Pregnenolone sulfate: from steroid metabolite to TRP channel ligand
Open accessAbstract
Pregnenolone sulfate is a steroid metabolite with a plethora of actions and functions. As a neurosteroid, pregnenolone sulfate modulates a variety of ion channels, transporters, and enzymes. Interestingly, as a sulfated steroid, pregnenolone sulfate is not the final- or waste-product of pregnenolone being sulfated via a phase II metabolism reaction and renally excreted, as one would presume from the pharmacology textbook knowledge. Pregnenolone sulfate is also the source and thereby the starting point for subsequent steroid synthesis pathways. Most recently, pregnenolone sulfate has been functionally "upgraded" from modulator of ion channels to an activating ion channel ligand. This review will focus on molecular aspects of the neurosteroid, pregnenolone sulfate, its metabolism, concentrations in serum and tissues and last not least will summarize the functional data.
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Pregnenolone sulfate may be produced by side chain cleavage of cholesterol sulfate by CYP11A1 rather than by sulfation of pregnenolone.
“Thus, pregnenolone sulfate which is an active neurosteroid in the brain [73], may be produced by side chain cleavage of cholesterol sulfate by CYP11A1 rather than by sulfation of pregnenolone.”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [73]
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The Regulation of Steroid Action by Sulfation and Desulfation
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Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
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- Authors
- Harteneck, C.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Harteneck, Christian
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2013-09-27
- Volume
- 18
- Issue
- 10
- Pages
- 12012-12028
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6270300
- OpenAlex
- W2049983327
- Cited by
- 89
- References
- 125
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 5 · 2014: 6
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- pregnenolone sulfate, neurosteroids, steroid sulfates, TRP channels, ion channel modulation, steroid metabolism, phase II metabolism, steroid synthesis
- MeSH terms
- Animals, Humans, Ligands, Pregnenolone, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Receptors, GABA, Transient Receptor Potential Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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