The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Chk1 and Chk2 kinases in checkpoint control and cancer

Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00110-7 · Cited by 1,513

Sensing and repairing DNA double-strand breaks

Jackson, S. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.687 · Cited by 1,149

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091

Untitled work

(1999) · PubMed · Cited by 1,030

Molecular views of recombination proteins and their control

West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 977

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951

Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death

Sonoda, E., Sasaki, M., Buerstedde, J., Bezzubova, O., Shinohara, A., Ogawa, H., Takata, M., Yamaguchi-Iwai, Y., & Takeda, S. (1998) · EMBO Journal · doi:10.1093/emboj/17.2.598 · Cited by 860

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y., & MoritaT (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6236 · Cited by 792

Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

Lee, K. Y., & Dutta, A. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108680 · Cited by 17

LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination‐mediated DNA double strand break repair

Chen, L., Hou, J., Zeng, X., Guo, Q., Deng, M., Kloeber, J. A., Tu, X., Zhao, F., Wu, Z., Huang, J., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.341 · Cited by 17

Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines

Johansson, F., Lagerqvist, A., Filippi, S., Palitti, F., Erixon, K., Helleday, T., & Jenssen, D. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.07.005 · Cited by 17

ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair

Brown, A., Sager, B. W., Gorthi, A., Tonapi, S. S., Brown, E. J., & Bishop, A. J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091222 · Cited by 17

Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival

Jadali, A., Ying, Y. M., & Kwan, K. Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00137 · Cited by 17

Replicating Damaged DNA in EukaryotesPreprint

Chatterjee, N., & Siede, W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019836 · Cited by 17

DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies

Lee, S., Kim, J., Jeong, E., & Myung, K. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103887 · Cited by 16

Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression

Watari, A., Hasegawa, M., Yagi, K., & Kondoh, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145631 · Cited by 16

DNA damage response is hijacked by human papillomaviruses to complete their life cycle

Hong, S.-Y. (2017) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1600306 · Cited by 17

Novel biological strategies to enhance the radiation therapeutic ratio

Kim, J. H., Jenrow, K. A., & Brown, S. L. (2018) · Radiation Oncology Journal · doi:10.3857/roj.2018.00332 · Cited by 16

Autophagy suppression enhances DNA damage and cell death upon treatment with PARP inhibitor Niraparib in laryngeal squamous cell carcinoma

Ji, Y., Wang, Q., Zhao, Q., Zhao, S., Li, L., Sun, G., & Ye, L. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10148-y · Cited by 16

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes

McIntosh, M. T., Koganti, S. R. K., Boatwright, J. L., Li, X., Spadaro, S., Brantly, A. C., Ayers, J. B., Perez, R. D., Burton, E. M., Burgula, S., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008849 · Cited by 16

ATR Inhibitors in Platinum-Resistant Ovarian Cancer

Li, S., Wang, T., Fei, X., & Zhang, M. (2022) · Cancers · doi:10.3390/cancers14235902 · Cited by 16

Human RECQL5 overcomes thymidine-induced replication stress

Blundred, R., Myers, K. N., Helleday, T., Goldman, A. S. H., & Bryant, H. E. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.06.009 · Cited by 16

Menin stimulates homology‐directed DNA repair

Gallo, A., Agnese, S., Esposito, I., Galgani, M., & Avvedimento, V. E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.032 · Cited by 16

Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability

Stellas, D., Souliotis, V. L., Bekyrou, M., Smirlis, D., Kirsch‐Volders, M., Degrassi, F., Cundari, E., & Kyrtopoulos, S. Α. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.07.004 · Cited by 16

Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit

Palii, S. S., Cui, Y., Innes, C. L., & Paules, R. S. (2013) · Cell Cycle · doi:10.4161/cc.24127 · Cited by 16

Saccharomyces cerevisiae RAD53 (CHK2) but not CHK1 is required for double-strand break-initiated SCE and DNA damage-associated SCE after exposure to X rays and chemical agents

Fasullo, M., Dong, Z., Sun, M., & Zeng, L. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.006 · Cited by 16

Chking And executing cell division to prevent genomic instability

Peddibhotla, S., & Rosen, J. M. (2009) · Cell Cycle · doi:10.4161/cc.8.15.9169 · Cited by 16

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

Fang, M., Deibler, S. K., Nana, A. L., Vatsavayai, S. C., Banday, S., Zhou, Y., Almeida, S., Weiss, A., Brown, R. H., Seeley, W. W., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1251228 · Cited by 17

The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer

Xu, W., Huang, M., Guo, J., Zhang, H., Wang, D., Liu, T., Liu, H., Chen, S., Gao, P., & Mu, K. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.41627 · Cited by 15

Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses

Soni, A., Mladenov, E., & Iliakis, G. E. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103076 · Cited by 16

Determinants of Homologous Recombination Deficiency in Pancreatic Cancer

Wattenberg, M. M., & Reiss, K. A. (2021) · Cancers · doi:10.3390/cancers13184716 · Cited by 15

ATR suppresses apoptosis after UVB light by controlling both translesion synthesis and alternative tolerance pathways

de Andrade-Lima, L. C., Andrade, L. N. D. S., & Menck, C. F. M. (2014) · Journal of Cell Science · doi:10.1242/jcs.161596 · Cited by 15

Translation of Targeted Radiation Sensitizers into Clinical Trials

Reichert, Z. R., Wahl, D. R., & Morgan, M. A. (2016) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2016.06.001 · Cited by 15

The Potential for Targeting G2/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy

Melia, E., & Parsons, J. L. (2024) · Cancers · doi:10.3390/cancers16173016 · Cited by 14

Post-translational modification of factors involved in homologous recombination

Argunhan, B., Iwasaki, H., & Tsubouchi, H. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103114 · Cited by 15

Chk1 inhibition-induced BRCAness synergizes with olaparib in p53-deficient cancer cells

Zhao, Y., Zhou, K., Xia, X., Guo, Y., & Li, T. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2111769 · Cited by 14

Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank

Cybulski, C., Zamani, N., Kluźniak, W., Milano, L., Wokołorczyk, D., Stempa, K., Rudnicka, H., Zhang, S., Zadeh, M., Huzarski, T., et al. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.03.002 · Cited by 15

BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder

Rocca, C. J., Soares, D. G., Bouzid, H., Henriques, J. A. P., Larsen, A. K., & Escargueil, A. E. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1042632 · Cited by 14

C. elegans Ring Finger Protein RNF-113 Is Involved in Interstrand DNA Crosslink Repair and Interacts with a RAD51C Homolog

Lee, H., Alpi, A. F., Park, M. S., Rose, A. M., & Koo, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060071 · Cited by 14

Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model

Yong, K. J., Milenic, D. E., Baidoo, K. E., & Brechbiel, M. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159904 · Cited by 14

The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

Iwata, T., Uchino, T., Koyama, A., Johmura, Y., Koyama, K., Saito, T., Ishiguro, S., Arikawa, T., Komatsu, S., Miyachi, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178221 · Cited by 14

Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors

Wang, W. T., Catto, J. W. F., & Meuth, M. (2014) · Oncogene · doi:10.1038/onc.2014.221 · Cited by 14

Potential Benefits of Combining Proton or Carbon Ion Therapy with DNA Damage Repair Inhibitors

Rødland, G. E., Temelie, M., Mariampillai, A. E., Hauge, S., Gilbert, A., Chevalier, F., Savu, D., & Syljuåsen, R. G. (2024) · Cells · doi:10.3390/cells13121058 · Cited by 14

PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development

Dong, M., Ouyang, Y., Gao, S.-C., Ma, X., Hou, Y., Schatten, H., Wang, Z., & Sun, Q. (2022) · Development · doi:10.1242/dev.200351 · Cited by 13

A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation

Fujimori, H., Sato, A., Kikuhara, S., Wang, J., Hirai, T., Sasaki, Y., Murakami, Y., Okayasu, R., & Masutani, M. (2015) · Scientific Reports · doi:10.1038/srep18231 · Cited by 13

Functional effects of diphosphomimetic mutations at cAbl-mediated phosphorylation sites on Rad51 recombinase activity

Alligand, B., Breton, M. L., Marquis, D., Vallette, F. M., & Fleury, F. (2017) · Biochimie · doi:10.1016/j.biochi.2017.05.020 · Cited by 13

Therapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors

Babiker, H. M., McBride, A., Cooke, L. S., & Mahadevan, D. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1360275 · Cited by 13

Mechanism of radioprotection by dihydroxy-1-selenolane (DHS): Effect of fatty acid conjugation and role of glutathione peroxidase (GPx)

Verma, P., Kunwar, A., Arai, K., Iwaoka, M., & Priyadarsini, K. I. (2017) · Biochimie · doi:10.1016/j.biochi.2017.10.021 · Cited by 13

Claspin: From replication stress and DNA damage responses to cancer therapy

Azenha, D., Lopes, M. C., & Martins, T. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.10.007 · Cited by 13

Traffic safety for the cell: Influence of cyclin-dependent kinase activity on genomic stability

Enders, G. H., & Maude, S. L. (2006) · Gene · doi:10.1016/j.gene.2005.11.017 · Cited by 13

The Interaction between Two Radiosensitizers: 5-Iododeoxyuridine and Caffeine

Seo, Y., Yan, T., Schupp, J. E., Yamane, K., Radivoyevitch, T., & Kinsella, T. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2766 · Cited by 13

Checkpoint kinase 1 negatively regulates somatic hypermutation

Frankenberger, S., Davari, K., Fischer‐Burkart, S., Böttcher, K., Tomi, N.-S., Zimber‐Strobl, U., & Jungnickel, B. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1378 · Cited by 13

Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types

Kutashev, K., Meschichi, A., Reeck, S., Fonseca, A., Sartori, K., White, C. I., Sicard, A., & Rosa, S. (2024) · New Phytologist · doi:10.1111/nph.19875 · Cited by 12

ATR function is indispensable to allow proper mammalian follicle development

Pacheco, S., Maldonado-Linares, A., Garcia-Caldés, M., & Roig, I. (2019) · Chromosoma · doi:10.1007/s00412-019-00723-7 · Cited by 12

Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling

Dibitetto, D., Sims, J. R., Ascenção, C. F. R., Feng, K., Kim, D.-S., Oberly, S., Freire, R., & Smolka, M. B. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa006 · Cited by 13

FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine

Peña-Gómez, M. J., Moreno-Gordillo, P., Narmontė, M., García-Calderón, C. B., Rukšėnaitė, A., Klimašauskas, S., & Rosado, I. V. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04952-0 · Cited by 12

Caffeine stabilizes Cdc 25 independently of Rad 3 in S chizosaccharomyces pombe contributing to checkpoint override

Alao, J. P., Sjölander, J. J., Baar, J., Özbaki‐Yagan, N., Kakoschky, B., & Sunnerhagen, P. (2014) · Molecular Microbiology · doi:10.1111/mmi.12592 · Cited by 12

Homologous recombination defects and how they affect replication fork maintenance

Son, M. Y., & Hasty, P. (2018) · Global Medical Genetics · doi:10.3934/genet.2018.4.192 · Cited by 14

DNA Repair Pathways and Human Cancer

D’Andrea, A. D. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4066-6.00004-4 · Cited by 13

Cell Cycle–Dependent Association of Rad51 with the Nuclear Matrix

Mladenov, E., Tsaneva, I. R., & Anachkova, B. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0503 · Cited by 12

Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction

Xiao, G., Kue, P., Bhosle, R., & Bargonetti, J. (2015) · Cell Cycle · doi:10.1080/15384101.2014.997517 · Cited by 11

Role of ataxia‐telangiectasia mutated (ATM) in porcine oocyte in vitro maturation

Lin, Z., & Kim, N. (2015) · Cell Biology International · doi:10.1002/cbin.10439 · Cited by 11

Amifostine Metabolite WR-1065 Disrupts Homologous Recombination in Mammalian Cells

Dziegielewski, J., Goetz, W., Murley, J. S., Grdina, D. J., Morgan, W. F., & Baulch, J. E. (2010) · Radiation Research · doi:10.1667/rr1982.1 · Cited by 11

Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination

McLachlan, J., Fernandez, S., Helleday, T., & Bryant, H. E. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.09.014 · Cited by 11

Posttranslational Modifications of Rad51 Protein and Its Direct Partners: Role and Effect on Homologous Recombination – Mediated DNA Repair

Popova, M., Henry, S., & Fleury, F. (2011) · InTech eBooks · doi:10.5772/21409 · Cited by 11

Checkpoint kinase 2 is required for efficient immunoglobulin diversification

Davari, K., Frankenberger, S., Schmidt, A., Tomi, N.-S., & Jungnickel, B. (2014) · Cell Cycle · doi:10.4161/15384101.2014.964112 · Cited by 11

The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks

Hyun, M., Choi, S., Stevnsner, T., & Ahn, B. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.12.006 · Cited by 11

DNA Damage Response/Repair in Cancer Stem Cells — Potential vs. Controversies

Louka, M. A., Boutou, E., Bakou, V., Pappa, V., Georgoulis, A., Stürzbecher, H.-W., Vorgias, C. E., & Vlachodimitropoulos, D. G. (2015) · InTech eBooks · doi:10.5772/61355 · Cited by 11

Targeting the DNA damage response in hematological malignancies

Mel, S. D., Lee, A. R. Y. B., Tan, J. H. I., Tan, R., Poon, L. M., Chan, E. H. L., Lee, J., Chee, Y. L., Lakshminarasappa, S. R., Jaynes, P. W., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1307839 · Cited by 11

The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer

Bouberhan, S., Bar‐Peled, L., Matoba, Y., Mazina, V., Philp, L., & Rueda, B. R. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2022.146 · Cited by 10

ATR activated by EB virus facilitates chemotherapy resistance to cisplatin or 5-fluorouracil in human nasopharyngeal carcinoma

Zhang, B., Cui, B., Du, J., Shen, X., Wang, K., Chen, J., Xiao, L., Sun, C., & Li, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s187099 · Cited by 10

DNA damage response and repair in pancreatic cancer development and therapy

Farnood, P. R., Pazhooh, R. D., Asemi, Z., & Yousefi, B. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103116 · Cited by 11

RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells

Zhu, X., Pan, Q., Huang, N. J., Wu, J., Zhen, N., Sun, F., Li, Z., & Yang, Q. (2016) · Tumor Biology · doi:10.1007/s13277-016-5455-6 · Cited by 11

MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers

Zhang, P., Wang, H., Rowe, P. S., Hu, B., & Wang, Y. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605572 · Cited by 10

Oncolytic adenovirus-mediated transfer of the antisense chk2 selectively inhibits tumor growth in vitro and in vivo

Chen, G., Zhou, J., Gao, Q., Huang, X., Li, K., Zhuang, L., Huang, M. N., Xu, G., Wang, S., Lu, Y., et al. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700967 · Cited by 10

Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas

Willman, G. H., Xu, H., Zeigler, T. M., McIntosh, M. T., & Bhaduri‐McIntosh, S. (2024) · Journal of Virology · doi:10.1128/jvi.00572-24 · Cited by 9

Design, Synthesis, and Biological Evaluation of 2‐Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors

Deng, M., Wang, P., Long, X., Xu, G., Wang, C., Li, J., Zhou, Y., & Liu, T. (2023) · ChemMedChem · doi:10.1002/cmdc.202200664 · Cited by 9

The Efficacy of CHK1 Inhibitors Is Not Altered by Hypoxia, but Is Enhanced after Reoxygenation

Hasvold, G., Nähse, V., Tkacz-Stachowska, K., Rofstad, E. K., & Syljuåsen, R. G. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0879 · Cited by 9

The Caenorhabditis elegans WRN helicase promotes double‐strand DNA break repair by mediating end resection and checkpoint activation

Ryu, J., & Koo, H. (2017) · FEBS Letters · doi:10.1002/1873-3468.12724 · Cited by 10

Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib via Regulation of Rad51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells

Cho, H. Y., Kim, Y.-B., Park, W.-H., & No, J. H. (2020) · Cancer Research and Treatment · doi:10.4143/crt.2020.1013 · Cited by 9

Metastasis-associated gene 1 (MTA1) enhances cisplatin resistance of malignant pleural mesothelioma by ATR-Chk1-mediated DNA repair

Xu, C., Hu, Y., Chen, B., Li, D., Liang, R., Shen, M., Wu, M., & Tao, M. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-941 · Cited by 9

Methods to Study Cancer Therapeutic Drugs That Target Cell Cycle Checkpoints

Dai, Y., & Grant, S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-273-1_19 · Cited by 10

The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance

de Anta, J. M., Perez-Castro, A., Freire, R., & Mayol, X. (2006) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000236311.73703.d2 · Cited by 9

A novel siRNA–gemcitabine construct as a potential therapeutic for treatment of pancreatic cancer

Simonenko, V., Lu, X., Roesch, E. B., Mutisya, D., Shao, C., Sun, Q., Patterson-Orazem, A. C., McNair, M., Shanmuganathan, A., Lu, P. Y., et al. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa016 · Cited by 9

Drugging the DNA damage response in the clinic: going beyond PARP

Torrado, C., González-Ortiz, Á., Xavier, C. B., Tan, H. N., Ngoi, N. Y. L., & Yap, T. A. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2575825 · Cited by 8

The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair

Li, Y., Kardell, M. B., Wang, F., Wang, L., Zhu, S., Bessho, T., & Peng, A. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103244 · Cited by 8

Targeting homologous recombination repair in cancer

Murfuni, I., & Rass, U. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803582-5.00008-5 · Cited by 8

Anti-proliferative and apoptotic effects of S1, a tetrandrine derivative, in human gastric cancer BGC-823 cells

Rong-Rong, L. E. I., Hu, H., Fan, B. A. I., Liu, Y., Wu, C., Huang, X., Xie, L., & Hu, Y. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30062-0 · Cited by 8

EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis

Santarelli, R., Evangelista, L., Pompili, C., Presti, S. L., Rossi, A., Arena, A., Gaeta, A., Gonnella, R., Montani, M. S. G., & Cirone, M. (2023) · Virus Research · doi:10.1016/j.virusres.2023.199236 · Cited by 7

The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia cells

Franza, M., Albanesi, J., Mancini, B., Pennisi, R., Leone, S., Acconcia, F., Bianchi, F., & di Masi, A. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115675 · Cited by 7

Polo-Like Kinase 1 and DNA Damage Response

Li, W., & Hao, Y. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0018 · Cited by 7

DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib

Dardare, J., Witz, A., Betz, M., François, A., Lamy, L., Husson, M., Demange, J., Rouyer, M., Lambert, A., Merlin, J., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02188-9 · Cited by 7

Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs

Jiang, S., Lin, T., Xie, Q., & Wang, L. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00383 · Cited by 7

Proliferative, pro-inflammatory, and angiogenesis regulator gene expression profile defines prognosis in different histopathological subtypes of nodal peripheral T-cell lymphoma

Lage, L. A. D. P. C., Levy, D., Xavier, F. D., Reis, D. C., Costa, R. O., Gonçalves, M. D. C., Rocha, V., Zerbini, M. C. N., & Pereira, J. C. (2019) · Oncotarget · doi:10.18632/oncotarget.27098 · Cited by 7

Expression level of miR-155, miR-15a and miR-19a in peripheral blood of ductal carcinoma breast cancer patients: Possible bioindicators for cellular inherent radiosensitivity

Rajabi, F., & Mozdarani, H. (2022) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2022.104758 · Cited by 7

A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells

Song, N., Che, X., Xu, L., Qu, J., Zheng, H., Hou, K., Qu, X., & Liu, Y. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3075-0 · Cited by 7

TLC388 Induces DNA Damage and G2 Phase Cell Cycle Arrest in Human Non-Small Cell Lung Cancer Cells

Wu, K.-M., Chi, C., Lai, J. C., Chen, Y.-J., & Kou, Y. R. (2020) · Cancer Control · doi:10.1177/1073274819897975 · Cited by 7

A Combined DNA-Affinic Molecule and N-Mustard Alkylating Agent Has an Anti-Cancer Effect and Induces Autophagy in Oral Cancer Cells

Lo, W., Chu, P., Lee, T.-H., Su, T., Chien, Y., Chen, Y., Huang, P., Tseng, L., Tu, P., Kao, S., et al. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13033277 · Cited by 7

BRCA/Fanconi anemia pathway genes in hereditary predisposition to breast cancer

Sólyom, S. (2011) · Cited by 7

RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer

Wang, Z., Jin, M., Zhai, L., Huang, B., Jin, X., Wang, X., Boudemia, A. E., Yang, X., Wei, Z., He, Y., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.01.020 · Cited by 6

DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy

Petermann, E., & Helleday, T. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351352 · Cited by 6

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

Cabrera, E., Raninga, P. V., Khanna, K. K., & Freire, R. (2019) · Cancers · doi:10.3390/cancers11081073 · Cited by 6

Dihydroouabain, a novel radiosensitizer for cervical cancer identified by automated high-throughput screening

Li, Z., Tamari, K., Seo, Y., Minami, K., Takahashi, Y., Tatekawa, S., Otani, K., Сузукі, О., Isohashi, F., & Ogawa, K. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.03.047 · Cited by 6

Deciphering the molecular interplay between pelvic inflammatory disease (PID) and ovarian cancer (OC)—A network biology approach

Christy, J., Harini, Vasudevan, S., Priyadharshini, L., & Anand, D. A. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101405 · Cited by 6

Terpenoids-enriched fraction of Celastrus orbiculatus sensitizes gemcitabine by disrupting Chk1/RAD51-mediated DNA damage response in pancreatic cancer

Zhao, Y., Jiang, Z., Ni, T., Jiang, W., Zhou, K., Liu, Y., Li, T., & Li, T. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00055-w · Cited by 6

A Radioprotective Effect of Imatinib (Gleevec®) in Human Squamous Carcinoma Cells

Bartkowiak, D., Hipp, P. R., Mendonca, M. S., & Röttinger, E. (2007) · Strahlentherapie und Onkologie · doi:10.1007/s00066-007-1680-7 · Cited by 6

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation

Badie, S., Liao, C., Thanasoula, M., Barber, P. R., Hill, M. A., & Tarsounas, M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811079 · Cited by 90

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

Bahassi, E. M., Ovesen, J. L., Riesenberg, A. L., Bernstein, W. Z., Hasty, P., & Stambrook, P. J. (2008) · Oncogene · doi:10.1038/onc.2008.17 · Cited by 180

RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells

Sleeth, K. M., Sørensen, C. S., Issaeva, N., Dziegielewski, J., Bártek, J., & Helleday, T. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.07.068 · Cited by 72

PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair

Peng, B., Shi, R., Bian, J., Li, Y., Wang, P., Wang, H., Liao, J., Zhu, W., & Xu, X. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab584 · Cited by 61

CHK1 Affecting Cell Radiosensitivity is Independent of Non-Homologous End Joining

Wang, H., Hu, B., Liu, R., & Wang, Y. (2004) · Cell Cycle · doi:10.4161/cc.4.2.1415 · Cited by 15