What would you do if you could sequence everything?
Open accessAbstract
It could be argued that the greatest transformative aspect of the Human Genome Project has been not the sequencing of the genome itself, but the resultant development of new technologies. A host of new approaches has fundamentally changed the way we approach problems in basic and translational research. Now, a new generation of high-throughput sequencing technologies promises to again transform the scientific enterprise, potentially supplanting array-based technologies and opening up many new possibilities. By allowing DNA/RNA to be assayed more rapidly than previously possible, these next-generation platforms promise a deeper understanding of genome regulation and biology. Significantly enhancing sequencing throughput will allow us to follow the evolution of viral and bacterial resistance in real time, to uncover the huge diversity of novel genes that are currently inaccessible, to understand nucleic acid therapeutics, to better integrate biological information for a complete picture of health and disease at a personalized level and to move to advances that we cannot yet imagine.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Modern sequencing instruments are generating quality data at truly enormous rates.
“Modern sequencing instruments, for instance (e.g. [2453-2457]) are generating quality data at truly enormous rates [2458], and innovative but computationally demanding algorithms are required to deal with them (e.g. [2459]).”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [2458]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696 · see citing works
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,557 · see citing works
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Self-citationMicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,592 · see citing works
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091 · see citing works
A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223 · see citing works
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505 · see citing works
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works
Global variation in copy number in the human genome
Redon, R., Ishikawa, S., Fitch, K. R., Feuk, L., Perry, G. H., Andrews, T. D., Fiegler, H., Shapero, M. H., Carson, A. R., Chen, W., et al. (2006) · Nature · doi:10.1038/nature05329 · Cited by 4,276 · see citing works
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129 · see citing works
Serial Analysis of Gene Expression
Velculescu, V. E., Zhang, L., Vogelstein, B., & Kinzler, K. W. (1995) · Science · doi:10.1126/science.270.5235.484 · Cited by 3,713 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
The Versatile Role of microRNA-30a in Human Cancer
Wang, C., Yang, X., Chen, Y., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471111 · Cited by 3,409 · see citing works
Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
Feng, H., Shuda, M., Chang, Y., & Moore, P. S. (2008) · Science · doi:10.1126/science.1152586 · Cited by 3,208 · see citing works
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161 · see citing works
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
The International SNP Map Working Group, Laboratories:, C. S. H., Sachidanandam, R., Weissman, D., Schmidt, S. C., Kakol, J. M., Stein, L. D., National Center for Biotechnology Information:, Marth, G., Sherry, S., et al. (2001) · Nature · doi:10.1038/35057149 · Cited by 2,977 · see citing works
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927 · see citing works
Detection of large-scale variation in the human genome
Iafrate, A. J., Feuk, L., Rivera, M. N., Listewnik, M. L., Donahoe, P. K., Qi, Y., Scherer, S. W., & Lee, C. (2004) · Nature Genetics · doi:10.1038/ng1416 · Cited by 2,892 · see citing works
The Genomic Landscapes of Human Breast and Colorectal Cancers
Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., Shen, D., Boca, S. M., Barber, T., Ptak, J., et al. (2007) · Science · doi:10.1126/science.1145720 · Cited by 2,833 · see citing works
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536 · see citing works
The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing
Nagalakshmi, U., Wang, Z., Waern, K., Shou, C., Raha, D., Gerstein, M., & Snyder, M. (2008) · Science · doi:10.1126/science.1158441 · Cited by 2,479 · see citing works
Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis
Lister, R., O’Malley, R. C., Tonti‐Filippini, J., Gregory, B. D., Berry, C. C., Millar, A. H., & Ecker, J. R. (2008) · Cell · doi:10.1016/j.cell.2008.03.029 · Cited by 2,424 · see citing works
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,267 · see citing works
The impact of next-generation sequencing technology on genetics
Mardis, E. R. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.12.007 · Cited by 2,050 · see citing works
Evolution of genes and genomes on the Drosophila phylogeny
Drosophila 12 Genomes Consortium (2007) · Nature · doi:10.1038/nature06341 · Cited by 2,010 · see citing works
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
Juma, S., Imrhan, V., Vijayagopal, P., & Prasad, C. (2014) · Lifestyle Genomics · doi:10.1159/000370213 · Cited by 1,905 · see citing works
The complete genome of an individual by massively parallel DNA sequencing
Wheeler, D. A., Srinivasan, M., Egholm, M., Shen, Y., Chen, L., McGuire, A., He, W., Chen, Y.-J., Makhijani, V., Roth, G. T., et al. (2008) · Nature · doi:10.1038/nature06884 · Cited by 1,838 · see citing works
Control of leaf morphogenesis by microRNAs
Palatnik, J. F., Allen, E. M., Wu, X., Schommer, C., Schwab, R., Carrington, J. C., & Weigel, D. (2003) · Nature · doi:10.1038/nature01958 · Cited by 1,833 · see citing works
Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis
Zhang, X., Yazaki, J., Sundaresan, A., Cokus, S. J., Chan, S. W.-L., Chen, H., Henderson, I. R., Shinn, P., Pellegrini, M. A., Jacobsen, S. E., et al. (2006) · Cell · doi:10.1016/j.cell.2006.08.003 · Cited by 1,818 · see citing works
The Diploid Genome Sequence of an Individual Human
Levy, S., Sutton, G., Ng, P. C., Feuk, L., Halpern, A. L., Walenz, B. P., Axelrod, N., Huang, J., Kirkness, E. F., Denisov, G., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050254 · Cited by 1,778 · see citing works
A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder
Cox-Foster, D., Conlan, S., Holmes, E. C., Palacios, G. F., Evans, J. D., Moran, N. A., Quan, P., Briese, T., Hornig, M., Geiser, D. M., et al. (2007) · Science · doi:10.1126/science.1146498 · Cited by 1,754 · see citing works
Genetics of gene expression surveyed in maize, mouse and man
Schadt, E., Monks, S. A., Drake, T., Lusis, A., Che, N., Colinayo, V. V., Ruff, T., Milligan, S. B., Lamb, J., Cavet, G., et al. (2003) · Nature · doi:10.1038/nature01434 · Cited by 1,594 · see citing works
Robertson, G., Hirst, M., Bainbridge, M., Bilenky, M., Zhao, Y., Zeng, T., Euskirchen, G., Bernier, B., Varhol, R., Delaney, A., et al. (2007) · Nature Methods · doi:10.1038/nmeth1068 · Cited by 1,454 · see citing works
DNA methylation profiling of human chromosomes 6, 20 and 22
Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., Burton, J. H., Cox, T. V., Davies, R., Down, T. A., et al. (2006) · Nature Genetics · doi:10.1038/ng1909 · Cited by 1,350 · see citing works
Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution
Cheng, J., Kapranov, P., Drenkow, J., Dike, S., Brubaker, S., Patel, S. A., Long, J. C., Stern, D., Tammana, H., Helt, G. A., et al. (2005) · Science · doi:10.1126/science.1108625 · Cited by 1,175 · see citing works
Alternative Splicing: New Insights from Global Analyses
Blencowe, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.023 · Cited by 1,122 · see citing works
Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol
Cohen, J. C., Kiss, R. S., Pertsemlidis, A., Marcel, Y. L., McPherson, R., & Hobbs, H. H. (2004) · Science · doi:10.1126/science.1099870 · Cited by 1,108 · see citing works
Morin, R. D., O’Connor, M. D., Griffith, M., Kuchenbauer, F. C., Delaney, A. D., Prabhu, A., Zhao, Y., McDonald, H., Zeng, T., Hirst, M., et al. (2008) · Genome Research · doi:10.1101/gr.7179508 · Cited by 1,094 · see citing works
MicroRNA-Cancer Connection: The Beginning of a New Tale
Calin, G. A., & Croce, C. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0800 · Cited by 1,054 · see citing works
Stem cell transcriptome profiling via massive-scale mRNA sequencing
Cloonan, N., Forrest, A. R. R., Kolle, G., Gardiner, B. B. A., Faulkner, G. J., Brown, M. K., Taylor, D. F., Steptoe, A. L., Wani, S., Bethel, G., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1223 · Cited by 1,035 · see citing works
Functional metagenomic profiling of nine biomes
Dinsdale, E. A., Edwards, R. A., Hall, D., Angly, F., Breitbart, M., Brulc, J. M., Furlan, M., Desnues, C., Haynes, M., Li, L., et al. (2008) · Nature · doi:10.1038/nature06810 · Cited by 980 · see citing works
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
Wilhelm, B. T., Marguerat, S., Watt, S. B., Schubert, F., Wood, V., Goodhead, I., Penkett, C. J., Rogers, J., & Bähler, J. (2008) · Nature · doi:10.1038/nature07002 · Cited by 974 · see citing works
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Huang, Q., Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S., Egan, D. A., Li, A., Huang, G., Klein–Szanto, A. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1681 · Cited by 973 · see citing works
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
Tomlins, S., Laxman, B., Dhanasekaran, S., Helgeson, B. E., Cao, X.-H., Morris, D. S., Menon, A., Jing, X.-J., Cao, Q., Han, B., et al. (2007) · Nature · doi:10.1038/nature06024 · Cited by 904 · see citing works
Variations in DNA elucidate molecular networks that cause disease
Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., et al. (2008) · Nature · doi:10.1038/nature06757 · Cited by 887 · see citing works
Large-Scale Transcriptional Activity in Chromosomes 21 and 22
Kapranov, P., Cawley, S. E., Drenkow, J., Bekiranov, S., Strausberg, R. L., Fodor, S. P. A., & Gingeras, T. (2002) · Science · doi:10.1126/science.1068597 · Cited by 871 · see citing works
Copy number variation: New insights in genome diversityPreprint
Freeman, J. L., Perry, G. H., Feuk, L., Redon, R., McCarroll, S. A., Altshuler, D., Aburatani, H., Jones, K. W., Tyler‐Smith, C., Hurles, M. E., et al. (2006) · Genome Research · doi:10.1101/gr.3677206 · Cited by 848 · see citing works
Bentley, D. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.10.009 · Cited by 805 · see citing works
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Yu, W., Gius, D. R., Onyango, P. O., Muldoon‐Jacobs, K., Karp, J. E., Feinberg, A. P., & Cui, H. (2008) · Nature · doi:10.1038/nature06468 · Cited by 801 · see citing works
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
Gilchrist, M., Thórsson, V., Li, B., Rust, A. G., Korb, M., Kennedy, K., Hai, T., Bolouri, H., & Aderem, A. A. (2006) · Nature · doi:10.1038/nature04768 · Cited by 796 · see citing works
Nucleosome organization in the Drosophila genome
Mavrich, T. N., Jiang, C., Ioshikhes, I. P., Li, X., Venters, B. J., Zanton, S. J., Tomsho, L. P., Qi, J., Glaser, R. L., Schuster, S. C., et al. (2008) · Nature · doi:10.1038/nature06929 · Cited by 719 · see citing works
Single-Molecule DNA Sequencing of a Viral Genome
Harris, T. D., Buzby, P. R., Babcock, H. P., Beer, E., Bowers, J., Braslavsky, I., Causey, M., Colonell, J. I., Dimeo, J. J., Efcavitch, J. W., et al. (2008) · Science · doi:10.1126/science.1150427 · Cited by 692 · see citing works
A New Arenavirus in a Cluster of Fatal Transplant-Associated Diseases
Palacios, G. F., Druce, J. D., Du, L., Tran, T., Birch, C. J., Briese, T., Conlan, S., Quan, P., Hui, J., Marshall, J., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa073785 · Cited by 692 · see citing works
Genetics of global gene expression
Rockman, M. V., & Kruglyak, L. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1964 · Cited by 666 · see citing works
Marcy, Y., Ouverney, C., Bik, E. M., Lösekann, T., Ivanova, N., Martín, H. G., Szeto, E., Platt, D., Hugenholtz, P., Relman, D. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704662104 · Cited by 632 · see citing works
Copy-number variation and association studies of human disease
McCarroll, S. A., & Altshuler, D. M. (2007) · Nature Genetics · doi:10.1038/ng2080 · Cited by 622 · see citing works
Valouev, A., Ichikawa, J. K., Tonthat, T., Stuart, J., Ranade, S., Peckham, H. E., Zeng, K., Malek, J. A., Costa, G. L., McKernan, K. J., et al. (2008) · Genome Research · doi:10.1101/gr.076463.108 · Cited by 580 · see citing works
Distinct epigenetic changes in the stromal cells of breast cancers
Hu, M., Yao, J., Cai, L., Bachman, K., van den Brûle, F., Velculescu, V. E., & Polyák, K. (2005) · Nature Genetics · doi:10.1038/ng1596 · Cited by 520 · see citing works
Bioinformatics challenges of new sequencing technology
Pop, M., & Salzberg, S. L. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.12.006 · Cited by 515 · see citing works
Broadbent, H. M., Peden, J. F., Stefan Lorkowski, A., Goel, A., Ongen, H., Green, F. R., Clarke, R., Collins, R., Franzosi, M. G., Tognoni, G., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm352 · Cited by 504 · see citing works
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Holt, K. E., Parkhill, J., Mazzoni, C. J., Roumagnac, P., Weill, F., Goodhead, I., Rance, R., Baker, S. G., Maskell, D. J., Wain, J. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.195 · Cited by 492 · see citing works
A survey of genetic human cortical gene expression
Myers, A. J., Gibbs, J. R., Webster, J. A., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., Leung, D., Bryden, L., Nath, P., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.16 · Cited by 479 · see citing works
Abbott, A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R., & Ambros, V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.009 · Cited by 467 · see citing works
The new cytogenetics: blurring the boundaries with molecular biology
Speicher, M. R., & Carter, N. P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1692 · Cited by 460 · see citing works
Colloquium: Physical approaches to DNA sequencing and detection
Zwolak, M., & Ventra, M. D. (2008) · Reviews of Modern Physics · doi:10.1103/revmodphys.80.141 · Cited by 451 · see citing works
Symbiosis insights through metagenomic analysis of a microbial consortium
Woyke, T., Teeling, H., Ivanova, N., Huntemann, M., Richter, M., Glöckner, F. O., Boffelli, D., Anderson, I., Barry, K., Shapiro, H., et al. (2006) · Nature · doi:10.1038/nature05192 · Cited by 450 · see citing works
Morin, R. D., Bainbridge, M. N., Fejes, A. P., Hirst, M., Krzywinski, M. I., Pugh, T. J., McDonald, H., Varhol, R., Jones, S. J. M., & Marra, M. A. (2008) · BioTechniques · doi:10.2144/000112900 · Cited by 416 · see citing works
Wang, C., Mitsuya, Y., Gharizadeh, B., Ronaghi, M., & Shafer, R. W. (2007) · Genome Research · doi:10.1101/gr.6468307 · Cited by 408 · see citing works
Whole-genome sequencing and variant discovery in C. elegans
Hillier, L. W., Marth, G., Quinlan, A. R., Dooling, D. J., Fewell, G. A., Barnett, D. W., Fox, P. M., Glasscock, J. I., Hickenbotham, M. T., Huang, W., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1179 · Cited by 405 · see citing works
Minsky, N., Shema, E., Field, Y., Schuster, M., Segal, E., & Oren, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1712 · Cited by 390 · see citing works
Yasui, D. H., Peddada, S., Bieda, M. C., Vallero, R. O., Hogart, A., Nagarajan, R. P., Thatcher, K. N., Farnham, P., & LaSalle, J. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707442104 · Cited by 381 · see citing works
Genetic basis of fitness differences in natural populations
Ellegren, H., & Sheldon, B. C. (2008) · Nature · doi:10.1038/nature06737 · Cited by 358 · see citing works
Liang, W. S., Dunckley, T. L., Beach, T. G., Grover, A., Mastroeni, D., Walker, D. G., Caselli, R. J., Kukull, W. A., McKeel, D. W., Morris, J. C., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00208.2006 · Cited by 342 · see citing works
The beginning of the end for microarrays?
Shendure, J. (2008) · Nature Methods · doi:10.1038/nmeth0708-585 · Cited by 331 · see citing works
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
Rauch, T. A., Zhong, X., Wu, X., Wang, M., Kernstine, K. H., Wang, Z., Riggs, A. D., & Pfeifer, G. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710735105 · Cited by 318 · see citing works
Kapranov, P., Drenkow, J., Cheng, J., Long, J. C., Helt, G. A., Dike, S., & Gingeras, T. (2005) · Genome Research · doi:10.1101/gr.3455305 · Cited by 316 · see citing works
Genome-wide analysis of transcript isoform variation in humans
Kwan, T., Benovoy, D., Dias, C., Gurd, S., Provencher, C., Beaulieu, P., Hudson, T. J., SLADEK, R. M., & Majewski, J. (2008) · Nature Genetics · doi:10.1038/ng.2007.57 · Cited by 305 · see citing works
Schizophrenia: a common disease caused by multiple rare alleles
McClellan, J. M., Susser, E., & King, M.-C. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.025585 · Cited by 296 · see citing works
Pernthaler, A., Dekas, A., Brown, C. T., Goffredi, S. K., Embaye, T., & Orphan, V. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711303105 · Cited by 291 · see citing works
Structural variants: changing the landscape of chromosomes and design of disease studies
Feuk, L., Marshall, C. R., Wintle, R. F., & Scherer, S. W. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl057 · Cited by 286 · see citing works
Gitan, R. S., Shi, H., Chen, C., Yan, P. S., & Huang, T. H. ‐. (2001) · Genome Research · doi:10.1101/gr.202801 · Cited by 280 · see citing works
A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter
Gobbi, M. D., Viprakasit, V., Hughes, J. R., Fisher, C. A., Buckle, V. J., Ayyub, H., Gibbons, R. J., Vernimmen, D., Yoshinaga, Y., de Jong, P., et al. (2006) · Science · doi:10.1126/science.1126431 · Cited by 277 · see citing works
The methylome: approaches for global DNA methylation profiling
Beck, S., & Rakyan, V. K. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.01.006 · Cited by 277 · see citing works
The road to genome-wide association studies
Kruglyak, L. (2008) · Nature reviews genetics · doi:10.1038/nrg2316 · Cited by 266 · see citing works
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
Agrelo, R., Cheng, W.-H., Setien, F., Ropero, S., Espada, J., Fraga, M. F., Herranz, M., Paz, M. F., Sanchez-Cespedes, M., Artiga, M. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600645103 · Cited by 264 · see citing works
DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations
Hoffmann, C., Minkah, N. K., Leipzig, J. N., Wang, G., Arens, M. Q., Tebas, P., & Bushman, F. D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm435 · Cited by 220 · see citing works
Genome-wide detection of human copy number variations using high-density DNA oligonucleotide arraysPreprint
河村, 大., Shen, F., Ishikawa, S., Fitch, K. R., Chen, W., Zhang, J., Liu, G., Ihara, S., Nakamura, H., Hurles, M. E., et al. (2006) · Genome Research · doi:10.1101/gr.5629106 · Cited by 208 · see citing works
Euskirchen, G. M., Rozowsky, J. S., Wei, C., Lee, W. H., Zhang, Z. D., Hartman, S. E., Emanuelsson, O., Štolc, V., Weissman, S. M., Gerstein, M., et al. (2007) · Genome Research · doi:10.1101/gr.5583007 · Cited by 203 · see citing works
Bundy, J. G., Sidhu, J. K., Rana, F., Spurgeon, D. J., Svendsen, C., Wren, J. F., Stürzenbaum, S. R., Morgan, A. J., & Kille, P. (2008) · BMC Biology · doi:10.1186/1741-7007-6-25 · Cited by 198 · see citing works
Chou, C.-C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh099 · Cited by 184 · see citing works
Genome-Wide Analysis of Protein-DNA Interactions
Kim, T. H., & Ren, B. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115634 · Cited by 171 · see citing works
A Blueprint for a Human Epigenome Project: The AACR Human Epigenome Workshop
Jones, P. A., & Martienssen, R. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3865 · Cited by 169 · see citing works
The necessity of a human epigenome project
Esteller, M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl033 · Cited by 166 · see citing works
SAGE is far more sensitive than EST for detecting low-abundance transcripts
Sun, M., Zhou, G., Lee, S., Chen, J., Shi, R., & Wang, S. M. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-1 · Cited by 150 · see citing works
Church, G. M. (2006) · Scientific American · doi:10.1038/scientificamerican0106-46 · Cited by 140 · see citing works
ヒト口腔からの微量の培養されないTM7微生物の単一細胞遺伝分析による生物学的「不明な物体」の詳細な分析
Marcy, Y., Ouverney, C., Elisabeth, M. B., Tina, L., Ivanova, N., Garcia, M. H., Szeto, E., Darren, P., Hugenholtz, P., David, A. R., et al. (2007) · Cited by 138 · see citing works
Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patternsPreprint
Roh, T., Wei, G., Farrell, C. M., & Zhao, K. (2006) · Genome Research · doi:10.1101/gr.5767907 · Cited by 131 · see citing works
Three microarray platforms: an analysis of their concordance in profiling gene expression
Petersen, D. W., Chandramouli, G., Geoghegan, J. M., Hilburn, J., Paarlberg, J., Kim, C. H., Munroe, D. J., Gangi, L., Han, J., Puri, R. K., et al. (2005) · BMC Genomics · doi:10.1186/1471-2164-6-63 · Cited by 108 · see citing works
Brena, R. M., Huang, T. H. ‐., & Plass, C. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0034-0 · Cited by 102 · see citing works
New developments in ancient genomics
Millar, C. D., Huynen, L., Subramanian, S., Mohandesan, E., & Lambert, D. M. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2008.04.002 · Cited by 95 · see citing works
Chromatin state maps: new technologies, new insights
Mendenhall, E. M., & Bernstein, B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.010 · Cited by 84 · see citing works
ChIPping away at gene regulation
Massie, C. E., & Mills, I. G. (2008) · EMBO Reports · doi:10.1038/embor.2008.44 · Cited by 77 · see citing works
A microarray configuration to quantify expression levels and relative abundance of splice variants
Fehlbaum, P. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni047 · Cited by 71 · see citing works
Transcriptome analysis for Caenorhabditis elegansbased on novel expressed sequence tags
Shin, H., Hirst, M., Bainbridge, M. N., Magrini, V. J., Mardis, E. R., Moerman, D. G., Marra, M. A., Baillie, D. L., & Jones, S. J. M. (2008) · BMC Biology · doi:10.1186/1741-7007-6-30 · Cited by 55 · see citing works
Chittenden, T. W., Howe, E., Culhane, A. C., Sultana, R., Taylor, J. M., Holmes, C. C., & Quackenbush, J. F. (2008) · Genomics · doi:10.1016/j.ygeno.2008.03.002 · Cited by 54 · see citing works
Self-citationSingleton SNPs in the human genome and implications for genome-wide association studies
Ke, X., Taylor, M. S., & Cardon, L. R. (2008) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201987 · Cited by 49 · see citing works
Genomics technology for assessing soil pollution
van Straalen, N. M., & Roelofs, D. (2008) · Journal of Biology · doi:10.1186/jbiol80 · Cited by 46 · see citing works
LongSAGE profiling of nine human embryonic stem cell lines
Hirst, M., Delaney, A. D., Rogers, S. A., Schnerch, A., Persaud, D. R., O’Connor, M. D., Zeng, T., Moksa, M., Fichter, K., Mah, D. G., et al. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-r113 · Cited by 28 · see citing works
Nardi, V., Raz, T., Cao, X., Wu, C. J., Stone, R. M., Cortes, J. E., Deininger, M. W., Church, G. M., Zhu, J., & Daley, G. Q. (2007) · Oncogene · doi:10.1038/sj.onc.1210698 · Cited by 21 · see citing works
XDR-TB Genome Sequencing: A Glimpse of the Microbiology of the Future
Loman, N. J., & Pallen, M. J. (2008) · Future Microbiology · doi:10.2217/17460913.3.2.111 · Cited by 20 · see citing works
Momentum Building for Human Epigenome Project
Garber, K. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj042 · Cited by 17 · see citing works
Flagged first, then by citations
4 of the 120 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
Ball, M. P., Li, J. B., Gao, Y., Lee, J., LeProust, E. M., Park, I., Xie, B., Daley, G. Q., & Church, G. M. (2009) · Nature Biotechnology · doi:10.1038/nbt.1533 · Cited by 1,087 · see citing works
Environmental metabolomics: a critical review and future perspectives
Bundy, J. G., Davey, M. P., & Viant, M. R. (2008) · Metabolomics · doi:10.1007/s11306-008-0152-0 · Cited by 817 · see citing works
Adey, A., Morrison, H. G., Asan, Xu, X., Kitzman, J. O., Turner, E. H., Stackhouse, B., MacKenzie, A. P., Caruccio, N. C., Zhang, X., et al. (2010) · Genome biology · doi:10.1186/gb-2010-11-12-r119 · Cited by 566 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore
Stoddart, D., Heron, A. J., Mikhailova, E., Maglia, G., & Bayley, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901054106 · Cited by 478 · see citing works
Gene Mapping via Bulked Segregant RNA-Seq (BSR-Seq)
Liu, S., Yeh, C., Tang, H. M., Nettleton, D. S., & Schnable, P. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036406 · Cited by 373 · see citing works
Accessing the Soil Metagenome for Studies of Microbial Diversity
Delmont, T. O., Robe, P., Cecillon, S., Clark, I. M., Constancias, F., Simonet, P., Hirsch, P. R., & Vogel, T. M. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01526-10 · Cited by 338 · see citing works
Aptamer Selection Technology and Recent Advances
Blind, M., & Blank, M. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.74 · Cited by 325 · see citing works
Nilsson, R. H., Ryberg, M. K., Abarenkov, K., Sjökvist, E., & Kristiansson, E. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01618.x · Cited by 308 · see citing works
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
Ho, C. H., Magtanong, L., Barker, S. L., Gresham, D., Nishimura, S., Natarajan, P., Koh, J. L. Y., Porter, J., Gray, C. A., Andersen, R. J., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1534 · Cited by 281 · see citing works
The challenges of sequencing by synthesis
Fuller, C. W., Middendorf, L. R., Benner, S. A., Church, G. M., Harris, T. D., Huang, X. C., Jovanovich, S. B., Nelson, J. R., Schloss, J. A., Schwartz, D. C., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1585 · Cited by 279 · see citing works
Structure, fluctuation and magnitude of a natural grassland soil metagenome
Delmont, T. O., Prestat, E., Keegan, K. P., Faubladier, M., Robe, P., Clark, I. M., Pelletier, É., Hirsch, P. R., Meyer, F., Gilbert, J. A., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2011.197 · Cited by 217 · see citing works
Wang, Y., Zhang, H., Li, H., & Miao, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018644 · Cited by 195 · see citing works
Optical Biosensors: A Revolution Towards Quantum Nanoscale Electronics Device Fabrication
Dey, D., & Goswami, T. (2011) · BioMed Research International · doi:10.1155/2011/348218 · Cited by 169 · see citing works
Gullapalli, R. R., Desai, K., Santana‐Santos, L., Kant, J. A., & Becich, M. J. (2012) · Journal of Pathology Informatics · doi:10.4103/2153-3539.103013 · Cited by 160 · see citing works
Nucleotide Discrimination with DNA Immobilized in the MspA Nanopore
Manrao, E. A., Derrington, I. M., Pavlenok, M., Niederweis, M., & Gundlach, J. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025723 · Cited by 160 · see citing works
de Hoon, M., Taft, R. J., Hashimoto, T., Kanamori-Katayama, M., Kawaji, H., Kawano, M., Kishima, M., Lassmann, T., Faulkner, G. J., Mattick, J. S., et al. (2010) · Genome Research · doi:10.1101/gr.095273.109 · Cited by 153 · see citing works
The properties and applications of single-molecule DNA sequencing
Thompson, J. F., & Milos, P. M. (2011) · Genome biology · doi:10.1186/gb-2011-12-2-217 · Cited by 146 · see citing works
Self-citationOverview of Electrochemical DNA Biosensors: New Approaches to Detect the Expression of Life
Cagnin, S., Caraballo, M., Guiducci, C., Martini, P. G. V., Ross, M., SantaAna, M., Danley, D. L., West, T. H., & Lanfranchi, G. (2009) · Sensors · doi:10.3390/s90403122 · Cited by 140 · see citing works
Virtual terminator nucleotides for next-generation DNA sequencing
Bowers, J., Mitchell, J., Beer, E., Buzby, P. R., Causey, M., Efcavitch, J. W., Jarosz, M. V., Krzymańska-Olejnik, E., Kung, L. A., Lipson, D., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1354 · Cited by 139 · see citing works
Self-citationComputational Peptidology: A New and Promising Approach to Therapeutic Peptide Design
Zhou, P., Wang, C., Ren, Y., Yang, C., & Tian, F. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320150005 · Cited by 124 · see citing works
Jin, L., Li, G., Yu, D., Huang, W., Cheng, C., Liao, S., Wu, Q., & Zhang, Y. (2017) · BMC Genomics · doi:10.1186/s12864-017-3507-y · Cited by 119 · see citing works
Next-generation sequencing technologies in diagnostic virology
Barzon, L., Lavezzo, E., Costanzi, G., Franchin, E., Toppo, S., & Palù, G. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2013.03.003 · Cited by 116 · see citing works
Single Molecule Sequencing with a HeliScope Genetic Analysis System
Thompson, J. F., & Steinmann, K. E. (2010) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb0710s92 · Cited by 110 · see citing works
Self-citationPerspectives and Challenges of Emerging Single‐Molecule DNA Sequencing Technologies
Xu, M., Fujita, D., & Hanagata, N. (2009) · Small · doi:10.1002/smll.200900976 · Cited by 109 · see citing works
Linear plasmid vector for cloning of repetitive or unstable sequences in Escherichia coli
Godiska, R., Mead, D. A., Dhodda, V. K., Wu, C., Hochstein, R. A., Karsi, A., Usdin, K., Entezam, A., & Ravin, N. V. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1181 · Cited by 106 · see citing works
Adaptive radiations: From field to genomic studies
Hodges, S. A., & Derieg, N. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901594106 · Cited by 98 · see citing works
Birzele, F., Schaub, J., Rust, W., Clemens, C., Baum, P., Kaufmann, H., Weith, A., Schulz, T. W., & Hildebrandt, T. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq116 · Cited by 98 · see citing works
High throughput DNA sequencing: The new sequencing revolution
Delseny, M., Han, B., & Hsing, Y. I. (2010) · Plant Science · doi:10.1016/j.plantsci.2010.07.019 · Cited by 96 · see citing works
Feng, J., Lupien, A., Gingras, H., Wasserscheid, J., Dewar, K., Légaré, D., & Ouellette, M. (2009) · Genome Research · doi:10.1101/gr.089342.108 · Cited by 93 · see citing works
SHI7 Is a Self-Learning Pipeline for Multipurpose Short-Read DNA Quality Control
Al‐Ghalith, G. A., Hillmann, B., Ang, K., Shields‐Cutler, R. R., & Knights, D. (2018) · mSystems · doi:10.1128/msystems.00202-17 · Cited by 92 · see citing works
Personal genomes in progress: from the Human Genome Project to the Personal Genome Project
Lunshof, J. E., Bobe, J. R., Aach, J., Angrist, M. H., Thakuria, J. V., Vorhaus, D. B., Hoehe, M. R., & Church, G. M. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.1/jlunshof · Cited by 90 · see citing works
Surfing on a new wave of single-molecule fluorescence methods
Hohlbein, J., Gryte, K., Heilemann, M., & Kapanidis, A. N. (2010) · Physical Biology · doi:10.1088/1478-3975/7/3/031001 · Cited by 88 · see citing works
Enabling technologies of genomic-scale sequence enrichment for targeted high-throughput sequencing
Summerer, D. (2009) · Genomics · doi:10.1016/j.ygeno.2009.08.012 · Cited by 87 · see citing works
Caruccio, N. C. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-089-8_17 · Cited by 85 · see citing works
Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human
Birzele, F., Fauti, T., Stahl, H. F., Lenter, M., Simon, E., Knebel, D., Weith, A., Hildebrandt, T., & Mennerich, D. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr444 · Cited by 84 · see citing works
Chen, K., Deng, S., Lu, H., Zheng, Y., Yang, G., Kim, D., Cao, Q., & Wu, J. Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072567 · Cited by 83 · see citing works
Kumaran, M., Subramanian, U., & Devarajan, B. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2928-9 · Cited by 80 · see citing works
The emerging roles of NGS in clinical oncology and personalized medicine
Hussen, B. M., Abdullah, S. T., Salihi, A. B., Sabir, D. K., Sidiq, K. R., Rasul, M. F., Hidayat, H. J., Ghafouri‐Fard, S., Taheri, M. N., & Jamali, E. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153760 · Cited by 80 · see citing works
Geyer, F. C., & Reis-Filho, J. S. (2008) · International Journal of Surgical Pathology · doi:10.1177/1066896908328577 · Cited by 79 · see citing works
Sequencing antibody repertoires
Fischer, N. (2011) · mAbs · doi:10.4161/mabs.3.1.14169 · Cited by 78 · see citing works
Otero, J. M., Vongsangnak, W., Asadollahi, M. A., Olivares‐Hernández, R., Maury, J., Farinelli, L., Bærlocher, L., Østerås, M., Schalk, M., Clark, A., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-723 · Cited by 73 · see citing works
Using Large Datasets to Understand Nanotechnology
Paunovska, K., Loughrey, D., Sago, C. D., Langer, R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201902798 · Cited by 67 · see citing works
Haspel, R. L., Arnaout, R., Briere, L. C., Kantarci, S., Marchand, K. F., Tonellato, P. J., Connolly, J. L., Boguski, M. S., & Saffitz, J. E. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcpn6q1qkclykxm · Cited by 66 · see citing works
Pem, D., Jeewon, R., Chethana, K. W. T., Hongsanan, S., Doilom, M., Suwannarach, N., & Hyde, K. D. (2021) · Fungal Diversity · doi:10.1007/s13225-021-00485-7 · Cited by 64 · see citing works
Rodovalho, C. D. M., Lyra, M. L., Ferro, M., & Bacci, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097117 · Cited by 62 · see citing works
Advances in Maize Genomics and Their Value for Enhancing Genetic Gains from Breeding
Xu, Y., Skinner, D. J., Wu, H., Palacios‐Rojas, N., Araus, J. L., Yan, J., Gao, S., Warburton, M. L., & Crouch, J. H. (2009) · International Journal of Plant Genomics · doi:10.1155/2009/957602 · Cited by 61 · see citing works
Susceptibility to Dental Caries and the Salivary Proline-Rich Proteins
Levine, M. (2011) · International Journal of Dentistry · doi:10.1155/2011/953412 · Cited by 60 · see citing works
Exome sequencing greatly expedites the progressive research of Mendelian diseases
Zhang, X. (2014) · Frontiers of Medicine · doi:10.1007/s11684-014-0303-9 · Cited by 58 · see citing works
Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells
Civit, L., Taghdisi, S. M., Jończyk, A., Haßel, S. K., Gröber, C., Blank, M., Stunden, H. J., Beyer, M., Schultze, J. L., Latz, E., et al. (2017) · Biochimie · doi:10.1016/j.biochi.2017.10.007 · Cited by 55 · see citing works
Wu, S., Li, R. W., Li, W., & Li, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036940 · Cited by 54 · see citing works
Nucleic acid-based drugs for patients with solid tumours
Huayamares, S. G., Loughrey, D., Kim, H., Dahlman, J. E., & Sorscher, E. J. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00883-1 · Cited by 50 · see citing works
The origin of dips for the graphene-based DNA sequencing device
Cho, Y., Min, S. K., Kim, W. Y., & Kim, K. S. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c1cp20760a · Cited by 48 · see citing works
Genetics of the myeloproliferative neoplasms
Abdel-Wahab, O. I. (2011) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328343998e · Cited by 48 · see citing works
Alternative splicing: An important mechanism in stem cell biology
Chen, K. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i1.1 · Cited by 48 · see citing works
High-throughput Sequencing Technology and Its Application
Zhu, Q., Liu, S., Peng, G., & Feishi, L. (2014) · Journal of Northeast Agricultural University (English edition) · doi:10.1016/s1006-8104(14)60073-8 · Cited by 47 · see citing works
Acousto-microfluidics for screening of ssDNA aptamer
Park, J.-W., Lee, S. J., Ren, S., Lee, S.-W., Kim, S., & Laurell, T. (2016) · Scientific Reports · doi:10.1038/srep27121 · Cited by 47 · see citing works
Barriers for integrating personalized medicine into clinical practice: A qualitative analysis
Najafzadeh, M., Davis, J. C., Joshi, P., & Marra, C. A. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35811 · Cited by 46 · see citing works
X chromosome association testing in genome wide association studies
Hickey, P. F., & Bahlo, M. (2011) · Genetic Epidemiology · doi:10.1002/gepi.20616 · Cited by 45 · see citing works
Hart, C. E., Lipson, D., Ozsolak, F., Raz, T., Steinmann, K. E., Thompson, J. F., & Milos, P. M. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)72002-4 · Cited by 45 · see citing works
Self-citationBeyond Element-Wise Interactions: Identifying Complex Interactions in Biological Processes
Ladroue, C., Guo, S., Kendrick, K. M., & Feng, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006899 · Cited by 44 · see citing works
Gresham, D., Curry, B., Ward, A., Gordon, D. B., Brizuela, L., Kruglyak, L., & Botstein, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913883107 · Cited by 43 · see citing works
Identifying molecular drivers of gastric cancer through next-generation sequencing
Liang, H., & Kim, Y. H. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.029 · Cited by 42 · see citing works
Common variants in PARK loci and related genes and Parkinson's disease
Chung, S. J., Armasu, S. M., Biernacka, J. M., Lesnick, T. G., Rider, D. N., Lincoln, S., Soto‐Ortolaza, A. I., Farrer, M. J., Cunningham, J. M., Rocca, W. A., et al. (2010) · Movement Disorders · doi:10.1002/mds.23376 · Cited by 42 · see citing works
Power of Deep Sequencing and Agilent Microarray for Gene Expression Profiling Study
Feng, L., Liu, H., Liu, Y., Lu, Z., Guo, G., Guo, S., Zheng, H., Gao, Y., Cheng, S., Wang, J., et al. (2010) · Molecular Biotechnology · doi:10.1007/s12033-010-9249-6 · Cited by 41 · see citing works
A comparison of mechanistic signaling pathway activity analysis methods
Amadoz, A., Hidalgo, M. R., Çubuk, C., Carbonell‐Caballero, J., & Dopazo, J. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby040 · Cited by 41 · see citing works
Clinical applications of next-generation sequencing in colorectal cancers
Kim, T. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i40.6784 · Cited by 40 · see citing works
High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA
Poulsen, J. B., Lescai, F., Grove, J., Bækvad‐Hansen, M., Christiansen, M., Hagen, C. M., Maller, J., Stevens, C. R., Li, S., Li, Q., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153253 · Cited by 40 · see citing works
Esteban‐Medina, M., Peña-Chilet, M., Loucera, C., & Dopazo, J. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2969-0 · Cited by 40 · see citing works
Efficient Selection of Biomineralizing DNA Aptamers Using Deep Sequencing and Population Clustering
Bawazer, L. A., Newman, A. M., Gu, Q., Ibish, A., Arcila, M. L., Cooper, J. B., Meldrum, F. C., & Morse, D. E. (2013) · ACS Nano · doi:10.1021/nn404448s · Cited by 39 · see citing works
Next-generation sequencing for genetic testing of familial colorectal cancer syndromes
Simbolo, M., Mafficini, A., Agostini, M., Pedrazzani, C., Bedin, C., Urso, E. D. L., Nitti, D., Turri, G., Scardoni, M., Fassan, M., et al. (2015) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-015-0039-9 · Cited by 38 · see citing works
Quantitative analysis of DNA with single-molecule sequencing
Ohshiro, T., Tsutsui, M., Yokota, K., & Taniguchi, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-26875-7 · Cited by 36 · see citing works
Characterizing Multi-omic Data in Systems Biology
Mason, C. E., Porter, S. G., & Smith, T. M. F. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8778-4_2 · Cited by 34 · see citing works
Using mechanistic models for the clinical interpretation of complex genomic variation
Peña-Chilet, M., Esteban‐Medina, M., Falco, M. M., Rian, K., Hidalgo, M. R., Loucera, C., & Dopazo, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-55454-7 · Cited by 34 · see citing works
Whole-exome sequencing reveals recurrent somatic mutation networks in cancer
Liu, X., Wang, J., & Chen, L. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.002 · Cited by 33 · see citing works
Ahead of the curve: next generation estimators of drug resistance in malaria infections
Mideo, N., Kennedy, D. A., Carlton, J. M., Bailey, J. A., Juliano, J. J., & Read, A. F. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.05.004 · Cited by 32 · see citing works
Customized care 2020: how medical sequencing and network biology will enable personalized medicine
Boguski, M. S., Arnaout, R., & Hill, C. (2009) · F1000 Biology Reports · doi:10.3410/b1-73 · Cited by 32 · see citing works
Efcavitch, J. W., & Thompson, J. F. (2010) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.111808.073558 · Cited by 28 · see citing works
Self-citationRethinking taxon sampling in the light of environmental sequencing
Nilsson, R. H., Ryberg, M. K., Sjökvist, E., & Abarenkov, K. (2010) · Cladistics · doi:10.1111/j.1096-0031.2010.00336.x · Cited by 27 · see citing works
Variants in estrogen‐related genes and risk of Parkinson's disease
Chung, S. J., Armasu, S. M., Biernacka, J. M., Lesnick, T. G., Rider, D. N., Cunningham, J. M., & Maraganore, D. M. (2011) · Movement Disorders · doi:10.1002/mds.23604 · Cited by 27 · see citing works
Shah, M. P. (2017) · International Journal of Molecular Biology Open Access · doi:10.15406/ijmboa.2016.02.00011 · Cited by 27 · see citing works
Blank, M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3197-2_7 · Cited by 25 · see citing works
Glenn, T. C., & Faircloth, B. C. (2016) · Molecular Ecology Resources · doi:10.1111/1755-0998.12574 · Cited by 24 · see citing works
Single-step capture and sequencing of natural DNA for detection of BRCA1 mutationsPreprint
Thompson, J. F., Reifenberger, J. G., Giladi, E., Kerouac, K., Gill, J., Hansen, E., Kahvejian, A., Kapranov, P., Knope, T., Lipson, D., et al. (2011) · Genome Research · doi:10.1101/gr.122192.111 · Cited by 24 · see citing works
Self-citationLi, C., Li, R. W., Baldwin, R. L., Blomberg, L. A., Wu, S., & Li, W. (2016) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s35607 · Cited by 23 · see citing works
Tumor suppressor genes in familial adenomatous polyposis.
Eshghifar, N., Farrokhi, N., Naji, T., & Zali, M. R. (2017) · Gastroenterology and hepatology from bed to bench. · Cited by 23 · see citing works
Systematic analysis and functional annotation of variations in the genome of an Indian individual
Patowary, A., Purkanti, R., Singh, M., Chauhan, R. K., Bhartiya, D., Dwivedi, O. P., Chauhan, G., Bharadwaj, D., Sivasubbu, S., & Scaria, V. (2012) · Human Mutation · doi:10.1002/humu.22091 · Cited by 23 · see citing works
Lee, S., Paik, S. H., Kim, H. J., Ryu, H. H., Cha, S., Jo, S. J., Eun, H. C., Seo, J., Kim, J., & Kwon, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053613 · Cited by 23 · see citing works
Min, S. K., Cho, Y., Mason, D. R., Lee, J. Y., & Kim, K. S. (2011) · The Journal of Physical Chemistry C · doi:10.1021/jp203748r · Cited by 22 · see citing works
Comprehensive Analysis of Somatic Mutations in Colorectal Cancer With Peritoneal Metastasis
Lee, J., Ahn, B. K., Baik, S. S., & Lee, K. H. (2019) · In Vivo · doi:10.21873/invivo.11493 · Cited by 22 · see citing works
Genetic identification in the 21st century—Current status and future developments
Decorte, R. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.02.029 · Cited by 22 · see citing works
Wu, L., Fredua‐Agyeman, R., Strelkov, S. E., Chang, K. F., & Hwang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179744 · Cited by 21 · see citing works
From Galactic archeology to soil metagenomics – surfing on massive data streams
Martin, N. F., & Martin, F. M. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2009.03138.x · Cited by 21 · see citing works
Analysis and simulation of gene expression profiles in pure and mixed cell populations
Hebenstreit, D., & Teichmann, S. A. (2011) · Physical Biology · doi:10.1088/1478-3975/8/3/035013 · Cited by 20 · see citing works
Liu, Y., Xu, L., Wang, Q., Zhou, X., Zhou, J., Pan, C., Zhang, J. G., Wu, Q., Li, Y., Xia, Y., et al. (2015) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.20758 · Cited by 20 · see citing works
Lavezzo, E., Toppo, S., Franchin, E., Camillo, B. D., Finotello, F., Falda, M., Manganelli, R., Palù, G., & Barzon, L. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-554 · Cited by 19 · see citing works
El estudio de la biodiversidad en la era de la secuenciación masiva
Escalante, A. E., Jardón‐Barbolla, L., Ramírez‐Barahona, S., & Eguiarte, L. E. (2015) · Revista Mexicana de Biodiversidad · doi:10.7550/rmb.43498 · Cited by 18 · see citing works
Ranade, S., Chung, C. B., Zon, G., & Boyd, V. L. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.04.020 · Cited by 18 · see citing works
Statistical Issues in the Analysis of ChIP-Seq and RNA-Seq Data
Ghosh, D., & Qin, Z. S. (2010) · Genes · doi:10.3390/genes1020317 · Cited by 18 · see citing works
Williams, R. M., Schuldt, B., & Müller, F. (2011) · BioEssays · doi:10.1002/bies.201100073 · Cited by 17 · see citing works
- Authors
- Kahvejian, A., Quackenbush, J., & Thompson, J. F.
- Affiliations
- Helicos Biosciences (United States) (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Quackenbush, John
- Venue
- Nature Biotechnology
- Published
- 2008-10
- Volume
- 26
- Issue
- 10
- Pages
- 1125-1133
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- PMC
- PMC4153598
- OpenAlex
- W2087444873
- Cited by
- 189
- References
- 120
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 11 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 10 · 2013: 18 · 2012: 18
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01lm010129-02)
- U.S. National Library of Medicine (R01-LM010129)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Keywords
- next-generation sequencing, Human Genome Project, sequencing technology development, genome regulation, gene discovery, nucleic acid therapeutics, personalized medicine, array-based technologies
- MeSH terms
- Chromosome Mapping, Forecasting, Health Knowledge, Attitudes, Practice, Human Genome Project, Sequence Analysis, DNA, Databases, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
