The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

Cano, A., Pérez‐Moreno, M., Rodrigo, I., Locascio, A., Blanco, M. J., Barrio, M. G. D., Portillo, F., & Nieto, M. A. (2000) · Nature Cell Biology · doi:10.1038/35000025 · Cited by 3,672 · see citing works

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Batlle, E., Sancho, E., Francı́, C., Dominguez-Sola, D., Monfar, M., Baulida, J., & de Herreros, A. G. (2000) · Nature Cell Biology · doi:10.1038/35000034 · Cited by 2,671 · see citing works

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

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Expression pattern of the mouse T gene and its role in mesoderm formation

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Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

Nieto, M. A., Sargent, M. G., Wilkinson, D. G., & Cooke, J. (1994) · Science · doi:10.1126/science.7513443 · Cited by 770 · see citing works

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

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twist and snail as positive and negative regulators during Drosophila mesoderm development.Preprint

Leptin, M. (1991) · Genes & Development · doi:10.1101/gad.5.9.1568 · Cited by 571 · see citing works

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

Savagner, P., Yamada, K. M., & Thiery, J. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1403 · Cited by 520 · see citing works

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.Preprint

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Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M., & De Robertis, E. M. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00125-1 · Cited by 460 · see citing works

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.Preprint

Ip, Y. T., Park, R., Kosman, D., Bier, E., & Levine, M. (1992) · Genes & Development · doi:10.1101/gad.6.9.1728 · Cited by 324 · see citing works

Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo

Sefton, M., Sánchez, S., & Nieto, M. A. (1998) · Development · doi:10.1242/dev.125.16.3111 · Cited by 315 · see citing works

The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers

Boulay, J., Dennefeld, C., & Alberga, A. (1987) · Nature · doi:10.1038/330395a0 · Cited by 310 · see citing works

Snail/Slug family of repressors: slowly going into the fast lane of development and cancer

Hemavathy, K. C., Ashraf, S. I., & Ip, Y. T. (2000) · Gene · doi:10.1016/s0378-1119(00)00371-1 · Cited by 299 · see citing works

The Slug Gene Is Not Essential for Mesoderm or Neural Crest Development in Mice

Jiang, R., Lan, Y., Norton, C. R., Sundberg, J. P., & Gridley, T. (1998) · Developmental Biology · doi:10.1016/s0012-1606(98)80005-5 · Cited by 260 · see citing works

Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation.

Oda, H., Tsukita, S., & Takeichi, M. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9047 · Cited by 259 · see citing works

Snail-Related Transcriptional Repressors Are Required in Xenopus for both the Induction of the Neural Crest and Its Subsequent Migration

LaBonne, C., & Bronner-Fraser, M. E. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9609 · Cited by 253 · see citing works

Embryonic Expression of Lim-1, the Mouse Homolog of Xenopus XLim-1, Suggests a Role in Lateral Mesoderm Differentiation and Neurogenesis

Barnes, J. D., Crosby, J. L., Jones, C. M., et al. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1018 · Cited by 218 · see citing works

The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers

Alberga, A., Boulay, J., Kempe, E., Dennefeld, C., & Haenlin, M. (1991) · Development · doi:10.1242/dev.111.4.983 · Cited by 210 · see citing works

The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak

Burdsal, C. A., Damsky, C. H., & Pedersen, R. A. (1993) · Development · doi:10.1242/dev.118.3.829 · Cited by 207 · see citing works

Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene

Nieto, M. A., Bennett, M. F., Sargent, M. G., & Wilkinson, D. G. (1992) · Development · doi:10.1242/dev.116.1.227 · Cited by 179 · see citing works

Short-range repression permits multiple enhancers to function autonomously within a complex promoter.Preprint

Gray, S., Szymanski, P., & Levine, M. (1994) · Genes & Development · doi:10.1101/gad.8.15.1829 · Cited by 156 · see citing works

Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration

Locascio, A., & Nieto, M. A. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00218-5 · Cited by 152 · see citing works

Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development

Smith, D. E., del Amo, F. F., & Gridley, T. (1992) · Development · doi:10.1242/dev.116.4.1033 · Cited by 145 · see citing works

Human Slug Is a Repressor That Localizes to Sites of Active Transcription

Hemavathy, K. C., Guru, S. C., Harris, J., Chen, J. D., & Ip, Y. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5087-5095.2000 · Cited by 136 · see citing works

MUTATIONS AND CHROMOSOMAL REARRANGEMENTS AFFECTING THE EXPRESSION OF SNAIL, A GENE INVOLVED IN EMBRYONIC PATTERNING IN DROSOPHILA MELANOGASTER

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The Transition to Endoreduplication in Trophoblast Giant Cells Is Regulated by the mSNA Zinc Finger Transcription Factor

Nakayama, H., Scott, I. C., & Cross, J. C. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8914 · Cited by 117 · see citing works

The Snail repressor establishes a muscle/notochord boundary in the Ciona embryo

Fujiwara, S., Corbo, J. C., & Levine, M. (1998) · Development · doi:10.1242/dev.125.13.2511 · Cited by 94 · see citing works

A novel Snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs

Kataoka, H. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.626 · Cited by 89 · see citing works

Slug Is a Mediator of Epithelial–Mesenchymal Cell Transformation in the Developing Chicken Heart

Romano, L. A., & Runyan, R. B. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9339 · Cited by 75 · see citing works

Gastrulation and the evolution of development

Wolpert, L. (1992) · Development · doi:10.1242/dev.116.supplement.7 · Cited by 63 · see citing works

Mechanisms of early Drosophila mesoderm formation

Leptin, M., Casal, J., Grunewald, B., et al. (1992) · Development · doi:10.1242/dev.116.supplement.23 · Cited by 55 · see citing works

Genomic organization and chromosomal localization of the mouse snail (Sna) gene

Jiang, R., Copeland, N. G., Gilbert, D. J., et al. (1997) · Mammalian Genome · doi:10.1007/s003359900537 · Cited by 9 · see citing works

Epithelial-Mesenchymal Transitions in Development and Disease

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492 · see citing works

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121 · see citing works

TGF-β-induced epithelial to mesenchymal transition

Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804 · see citing works

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539 · see citing works

EMT in cancer

Brabletz, T., Kalluri, R., Nieto, M. A., & Weinberg, R. A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.118 · Cited by 1,961 · see citing works

The snail superfamily of zinc-finger transcription factors

Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719 · see citing works

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816 · see citing works

Epithelial-mesenchymal transitions: insights from development

Lim, J., & Thiery, J. P. (2012) · Development · doi:10.1242/dev.071209 · Cited by 661 · see citing works

Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail

Ikenouchi, J., Matsuda, M., Furuse, M., & Tsukita, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00389 · Cited by 678 · see citing works

Non-redundant functions of EMT transcription factors

Stemmler, M. P., Eccles, R. L., Brabletz, S., & Brabletz, T. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0196-y · Cited by 524 · see citing works

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477 · see citing works

Conserved Patterns of Cell Movements during Vertebrate Gastrulation

Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391 · see citing works

Analysis of forkhead and snail expression reveals epithelial–mesenchymal transitions during embryonic and larval development of Nematostella vectensis

Fritzenwanker, J. H., Saina, M., & Technau, U. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.014 · Cited by 165 · see citing works

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

Kim, B. J., Hancock, B. M., Bermudez, A., Cid, N. D., Reyes, E., van Sorge, N. M., Lauth, X., Smurthwaite, C. A., Hilton, B. J., Stotland, A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74159 · Cited by 145 · see citing works

Mouse Snail Is a Target Gene for HIF

Luo, D., Wang, J., Li, J., & Post, M. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0214 · Cited by 116 · see citing works

A right-handed signalling pathway drives heart looping in vertebrates

Ocaña, O. H., Coskun, H., Minguillón, C., Murawala, P., Tanaka, E. M., Galcerán, J., Muñoz-Chápuli, R., & Nieto, M. A. (2017) · Nature · doi:10.1038/nature23454 · Cited by 102 · see citing works

The endoderm: a divergent cell lineage with many commonalities

Nowotschin, S., Hadjantonakis, A.-K., & Campbell, K. (2019) · Development · doi:10.1242/dev.150920 · Cited by 94 · see citing works

Heart Valve Development, Maintenance, and Disease

Tao, G., Kotick, J. D., & Lincoln, J. (2012) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00006-3 · Cited by 89 · see citing works

BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm

Paca, A., Séguin, C. A., Clements, M., Ryczko, M., Rossant, J., Rodriguez, T. A., & Kunath, T. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2011.10.013 · Cited by 87 · see citing works

Cellular dynamics in the early mouse embryo: from axis formation to gastrulation

Nowotschin, S., & Hadjantonakis, A.-K. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.05.008 · Cited by 79 · see citing works

BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion

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Generation of a Snail1 (<i>Snai1</i>) conditional null allele

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Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects

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The mesenchymal transcription factor SNAI-1 instructs human liver specification

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Epiblast and primitive-streak origins of the endoderm in the gastrulating chick embryo

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Differential expression of type II cytokeratin mRNA defines early developmental boundaries within the ectoderm, mesoderm and endoderm during chick development

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The problem of germ layers in sponges (Porifera) and some issues concerning early metazoan evolution

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Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

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Tissue-intrinsic Wnt signals antagonize Nodal-driven AVE differentiationPreprint

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