Cited by 1,132Autophagy in Disease and TherapyCancer-related Molecular PathwaysUbiquitin and proteasome pathways

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Regulation of autophagy by cytoplasmic p53

Open access

Tasdemir, Ezgi, Maiuri, M. Chiara, Galluzzi, Lorenzo, Vitale, Ilio, Djavaheri-Mergny, Mojgan, D'Amelio, Marcello, Criollo, Alfredo, Morselli, Eugenia, Zhu, Changlian, Harper, Francis, Nannmark, Ulf, Samara, Chrysanthi, Pinton, Paolo, Vicencio, José Miguel, Carnuccio, Rosa, Moll, Ute M., Madeo, Frank, Paterlini-Brechot, Patrizia, Rizzuto, Rosario, Szabadkai, Gyorgy, Pierron, Gérard, Blomgren, Klas, Tavernarakis, Nektarios, Codogno, Patrice, Cecconi, Francesco, Kroemer, Guido·2008·Nature Cell Biology

DOI 10.1038/ncb1730PMC PMC2676564

Open this paper in CoChat — free account

Abstract

Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that deletion, depletion or inhibition of p53 can induce autophagy in human, mouse and nematode cells subjected to knockout, knockdown or pharmacological inhibition of p53. Enhanced autophagy improved the survival of p53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels. Inhibition of p53 led to autophagy in enucleated cells, and cytoplasmic, not nuclear, p53 was able to repress the enhanced autophagy of p53(-/-) cells. Many different inducers of autophagy (for example, starvation, rapamycin and toxins affecting the endoplasmic reticulum) stimulated proteasome-mediated degradation of p53 through a pathway relying on the E3 ubiquitin ligase HDM2. Inhibition of p53 degradation prevented the activation of autophagy in several cell lines, in response to several distinct stimuli. These results provide evidence of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53.

Integrity signals

Registry

Crossref · 10.1038/ncb1730

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Self-citation
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638
Self-citation
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 1×
“Overexpression of wild-type p53 and a p53 mutant that is resistant to HDM2-dependent degradation (p53ΔI”
Background
How to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 601–700 of 999

Autophagy and Self-Defense
Martı́nez-Borra, J., & López‐Larrea, C. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1680-7_11 · Cited by 36
MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation
Borthakur, G. M., Duvvuri, S. R., Ruvolo, V. R., Tripathi, D. N., Piya, S., Burks, J. K., Jacamo, R. O., Kojima, K., Ruvolo, P. P., Fueyo-Margareto, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139254 · Cited by 34
A curated census of autophagy-modulating proteins and small molecules
Lorenzi, P. L., Claerhout, S., Mills, G. B., & Weinstein, J. N. (2014) · Autophagy · doi:10.4161/auto.28773 · Cited by 35
Manipulation of Autophagy in Cancer Cells: An Innovative Strategy to Fight Drug Resistance
Aredia, F., & Scovassi, A. I. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.85 · Cited by 33
Inhibition of the MDM2 E3 Ligase Induces Apoptosis and Autophagy in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically with ABT-737
Gu, D., Wang, S., Kuiatse, I., Wang, H., He, J., Dai, Y., Jones, R. J., Bjorklund, C. C., Yang, J., Grant, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103015 · Cited by 34
Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
Slator, C., Molphy, Z. E., McKee, V., & Kellett, A. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.024 · Cited by 36
The induction of AMPK-dependent autophagy leads to P53 degradation and affects cell growth and migration in kidney cancer cells
Patergnani, S., Guzzo, S., Mangolini, A., Dell’Atti, L., Pinton, P., & Aguiari, G. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112190 · Cited by 35
Self-citation
Cancer-related Mutations with Local or Long-range Effects on an Allosteric Loop of p53
Degn, K., Beltrame, L., Hede, F. D., Sora, V., Nicolaci, V., Vabistsevits, M., Schmiegelow, K., Wadt, K., Tiberti, M., Lambrughi, M., et al. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167663 · Cited by 28
Cadmium Induced p53-Dependent Activation of Stress Signaling, Accumulation of Ubiquitinated Proteins, and Apoptosis in Mouse Embryonic Fibroblast Cells
Yu, X., Sidhu, J. S., Hong, S.-W., Robinson, J. F., Ponce, R. A., & Faustman, E. M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr010 · Cited by 34
A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy
Xu, J., Xia, L., Shang, Q., Du, J., Zhu, D., Wang, Y., Bi, D., Song, J., Ma, C., Gao, C., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00407 · Cited by 34
Self-citation
The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle
Beyfuss, K. A., Erlich, A. T., Triolo, M., & Hood, D. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32887-0 · Cited by 35
A review of medicine and food homology on traditional Chinese medicine as functional food
Law, S., & Au, D. C. T. (2025) · Food & medicine homology. · doi:10.26599/fmh.2026.9420091 · Cited by 33
The Interplay between Autophagy and Aging
Pyo, J.-O., Yoo, S., & Jung, Y. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.5.333 · Cited by 36
Nanomicelle curcumin-induced DNA fragmentation in testicular tissue; Correlation between mitochondria dependent apoptosis and failed PCNA-related hemostasis
Moshari, S., Nejati, V., Najafi, G., & Razi, M. (2017) · Acta Histochemica · doi:10.1016/j.acthis.2017.03.007 · Cited by 33
Exploiting locational and topological overlap model to identify modules in protein interaction networks
Cheng, L., Liu, P., Wang, D., & Leung, K. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2598-7 · Cited by 32
Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
Allende-Vega, N., & Villalba, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-42220-y · Cited by 32
Autophagy and senescence in cancer therapy
Patel, N. H., Bloukh, S., Alwohosh, E., Alhesa, A., Saleh, T., & Gewirtz, D. A. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.002 · Cited by 36
A role for p53 in mitochondrial stress response control of longevity in C. elegans
Torgovnick, A., Schiavi, A., Testi, R., & Ventura, N. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.007 · Cited by 33
Inhibition of Autophagy via p53-Mediated Disruption of ULK1 in a SCA7 Polyglutamine Disease Model
Yu, X., Muñoz‐Alarcón, A., Ajayi, A., Webling, K., Steinhof, A., Langel, Ü., & Ström, A. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0012-x · Cited by 33
How does the heart (not) die? The role of autophagy in cardiomyocyte homeostasis and cell death
Dhesi, P., Tehrani, F., Fuess, J., & Schwarz, E. R. (2009) · Heart Failure Reviews · doi:10.1007/s10741-009-9137-y · Cited by 34
Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy
Fu, W., Liu, Y., Sun, C., & Yin, H. (2018) · The FASEB Journal · doi:10.1096/fj.201800577r · Cited by 33
GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3
Zhang, D., Zhang, W., Li, D., Fu, M., Chen, R., & Zhan, Q. (2015) · Autophagy · doi:10.1080/15548627.2015.1112484 · Cited by 32
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Upadhyay, A., Amanullah, A., Chhangani, D., Mishra, R., & Mishra, A. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.07.009 · Cited by 33
Endoplasmic reticulum stress up‐regulates Nedd4‐2 to induce autophagy
Wang, H., Sun, R., Camera, D., Zeng, X., Jo, E., Chan, S. M. H., Herbert, T. P., Molero, J. C., & Ye, J. (2016) · The FASEB Journal · doi:10.1096/fj.201500119 · Cited by 32
A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages
Abate, G., Vezzoli, M., Polito, L., Guaita, A., Albani, D., Marizzoni, M., Garrafa, E., Marengoni, A., Forloni, G., Frisoni, G. B., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm11010014 · Cited by 31
Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer
Mi, W., Wang, C., Luo, G., Li, J., Zhang, Y., Jiang, M., Zhang, C., Liu, N., Jiang, X., Yang, G., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00677-9 · Cited by 34
Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells
Kundu, S., Kim, T. H., Yoon, J. H., Shin, H.-S., Lee, J., Jung, J. H., & Kim, H. S. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2659 · Cited by 33
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells
Huang, S., Wu, C., Wang, Y., Kao, J., Lin, C., Chang, C., Mu, S.-W., Chen, Y.-Y., Chiu, H.-W., Chang, C.-H., et al. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.12.016 · Cited by 32
Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer
Titone, R., Morani, F., Follo, C., Vidoni, C., Mezzanzanica, D., & Isidoro, C. (2014) · BioMed Research International · doi:10.1155/2014/343542 · Cited by 33
p53 and regulation of tumor metabolism
Yang, X., Jiang, P., & Du, W. (2013) · Journal of Carcinogenesis · doi:10.4103/1477-3163.122760 · Cited by 32
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
Zhang, W., Hou, J., Wang, X., Jiang, R., Yin, Y., Ji, J., Deng, L., Huang, X., Wang, K., & Sun, B. (2015) · Oncotarget · doi:10.18632/oncotarget.3353 · Cited by 31
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
Wilfinger, N., Austin, S., Scheiber‐Mojdehkar, B., Berger, W., Reipert, S., Praschberger, M., Paur, J., Trondl, R., Keppler, B. K., Zielinski, C. C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6233 · Cited by 31
The family that eats together stays together: new p53 family transcriptional targets in autophagyPreprint
Napoli, M., & Flores, E. R. (2013) · Genes & Development · doi:10.1101/gad.219147.113 · Cited by 34
A short exposure to polychlorinated biphenyls deregulates cellular autophagy in mammalian blastocyst in vitro
Ptak, G., Zacchini, F., Czernik, M., Fidanza, A., Palmieri, C., Salda, L. D., Scapolo, P. A., & Loi, P. (2012) · Human Reproduction · doi:10.1093/humrep/der454 · Cited by 30
PBK attenuates paclitaxel‐induced autophagic cell death by suppressing p53 in H460 non‐small‐cell lung cancer cells
Park, J., Park, S., Lee, Y., Park, H., & Oh, S. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12855 · Cited by 32
Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells
Yu, H., Zhou, X., Wang, Y., Huang, X., Yang, J. J., Zeng, J., Li, G., Xie, X., & Zhang, J. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01279-8 · Cited by 30
Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication
Li, C., Wang, L., Liu, J., Yu, Y., Huang, Y., Huang, X., Wei, J., & Qin, Q. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01446 · Cited by 30
Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin
Therachiyil, L., Haroon, J., Sahir, F., Siveen, K. S., Shahab Uddin, M. S., Kuliński, M., Buddenkotte, J., Steinhoff, M. S., & Krishnankutty, R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01744 · Cited by 31
Regulation of autophagy by protein methylation and acetylation in cancer
Jeon, M., Park, J., Yang, E., Baek, H., & Kim, H.-K. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30502 · Cited by 32
Autophagy process is associated with anti-neoplastic function
Wang, C., Wang, Y., McNutt, M. A., & Zhu, W. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr028 · Cited by 31
Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells
Wu, X., Jiang, L., Sun, X., Yao, X., Bai, Y., Liu, X., Liu, N., Zhai, X., Wang, S., & Yang, G. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.069 · Cited by 31
Transglutaminase type 2 in the regulation of proteostasis
D’Eletto, M., Rossin, F., Fedorova, O., Farrace, M. G., & Piacentini, M. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0217 · Cited by 32
Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection
Huang, J., Li, Y., Qi, Y., Zhang, Y., Zhang, L., Wang, Z., Zhang, X., & Gui, L. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2183-3 · Cited by 29
PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53
Russo, D., Ottaggio, L., Foggetti, G., Masini, M., Masiello, P., Fronza, G., & Menichini, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.03.020 · Cited by 29
A systems biology analysis of autophagy in cancer therapy
Shi, Z., Li, C., Zhao, S., Yu, Y., An, N., Liu, Y.-X., Wu, C., Yue, B., & Bao, J. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.06.004 · Cited by 29
The energy blockers bromopyruvate and lonidamine lead GL15 glioblastoma cells to death by different p53-dependent routes
Davidescu, M., Macchioni, L., Scaramozzino, G., Marchetti, M. C., Migliorati, G., Vitale, R., Corcelli, A., Roberti, R., Castigli, E., & Corazzi, L. (2015) · Scientific Reports · doi:10.1038/srep14343 · Cited by 29
Full Characterization of Localization Diversity in the Human Protein Interactome
Cheng, L., Fan, K., Huang, Y., Wang, D., & Leung, K.-S. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00306 · Cited by 28
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells
Li, C., Sun, J., Gao, Y., Shi, F., Pan, Y., Wang, Y., & Sun, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0185-2 · Cited by 29
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis
Suzuki, N., Johmura, Y., Wang, T.-W., Migita, T., Wu, W., Noguchi, R., Yamaguchi, K., Furukawa, Y., Nakamura, S., Miyoshi, I., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1897961 · Cited by 33
Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro
Li, W., Li, X., Wang, W., Yi, M., Zhou, Y., Zheng, P., Xiong, W., Yang, J., Peng, S., McCarthy, J. B., et al. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.020 · Cited by 29
Autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells
Hsieh, M., Yang, S., Hsieh, Y., Chen, T.-Y., & Chiou, H. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/134512 · Cited by 28
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53
Love, I. M., & Grossman, S. R. (2012) · Genes & Cancer · doi:10.1177/1947601912455198 · Cited by 28
Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells
Huang, Y., & Ratovitski, E. A. (2010) · Aging · doi:10.18632/aging.100249 · Cited by 28
Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes
Yu, Y., & Zhao, J. (2019) · BioMed Research International · doi:10.1155/2019/1484152 · Cited by 28
Physiological and pathological regulation of autophagy in pregnancy
Zhao, X., Jiang, Y., Jiang, T., Han, X., Wang, Y., Chen, L., & Feng, X. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05607-1 · Cited by 28
Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy
Izadi, M., Ali, T. A., & Pourkarimi, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212466 · Cited by 30
Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds
Zhang, L., Zhu, Y., Zhang, J., Zhang, L., & Chen, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.966012 · Cited by 29
Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress
Yu, Y. S., Kim, H.-K., Kim, K. I., & Baek, S. H. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01154-9 · Cited by 31
Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors
Singh, P., Godbole, M. M., Rao, G., Annarao, S., Mitra, K., Roy, R., Ingle, A., Agarwal, G., & Tiwari, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.054 · Cited by 28
E4F1 deficiency results in oxidative stress–mediated cell death of leukemic cells
Hatchi, E., Rodier, G., Lacroix, M., Caramel, J., Kirsh, O., Jacquet, C., Schrepfer, E., Lagarrigue, S., Linares, L. K., Lledo, G., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101995 · Cited by 33
Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells
Chitta, K. S., Khan, A. N. H., Ersing, N., Swaika, A., Masood, A., Paulus, A., Qadeer, A., Advani, P. P., Sher, T., Miller, K. C., et al. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.807927 · Cited by 29
The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB
Zhang, Z., Wang, H., Ding, Q., Xing, Y., Xu, D., Xu, Z., Zhou, T., Qian, B., Ji, C., Pan, X., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.103 · Cited by 27
Stress – (self) eating: Epigenetic regulation of autophagy in response to psychological stress
Puri, D., & Subramanyam, D. (2019) · FEBS Journal · doi:10.1111/febs.14826 · Cited by 26
WDR63 inhibits Arp2/3‐dependent actin polymerization and mediates the function of p53 in suppressing metastasis
Zhao, K., Wang, D., Zhao, X., Wang, C., Gao, Y., Liu, K., Wang, F., Wu, X., Wang, X., Sun, L., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949269 · Cited by 27
Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis
Timmerman, D. M., Remmers, T. L., Hillenius, S., & Looijenga, L. H. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105377 · Cited by 26
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology
Kargapolova, Y., Rehimi, R., Kayserili, H., Brühl, J., Sofiadis, K., Zirkel, A., Palikyras, S., Mizi, A., Li, Y., Yigit, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23327-1 · Cited by 31
Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells
Wang, Y., Liu, Y., Liu, X., Jiang, L., Yang, G., Sun, X., Geng, C., Li, Q., Yao, X., & Chen, M. (2015) · Toxins · doi:10.3390/toxins7083030 · Cited by 27
Autophagy in the Heart
Wang, E. Y., Biala, A. K., Gordon, J. W., & Kirshenbaum, L. A. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31824cc427 · Cited by 27
Ubiquitin and Ubiquitin-Like Proteins in the Nucleolus: Multitasking Tools for a Ribosome Factory
Shcherbik, N., & Pestov, D. G. (2010) · Genes & Cancer · doi:10.1177/1947601910381382 · Cited by 26
Autophagy induction by low-dose cisplatin: The role of p53 in autophagy
Cho, K.-H., Park, J., Kwon, K., Lee, Y., So, H., Lee, K.-K., Lee, S.-Y., Moon, S., & Yang, S. (2013) · Oncology Reports · doi:10.3892/or.2013.2809 · Cited by 28
Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells
Chen, L., Jiang, Z., Ma, H., Ning, L. G., Chen, H., Li, L., & Qi, H. (2016) · Scientific Reports · doi:10.1038/srep21148 · Cited by 26
TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death
Roy, M., Tomar, D., Singh, K., Sripada, L., Prajapati, P., Bhatelia, K., Gohel, D., & Singh, R. K. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.04.003 · Cited by 26
Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells
Patel, N. H., Xu, J., Saleh, T., Wu, Y., Lima, S., & Gewirtz, D. A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113896 · Cited by 26
Role of Autophagy in Cancer Cell Response to Nucleolar and Endoplasmic Reticulum Stress
Pecoraro, A., Pagano, M., Russo, G., & Russo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197334 · Cited by 26
Crosslink between p53 and metastasis: focus on epithelial–mesenchymal transition, cancer stem cell, angiogenesis, autophagy, and anoikis
Babaei, G., Aliarab, A., Vostakolaei, M. A., Hotelchi, M., Neisari, R., Aziz, S. G., & Bazl, M. R. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06706-1 · Cited by 29
Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells
Jiang, Y., Yang, R., Wang, H., Huang, H., Wu, D., Tashiro, S., Onodera, S., & Ikejima, T. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.043 · Cited by 26
Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
Hwang, W. C., Kim, M. K., Song, J., Choi, K.-Y., & Min, D.-S. (2014) · Experimental and Molecular Medicine · doi:10.1038/emm.2014.74 · Cited by 23
Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants
Giorgi, C., Bonora, M., Missiroli, S., Morganti, C., Morciano, G., Wieckowski, M. R., & Pinton, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00042 · Cited by 26
Self-citation
Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia
Sun, Y., Li, T., Xie, C., Xu, Y., Zhou, K., Rodríguez, J., Han, W., Wang, X., Kroemer, G., Modjtahedi, N., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.196 · Cited by 26
Self-citation
Hyperbaric oxygen protects against myocardial ischemia‑reperfusion injury through inhibiting mitochondria dysfunction and autophagy
Chen, W., Lv, L., Nong, Z., Chen, X., Pan, X., & Chen, C. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11497 · Cited by 27
The Role of Long Non-Coding RNAs in Cardiovascular Diseases
Le, L. T. T., & Nhu, C. X. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813805 · Cited by 26
cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53
Skah, S., Richartz, N., Duthil, E., Gilljam, K. M., Bindesbøll, C., Naderi, E. H., Eriksen, A. B., Ruud, E., Dirdal, M. M., Simonsen, A., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25758 · Cited by 21
MiR-129-3p favors intracellular BCG survival in RAW264.7 cells by inhibiting autophagy via Atg4b
Qu, Y., Ding, S., Ma, Z., Jiang, D., Xu, X., Zhang, Y., Zhang, A., & Xu, G. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.01.004 · Cited by 27
Double‐edged sword role of shrimp miRNA explains an evolutionary language between shrimp‐pathogen interactions that unties the knot of shrimp infection
Haridevamuthu, B., Guru, A., Sudhakaran, G., Murugan, R., Arshad, A., & Arockiaraj, J. (2021) · Reviews in Aquaculture · doi:10.1111/raq.12613 · Cited by 25
Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
Li, H., Li, C., Zhai, W., Zhang, X., Li, L., Wu, B., Yu, B., Zhang, P., Li, J., Cui, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111435 · Cited by 24
Boesenbergia rotunda displayed anti-inflammatory, antioxidant and anti-apoptotic efficacy in doxorubicin‐induced cardiotoxicity in rats
Zhang, L., Jiang, Q., Wang, X., Jaisi, A., & Olatunji, O. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-38560-5 · Cited by 29
Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy
Huang, P., Ho, S., Wang, K., Roessler, B. C., Zhang, F., Hu, Y. W., Bowe, D. B., Kudlow, J. E., & Paterson, A. J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00124.2010 · Cited by 25
Electron microscopic visualization of autophagosomes induced by infection of human papillomavirus pseudovirions
Ishii, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.130 · Cited by 25
Autophagic Cell Death Is Induced by Acetone and Ethyl Acetate Extracts fromEupatorium odoratum In Vitro: Effects on MCF-7 and Vero Cell Lines
Harun, F. B., Jamalullail, S. M. S., Khoo, B. Y., Othman, Z., Tilwari, A., & Balaram, P. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/439479 · Cited by 25
Distinct cellular responses induced by saporin and a transferrin–saporin conjugate in two different human glioblastoma cell lines
Cimini, A., Mei, S., Benedetti, E., Laurenti, G., Koutris, I., Cinque, B., Cifone, M. G., Galzio, R. J., Pitari, G., Leandro, L. D., et al. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22805 · Cited by 26
Temporal relationship of autophagy and apoptosis in neurons challenged by low molecular weight β-amyloid peptide
Cheung, Y.-T., Zhang, N. Q., Hung, C. H.-L., Lai, C. S.-W., Yu, M.-S., So, K., & Chang, R. C. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00990.x · Cited by 25
Safety assessment of nanoparticles for drug delivery by means of classic in vitro assays and beyond
Lorscheidt, S., & Lamprecht, A. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1198773 · Cited by 25
Oxidative Stress and Cell Death in Cardiovascular Disease
Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00014-7 · Cited by 26
SMILE: a novel procedure for subcellular module identification with localisation expansion
Cheng, L., Liu, P., & Leung, K. (2017) · IET Systems Biology · doi:10.1049/iet-syb.2017.0085 · Cited by 24
Autophagy in Caenorhabditis elegans
Megalou, E. V., & Tavernarakis, N. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.010 · Cited by 26
Self-citation
Could sirtuin activities modify ALS onset and progression?
Tang, B. L. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0452-2 · Cited by 24
Autophagy in aquatic animals: mechanisms, implications, and future directions
Kawsar, M. A., Adikari, D., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1612178 · Cited by 26
Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer
Kim, T. W., Lee, S., Kim, J., Kim, S. J., Min, J., Bae, K., Jung, H., Kim, B.-Y., Lim, J., Yang, Y. D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13352 · Cited by 24
The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1–p53–Beclin1 Axis Under Metabolic Stress
Paek, A. R., Mun, J. Y., Jo, M. J., Choi, H., Lee, Y. J., Cheong, H., Myung, J., Hong, D., Park, J., Kim, K., et al. (2019) · Cells · doi:10.3390/cells8040296 · Cited by 24
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle
Ruan, X., Cao, M., Yan, W., Jones, Y., Gustafsson, Å. B., Patel, H. H., Schenk, S., & Wang, S. E. (2023) · EMBO Reports · doi:10.15252/embr.202256464 · Cited by 23

Authors: Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., Nannmark, U., Samara, C., Pinton, P., Vicencio, J. M., Carnuccio, R., Moll, U. M., Madeo, F., Paterlini-Brechot, P., Rizzuto, R., Szabadkai, G., Pierron, G., Blomgren, K., Tavernarakis, N., Codogno, P., Cecconi, F., & Kroemer, G.
Affiliations: Université Paris-Sud (FR)
Inserm (FR)
Drottning Silvias barn- och ungdomssjukhus (SE)
Centre National de la Recherche Scientifique (FR)
University of Gothenburg (SE)
Foundation for Research and Technology Hellas (GR)
University of Ferrara (IT)
University of Naples Federico II (IT)
Stony Brook University (US)
University of Graz (AT)
University of Rome Tor Vergata (IT)
Corresponding author: Kroemer, Guido
ORCID: Maiuri, M. Chiara
Galluzzi, Lorenzo
Vitale, Ilio
Criollo, Alfredo
Morselli, Eugenia
Zhu, Changlian
Pinton, Paolo
Moll, Ute M.
Madeo, Frank
Rizzuto, Rosario
Pierron, Gérard
Blomgren, Klas
Tavernarakis, Nektarios
Codogno, Patrice
Cecconi, Francesco
Kroemer, Guido
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-05-04
Volume: 10
Issue: 6
Pages: 676-687
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb1730
PMC: PMC2676564
OpenAlex: W2157699677
Cited by: 1,132
References: 50
Citations by year: 2026: 20 · 2025: 34 · 2024: 40 · 2023: 44 · 2022: 48 · 2021: 62 · 2020: 65 · 2019: 58 · 2018: 68 · 2017: 58 · 2016: 68 · 2015: 57 · 2014: 74 · 2013: 96 · 2012: 91
FWCI: 61.61
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Funders: National Institute on Aging (P01AG025532)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagy, cytoplasmic p53, p53 degradation, MDM2, E3 ubiquitin ligase, proteasomal degradation, hypoxia, nutrient depletion, ATP maintenance, enucleated cells, starvation, rapamycin, endoplasmic reticulum stress, tumour suppressor
MeSH terms: Animals, Hypoxia, Autophagy, Cytoplasm, Endoplasmic Reticulum, Gene Expression Regulation, Humans, Lysosomes, Mice, Transgenic, Models, Biological, Genes, p53, Tumor Suppressor Protein p53, Cell Line, Tumor, Proteasome Endopeptidase Complex, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of autophagy by cytoplasmic p53

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks