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Toward fluorescence nanoscopy
Open accessAbstract
For more than a century, the resolution of focusing light microscopy has been limited by diffraction to 180 nm in the focal plane and to 500 nm along the optic axis. Recently, microscopes have been reported that provide three- to sevenfold improved axial resolution in live cells. Moreover, a family of concepts has emerged that overcomes the diffraction barrier altogether. Its first exponent, stimulated emission depletion microscopy, has so far displayed a resolution down to 28 nm. Relying on saturated optical transitions, these concepts are limited only by the attainable saturation level. As strong saturation should be feasible at low light intensities, nanoscale imaging with focused light may be closer than ever.
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Cited by
Hell, S. W. (2007) · Science · doi:10.1126/science.1137395 · Cited by 2,967
Self-citationSchermelleh, L., Carlton, P. M., Haase, S., Shao, L., Winoto, L., Kner, P., Burke, B., Cardoso, M. C., Agard, D. A., Gustafsson, M. G. L., et al. (2008) · Science · doi:10.1126/science.1156947 · Cited by 1,123
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Kittel, R. J., Wichmann, C., Rasse, T. M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D. A., Pawlu, C., Kellner, R. R., Willig, K. I., et al. (2006) · Science · doi:10.1126/science.1126308 · Cited by 772
Self-citationDiffraction-unlimited all-optical imaging and writing with a photochromic GFP
Grotjohann, T., Testa, I., Leutenegger, M., Bock, H., Urban, N. T., Lavoie-Cardinal, F., Willig, K. I., Eggeling, C., Jakobs, S., & Hell, S. W. (2011) · Nature · doi:10.1038/nature10497 · Cited by 501
Self-citationResolution scaling in STED microscopy
Harke, B., Keller, J., Ullal, C. K., Westphal, V., Schönle, A., & Hell, S. W. (2008) · Optics Express · doi:10.1364/oe.16.004154 · Cited by 438
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Metadata
- Authors
- Hell, S. W.
- Venue
- Nature Biotechnology
- Published
- 2003-10-31
- Volume
- 21
- Issue
- 11
- Pages
- 1347-1355
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2054358220
- Cited by
- 1,003
- References
- 0
- FWCI
- 24.04
- Type
- journal article
- Language
- en
- Open access
- green
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