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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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Sirtuins as regulators of metabolism and healthspan

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

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Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

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State of play in amyotrophic lateral sclerosis genetics

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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Mutations of optineurin in amyotrophic lateral sclerosis

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

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SIRT1 and other sirtuins in metabolism

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Regulation of autophagy by cytoplasmic p53

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Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

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Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

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A Mutation in the Vesicle-Trafficking Protein VAPB Causes Late-Onset Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis

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Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with <i>SOD1</i> mutations

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Stress granules as crucibles of ALS pathogenesis

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The many faces of insulin-like peptide signalling in the brain

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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

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Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

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TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

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Mitochondria, oxidative stress and neurodegeneration

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

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Sirt1 and the Mitochondria

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A comprehensive review of amyotrophic lateral sclerosis

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Resveratrol stimulates AMP kinase activity in neurons

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Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

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Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

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Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

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&lt;emph type="ital"&gt;SQSTM1&lt;/emph&gt; Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

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VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

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Small molecule SIRT1 activators for the treatment of aging and age-related diseases

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SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

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Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

Wen, X., Tan, W., Westergard, T., Krishnamurthy, K., Markandaiah, S. S., Shi, Y., Lin, S., Shneider, N. A., Monaghan, J., Pandey, U. B., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.12.010 · Cited by 513 · see citing works

Redox regulation of SIRT1 in inflammation and cellular senescence

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Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

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Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation

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SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

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A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

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Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

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Calorie restriction and sirtuins revisited

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

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Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

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SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.

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Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

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FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

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Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

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Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

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Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells

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SIRT1 as a therapeutic target for Alzheimer’s disease

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Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

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Amyotrophic lateral sclerosis: an update on recent genetic insights

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Heat‐shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS

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Knockout of Silent Information Regulator 2 (SIRT2) Preserves Neurological Function after Experimental Stroke in Mice

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A Single-Dose Resveratrol Treatment in a Mouse Model of Amyotrophic Lateral Sclerosis

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Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways

Valle, C., Salvatori, I., Gerbino, V., Rossi, S., Palamiuc, L., René, F., & Carrı̀, M. T. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.247 · Cited by 52 · see citing works

Old versus New Mechanisms in the Pathogenesis of ALS

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The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper, P. L., Durham, H. D., Török, Z., Hooper, P. L., Crul, T., & Vı́gh, L. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0709-1 · Cited by 47 · see citing works

Sirt1's systemic protective roles and its promise as a target in antiaging medicine

Tang, B. L. (2010) · Translational research · doi:10.1016/j.trsl.2010.11.006 · Cited by 45 · see citing works

Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation inCaenorhabditis elegans

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β 2 -Adrenoceptor agonists as novel, safe and potentially effective therapies for Amyotrophic lateral sclerosis (ALS)

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DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS

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Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease

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Prevalence of brain and spinal cord inclusions, including dipeptide repeat proteins, in patients with the C 9 ORF 72 hexanucleotide repeat expansion: a systematic neuropathological review

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Early gene expression changes in spinal cord from SOD1G93A Amyotrophic Lateral Sclerosis animal model

de Oliveira, G. P., Alves, C. J., & Chadi, G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00216 · Cited by 40 · see citing works

Sirtuins as modifiers of Parkinson's disease pathology

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Stem cells therapy for ALS

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Inclusions of amyotrophic lateral sclerosis–linked superoxide dismutase in ventral horns, liver, and kidney

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Sirt1-deficiency causes defective protein quality control

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Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

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Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALSC9orf72Expansion Cases

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SIRT1 Regulation Modulates Stroke Outcome

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Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye

Cragnaz, L., Klima, R., Skoko, N., Budini, M., Feiguin, F. M., & Baralle, F. E. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.009 · Cited by 29 · see citing works

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

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Altered Expression of DJ-1 and PINK1 in Sporadic ALS and in the SOD1G93AALS Mouse Model

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Temporal gene expression patterns in G93A/SOD1 mouse

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Adeno Associated Viral Vector Delivered RNAi for Gene Therapy of SOD1 Amyotrophic Lateral Sclerosis

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Sirtuins as therapeutic targets of ALS

Pasinetti, G. M., Bilski, A. E., & Zhao, W. (2013) · Cell Research · doi:10.1038/cr.2013.94 · Cited by 22 · see citing works

Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS

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Age-related Changes in Tau Expression in Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

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NAD+ in Brain Aging and Neurodegenerative Disorders

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Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

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Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

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The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS

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Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

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Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

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Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

Carrera‐Juliá, S., Moreno, M. L., Barrios, C., Ortí, J. E. D. L. R., & Drehmer, E. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00063 · Cited by 83 · see citing works

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

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Opportunities for histone deacetylase inhibition in amyotrophic lateral sclerosis

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Molecular hallmarks of ageing in amyotrophic lateral sclerosis

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Associations of Patient Mood, Modulators of Quality of Life, and Pharmaceuticals with Amyotrophic Lateral Sclerosis Survival Duration

Bond, L., Bowen, G., Mertens, B., Denson, K., Jordan, K., Vidakovic, B., & Mitchell, C. S. (2020) · Behavioral Sciences · doi:10.3390/bs10010033 · Cited by 27 · see citing works

Sirtuins as Modifiers of Huntington's Disease (HD) Pathology

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Metabolomics as a Crucial Tool to Develop New Therapeutic Strategies for Neurodegenerative Diseases

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Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice

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The Scientific and Therapeutic Rationale for Off‐Label Treatments in Amyotrophic Lateral Sclerosis

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Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson’s disease in mouse

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Amyotrophic lateral sclerosis disease modifying therapeutics: a cell biological perspective

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Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis

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The Epigenetics of Alzheimer's and Other Neurodegenerative Disorders

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ALSUntangled 42: Elysium health’s “basis”

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Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?

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NAMPT deficiency triggers dopaminergic neurodegeneration in the substantia nigra of mousePreprint

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TDP-43 Acetylation at the Neuroimmune Interface: A Hypothesis-Driven Framework for Peripheral Inflammatory Stratotypes in ALS

Condorelli, G. A., Iozzia, A., Bonifacio, D., & Pelin, A.-M. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04770-2

Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?

Körner, S., Böselt, S., Thau, N., Rath, K. J., Dengler, R., & Petri, S. (2013) · Neurodegenerative Diseases · doi:10.1159/000338048 · Cited by 64 · see citing works

Sirtuins as therapeutic targets of ALS

Pasinetti, G. M., Bilski, A. E., & Zhao, W. (2013) · Cell Research · doi:10.1038/cr.2013.94 · Cited by 22 · see citing works

Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways

Valle, C., Salvatori, I., Gerbino, V., Rossi, S., Palamiuc, L., René, F., & Carrı̀, M. T. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.247 · Cited by 52 · see citing works

Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis

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Comparison of sirtuin 3 levels in ALS and Huntington's disease-differential effects in human tissue samples vs. transgenic mouse models

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