The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Regulation of autophagy by cytoplasmic p53
Open accessAbstract
Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that deletion, depletion or inhibition of p53 can induce autophagy in human, mouse and nematode cells subjected to knockout, knockdown or pharmacological inhibition of p53. Enhanced autophagy improved the survival of p53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels. Inhibition of p53 led to autophagy in enucleated cells, and cytoplasmic, not nuclear, p53 was able to repress the enhanced autophagy of p53(-/-) cells. Many different inducers of autophagy (for example, starvation, rapamycin and toxins affecting the endoplasmic reticulum) stimulated proteasome-mediated degradation of p53 through a pathway relying on the E3 ubiquitin ligase HDM2. Inhibition of p53 degradation prevented the activation of autophagy in several cell lines, in response to several distinct stimuli. These results provide evidence of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Autophagy is another cellular program that is triggered by cell stress and p53.195, 208”
From Census and evaluation of p53 target genes (2017) · cites this paper as [208]
Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Self-citationLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638
Self-citationBcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 1×
“Overexpression of wild-type p53 and a p53 mutant that is resistant to HDM2-dependent degradation (p53ΔI”
BackgroundHow to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 999
Mutant p53 protein localized in the cytoplasm inhibits autophagy
Morselli, E., Tasdemir, E., Maiuri, M. C., Galluzzi, L., Kepp, O., Criollo, A., Vicencio, J. M., Soussi, T., & Kroemer, G. (2008) · Cell Cycle · doi:10.4161/cc.7.19.6751 · Cited by 288
Self-citationCytoplasmic STAT3 represses autophagy by inhibiting PKR activity
Shen, S., Niso-Santano, M., Adjemian, S., Takehara, T., Malik, S. A., Minoux, H., Souquere, S., Mariño, G., Lachkar, S., Senovilla, L., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.013 · Cited by 285
Self-citationRegulation of the aging process by autophagy.
Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270
Tumor suppressor p53 and its mutants in cancer metabolism
Liu, J., Zhang, C., Hu, W., & Feng, Z. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.12.025 · Cited by 276
Fueling the Cell Division Cycle
Salazar‐Roa, M., & Malumbres, M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.08.009 · Cited by 287
Regulation of autophagy by stress-responsive transcription factors
Pietrocola, F., Izzo, V., Niso‐Santano, M., Vacchelli, E., Galluzzi, L., Maiuri, M. C., & Kroemer, G. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.008 · Cited by 277
Self-citationCytoprotective roles for autophagy
Moreau, K., Luo, S., & Rubinsztein, D. C. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.002 · Cited by 264
p53/HMGB1 Complexes Regulate Autophagy and Apoptosis
Livesey, K. M., Kang, R., Vernon, P. J., Buchser, W., Loughran, P., Watkins, S. C., Zhang, L., Manfredi, J. J., Zeh, H. J., Li, L., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2291 · Cited by 270
Therapeutic Targeting of Autophagy in Disease: Biology and Pharmacology
Cheng, Y., Ren, X., Hait, W. N., & Yang, J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007120 · Cited by 262
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
Singh, S., Ornatowski, W., Vergne, I., Naylor, J., Delgado, M. A., Roberts, E. A., Ponpuak, M., Master, S. S., Pilli, M., White, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2119 · Cited by 268
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4
Wu, H., Liu, Q., Shan, X., Gao, W., & Chen, Q. (2023) · Autophagy · doi:10.1080/15548627.2023.2170960 · Cited by 267
Protein damage, repair and proteolysis
Chondrogianni, N., Petropoulos, I., Grimm, S., Georgila, K., Catalgol, B., Friguet, B., Grune, T., & Gonos, E. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.09.001 · Cited by 271
p65/RelA Modulates BECN1 Transcription and Autophagy
Copetti, T., Bertoli, C., Dalla, E., Demarchi, F., & Schneider, C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01396-08 · Cited by 262
TOR-dependent control of autophagy: biting the hand that feeds
Neufeld, T. P. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.005 · Cited by 261
Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours
Missiroli, S., Perrone, M., Genovese, I., Pinton, P., & Giorgi, C. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102943 · Cited by 263
Self-citationEmerging role of autophagy in kidney function, diseases and aging
Huber, T. B., Edelstein, C. L., Hartleben, B., Inoki, K., Jiang, M., Koya, D., Kume, S., Lieberthal, W., Pallet, N., Quiroga, A., et al. (2012) · Autophagy · doi:10.4161/auto.19821 · Cited by 261
Targeting autophagy to overcome drug resistance: further developments
Chang, H., & Zou, Z. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01000-2 · Cited by 259
Autophagy regulation and its role in cancer
Lorin, S., Hamaï, A., Mehrpour, M., & Codogno, P. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.007 · Cited by 261
Self-citationThe autophagic paradox in cancer therapy
Wu, W. K. K., Coffelt, S. B., Cho, C. H., Wang, X. J., Lee, C., Chan, F. K. L., Yu, J. Q., & Sung, J. J. �. (2011) · Oncogene · doi:10.1038/onc.2011.295 · Cited by 250
Programmed Cell Death in Parkinson's DiseasePreprint
Venderová, K., & Park, D. S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009365 · Cited by 246
The Impact of Autophagy on Cell Death Modalities
Ryter, S. W., Mizumura, K., & Choi, A. M. K. (2014) · International Journal of Cell Biology · doi:10.1155/2014/502676 · Cited by 256
Does autophagy have a license to kill mammalian cells?
Scarlatti, F., Granata, R., Meijer, A. J., & Codogno, P. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.101 · Cited by 248
Self-citationSignaling pathways in mitochondrial dysfunction and aging
Mammucari, C., & Rizzuto, R. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.07.003 · Cited by 242
Self-citationPUMA- and Bax-induced autophagy contributes to apoptosis
Yee, K. S. Y., Wilkinson, S., James, J., Ryan, K. M., & Vousden, K. H. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.28 · Cited by 242
Scherz‐Shouval, R., Weidberg, H., Gonen, C., Wilder, S., Elazar, Z., & Oren, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006124107 · Cited by 243
Surf the Post-translational Modification Network of p53 Regulation
Gu, B., & Zhu, W. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4283 · Cited by 252
Selective Autophagy Regulates Cell Cycle in Cancer Therapy
Zheng, K., He, Z., Kitazato, K., & Wang, Y. (2018) · Theranostics · doi:10.7150/thno.30308 · Cited by 229
Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy
Tan, C., Yu, J., Tan, M., Jiang, T., Zhu, X., & Tan, L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.019 · Cited by 224
Chen, N., & Debnath, J. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.034 · Cited by 233
AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
Mack, H. I. D., Zheng, B., Asara, J. M., & Thomas, S. Μ. (2012) · Autophagy · doi:10.4161/auto.20586 · Cited by 227
SIRT1: Regulation of longevity via autophagy
Salminen, A., & Kaarniranta, K. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.02.014 · Cited by 227
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
Hoshino, A., Ariyoshi, M., Okawa, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Iwai‐Kanai, E., Ikeda, K., Ueyama, T., Ogata, T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318951111 · Cited by 225
Autophagy and cancer – issues we need to digest
Liu, E. Y., & Ryan, K. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.093708 · Cited by 225
Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol
Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213
Self-citationAutophagy and genomic integrity
Vessoni, A. T., Filippi‐Chiela, E. C., Menck, C. F. M., & Lenz, G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.103 · Cited by 214
The paradox of autophagy and its implication in cancer etiology and therapy
Eisenberg‐Lerner, A., & Kimchi, A. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0307-5 · Cited by 220
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
Long, J. S., & Ryan, K. M. (2012) · Oncogene · doi:10.1038/onc.2012.7 · Cited by 213
Autophagy and the Cell Cycle: A Complex Landscape
Mathiassen, S. G., Zio, D. D., & Cecconi, F. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00051 · Cited by 214
Self-citationThe Role of Autophagy in Cancer
Santana-Codina, N., Mancias, J. D., & Kimmelman, A. C. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-041816-122338 · Cited by 214
Ma, Y., Su, Q., Yue, C., Zou, H., Zhu, J., Zhao, H., Song, R., & Liu, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113491 · Cited by 214
Shu, X., Sun, Y., Sun, X., Zhou, Y., Bian, Y., Shu, Z., Ding, J., Lu, M., & Hu, G. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1813-9 · Cited by 203
Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.03.002 · Cited by 211
Levine, B., & Abrams, J. (2008) · Nature Cell Biology · doi:10.1038/ncb0608-637 · Cited by 206
Budanov, A. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3530 · Cited by 208
Immunogenic cell death modalities and their impact on cancer treatment
Kepp, O., Tesnière, A., Schlemmer, F., Michaud, M., Senovilla, L., Zitvogel, L., & Kroemer, G. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0303-9 · Cited by 210
Self-citationThe multifaceted role of autophagy in cancer and the microenvironment
Folkerts, H., Hilgendorf, S., Vellenga, E., Bremer, E., & Wiersma, V. R. (2018) · Medicinal Research Reviews · doi:10.1002/med.21531 · Cited by 203
Jing, K., Song, K., Shin, S., Kim, N., Jeong, S., Oh, H.-R., Park, J.-H., Seo, K.-S., Heo, J. Y., Han, J., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.16658 · Cited by 208
Autophagy: Regulation and role in disease
Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 215
Self-citationThe role of autophagy in tumour development and cancer therapy
Rosenfeldt, M. T., & Ryan, K. M. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001306 · Cited by 203
Ou, L., Lin, S., Song, B., Liu, J., Lai, R., & Shao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s140526 · Cited by 203
Sugar-free approaches to cancer cell killing
Mjiyad, N. E., Caro‐Maldonado, A., Ramírez‐Peinado, S., & Muñoz‐Pinedo, C. (2010) · Oncogene · doi:10.1038/onc.2010.466 · Cited by 198
Transcriptional regulation of mammalian autophagy at a glance
Füllgrabe, J., Ghislat, G., Cho, D., & Rubinsztein, D. C. (2016) · Journal of Cell Science · doi:10.1242/jcs.188920 · Cited by 200
Rodríguez‐Rocha, H., García‐García, A., Panayiotidis, M. I., & Franco, R. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.03.007 · Cited by 205
Sirtuins' modulation of autophagy
Ng, F., & Tang, B. L. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24399 · Cited by 198
Metabolism and proliferation share common regulatory pathways in cancer cells
Fritz, V., & Fajas, L. (2010) · Oncogene · doi:10.1038/onc.2010.182 · Cited by 196
Autophagy in tumour suppression and promotion
Brech, A., Ahlquist, T. C., Lothe, R. A., & Stenmark, H. (2009) · Molecular Oncology · doi:10.1016/j.molonc.2009.05.007 · Cited by 194
Brooks, C. L., & Gu, W. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.022 · Cited by 186
Autophagy in disease: a double-edged sword with therapeutic potential
Martinet, W., Agostinis, P., Vanhoecke, B., Dewaele, M., & de Meyer, G. R. Y. (2009) · Clinical Science · doi:10.1042/cs20080508 · Cited by 186
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells
Zou, Z., Yuan, Z., Zhang, Q., Long, Z., Chen, J., Tang, Z., Zhu, Y., Chen, S., Xu, J., Yan, M., et al. (2012) · Autophagy · doi:10.4161/auto.22110 · Cited by 184
Liu, R., Li, J., Zhang, T., Zou, L., Chen, Y., Wang, K., Lei, Y., Yuan, K., Li, Y., Lan, J., et al. (2014) · Autophagy · doi:10.4161/auto.28912 · Cited by 178
Regulation of autophagy in mammals and its interplay with apoptosis
Fimia, G. M., & Piacentini, M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0284-z · Cited by 185
Gao, W., Shen, Z., Shang, L., & Wang, X. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.33 · Cited by 178
Emerging role of mitophagy in cardiovascular physiology and pathology
Morales, P. E., Arias-Durán, C., Ávalos-Guajardo, Y., Aedo, G., Verdejo, H., Parra, V., & Lavandero, S. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.09.006 · Cited by 179
Autophagy as a therapeutic target in cardiovascular disease
Nemchenko, A., Chiong, M., Turer, A. T., Lavandero, S., & Hill, J. A. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.06.010 · Cited by 180
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Jaeger, P. A., & Wyss‐Coray, T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-16 · Cited by 181
Vellai, T. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.126 · Cited by 173
Lavandero, S., Troncoso, R., Rothermel, B. A., Martinet, W., Sadoshima, J., & Hill, J. A. (2013) · Autophagy · doi:10.4161/auto.25969 · Cited by 174
Autophagy and endocrine resistance in breast cancer
Cook, K. L., Shajahan‐Haq, A. N., & Clarke, R. C. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.11.111 · Cited by 171
Targeting apoptotic and autophagic pathways for cancer therapeutics
Liu, J., Mou, L., Yu, J., Liu, B., & Bao, J. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.10.001 · Cited by 175
Autophagy in cellular growth control
Wang, R. C., & Levine, B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.009 · Cited by 172
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology
Periyasamy‐Thandavan, S., Jiang, M., Schoenlein, P. V., & Dong, Z. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00033.2009 · Cited by 170
DNA Damage Response and Autophagy: A Meaningful Partnership
Eliopoulos, A. G., Havaki, S., & Gorgoulis, V. G. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00204 · Cited by 169
p53-Mediated Molecular Control of Autophagy in Tumor Cells
Mrakovcic, M., & Fröhlich, L. F. (2018) · Biomolecules · doi:10.3390/biom8020014 · Cited by 170
The role of ubiquitin modification in the regulation of p53
Hock, A. K., & Vousden, K. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.022 · Cited by 168
p53 and mitochondrial function in neurons
Wang, D. B., Kinoshita, C., Kinoshita, Y., & Morrison, R. S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.015 · Cited by 174
Autophagy in tumor suppression and cancer therapy
Kung, C.-P., Budina, A., Balaburski, G. M., Bergenstock, M., & Murphy, M. E. (2011) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v21.i1.50 · Cited by 168
Pro-survival autophagy and cancer cell resistance to therapy
Das, C. K., Mandal, M., & Kögel, D. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9727-z · Cited by 172
Autophagy and CancerPreprint
Mah, L. Y., & Ryan, K. M. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008821 · Cited by 169
Kaminskyy, V. O., Piskunova, T. S., Zborovskaya, I. B., Tchevkina, E. M., & Zhivotovsky, B. (2012) · Autophagy · doi:10.4161/auto.20123 · Cited by 166
Autophagy and intermittent fasting: the connection for cancer therapy?
Antunes, F., Erustes, A. G., Costa, A. J., Nascimento, A. C., Bincoletto, C., Ureshino, R. P., Pereira, G. J. S., & Smaili, S. S. (2018) · Clinics · doi:10.6061/clinics/2018/e814s · Cited by 179
mTOR's role in ageing: protein synthesis or autophagy?
Hands, S. L., Proud, C. G., & Wyttenbach, A. (2009) · Aging · doi:10.18632/aging.100070 · Cited by 162
Regulatory Coordination between Two Major Intracellular Homeostatic Systems
Dokładny, K., Zuhl, M., Mandell, M. A., Bhattacharya, D., Schneider, S. M., Deretic, V. P., & Moseley, P. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.462408 · Cited by 164
Bhat, P., Kriel, J., Priya, B. S., Basappa, B., Shivananju, N. S., & Loos, B. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.11.021 · Cited by 159
The role of tumor suppressor p53 in the antioxidant defense and metabolism
Budanov, A. V. (2014) · Subcellular Biochemistry · doi:10.1007/978-94-017-9211-0_18 · Cited by 157
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
Yang, J., Chen, D., He, Y., Meléndez, A., Feng, Z., Hong, Q., Bai, X., Li, Q., Cai, G., Wang, J., et al. (2011) · AGE · doi:10.1007/s11357-011-9324-3 · Cited by 160
p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy
Sun, M., Li, J., Mao, L., Wu, J., Deng, Z., He, M., An, S. L., Zeng, Z., Huang, Q., & Chen, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.685523 · Cited by 156
Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies
Yang, P., Liu, Y.-L., Lin, Y.-C., Shun, C., Wu, M., & Chen, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1626 · Cited by 154
Exploring the multiple roles of guardian of the genome: P53
Feroz, W., & Sheikh, A. M. A. (2020) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-020-00089-x · Cited by 172
Olovnikov, I. A., Kravchenko, J. E., & Chumakov, P. M. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.005 · Cited by 156
mTORC1 pathway in DNA damage response
Ma, Y., Vassetzky, Y. S., & Dokudovskaya, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.06.011 · Cited by 157
Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment
Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 154
Missiroli, S., Bonora, M., Patergnani, S., Poletti, F., Perrone, M., Gafà, R., Magri, E., Raimondi, A., Lanza, G., Tacchetti, C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.082 · Cited by 154
Self-citationMokarram, P., Albokashy, M., Zarghooni, M., Moosavi, M. A., Sepehri, Z., Chen, Q. M., Hudecki, A., Sargazi, A., Alizadeh, J., Moghadam, A. R., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1290751 · Cited by 150
Li, M., Gao, P., & Zhang, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030332 · Cited by 156
Bommareddy, A., Hahm, E.-R., Xiao, D., Powolny, A., Fisher, A. L., Jiang, Y., & Singh, S. V. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4344 · Cited by 152
Davalli, P., Marverti, G., Lauriola, A., & D’Arca, D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2389523 · Cited by 156
Calcium signaling alterations, oxidative stress, and autophagy in aging
Ureshino, R. P., Rocha, K. K., Lopes, G. S., Bincoletto, C., & Smaili, S. S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5777 · Cited by 143
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy
Shetty, A. K., Kodali, M., Upadhya, R., & Madhu, L. N. (2018) · Aging and Disease · doi:10.14336/ad.2018.1026 · Cited by 149
Zhang, X., Qi, Z., Yin, H., & Yang, G. S. (2019) · Theranostics · doi:10.7150/thno.29673 · Cited by 148
Mechanisms and disease implications of sirtuin-mediated autophagic regulation
Lee, I. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0302-7 · Cited by 151
Metadata
- Authors
- Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., Nannmark, U., Samara, C., Pinton, P., Vicencio, J. M., Carnuccio, R., Moll, U. M., Madeo, F., Paterlini-Brechot, P., Rizzuto, R., Szabadkai, G., Pierron, G., Blomgren, K., Tavernarakis, N., Codogno, P., Cecconi, F., & Kroemer, G.
- Affiliations
- Université Paris-Sud (FR)
- Inserm (FR)
- Drottning Silvias barn- och ungdomssjukhus (SE)
- Centre National de la Recherche Scientifique (FR)
- University of Gothenburg (SE)
- Foundation for Research and Technology Hellas (GR)
- University of Ferrara (IT)
- University of Naples Federico II (IT)
- Stony Brook University (US)
- University of Graz (AT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Kroemer, Guido
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2008-05-04
- Volume
- 10
- Issue
- 6
- Pages
- 676-687
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC2676564
- OpenAlex
- W2157699677
- Cited by
- 1,132
- References
- 50
- Citations by year
- 2026: 20 · 2025: 34 · 2024: 40 · 2023: 44 · 2022: 48 · 2021: 62 · 2020: 65 · 2019: 58 · 2018: 68 · 2017: 58 · 2016: 68 · 2015: 57 · 2014: 74 · 2013: 96 · 2012: 91
- FWCI
- 61.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institute on Aging (P01AG025532)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- autophagy, cytoplasmic p53, p53 degradation, MDM2, E3 ubiquitin ligase, proteasomal degradation, hypoxia, nutrient depletion, ATP maintenance, enucleated cells, starvation, rapamycin, endoplasmic reticulum stress, tumour suppressor
- MeSH terms
- Animals, Hypoxia, Autophagy, Cytoplasm, Endoplasmic Reticulum, Gene Expression Regulation, Humans, Lysosomes, Mice, Transgenic, Models, Biological, Genes, p53, Tumor Suppressor Protein p53, Cell Line, Tumor, Proteasome Endopeptidase Complex, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
