Institute of Science (IL)
- University of California San Diego (US)
- University of Hong Kong (HK)
- Stanford University (US)
- University of California, San Francisco (US)
- University of Southern California (US)
- Corresponding author
- Chang, Howard Y
- Kuo, Michael D
- ORCID
- Venue
- Nature Biotechnology
- Published
- 2007-05-21
- Volume
- 25
- Issue
- 6
- Pages
- 675-680
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2055575746
- Cited by
- 629
- References
- 22
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 51 · 2023: 47 · 2022: 44 · 2021: 63 · 2020: 62 · 2019: 49 · 2018: 54 · 2017: 46 · 2016: 31 · 2015: 33 · 2014: 30 · 2013: 14 · 2012: 19
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- liver cancer, hepatocellular carcinoma, gene expression profiling, computed tomography, noninvasive molecular imaging, cell proliferation, liver synthetic function, prognosis, personalized medicine
- MeSH terms
- Carcinoma, Hepatocellular, Humans, Liver, Liver Neoplasms, Neoplasm Proteins, Radiographic Image Interpretation, Computer-Assisted, Tomography, X-Ray Computed, Biomarkers, Tumor, Gene Expression Profiling
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