The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

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Items 101–200 of 662

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    Bing Xu, Zhao-Liang Sun, Zhaojian Liu, Haiyang Guo, Qiao Liu, Haiyan Jiang, Yongxin Zou, Yaoqin Gong, Jay A. Tischfield, Changshun Shao · 2011 · PLoS ONE
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  3. The consequences of structural genomic alterations in humans: Genomic Disorders, genomic instability and cancer
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  4. A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress
    Kelly M. Brooks, Vanessa Oakes, Brooke Edwards, Max V. Ranall, Paul Leo, Sandra J. Pavey, Alex Pinder, Heather Beamish, Pamela Mukhopadhyay, Duncan Lambie et al. · 2012 · Oncogene
  5. PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization
    Shirley M.-H. Sy, Michael S.Y. Huen, Yongyou Zhu, Junjie Chen · 2009 · Journal of Biological Chemistry
  6. XPO1 Inhibition using Selinexor Synergizes with Chemotherapy in Acute Myeloid Leukemia by Targeting DNA Repair and Restoring Topoisomerase IIα to the Nucleus
    Parvathi Ranganathan, Trinayan Kashyap, Xueyan Yu, Xiaomei Meng, Tzung-Huei Lai, Betina McNeil, Bhavana Bhatnagar, Sharon Shacham, Michael G. Kauffman, Adrienne M. Dorrance et al. · 2016 · Clinical Cancer Research
  7. Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
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  8. DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer
    Denis Velic, Anthony M. Couturier, Maria Ferreira, Amélie Rodrigue, Guy G. Poirier, Fabrice Fleury, Jean‐Yves Masson · 2015 · Biomolecules
  9. Targeting the Double-Strand DNA Break Repair Pathway as a Therapeutic Strategy
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  10. Phosphorylation of Rad55 on Serines 2, 8, and 14 Is Required for Efficient Homologous Recombination in the Recovery of Stalled Replication Forks
    Herzberg, Kristina, Bashkirov, Vladimir I., Rolfsmeier, Michael, Haghnazari, Edwin, McDonald, W. Hayes, Anderson, Scott, Bashkirova, Elena V., Yates, John R., Heyer, Wolf-Dietrich · 2006 · Molecular and Cellular Biology
  11. The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
    Wei Shi, Zhihui Feng, Jiuqin Zhang, Ignacio González-Suárez, Robert P. Vanderwaal, Xiaohua Wu, Simon N. Powell, Joseph L. Roti Roti, Susana Gonzalo, Junran Zhang · 2010 · Carcinogenesis
  12. Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells
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  13. Rad17 recruits the MRE11‐RAD50‐NBS1 complex to regulate the cellular response to DNA double‐strand breaks
    Qinhong Wang, Michael Goldstein, Peter B. Alexander, Timothy P. Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B. Kastan, X.-F. Wang · 2014 · The EMBO Journal
  14. CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs
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  15. Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair
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  16. Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller
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  17. In vitro and in vivo genotoxicity of oxygenated polycyclic aromatic hydrocarbons
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  18. Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies
    Brian G. Gabrielli, Kelly M. Brooks, Sandra J. Pavey · 2012 · Frontiers in Pharmacology
  19. Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition
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  20. Human Embryonic Stem Cells Fail to Activate CHK1 and Commit to Apoptosis in Response to DNA Replication Stress
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  21. Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint
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  22. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130
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    Ray, Alo, Milum, Keisha, Battu, Aruna, Wani, Gulzar, Wani, Altaf A. · 2013 · DNA Repair
  24. Targeting Poly(ADP-Ribose) Polymerase and the c-Myb–Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer
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  25. Regulation and pharmacological targeting of RAD51 in cancer
    McKenzie K. Grundy, Ronald J. Buckanovich, Kara Anne Bernstein · 2020 · NAR Cancer
  26. ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells
    Despras, Emmanuelle, Daboussi, Fayza, Hyrien, Olivier, Marheineke, Kathrin, Kannouche, Patricia L. · 2010 · Human Molecular Genetics
  27. The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis
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  28. Long noncoding RNA LINC02582 acts downstream of miR-200c to promote radioresistance through CHK1 in breast cancer cells
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  29. Discovery and in silico evaluation of aminoarylbenzosuberene molecules as novel checkpoint kinase 1 inhibitor determinants
    Rahul Singh, Vijay Kumar Bhardwaj, Jatin Sharma, Pralay Das, Rituraj Purohit · 2020 · Genomics
  30. Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
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  31. Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
    Amy D. Guertin, Melissa M. Martin, Brian S. Roberts, Melissa S. Hurd, Xianlu Qu, Nathan R. Miselis, Yaping Liu, Jing Li, Igor Feldman, Yair Benita et al. · 2012 · Cancer Cell International
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  33. Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer
    Ethan Brill, Takuhei Yokoyama, Jayakumar R. Nair, Minshu Yu, Yeong-Ran Ahn, Jung‐Min Lee · 2017 · Oncotarget
  34. Regulators of homologous recombination repair as novel targets for cancer treatment
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  35. Uracil in DNA: Consequences for carcinogenesis and chemotherapy
    Sondra H. Berger, Douglas L. Pittman, Michael D. Wyatt · 2008 · Biochemical Pharmacology
  36. Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
    Kurtis D. Davies, P. LouAnn Cable, Jennifer E. Garrus, Francis X. Sullivan, Ira von Carlowitz, Yvan Le Huérou, Eli M. Wallace, Richard D. Woessner, Stefan David Gross · 2011 · Cancer Biology & Therapy
  37. Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo
    Ryan E. Montano, Ruth H. Thompson, Injae Chung, Huagang G. Hou, Nadeem Israr Khan, Alan R. Eastman · 2013 · BMC Cancer
  38. An ATR- and BRCA1-Mediated Fanconi Anemia Pathway Is Required for Activating the G2/M Checkpoint and DNA Damage Repair upon Rereplication
    Wenge Zhu, Anindya Dutta · 2006 · Molecular and Cellular Biology
  39. Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer
    Nicola J. Curtin · 2013 · British Journal of Pharmacology
  40. Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
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  41. Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor
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  42. Dancing on Damaged Chromatin: Functions of ATM and the RAD50/MRE11/NBS1 Complex in Cellular Responses to DNA Damage
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  43. Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations)
    Haider Mahdi, Navid Hafez, Deborah B. Doroshow, Davendra P. S. Sohal, Vickie L. Keedy, Khanh T Do, Patricia Mucci LoRusso, Juliane Margarete Jürgensmeier, Manuel Avedissian, Jeffrey Sklar et al. · 2021 · JCO Precision Oncology
  44. Chk1 Inhibits E2F6 Repressor Function in Response to Replication Stress to Maintain Cell-Cycle Transcription
    Cosetta Bertoli, Steffi Klier, Clare H. McGowan, Curt Wittenberg, Robertus A.M. de Bruin · 2013 · Current Biology
  45. A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
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  46. Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function
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  47. Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
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  48. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy
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  49. Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control
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  50. CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
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  51. RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells
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  52. Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery
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  53. The fork and the kinase: A DNA replication tale from a CHK1 perspective
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  54. USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
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  55. DNA Structure and Integrity Checkpoints during the Cell Cycle and Their Role in Drug Targeting and Sensitivity of Tumor Cells to Anticancer Treatment
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  56. The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers
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  57. Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy
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  58. The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma
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  59. Inhibiting homologous recombination for cancer therapy
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  60. Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins
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  62. Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
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  67. Chk1 knockdown confers radiosensitization in prostate cancer stem cells
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  73. Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics
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  75. ATM/ATR‐mediated phosphorylation of PALB2 promotes RAD51 function
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  76. Synergism between Etoposide and 17-AAG in Leukemia Cells: Critical Roles for Hsp90, FLT3, Topoisomerase II, Chk1, and Rad51
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  77. Chk1 as a new therapeutic target in triple-negative breast cancer
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  78. Regulation of the Life Cycle of HPVs by Differentiation and the DNA Damage Response
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  79. Translational research in radiation-induced DNA damage signaling and repair
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  80. Sub‐nuclear localization of Rad51 in response to DNA damage
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  81. PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair
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  82. The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition
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  83. CBP and p300 Histone Acetyltransferases Contribute to Homologous Recombination by Transcriptionally Activating the BRCA1 and RAD51 Genes
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  84. Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank
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  85. Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia
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  86. Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy
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  87. Recql5 Plays an Important Role in DNA Replication and Cell Survival after Camptothecin Treatment
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  88. ATR is a multifunctional regulator of male mouse meiosis
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  89. Inhibiting homologous recombination by targeting RAD51 protein
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  90. HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells
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  91. Detection of Impaired Homologous Recombination Repair in NSCLC Cells and Tissues
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  92. Checkpoint Kinase 1 Inhibition Enhances Cisplatin Cytotoxicity and Overcomes Cisplatin Resistance in SCLC by Promoting Mitotic Cell Death
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  93. ATR-Chk1 Axis Protects BCR/ABL Leukemia Cells from the Lethal Effect of DNA Double-Strand Breaks
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  95. Emerging links between the biological clock and the DNA damage response
    Spencer James Collis, Simon J. Boulton · 2007 · Chromosoma
  96. Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer
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  97. Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
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  98. Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase
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  99. The inhibition of PARP but not EGFR results in the radiosensitization of HPV/p16-positive HNSCC cell lines
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  100. Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
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