Cited by 2,201Gold and Silver Nanoparticles Synthesis and ApplicationsNanoplatforms for cancer theranosticsSpectroscopy Techniques in Biomedical and Chemical Research

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

Qian, Ximei, Peng, Xiang-Hong, Ansari, Dominic O, Yin-Goen, Qiqin, Chen, Georgia Z, Shin, Dong M, Yang, Lily, Young, Andrew N, Wang, May D, Nie, Shuming·2008·Nature Biotechnology

DOI 10.1038/nbt1377

Open this paper in CoChat — free account

Abstract

We describe biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold nanoparticles and surface-enhanced Raman scattering (SERS). Colloidal gold has been safely used to treat rheumatoid arthritis for 50 years, and has recently been found to amplify the efficiency of Raman scattering by 14-15 orders of magnitude. Here we show that large optical enhancements can be achieved under in vivo conditions for tumor detection in live animals. An important finding is that small-molecule Raman reporters such as organic dyes were not displaced but were stabilized by thiol-modified polyethylene glycols. These pegylated SERS nanoparticles were considerably brighter than semiconductor quantum dots with light emission in the near-infrared window. When conjugated to tumor-targeting ligands such as single-chain variable fragment (ScFv) antibodies, the conjugated nanoparticles were able to target tumor biomarkers such as epidermal growth factor receptors on human cancer cells and in xenograft tumor models.

Integrity signals

Registry

Crossref · 10.1038/nbt1377

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
Nie, S., & Emory, S. R. (1997) · Science · doi:10.1126/science.275.5303.1102 · Cited by 10,316
Self-citation
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,794
Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
Kneipp, K. D., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R. R., & Feld, M. S. (1997) · Physical Review Letters · doi:10.1103/physrevlett.78.1667 · Cited by 6,824
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
Huang, X., El‐Sayed, I. H., Qian, W. P., & El‐Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,442
In vivo cancer targeting and imaging with semiconductor quantum dots
Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,775
Self-citation
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,961

Flagged first, then by citations

Show all 55 references

Research works printed but not linked: 2

Mahmood, U. & Weissleder, R. Near-infrared optical imaging of proteases in cancer. Mol. Cancer Ther. 2, 489–496 (2003).
Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387–6392 (1986).

Sorted by citations

Items 301–400 of 1,003

SERS‐based detection of biomolecules
Cialla‐May, D., Pollok, S., Steinbrücker, C., Weber, K., & Popp, J. (2013) · Nanophotonics · doi:10.1515/nanoph-2013-0024 · Cited by 172
Spatially offset Raman spectroscopy for biomedical applications
Nicolson, F., Kircher, M. F., Stone, N., & Matousek, P. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00855a · Cited by 177
Laser spectrometry for multi-elemental imaging of biological tissues
Sancey, L., Motto‐Ros, V., Busser, B., Kotb, S., Benoit, J., Piednoir, A., Lux, F., Tillement, O., Panczer, G., & Yu, J. (2014) · Scientific Reports · doi:10.1038/srep06065 · Cited by 181
Targeted Radiotherapy with Gold Nanoparticles: Current Status and Future Perspectives
Ngwa, W. F., Kumar, R., Sridhar, S., Korideck, H., Zygmanski, P., Cormack, R. A., Berbeco, R. I., & Makrigiorgos, G. M. (2014) · Nanomedicine · doi:10.2217/nnm.14.55 · Cited by 173
Design and Synthesis of SERS Materials for In Vivo Molecular Imaging and Biosensing
Li, Q., Huo, H., Wu, Y., Chen, L., Su, L., Zhang, X., Song, J., & Yang, H. (2023) · Advanced Science · doi:10.1002/advs.202202051 · Cited by 171
Precision Nanotoxicology in Drug Development: Current Trends and Challenges in Safety and Toxicity Implications of Customized Multifunctional Nanocarriers for Drug-Delivery Applications
Ahmad, A., Imran, M., & Sharma, N. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112463 · Cited by 170
On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles
Lukianova‐Hleb, E. Y., Ren, X., Sawant, R. R., Wu, X., Torchilin, V. P., & Lapotko, D. O. (2014) · Nature Medicine · doi:10.1038/nm.3484 · Cited by 167
Metallic Nanostructures as Localized Plasmon Resonance Enhanced Scattering Probes for Multiplex Dark-Field Targeted Imaging of Cancer Cells
Hu, R., Yong, K., Roy, I., Ding, H. Y., He, S., & Prasad, P. N. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp8076672 · Cited by 167
Raman spectrum of graphene with its versatile future perspectives
Nanda, S. S., Kim, M. J., Yeom, K. S., An, S. S. A., Ju, H., & Yi, D. K. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2016.02.024 · Cited by 170
X-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects using 110 kVp x-rays
Cheong, S.-K., Jones, B. L., Siddiqi, A. K., Liu, F., Manohar, N., & Cho, S. H. (2010) · Physics in Medicine and Biology · doi:10.1088/0031-9155/55/3/007 · Cited by 166
Gold nanoparticles: recent aspects for human toxicology
Gerber, A., Bundschuh, M., Klingelhöfer, D., & Groneberg, D. A. (2013) · Journal of Occupational Medicine and Toxicology · doi:10.1186/1745-6673-8-32 · Cited by 166
Near‐infrared light‐responsive nanomaterials for cancer theranostics
Kim, H.-J., Chung, K., Lee, S., Kim, D. H., & Lee, H. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1347 · Cited by 166
Graphene oxide wrapped gold nanoparticles for intracellular Raman imaging and drug delivery
Ma, X., Qu, Q., Zhao, Y., Luo, Z. Y., Zhao, Y., Ng, K. W., & Zhao, Y. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21385d · Cited by 166
Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics
Darabdhara, G., Das, M. R., Singh, S. P., Rengan, A. K., Szunerits, S., & Boukherroub, R. (2019) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2019.101991 · Cited by 166
Cucumber mosaic virus as drug delivery vehicle for doxorubicin
Zeng, Q., Wen, H., Wen, Q., Chen, X., Wang, Y., Xuan, W., Liang, J.-S., & Wan, S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.017 · Cited by 164
Plasmonics for pulsed-laser cell nanosurgery: Fundamentals and applications
Boulais, É., Lachaine, R., Hatef, A., & Meunier, M. (2013) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2013.06.001 · Cited by 164
Alkyne-Functionalized Superstable Graphitic Silver Nanoparticles for Raman Imaging
Song, Z., Chen, Z., Bian, X., Zhou, L., Ding, D., Liang, H., Zou, Y., Wang, S.-S., Chen, L., Yang, C., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja507368z · Cited by 164
Applications and strategies in nanodiagnosis and nanotherapy in lung cancer
Woodman, C. B. J., Vundu, G., George, A., & Wilson, C. M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.02.009 · Cited by 168
Raman microspectroscopy for microbiology
Lee, K. S., Landry, Z., Pereira, F. C., Wagner, M., Berry, D., Huang, W. E., Taylor, G. T., Kneipp, J., Popp, J., Zhang, M., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00075-6 · Cited by 168
Bioconjugation and characterisation of gold colloid-labelled proteins
Thobhani, S., Attree, S., Boyd, R. D., Kumarswami, N., Noble, J. E., Szymański, M., & Porter, R. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.02.007 · Cited by 162
Functionalizing Metal Nanostructured Film with Graphene Oxide for Ultrasensitive Detection of Aromatic Molecules by Surface-Enhanced Raman Spectroscopy
Liu, X., Cao, L., Song, W., Ai, K., & Lu, L. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am200737b · Cited by 162
Monitoring of Endogenous Hydrogen Sulfide in Living Cells Using Surface‐Enhanced Raman Scattering
Li, D., Qu, L., Hu, K., Long, Y., & Tian, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505025 · Cited by 161
Medical applications of surface-enhanced Raman scattering
Xie, W. L., & Schlücker, S. (2013) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp43858a · Cited by 160
Plasmonic Gold Nanocrosses with Multidirectional Excitation and Strong Photothermal Effect
Ye, E., Win, K. Y., Tan, H. R., Lin, M., Teng, C. P., Mlayah, A., & Han, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja202832r · Cited by 160
Novel SERS labels: Rational design, functional integration and biomedical applications
Shan, B., Pu, Y., Chen, Y., Liao, M., & Li, M. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.05.007 · Cited by 161
SERS-Active Gold Lace Nanoshells with Built-in Hotspots
Yang, M., Álvarez‐Puebla, R. A., Kim, H.-S., Aldeanueva‐Potel, P., Liz‐Marzán, L. M., & Kotov, N. A. (2010) · Nano Letters · doi:10.1021/nl101946c · Cited by 159
A Monte Carlo-based model of gold nanoparticle radiosensitization accounting for increased radiobiological effectiveness
Lechtman, E., Mashouf, S., Chattopadhyay, N., Keller, B. M., Lai, P., Cai, Z., Reilly, R. M., & Pignol, J. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/10/3075 · Cited by 159
Bilayered Raman‐Intense Gold Nanostructures with Hidden Tags (BRIGHTs) for High‐Resolution Bioimaging
Gandra, N., & Singamaneni, S. (2012) · Advanced Materials · doi:10.1002/adma.201203415 · Cited by 159
Hybrid Graphene Oxide Based Ultrasensitive SERS Probe for Label-Free Biosensing
Fan, Z., Kanchanapally, R., & Ray, P. C. (2013) · The Journal of Physical Chemistry Letters · doi:10.1021/jz4020597 · Cited by 159
Rational design and synthesis of SERS labels
Wang, Y., & Schlücker, S. (2013) · The Analyst · doi:10.1039/c3an36866a · Cited by 159
Targeted Delivery of Cisplatin to Lung Cancer Using ScFvEGFR-Heparin-Cisplatin Nanoparticles
Peng, X.-H., Wang, Y., Huang, D., Wang, Y., Shin, H. J., Chen, Z., Spewak, M. B., Mao, H. Z., Wang, X., Wang, Y., et al. (2011) · ACS Nano · doi:10.1021/nn202410f · Cited by 158
Self-citation
Optical probing and imaging of live cells using SERS labels
Kneipp, J., Kneipp, H., Rajadurai, A., Redmond, R. W., & Kneipp, K. D. (2008) · Journal of Raman Spectroscopy · doi:10.1002/jrs.2060 · Cited by 157
Improved SERS Nanoparticles for Direct Detection of Circulating Tumor Cells in the Blood
Wu, X., Luo, L., Yang, S., Ma, X., Li, Y., Chen, D., Tian, Y., Zhang, L., Shen, Z., & Wu, A. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b02276 · Cited by 157
Rational Design and Synthesis of γFe2O3@Au Magnetic Gold Nanoflowers for Efficient Cancer Theranostics
Huang, J., Guo, M., Ke, H., Zong, C., Ren, B. W., Liu, G., Shen, H., Ma, Y., Wang, X., Zhang, H., et al. (2015) · Advanced Materials · doi:10.1002/adma.201501942 · Cited by 156
Single-walled carbon nanotubes in biomedical imaging
Liu, Z., Yang, K., & Lee, S. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm02020f · Cited by 155
Development of Polymer‐Encapsulated Metal Nanoparticles as Surface‐Enhanced Raman Scattering Probes
Yang, M., Chen, T., Lau, W. S., Wang, Y., Tang, Q., Yang, Y., & Chen, H. (2008) · Small · doi:10.1002/smll.200800777 · Cited by 155
Quantitative Surface-Enhanced Resonant Raman Scattering Multiplexing of Biocompatible Gold Nanostars for in Vitro and ex Vivo Detection
Yuan, H., Liu, Y., Fales, A. M., Li, Y. L., Liu, J., & Vo‐Dinh, T. (2012) · Analytical Chemistry · doi:10.1021/ac302510g · Cited by 154
Plasmonic Nanorice Antenna on Triangle Nanoarray for Surface-Enhanced Raman Scattering Detection of Hepatitis B Virus DNA
Li, M., Cushing, S. K., Liang, H., Suri, S., Ma, D., & Wu, N. (2013) · Analytical Chemistry · doi:10.1021/ac303387a · Cited by 154
Gold Nanoparticles with Tipped Surface Structures as Substrates for Single-Particle Surface-Enhanced Raman Spectroscopy: Concave Nanocubes, Nanotrisoctahedra, and Nanostars
Zhang, Q., Large, N., & Wang, H. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am505245z · Cited by 154
Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography
Manohar, N., Reynoso, F. J., Diagaradjane, P., Krishnan, S., & Cho, S. H. (2016) · Scientific Reports · doi:10.1038/srep22079 · Cited by 154
Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles
Li, S., Zhang, Y., Ho, S., Li, B., Wang, M., Deng, X., Yang, N., Liu, G., Lu, Z., Xu, J., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-0573-2 · Cited by 154
Self-citation
In Vitro Cytotoxicity Assay on Gold Nanoparticles with Different Stabilizing Agents
Vijayakumar, S., & Ganesan, S. (2012) · Journal of Nanomaterials · doi:10.1155/2012/734398 · Cited by 153
Bioconjugated Nanoparticles for Biosensing, in Vivo Imaging, and Medical Diagnostics
Kairdolf, B. A., Qian, X., & Nie, S. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04873 · Cited by 158
Self-citation
Non-invasive In Vivo Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS)
Nicolson, F., Andreiuk, B., Andreou, C., Hsu, H.-T., Rudder, S., & Kircher, M. F. (2019) · Theranostics · doi:10.7150/thno.36321 · Cited by 152
Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes
Díaz, M., & Vivas‐Mejía, P. E. (2013) · Pharmaceuticals · doi:10.3390/ph6111361 · Cited by 152
Gold Nanostructures as a Platform for Combinational Therapy in Future Cancer Therapeutics
Jelveh, S., & Chithrani, D. B. (2011) · Cancers · doi:10.3390/cancers3011081 · Cited by 153
Molecular imaging with single-walled carbon nanotubes
Hong, H., Gao, T., & Cai, W. (2009) · Nano Today · doi:10.1016/j.nantod.2009.04.002 · Cited by 153
Fluorescence-surface enhanced Raman scattering co-functionalized gold nanorods as near-infrared probes for purely optical in vivo imaging
Qian, J., Jiang, L., Cai, F., Wang, D., & He, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.058 · Cited by 149
Progress in research on gold nanoparticles in cancer management
Peng, J., & Liang, X.-Q. (2019) · Medicine · doi:10.1097/md.0000000000015311 · Cited by 149
Surface-enhanced Raman scattering imaging of cancer cells and tissues via sialic acid-imprinted nanotags
Yin, D., Wang, S., He, Y., Liu, J., Zhou, M., Ouyang, J., Liu, B., Chen, H., & Liu, Z. (2015) · Chemical Communications · doi:10.1039/c5cc05174f · Cited by 148
Building Electromagnetic Hot Spots in Living Cells via Target-Triggered Nanoparticle Dimerization
Zhou, W. J., Li, Q., Liu, H., Yang, J. A., & Liu, D. (2017) · ACS Nano · doi:10.1021/acsnano.7b00531 · Cited by 148
Near‐Infrared SERS Nanoprobes with Plasmonic Au/Ag Hollow‐Shell Assemblies for In Vivo Multiplex Detection
Kang, H., Jeong, S., Park, Y., Yim, J., Jun, B., Kyeong, S., Yang, J., Kim, G., Hong, S., Lee, L. P., et al. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201203726 · Cited by 147
Nanoplasmonic optical antennas for life sciences and medicine
Xin, H., Namgung, B., & Lee, L. P. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0033-8 · Cited by 151
Plasmon-Free Surface-Enhanced Raman Spectroscopy Using Metallic 2D Materials
Song, X., Wang, Y., Zhao, F., Li, Q., Ta, H. Q., Rümmeli, M. H., Tully, C. G., Li, Z., Yin, W., Yang, L., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03761 · Cited by 147
Self-citation
Silver Nanosphere SERS Probes for Sensitive Identification of Pathogens
Wang, Y., Lee, K., & Irudayaraj, J. (2010) · The Journal of Physical Chemistry C · doi:10.1021/jp1015406 · Cited by 146
Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents
Kim, D., Yu, M. K., Lee, T. S., Park, J. J., Jeong, Y. Y., & Jon, S. (2011) · Nanotechnology · doi:10.1088/0957-4484/22/15/155101 · Cited by 150
Assessing Iron Oxide Nanoparticle Toxicity In Vitro : Current Status and Future Prospects
Soenen, S. J., & Cuyper, M. D. (2010) · Nanomedicine · doi:10.2217/nnm.10.106 · Cited by 152
Prussian Blue as a Highly Sensitive and Background-Free Resonant Raman Reporter
Yin, Y., Li, Q., Ma, S., Liu, H., Dong, B., Yang, J. A., & Liu, D. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03521 · Cited by 148
Translational nanomedicine: status assessment and opportunities
Murday, J. S., Siegel, R. W., Stein, J. A., & Wright, J. F. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.06.001 · Cited by 153
Highly sensitive SERS detection of cancer proteins in low sample volume using hollow core photonic crystal fiber
Dinish, U. S., Fu, C. Y., Soh, K. S., Ramaswamy, B., Kumar, A., & Olivo, M. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.12.056 · Cited by 145
Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
Xue, C., Hu, S., Gao, Z., Wang, L., Luo, M.-X., Yu, X., Li, B., Shen, Z., & Wu, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-23250-5 · Cited by 145
Simultaneous Stabilization and Functionalization of Gold Nanoparticles via Biomolecule Conjugation: Progress and Perspectives
Lee, J. W., Choi, S.-R., & Heo, J. H. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c10436 · Cited by 145
Advances and Prospects of Gold Nanorods
Yang, D., & Cui, D. (2008) · Chemistry - An Asian Journal · doi:10.1002/asia.200800195 · Cited by 144
Affibody‐Functionalized Gold–Silica Nanoparticles for Raman Molecular Imaging of the Epidermal Growth Factor Receptor
Jokerst, J. V., Miao, Z., Zavaleta, C. L., Cheng, Z., & Gambhir, S. S. (2011) · Small · doi:10.1002/smll.201002291 · Cited by 146
Engineering Plasmonic Gold Nanostructures and Metamaterials for Biosensing and Nanomedicine
Jin, Y. (2012) · Advanced Materials · doi:10.1002/adma.201200622 · Cited by 148
Gold nanoparticles as sensors in the colorimetric and fluorescence detection of chemical warfare agents
Yue, G., Su, S., Li, N., Shuai, M., Lai, X., Astruc, D., & Zhao, P. (2015) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2015.11.009 · Cited by 147
Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles
Harmsen, S., Wall, M. A., Huang, R., & Kircher, M. F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.031 · Cited by 144
Solution-phase, dual LSPR-SERS plasmonic sensors of high sensitivity and stability based on chitosan-coated anisotropic silver nanoparticles
Potara, M., Gabudean, A.-M., & Astilean, S. (2011) · Journal of Materials Chemistry · doi:10.1039/c0jm03329d · Cited by 143
Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: assessment of safety and biological identity for nanomedicine applications
Braguer, D., Corréard, F., Maximova, K. A., Villard, C., Roy, M., Al‐Kattan, A., Sentis, M. L., Gingras, M., Kabashin, A. V., & Estève, M. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s65817 · Cited by 146
Bioinspired Nanocorals with Decoupled Cellular Targeting and Sensing Functionality
Wu, L. Y., Ross, B. M., Hong, S., & Lee, L. P. (2010) · Small · doi:10.1002/smll.200901604 · Cited by 143
Simultaneous Time-Dependent Surface-Enhanced Raman Spectroscopy, Metabolomics, and Proteomics Reveal Cancer Cell Death Mechanisms Associated with Gold Nanorod Photothermal Therapy
Ali, M. R. K., Wu, Y., Han, T., Zang, X., Xiao, H., Tang, Y., Wu, R., Fernández, F. M., & El‐Sayed, M. A. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08787 · Cited by 143
Metalloporphyrin nanoparticles: Coordinating diverse theranostic functions
Shao, S., Rajendiran, V., & Lovell, J. F. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.002 · Cited by 146
Biocompatibility and Biodistribution of Surface-Enhanced Raman Scattering Nanoprobes in Zebrafish Embryos: In vivo and Multiplex Imaging
Wang, Y., Seebald, J. L., Szeto, D. P., & Irudayaraj, J. (2010) · ACS Nano · doi:10.1021/nn100351h · Cited by 142
SERS-based plasmonic nanobiosensing in single living cells
Scaffidi, J. P., Gregas, M. K., Seewaldt, V. L., & Vo‐Dinh, T. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2521-y · Cited by 142
Gold nanoparticles and quantum dots for bioimaging
Hutter, E., & Maysinger, D. (2010) · Microscopy Research and Technique · doi:10.1002/jemt.20928 · Cited by 144
3D graphene oxide-encapsulated gold nanoparticles to detect neural stem cell differentiation
Kim, T. P., Lee, K., & Choi, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.101 · Cited by 142
Surface-Enhanced Raman Scattering-Active Nanostructures and Strategies for Bioassays
Jun, B., Kim, G., Noh, M. S., Kang, H., Kim, Y.-K., Cho, M., Jeong, D. H., & Lee, Y. (2011) · Nanomedicine · doi:10.2217/nnm.11.123 · Cited by 141
Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source
Bagley, A. F., Hill, S., Rogers, G. S., & Bhatia, S. N. (2013) · ACS Nano · doi:10.1021/nn4033757 · Cited by 141
Prospects of Deep Raman Spectroscopy for Noninvasive Detection of Conjugated Surface Enhanced Resonance Raman Scattering Nanoparticles Buried within 25 mm of Mammalian Tissue
Stone, N., Faulds, K., Graham, D., & Matousek, P. (2010) · Analytical Chemistry · doi:10.1021/ac100039c · Cited by 140
Multiplex optical sensing with surface-enhanced Raman scattering: A critical review
Rodríguez‐Lorenzo, L., Fabris, L., & Álvarez‐Puebla, R. A. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.08.003 · Cited by 139
Applications of Nanoparticles for MRI Cancer Diagnosis and Therapy
Błasiak, B., van Veggel, F. C. J. M., & Tomanek, B. (2013) · Journal of Nanomaterials · doi:10.1155/2013/148578 · Cited by 138
Sensing Glucose in Urine and Serum and Hydrogen Peroxide in Living Cells by Use of a Novel Boronate Nanoprobe Based on Surface-Enhanced Raman Spectroscopy
Gu, X., Wang, H., Schultz, Z. D., & Camden, J. P. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01378 · Cited by 138
Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications
Genç, A., Patarroyo, J., Sancho‐Parramon, J., Bastús, N. G., Puntes, V., & Arbiol, J. (2016) · Nanophotonics · doi:10.1515/nanoph-2016-0124 · Cited by 138
Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity
Harmsen, S., Bedics, M. A., Wall, M. A., Huang, R., Detty, M. R., & Kircher, M. F. (2015) · Nature Communications · doi:10.1038/ncomms7570 · Cited by 137
Powering the programmed nanostructure and function of gold nanoparticles with catenated DNA machines
Elbaz, J., Cecconello, A., Fan, Z., Govorov, A. O., & Willner, I. (2013) · Nature Communications · doi:10.1038/ncomms3000 · Cited by 137
Surface-Enhanced Raman Scattering Hybrid Nanoprobe Multiplexing and Imaging in Biological Systems
Matschulat, A., Drescher, D., & Kneipp, J. (2010) · ACS Nano · doi:10.1021/nn100280z · Cited by 137
Goldnanopartikel in Biologie und Medizin
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie · doi:10.1002/ange.200904359 · Cited by 138
The Astrobiology Primer v2.0
Domagal-Goldman, S. D., Wright, K. E., Domagal-Goldman, S. D., Wright, K. E., Adamala, K., Arina de la Rubia, L., Bond, J., Dartnell, L. R., Goldman, A. D., Lynch, K., et al. (2016) · Astrobiology · doi:10.1089/ast.2015.1460 · Cited by 136
“For example, Raman spectroscopy, a laboratory technique used to observe vibrational, rotational, and other low-frequency changes in molecules of a system, is now being used for in vivo detection of tumors (Qian et al., 2008).”
Method
Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions
Belykh, E. G., Martirosyan, N. L., Yağmurlu, K., Miller, E. J., Eschbacher, J. M., Izadyyazdanabadi, M., Bardonova, L., Byvaltsev, V. A., Nakaji, P., & Preul, M. C. (2016) · Frontiers in Surgery · doi:10.3389/fsurg.2016.00055 · Cited by 143
Spectral Analysis of Multiplex Raman Probe Signatures
Lutz, B. R., Dentinger, C. E., Nguyen, L. N., Sun, L., Zhang, J., Allen, A. N., Chan, S., & Knudsen, B. S. (2008) · ACS Nano · doi:10.1021/nn800243g · Cited by 135
Gold Nanoparticles: Promising Nanomaterials for the Diagnosis of Cancer and HIV/AIDS
Kumar, A., Boruah, B. M., & Liang, X. (2011) · Journal of Nanomaterials · doi:10.1155/2011/202187 · Cited by 135
Tailored necklace-like Ag@ZIF-8 core/shell heterostructure nanowires for high-performance plasmonic SERS detection
Li, Q., Gong, S., Zhang, H., Huang, F., Zhang, L., & Li, S. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.03.236 · Cited by 135
Augmented Anticancer Activity of a Targeted, Intracellularly Activatable, Theranostic Nanomedicine Based on Fluorescent and Radiolabeled, Methotrexate-Folic Acid-Multiwalled Carbon Nanotube Conjugate
Das, M., Datir, S. R., Singh, R. P., & Jain, S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300701e · Cited by 134
Self‐Organized Hexagonal‐Nanopore SERS Array
Choi, D., Choi, Y., Hong, S., Kang, T., & Lee, L. P. (2010) · Small · doi:10.1002/smll.200901937 · Cited by 134
Bidirectional Optical Sorting of Gold Nanoparticles
Plöschner, M., Čižmár, T., Mazilu, M., Falco, A. D., & Dholakia, K. (2012) · Nano Letters · doi:10.1021/nl204378r · Cited by 134
A small animal Raman instrument for rapid, wide-area, spectroscopic imaging
Bohndiek, S. E., Wagadarikar, A., Zavaleta, C. L., Van de Sompel, D., Garai, E., Jokerst, J. V., Yazdanfar, S., & Gambhir, S. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301379110 · Cited by 133
Imaging with Raman Spectroscopy
Zhang, Y., Hong, H., & Cai, W. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110792246483 · Cited by 133
Raman spectroscopy and microscopy of individual cells and cellular components
Chan, J. W., Fore, S., Wachsmann‐Hogiu, S., & Huser, T. R. (2008) · Laser & Photonics Review · doi:10.1002/lpor.200810012 · Cited by 133
Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds
Köker, T., Tang, N., Tian, C., Zhang, W., Wang, X., Martel, R., & Pinaud, F. F. (2018) · Nature Communications · doi:10.1038/s41467-018-03046-w · Cited by 133
Plasmonic biosensors
Hill, R. T. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1314 · Cited by 133

Authors: Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S.
Affiliations: Georgia Institute of Technology (US)
Emory University (US)
Corresponding author: Nie, Shuming
ORCID: Shin, Dong M
Yang, Lily
Wang, May D
Nie, Shuming
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2007-12-23
Volume: 26
Issue: 1
Pages: 83-90
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt1377
OpenAlex: W4234368842
Cited by: 2,201
References: 55
Citations by year: 2026: 38 · 2025: 43 · 2024: 62 · 2023: 57 · 2022: 74 · 2021: 82 · 2020: 100 · 2019: 116 · 2018: 121 · 2017: 163 · 2016: 149 · 2015: 183 · 2014: 199 · 2013: 165 · 2012: 166
FWCI: 51.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA108468, U54CA119338, P50CA128613)
National Institute of General Medical Sciences (T32GM008169)
Topics: Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Keywords: surface-enhanced Raman scattering, gold nanoparticles, PEGylated nanoparticles, Raman imaging, scFv, epidermal growth factor receptor, tumor xenografts, cancer detection, biocompatible nanoparticles
MeSH terms: Animals, Carcinoma, Squamous Cell, Humans, Particle Size, Spectrum Analysis, Raman, Drug Delivery Systems, Cell Line, Tumor, Mice, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks