Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1

The Calpain System

Goll, D. E., Thompson, V. F., Li, H., WEI, W., & Cong, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00029.2002 · Cited by 2,826 · see citing works

Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton

Ren, X. D., Kiosses, W. B., & Schwartz, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.578 · Cited by 1,573 · see citing works

Coordination of Rho GTPase activities during cell protrusion

Machacek, M., Hodgson, L., Welch, C. M., Elliott, H. L., Pertz, O. C., Nalbant, P., Abell, A. N., Johnson, G. L., Hahn, K. M., & Danuser, G. M. (2009) · Nature · doi:10.1038/nature08242 · Cited by 1,001 · see citing works

Adhesion signaling – crosstalk between integrins, Src and Rho

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Conserved microtubule–actin interactions in cell movement and morphogenesis

Rodriguez, O. C., Schaefer, A. W., Mandato, C. A., Forscher, P., Bement, W. M., & Waterman-Storer, C. M. (2003) · Nature Cell Biology · doi:10.1038/ncb0703-599 · Cited by 844 · see citing works

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. M., & Narumiya, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3044 · Cited by 823 · see citing works

The many faces of actin: matching assembly factors with cellular structures

Chhabra, E. S., & Higgs, H. N. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1110 · Cited by 744 · see citing works

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

Krendel, M., Zenke, F. T., & Bokoch, G. M. (2002) · Nature Cell Biology · doi:10.1038/ncb773 · Cited by 669 · see citing works

mDia mediates Rho-regulated formation and orientation of stable microtubules

Palazzo, A. F., Cook, T. A., Alberts, A. S., & Gundersen, G. G. (2001) · Nature Cell Biology · doi:10.1038/35087035 · Cited by 582 · see citing works

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

Narumiya, S., Tanji, M., & Ishizaki, T. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9170-7 · Cited by 530 · see citing works

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

Waterman-Storer, C. M., Worthylake, R. A., Liu, B. P., Burridge, K., & Salmon, E. D. (1999) · Nature Cell Biology · doi:10.1038/9018 · Cited by 491 · see citing works

Beyond polymer polarity: how the cytoskeleton builds a polarized cell

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GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

Chang, Y.-C., Nalbant, P., Birkenfeld, J., Chang, Z.-F., & Bokoch, G. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1269 · Cited by 357 · see citing works

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

Hanna, R. A., Campbell, R. L., & Davies, P. L. (2008) · Nature · doi:10.1038/nature07451 · Cited by 318 · see citing works

C1 domains exposed: From diacylglycerol binding to protein–protein interactions

COLONGONZALEZ, F., & KAZANIETZ, M. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.05.001 · Cited by 308 · see citing works

Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases

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Microtubule-induced cortical cell polarityPreprint

Siegrist, S. E., & Doe, C. Q. (2007) · Genes & Development · doi:10.1101/gad.1511207 · Cited by 239 · see citing works

The calpains: modular designs and functional diversity

Croall, D. E., & Ersfeld, K. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-218 · Cited by 221 · see citing works

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

Tsuji, T., Ishizaki, T., Okamoto, M., Higashida, C., Kimura, K., Furuyashiki, T., Arakawa, Y., Birge, R. B., Nakamoto, T., Hirai, H., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112107 · Cited by 219 · see citing works

Microtubule Disruption Induces the Formation of Actin Stress Fibers and Focal Adhesions in Cultured Cells: Possible Involvement of the Rho Signal Cascade.

Enomoto, T. (1996) · Cell Structure and Function · doi:10.1247/csf.21.317 · Cited by 218 · see citing works

Identification of a tight junction–associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

Benais-Pont, G., Punn, A., Flores-Maldonado, C., Eckert, J. J., Raposo, G., Fleming, T. P., Cereijido, M., Balda, M. S., & Matter, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211047 · Cited by 202 · see citing works

Localized RhoA Activation as a Requirement for the Induction of Membrane Ruffling

Kurokawa, K., & Matsuda, M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-12-1076 · Cited by 193 · see citing works

Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

Birkenfeld, J., Nalbant, P., Yoon, S.-H., & Bokoch, G. M. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.02.006 · Cited by 190 · see citing works

p21-activated Kinase 1 Phosphorylates and Regulates 14-3-3 Binding to GEF-H1, a Microtubule-localized Rho Exchange Factor

Zenke, F. T., Krendel, M., DerMardirossian, C. M., King, C. C., Bohl, B. P., & Bokoch, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400084200 · Cited by 181 · see citing works

GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction

Birukova, A. A., Adyshev, D., Gorshkov, B., Bokoch, G. M., Birukov, K. G., & Verin, A. D. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00259.2005 · Cited by 173 · see citing works

PAK4 mediates morphological changes through the regulation of GEF-H1

Callow, M. G., Zozulya, S., Gishizky, M. L., Jallal, B., & Smeal, T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02313 · Cited by 169 · see citing works

The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells

Glaven, J. A., Whitehead, I., Bagrodia, S., Kay, R., & Cerione, R. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2279 · Cited by 156 · see citing works

Guanine Nucleotide Exchange Factor-H1 Regulates Cell Migration via Localized Activation of RhoA at the Leading Edge

Nalbant, P., Chang, Y.-C., Birkenfeld, J., Chang, Z.-F., & Bokoch, G. M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0041 · Cited by 148 · see citing works

A New Subfamily of Vertebrate Calpains Lacking a Calmodulin-Like Domain: Implications for Calpain Regulation and Evolution

Dear, N. T., Matena, K., Vingron, M., & Boehm, T. L. J. (1997) · Genomics · doi:10.1006/geno.1997.4870 · Cited by 136 · see citing works

The tra‐3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.

Barnes, T. M., & Hodgkin, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00825.x · Cited by 108 · see citing works

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

Ojima, K., Kawabata, Y., Nakao, H., Nakao, K., Doi, N., Kitamura, F., Ono, Y., Hata, S., Suzuki, H., Kawahara, H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40658 · Cited by 102 · see citing works

Calpain 6 Is Involved in Microtubule Stabilization and Cytoskeletal Organization

Tonami, K., Kurihara, Y., Aburatani, H., Uchijima, Y., Asano, T., & Kurihara, H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00992-06 · Cited by 97 · see citing works

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

El‐Sibai, M., Pertz, O. C., Pang, H., Yip, S.-C., Lorenz, M., Symons, M. H., Condeelis, J. S., Hahn, K. M., & Backer, J. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.016 · Cited by 95 · see citing works

Calpain 8/nCL-2 and Calpain 9/nCL-4 Constitute an Active Protease Complex, G-Calpain, Involved in Gastric Mucosal Defense

Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama‐Sorimachi, N., Abe, K., Sakimura, K., & Sorimachi, H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001040 · Cited by 82 · see citing works

Identification of a Novel, Tissue-Specific Calpainhtra-3;a Human Homologue of theCaenorhabditis elegansSex Determination Gene

Mugita, N., Kimura, Y., Ogawa, M., Saya, H., & Nakao, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7571 · Cited by 36 · see citing works

Microtubules regulate GEF-H1 in response to extracellular matrix stiffness

Heck, J. N., Ponik, S. M., Garcia-Mendoza, M. G., Pehlke, C. A., Inman, D. R., Eliceiri, K. W., & Keely, P. J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0876 · Cited by 96 · see citing works

Calpain 6 Is Involved in Microtubule Stabilization and Cytoskeletal Organization

Tonami, K., Kurihara, Y., Aburatani, H., Uchijima, Y., Asano, T., & Kurihara, H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00992-06 · Cited by 97 · see citing works

BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation

Pan, M., Chew, T. W., Wong, D. C. P., Xiao, J., Ong, H. T., Chin, J. F. L., & Low, B. C. (2020) · Science Advances · doi:10.1126/sciadv.aaz1534 · Cited by 28 · see citing works

Cross-talk between Rac and Rap GTPases in migrating cells

Lüttig, R., Nanda, S., Chandran, H. T., & Dehmelt, L. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-02-0058

Regulation of leading edge microtubule and actin dynamics downstream of Rac1

Wittmann, T., Bokoch, G., & Waterman, C. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303082 · Cited by 273 · see citing works

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

Krendel, M., Zenke, F. T., & Bokoch, G. M. (2002) · Nature Cell Biology · doi:10.1038/ncb773 · Cited by 669 · see citing works