Biological wires, communication systems, and implications for disease
Abstract
Microtubules, actin, and collagen are macromolecular structures that compose a large percentage of the proteins in the human body, helping form and maintain both intracellular and extracellular structure. They are biological wires and are structurally connected through various other proteins. Microtubules (MTs) have been theorized to be involved in classical and quantum information processing, and evidence continues to suggest possible semiconduction through MTs. The previous Dendritic Cytoskeleton Information Processing Model has hypothesized how MTs and actin form a communication network in neurons. Here, we review information transfer possibilities involving MTs, actin, and collagen, and the evidence of an organism-wide high-speed communication network that may regulate morphogenesis and cellular proliferation. The direct and indirect evidence in support of this hypothesis, and implications for chronic diseases such as cancer and neurodegenerative diseases are discussed.
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From Priel et al.'s conductance data, the approximate ionic conductivity of MTs is found to be 367 S/m.
“From Priel et al.’s conductance data, the approximate ionic conductivity of MTs is found to be an astonishing 367 S/m [74].”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [74]
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Niraula, D., Naqa, I. E., Tuszyński, J. A., & Gatenby, R. A. (2024) · iScience · doi:10.1016/j.isci.2024.109614 · Cited by 8 · see citing works
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Towards Cytoskeleton Computers. A Proposal
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Structural Stability of Peptidic His-Containing Proton Wire in Solution and in the Adsorbed State
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- Authors
- Friesen, D. E., Craddock, T. J. A., Kalra, A. P., & Tuszynski, J. A.
- Affiliations
- University of Alberta (CA)
- Nova Southeastern University (US)
- Dayalbagh Educational Institute (IN)
- Venue
- Biosystems
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 127
- Pages
- 14-27
- ISSN
- 0303-2647 (ISSN-L)
- OpenAlex
- W2028671607
- Cited by
- 48
- References
- 204
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 5
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biosystems (publishedVersion)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Funders
- Nova Southeastern University’s Center for Psychological Studies and Institute for Neuro-Immune Medicine
- NSERC (Canada)
- Topics
- Health Sciences › Medicine › Physiology › Biofield Effects and Biophysics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- microtubules, actin, collagen, quantum information processing, morphogenesis, cell proliferation, cancer, neurodegenerative diseases
- MeSH terms
- Actins, Cell Communication, Collagen, Electric Conductivity, Extracellular Matrix, Humans, Microtubules, Models, Biological, Signal Transduction, Gap Junctions
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