Clusterin inhibits apoptosis by interacting with activated Bax

Zhang, Honglai; Kim, Jin Koo; Edwards, Chris A.; Xu, Zhaohui; Taichman, Russell; Wang, Cun-Yu

doi:10.1038/ncb1291

Cited by 453Clusterin in disease pathologyCell death mechanisms and regulationBiomarkers in Disease Mechanisms

Clusterin inhibits apoptosis by interacting with activated Bax

Zhang, Honglai, Kim, Jin Koo, Edwards, Chris A., Xu, Zhaohui, Taichman, Russell, Wang, Cun-Yu·2005·Nature Cell Biology

DOI 10.1038/ncb1291

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Abstract

Clusterin is an enigmatic glycoprotein that is overexpressed in several human cancers such as prostate and breast cancers, and squamous cell carcinoma. Because the suppression of clusterin expression renders human cancer cells sensitive to chemotherapeutic drug-mediated apoptosis, it is currently an antisense target in clinical trials for prostate cancer. However, the molecular mechanisms by which clusterin inhibits apoptosis in human cancer cells are unknown. Here we report that intracellular clusterin inhibits apoptosis by interfering with Bax activation in mitochondria. Intriguingly, in contrast to other inhibitors of Bax, clusterin specifically interacts with conformation-altered Bax in response to chemotherapeutic drugs. This interaction impedes Bax oligomerization, which leads to the release of cytochrome c from mitochondria and caspase activation. Moreover, we also find that clusterin inhibits oncogenic c-Myc-mediated apoptosis by interacting with conformation-altered Bax. Clusterin promotes c-Myc-mediated transformation in vitro and tumour progression in vivo. Taken together, our results suggest that the elevated level of clusterin in human cancers may promote oncogenic transformation and tumour progression by interfering with Bax pro-apoptotic activities.

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Ku70 suppresses the apoptotic translocation of Bax to mitochondria
Sawada, M., Sun, W., Hayes, P. L., Leskov, K., Boothman, D. A., & Matsuyama, S. (2003) · Nature Cell Biology · doi:10.1038/ncb950 · Cited by 353 · see citing works
Retracted
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445 · see citing works
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988 · see citing works
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355 · see citing works
Untitled work
(2001) · PubMed · Cited by 2,381 · see citing works
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
Cheng, E. H. Y., Wei, M. C., Weiler, S., Flavell, R. A., Mak, T. W., Lindsten, T., & Korsmeyer, S. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00320-3 · Cited by 1,708 · see citing works
Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
Kuwana, T., Mackey, M. R., Perkins, G. A., Ellisman, M. H., Latterich, M., Schneiter, R., Green, D. R., & Newmeyer, D. D. (2002) · Cell · doi:10.1016/s0092-8674(02)01036-x · Cited by 1,480 · see citing works
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109 · see citing works
Apoptotic cell death induced by c-myc is inhibited by bcl-2
Bissonnette, R. P., Echeverri, F., Mahboubi, A., & Green, D. R. (1992) · Nature · doi:10.1038/359552a0 · Cited by 957 · see citing works
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and BakPreprint
Zong, W., Lindsten, T., Ross, A. J., MacGregor, G. R., & Thompson, C. B. (2001) · Genes & Development · doi:10.1101/gad.897601 · Cited by 809 · see citing works
Humanin peptide suppresses apoptosis by interfering with Bax activation
Guo, B., Zhai, D., Cabezas, E., Welsh, K., Nouraini, S., Satterthwait, A. C., & Reed, J. C. (2003) · Nature · doi:10.1038/nature01627 · Cited by 619 · see citing works
Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations
Hsu, Y., & Youle, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10777 · Cited by 504 · see citing works
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak‐mediated permeabilization
Arnoult, D., Gaume, B. R., Karbowski, M., Sharpe, J. C., Cecconi, F., & Youle, R. J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg423 · Cited by 451 · see citing works
Synthesis and Functional Analyses of Nuclear Clusterin, a Cell Death Protein
Leskov, K., Klokov, D. Y., Li, J., Kinsella, T. J., & Boothman, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209233200 · Cited by 395 · see citing works
Clusterin/Apolipoprotein J in human aging and cancer
Trougakos, I. P., & Gonos, E. S. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00041-9 · Cited by 376 · see citing works
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis
You, Z., Saims, D., Chen, S., Zhang, Z., D, D. C. G., Guan, K., MacDougald, O. A., Brown, A. M. C., Evan, G. I., Kitajewski, J., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201110 · Cited by 209 · see citing works
Self-citation
Silencing Expression of the Clusterin/Apolipoprotein J Gene in Human Cancer Cells Using Small Interfering RNA Induces Spontaneous Apoptosis, Reduced Growth Ability, and Cell Sensitization to Genotoxic and Oxidative Stress
Trougakos, I. P., So, A., Jansen, B., Gleave, M. E., & Gonos, E. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2664 · Cited by 207 · see citing works
TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K
Perez, D., & White, E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00013-4 · Cited by 195 · see citing works
Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis
Eischen, C. M., Roussel, M. F., Korsmeyer, S. J., & Cleveland, J. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7653-7662.2001 · Cited by 183 · see citing works
Clusterin Gene Expression Mediates Resistance to Apoptotic Cell Death Induced by Heat Shock and Oxidative Stress
Viard, I., Wehrli, P., Jornot, L., Bullani, R. R., Vechietti, J.-L., French, L. E., Schifferli, J. A., & Tschopp, J. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00531.x · Cited by 181 · see citing works
c-Myc Functionally Cooperates with Bax To Induce Apoptosis
Juin, P. P., Hunt, A. E., Littlewood, T. D., Griffiths, B. L., Swigart, L. B., Korsmeyer, S. J., & Evan, G. I. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6158-6169.2002 · Cited by 149 · see citing works
Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria
Soucie, E. L., Annis, M. G., Sedivy, J. M., Filmus, J., Leber, B. F., Andrews, D. W., & Penn, L. Z. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4725-4736.2001 · Cited by 148 · see citing works
Clusterin as a biomarker in murine and human intestinal neoplasia
Chen, X. F., Halberg, R. B., Ehrhardt, W. M., Torrealba, J. R., & Dove, W. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1233633100 · Cited by 121 · see citing works
Remodeling for Demolition
Reed, J. C., & Green, D. R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00437-9 · Cited by 116 · see citing works
Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis
O'Sullivan, J. N., Whyte, L., Drake, J., & Tenniswood, M. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401254 · Cited by 91 · see citing works
Resistance to cytotoxic chemotherapy-induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression
Miyake, H., Hara, I., Kamidono, S., Gleave, M. E., & Eto, H. (2003) · Oncology Reports · doi:10.3892/or.10.2.469 · Cited by 48 · see citing works
Clusterin and IGFBPs as Antisense Targets in Prostate Cancer
Gleave, M. E., & Jansen, B. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1281.020 · Cited by 39 · see citing works

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Li, J., Hansen, K. C., Zhang, Y., Dong, C., Dinu, C. Z., Dzieciątkowska, M., & Pei, M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.099 · Cited by 103 · see citing works
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Gibson, J. H., Slobedman, B., Kurup, H. K. N., Williamson, S. L., Minchenko, D., El‐Osta, A., Stern, J. L., & Christodoulou, J. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-53 · Cited by 101 · see citing works
Slow Excitotoxicity in Alzheimer's Disease
Ong, W.-Y., Tanaka, K., Dawe, G. S., Ittner, L. M., & Farooqui, A. A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121990 · Cited by 101 · see citing works
Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants
Hoogmartens, J., Cacace, R., & Broeckhoven, C. V. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12155 · Cited by 101 · see citing works
Protective Effect of Clusterin from Oxidative Stress–Induced Apoptosis in Human Retinal Pigment Epithelial Cells
Kim, J. H., Kim, J. H., Jun, H. O., Yu, Y. S., Min, B.-H., Park, K. H., & Kim, K.-W. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3774 · Cited by 101 · see citing works
Self-citation
Interaction of Clusterin and Matrix Metalloproteinase-9 and Its Implication for Epithelial Homeostasis and Inflammation
Jeong, S., Ledee, D. R., Gordon, G. M., Itakura, T., Patel, N. N., Martin, A. J., & Fini, M. E. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.025 · Cited by 101 · see citing works
Resveratrol Induces p53-independent, X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Bax Protein Oligomerization on Mitochondria to Initiate Cytochrome c Release and Caspase Activation
Gogada, R., Prabhu, V. V., Amadori, M., Scott, R., Hashmi, S., & Chandra, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202440 · Cited by 99 · see citing works
Custirsen (OGX-011) combined with cabazitaxel and prednisone versus cabazitaxel and prednisone alone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel (AFFINITY): a randomised, open-label, international, phase 3 trial
Beer, T. M., Hotte, S. J., Fred Saad, C., Alekseev, B. Y., Matveev, V. B., Fléchon, A., Gravis, G., Joly, F., Chi, K. N., Malik, Z., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30605-8 · Cited by 94 · see citing works
Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin
Tripathi, S., Batra, J., Cao, W., Sharma, K., Patel, J. R., Ranjan, P., Kumar, A., Katz, J. M., Cox, N. J., Lal, R. B., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.89 · Cited by 94 · see citing works
The CLU-files: disentanglement of a mystery
Rohne, P., Prochnow, H., & Koch-Brandt, C. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0026 · Cited by 94 · see citing works
Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer
Kretschmer, A., Zhang, F., Somasekharan, S. P., Tse, C., Leachman, L., Gleave, A., Li, B., Asmaro, I., Huang, T., Kotula, L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44346-5 · Cited by 92 · see citing works
Parkinson patient fibroblasts show increased alpha-synuclein expression
Hoepken, H.-H., Gispert, S., Azizov, M., Klinkenberg, M., Ricciardi, F., Kurz, A., Morales-Gordo, B., von Bonin, M., Rieß, O., Gasser, T., et al. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.004 · Cited by 91 · see citing works
Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial
Chi, K. N., Higano, C. S., Blumenstein, B. A., Ferrero, J.-., Reeves, J. A., Feyerabend, S., Gravis, G., Merseburger, A. S., Stenzl, A., Bergman, A. M., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30168-7 · Cited by 90 · see citing works
Pathways of chemotherapy resistance in castration-resistant prostate cancer
Mahon, K. L., Henshall, S. M., Sutherland, R. L., & Horvath, L. G. (2011) · Endocrine Related Cancer · doi:10.1530/erc-10-0343 · Cited by 89 · see citing works
Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells
Sezer, E., Oktay, L. M., Karadadaş, E., Memmedov, H., Günel, N. S., & Sözmen, E. Y. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.0098 · Cited by 89 · see citing works
Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer
Laskin, J. J., Nicholas, G. A., Lee, C., Gitlitz, B. J., Vincent, M. D., Cormier, Y. F., Stephenson, J., Ung, Y., Sanborn, R. E., Pressnail, B., et al. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31823f459c · Cited by 87 · see citing works
RETRACTED: Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up‐regulation of clusterin/apolipoprotein J
Lourda, M., Trougakos, I. P., & Gonos, E. S. (2006) · International Journal of Cancer · doi:10.1002/ijc.22327 · Cited by 86 · see citing works
Retracted
Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease
Zhou, Y., Hayashi, I., Wong, J., Tugusheva, K., Renger, J. J., & Zerbinatti, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103187 · Cited by 86 · see citing works
Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death
Kerr, L. E., Birse-Archbold, J.-L. A., Short, D. M., McGregor, A. L., Héron, I., MacDonald, D. C., Thompson, J.-L., Carlson, G. J., Kelly, J. S., McCulloch, J., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1210044 · Cited by 85 · see citing works
Clusterin, a Haploinsufficient Tumor Suppressor Gene in Neuroblastomas
Chayka, O., Corvetta, D., Dews, M., Caccamo, A. E., Piotrowska, I., Santilli, G., Gibson, S., Sebire, N. J., Himoudi, N., Hogarty, M. D., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp063 · Cited by 85 · see citing works
Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control
Shannan, B., Seifert, M., Boothman, D. A., Tilgen, W., & Reichrath, J. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9052-7 · Cited by 83 · see citing works
Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential
Pei, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.049 · Cited by 83 · see citing works
The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease
Grimm, M. O. W., Zimmer, V. C., Lehmann, J., Grimm, H. S., & Hartmann, T. (2013) · BioMed Research International · doi:10.1155/2013/814390 · Cited by 81 · see citing works
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Shaashua, L., Ben-Shmuel, A., Pevsner-Fischer, M., Friedman, G., Levi-Galibov, O., Nandakumar, S., Barki, D., Nevo, R., Brown, L. E., Zhang, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34081-3 · Cited by 79 · see citing works
Kinetics of gene expression and signaling in bovine cumulus cells throughout IVM in different mediums in relation to oocyte developmental competence, cumulus apoptosis and progesterone secretion
Salhab, M., Tosca, L., Cabau, C., Papillier, P., Perreau, C., Dupont, J., Mermillod, P., & Uzbekova, S. (2010) · Theriogenology · doi:10.1016/j.theriogenology.2010.07.014 · Cited by 79 · see citing works
Relationship of clusterin with renal inflammation and fibrosis after the recovery phase of ischemia-reperfusion injury
Guo, J., Guan, Q., Liu, X., Wang, H., Gleave, M. E., Nguan, C. Y. C., & Du, C. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0348-x · Cited by 79 · see citing works
Castration-resistant prostate cancer: latest evidence and therapeutic implications
Suzman, D. L., & Antonarakis, E. S. (2014) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834014529176 · Cited by 78 · see citing works
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells
Schouten, M., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., Bielefeld, P., Voskuyl, R. A., Lucassen, P. J., Jiménez, C. R., & Fitzsimons, C. P. (2015) · Scientific Reports · doi:10.1038/srep12448 · Cited by 76 · see citing works
Semen Clusterin Is a Novel DC-SIGN Ligand
Sabatté, J., Faigle, W., Ceballos, A., Morelle, W., Rodrígues, C. R., Lenicov, F. R., Thépaut, M., Fieschi, F., Malchiodi, E. L., Fernández, M. M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101889 · Cited by 75 · see citing works
siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
Yamamoto, Y., Lin, P. J. C., Beraldi, E., Zhang, F., Kawai, Y., Leong, J., Katsumi, H., Fazli, L., Fraser, R., Cullis, P. R., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0866 · Cited by 75 · see citing works
Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
Ling, I., Bhongsatiern, J., Simpson, J. F., Fardo, D. W., & Estus, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033923 · Cited by 75 · see citing works
Clusterin Protects Hepatocellular Carcinoma Cells from Endoplasmic Reticulum Stress Induced Apoptosis through GRP78
Wang, C., Jiang, K., Gao, D., Kang, X., Sun, C., Zhang, Q., Li, Y., Sun, L., Zhang, S., Guo, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055981 · Cited by 73 · see citing works
Self-citation
Proteomic analysis of electronegative low-density lipoprotein
Bancells, C., Canals, F., Benı́tez, S., Colomé, N., Julve, J., Ordóñez‐Llanos, J., & Sánchez‐Quesada, J. L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009258 · Cited by 72 · see citing works
Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability
Matsumoto, H., Yamamoto, Y., Shiota, M., Kuruma, H., Beraldi, E., Matsuyama, H., Zoubeidi, A., & Gleave, M. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0359 · Cited by 72 · see citing works
Clusterin Expression in Normal Mucosa and Colorectal Cancer
Andersen, C. L., Schepeler, T., Thorsen, K., Birkenkamp‐Demtröder, K., Mansilla, F., Aaltonen, L. A., Laurberg, S., & Orntoft, T. F. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600261-mcp200 · Cited by 71 · see citing works
Effects of clusterin over-expression on metastatic progression and therapy in breast cancer
Flanagan, L., Whyte, L., Chatterjee, N., & Tenniswood, M. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-107 · Cited by 69 · see citing works
Chapter 6 The Chaperone Action of Clusterin and Its Putative Role in Quality Control of Extracellular Protein Folding
Wyatt, A. R., Yerbury, J. J., Poon, S., Dabbs, R. A., & Wilson, M. R. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)04006-8 · Cited by 69 · see citing works
Roles of clusterin in progression, chemoresistance and metastasis of human ovarian cancer
Wei, L., Xue, T., Song, J., Chen, B., Lei, Y., Huang, Y., Wang, H., & Xin, X. (2009) · International Journal of Cancer · doi:10.1002/ijc.24316 · Cited by 69 · see citing works
Differentially expressed genes and gene networks involved in pig ovarian follicular atresia
Terenina, E. E., Fabre, S., Bonnet, A., Monniaux, D., Robert-Granié, C., SanCristobal, M., Sarry, J., Vignoles, F., Gondret, F., Monget, P., et al. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00069.2016 · Cited by 69 · see citing works
Inhibition of NF-κB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis
Takase, O., Minto, A. W., Puri, T. S., Cunningham, P. N., Jacob, A., Hayashi, M., & Quigg, R. J. (2007) · Kidney International · doi:10.1038/sj.ki.5002563 · Cited by 68 · see citing works
The Chaperone Activity of Clusterin is Dependent on Glycosylation and Redox Environment
Rohne, P., Prochnow, H., Wolf, S., Renner, B., & Koch-Brandt, C. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000366365 · Cited by 68 · see citing works
Clusterin protects neurons against intracellular proteotoxicity
Gregory, J. M., Whiten, D. R., Brown, R., de Barros, T. P., Kumita, J. R., Yerbury, J. J., Satapathy, S., McDade, K., Smith, C., Luheshi, L. M., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0481-1 · Cited by 68 · see citing works
Targeting molecular resistance in castration-resistant prostate cancer
Chandrasekar, T., Yang, J. C., Gao, A. C., & Evans, C. P. (2015) · BMC Medicine · doi:10.1186/s12916-015-0457-6 · Cited by 66 · see citing works
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
Mamidipudi, V., & Cartwright, C. A. (2009) · Oncogene · doi:10.1038/onc.2009.293 · Cited by 65 · see citing works
The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer
Hoter, A., Rizk, S. E., & Naim, H. Y. (2019) · Cancers · doi:10.3390/cancers11081194 · Cited by 63 · see citing works
c-Myc Blazing a Trail of Death: Coupling of the Mitochondrial and Death Receptor Apoptosis Pathways by c-Myc
Nieminen, A. I., Partanen, J. I., & Klefström, J. T. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4917 · Cited by 63 · see citing works
RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors
Su, Y., Vilgelm, A. E., Kelley, M. C., Hawkins, O. E., Liu, Y., Boyd, K. L., Kantrow, S. M., Splittgerber, R. C., Short, S. P., Sobolik, T., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1122 · Cited by 62 · see citing works
Clusterin in Alzheimer's disease
Wu, Z., Yu, J., Li, Y., & Tan, L. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394317-0.00011-x · Cited by 62 · see citing works
Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl‐2 and Bcl‐xL genes
Yamanaka, K., Rocchi, P., Miyake, H., Fazli, L., So, A., Zangemeister‐Wittke, U., & Gleave, M. E. (2006) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06147.x · Cited by 61 · see citing works
Clusterin in human gut-associated lymphoid tissue, tonsils, and adenoids: localization to M cells and follicular dendritic cells
Verbrugghe, P., Kujala, P., Waelput, W., Peters, P. J., & Cuvelier, C. A. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0369-4 · Cited by 61 · see citing works

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex
Trougakos, I. P., Lourda, M., Antonelou, M. H., Kletsas, D., Gorgoulis, V. G., Papassideri, I. S., Zou, Y., Margaritis, L. H., Boothman, D. A., & Gonos, E. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1805 · Cited by 160 · see citing works
The anti-apoptotic protein clusterin is induced by cancer chemotherapy, stabilized by the proteasome, and degraded by intracellular proteases
Craven, R. J., Ranney, M., & Ahmed, I. (2006) · Clinical Cancer Research
CLU blocks HDACI-mediated killing of neuroblastoma
Subramanian, C., Jarzembowski, J. A., Halsey, S. M., Kuick, R. D., Opipari, A. W., Castle, V. P., & Kwok, R. P. S. (2010) · Tumor Biology · doi:10.1007/s13277-010-0120-y · Cited by 7 · see citing works
Resistance to cytotoxic chemotherapy-induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression
Miyake, H., Hara, I., Kamidono, S., Gleave, M. E., & Eto, H. (2003) · Oncology Reports · doi:10.3892/or.10.2.469 · Cited by 48 · see citing works
Clusterin-Mediated Apoptosis Is Regulated by Adenomatous Polyposis Coli and Is p21 Dependent but p53 Independent
Chen, T., Turner, J. G., McCarthy, S. M., Scaltriti, M., Bettuzzi, S., & Yeatman, T. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2077 · Cited by 82 · see citing works

Authors: Zhang, H., Kim, J. K., Edwards, C. A., Xu, Z., Taichman, R., & Wang, C.-Y.
Affiliations: University of Michigan (US)
Corresponding author: Wang, Cun-Yu
ORCID: Zhang, Honglai
Kim, Jin Koo
Xu, Zhaohui
Taichman, Russell
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2005-08-21
Volume: 7
Issue: 9
Pages: 909-915
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb1291
OpenAlex: W2093107372
Cited by: 453
References: 27
Citations by year: 2026: 5 · 2025: 7 · 2024: 13 · 2023: 18 · 2022: 19 · 2021: 22 · 2020: 21 · 2019: 16 · 2018: 19 · 2017: 16 · 2016: 18 · 2015: 20 · 2014: 24 · 2013: 27 · 2012: 31
FWCI: 10.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Army Research Office
Topics: Health Sciences › Medicine › Oncology › Clusterin in disease pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords: clusterin, apoptosis inhibition, Bax activation, Bax oligomerization, cytochrome c release, caspase activation, c-Myc, oncogenic transformation, tumor progression, chemosensitization, prostate cancer, breast cancer, squamous cell carcinoma, mitochondrial apoptosis
MeSH terms: Animals, Antineoplastic Agents, Cell Transformation, Neoplastic, Glycoproteins, Humans, Mitochondria, Neoplasms, Protein Conformation, Proto-Oncogene Proteins c-myc, Apoptosis, Molecular Chaperones, Drug Resistance, Neoplasm, Proto-Oncogene Proteins c-bcl-2, Caspases, Cytochromes c, Cell Line, Tumor, bcl-2-Associated X Protein, Clusterin, Rats

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Clusterin inhibits apoptosis by interacting with activated Bax

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