Cited by 284Cellular transport and secretionPhagocytosis and Immune RegulationAutophagy in Disease and Therapy

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A pathway for phagosome maturation during engulfment of apoptotic cells

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Kinchen, Jason M., Doukoumetzidis, Kimon, Almendinger, Johann, Stergiou, Lilli, Tosello-Trampont, Annie, Sifri, Costi D., Hengartner, Michael O., Ravichandran, Kodi S.·2008·Nature Cell Biology

DOI 10.1038/ncb1718PMC PMC2851549

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Abstract

Removal of apoptotic cells is critical for the physiological well-being of the organism and defects in corpse removal have been linked to disease states. Genes regulating corpse recognition and internalization have been identified, but few molecules involved in the processing of internalized corpses are known. Through a combination of targeted and unbiased reverse genetic screens in Caenorhabditis elegans, and studies in mammalian cells, we have identified genes required for maturation of apoptotic-cell-containing phagosomes. We have further ordered these candidates, which include the GTPases RAB-5 and RAB-7 and the HOPS complex, into a coherent linear pathway for the maturation of apoptotic cells within phagosomes. In depth analysis of two additional candidate genes, the phosphatidylinositol 3 kinase (PI(3)K) vps-34 (A001762) and dyn-1/dynamin, showed an accumulation of internalized, but undegraded, corpses within abnormal Rab5-negative phagosomes. We ordered these candidates in our pathway, with DYN-1 functioning upstream of VPS-34 in the recruitment and/or retention of RAB-5 to the phagosome. Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome.

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Grimsley‐Myers, C. M., Lu, M., Haney, L. B., Kinchen, J. M., & Ravichandran, K. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510647200 · Cited by 43
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Engulfment: Ingestion and Migration with Rac, Rho and TRIO
Henson, P. M. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.017 · Cited by 36
Apoptosis and autoimmunity: When apoptotic cells break their silence
Franz, S., Gaipl, U. S., Munoz, L. E., Sheriff, A., Beer, A., Kalden, J. R., & i, M. H. (2006) · Current Rheumatology Reports · doi:10.1007/s11926-006-0001-y · Cited by 34

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The emerging mechanisms of isoform-specific PI3K signalling
Vanhaesebroeck, B., Guillermet-Guibert, J., Graupera, M., & Bilanges, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2882 · Cited by 1,767
Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989
Apoptosis and apoptotic body: disease message and therapeutic target potentials
Xu, X., Lai, Y., & Hua, Z. (2018) · Bioscience Reports · doi:10.1042/bsr20180992 · Cited by 953
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing
Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 906
RETRACTED: Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O., & Green, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113421108 · Cited by 655
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Authors: Kinchen, J. M., Doukoumetzidis, K., Almendinger, J., Stergiou, L., Tosello-Trampont, A., Sifri, C. D., Hengartner, M. O., & Ravichandran, K. S.
Affiliations: University of Virginia (US)
University of Zurich (CH)
Corresponding author: Hengartner, Michael O.
Ravichandran, Kodi S.
ORCID: Kinchen, Jason M.
Sifri, Costi D.
Ravichandran, Kodi S.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-04-20
Volume: 10
Issue: 5
Pages: 556-566
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb1718
PMC: PMC2851549
OpenAlex: W2136243038
Cited by: 284
References: 89
Citations by year: 2026: 5 · 2025: 14 · 2024: 10 · 2023: 18 · 2022: 16 · 2021: 15 · 2020: 8 · 2019: 6 · 2018: 17 · 2017: 15 · 2016: 24 · 2015: 15 · 2014: 19 · 2013: 21 · 2012: 21
FWCI: 8.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
PubMed Central (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Institute of General Medical Sciences (R01GM069998, R01GM064709)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: phagosome maturation, efferocytosis, corpse removal, Rab5, Rab7, HOPS complex, dynamin, phosphatidylinositol 3-kinase, Caenorhabditis elegans, phagocytosis, reverse genetic screen
MeSH terms: rab7 GTP-Binding Proteins, Animals, Humans, Phagocytosis, Phagosomes, Recombinant Fusion Proteins, Caenorhabditis elegans, Apoptosis, Phosphatidylinositol 3-Kinases, rab GTP-Binding Proteins, rab5 GTP-Binding Proteins, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Dynamins, RNA Interference, Multiprotein Complexes

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A pathway for phagosome maturation during engulfment of apoptotic cells

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