The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission
Abstract
Transmission of HIV-1 via intercellular connections has been estimated as 100-1000 times more efficient than a cell-free process, perhaps in part explaining persistent viral spread in the presence of neutralizing antibodies. Such effective intercellular transfer of HIV-1 could occur through virological synapses or target-cell filopodia connected to infected cells. Here we report that membrane nanotubes, formed when T cells make contact and subsequently part, provide a new route for HIV-1 transmission. Membrane nanotubes are known to connect various cell types, including neuronal and immune cells, and allow calcium-mediated signals to spread between connected myeloid cells. However, T-cell nanotubes are distinct from open-ended membranous tethers between other cell types, as a dynamic junction persists within T-cell nanotubes or at their contact with cell bodies. We also report that an extracellular matrix scaffold allows T-cell nanotubes to adopt variably shaped contours. HIV-1 transfers to uninfected T cells through nanotubes in a receptor-dependent manner. These data lead us to propose that HIV-1 can spread using nanotubular connections formed by short-term intercellular unions in which T cells specialize.
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“Later, HIV-1 and HTLV-1 cell-to-cell transmission via TNT was reported.”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [108]
Citations
Cites
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Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
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Imaging of Germinal Center Selection Events During Affinity Maturation
Allen, C. D. C., Okada, T., Tang, H. L., & Cyster, J. G. (2006) · Science · doi:10.1126/science.1136736 · Cited by 784
HIV-1 Gag proteins: diverse functions in the virus life cycle
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Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
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HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse
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Self-citationImaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes
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GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
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Prions hijack tunnelling nanotubes for intercellular spread
Gousset, K., Schiff, E., Langevin, C., Marijanovic, Z., Caputo, A., Browman, D., Chenouard, N., de Chaumont, F., Martino, A., Enninga, J., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1841 · Cited by 639
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Self-citation
Metadata
- Authors
- Sowinski, S., Jolly, C., Berninghausen, O., Purbhoo, M. A., Chauveau, A., Köhler, K., Oddos, S., Eissmann, P., Brodsky, F. M., Hopkins, C., Önfelt, B., Sattentau, Q., & Davis, D. M.
- Affiliations
- Imperial College London (GB)
- University of Oxford (GB)
- University of California, San Francisco (US)
- Karolinska Institutet (SE)
- Corresponding author
- Davis, Daniel M.
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2008-01-13
- Volume
- 10
- Issue
- 2
- Pages
- 211-219
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2088757776
- Cited by
- 754
- References
- 31
- Citations by year
- 2026: 22 · 2025: 19 · 2024: 30 · 2023: 24 · 2022: 38 · 2021: 45 · 2020: 47 · 2019: 37 · 2018: 46 · 2017: 41 · 2016: 48 · 2015: 35 · 2014: 38 · 2013: 32 · 2012: 58
- FWCI
- 20.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BB/D011663/1)
- National Institute of Allergy and Infectious Diseases (P01AI064520)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- tunneling nanotubes, HIV-1 transmission, T cells, cell-cell contact, virological synapse, extracellular matrix scaffolds, calcium signaling
- MeSH terms
- Humans, Intercellular Junctions, T-Lymphocytes, Virulence, HIV-1, Jurkat Cells, Cell Surface Extensions
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