Cited by 2,201Gold and Silver Nanoparticles Synthesis and ApplicationsNanoplatforms for cancer theranosticsSpectroscopy Techniques in Biomedical and Chemical Research

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In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

Qian, Ximei, Peng, Xiang-Hong, Ansari, Dominic O, Yin-Goen, Qiqin, Chen, Georgia Z, Shin, Dong M, Yang, Lily, Young, Andrew N, Wang, May D, Nie, Shuming·2008·Nature Biotechnology

DOI 10.1038/nbt1377

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Abstract

We describe biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold nanoparticles and surface-enhanced Raman scattering (SERS). Colloidal gold has been safely used to treat rheumatoid arthritis for 50 years, and has recently been found to amplify the efficiency of Raman scattering by 14-15 orders of magnitude. Here we show that large optical enhancements can be achieved under in vivo conditions for tumor detection in live animals. An important finding is that small-molecule Raman reporters such as organic dyes were not displaced but were stabilized by thiol-modified polyethylene glycols. These pegylated SERS nanoparticles were considerably brighter than semiconductor quantum dots with light emission in the near-infrared window. When conjugated to tumor-targeting ligands such as single-chain variable fragment (ScFv) antibodies, the conjugated nanoparticles were able to target tumor biomarkers such as epidermal growth factor receptors on human cancer cells and in xenograft tumor models.

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Authors: Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S.
Affiliations: Georgia Institute of Technology (US)
Emory University (US)
Corresponding author: Nie, Shuming
ORCID: Shin, Dong M
Yang, Lily
Wang, May D
Nie, Shuming
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2007-12-23
Volume: 26
Issue: 1
Pages: 83-90
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt1377
OpenAlex: W4234368842
Cited by: 2,201
References: 55
Citations by year: 2026: 38 · 2025: 43 · 2024: 62 · 2023: 57 · 2022: 74 · 2021: 82 · 2020: 100 · 2019: 116 · 2018: 121 · 2017: 163 · 2016: 149 · 2015: 183 · 2014: 199 · 2013: 165 · 2012: 166
FWCI: 51.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA108468, U54CA119338, P50CA128613)
National Institute of General Medical Sciences (T32GM008169)
Topics: Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Keywords: surface-enhanced Raman scattering, gold nanoparticles, PEGylated nanoparticles, Raman imaging, scFv, epidermal growth factor receptor, tumor xenografts, cancer detection, biocompatible nanoparticles
MeSH terms: Animals, Carcinoma, Squamous Cell, Humans, Particle Size, Spectrum Analysis, Raman, Drug Delivery Systems, Cell Line, Tumor, Mice, Nanoparticles

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