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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Baker, Darren J., Dawlaty, Meelad M., Wijshake, Tobias, Jeganathan, Karthik B., Malureanu, Liviu, van Ree, Janine H., Crespo-Diaz, Ruben, Reyes, Santiago, Seaburg, Lauren, Shapiro, Virginia, Behfar, Atta, Terzic, Andre, van de Sluis, Bart, van Deursen, Jan M.·2013·Nature Cell Biology
DOI 10.1038/ncb2643PMC PMC3707109
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  2. Matsumoto, T. et al. Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke 38, 1050–1056 (2007). · DOI · Paper page
  3. Hartman, T. K., Wengenack, T. M., Poduslo, J. F. & van Deursen, J. M. Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. Neurobiol. Aging 28, 921–927 (2007). · DOI · Paper page
  4. Matsuura, S. et al. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. Am. J. Med. Genet. A 140, 358–367 (2006). · DOI
  5. Hanks, S. et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat. Genet. 36, 1159–1161 (2004). · DOI
  6. Sotillo, R. et al. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11, 9–23 (2007). · DOI · Paper page
  7. Van Ree, J. H., Jeganathan, K. B., Malureanu, L. & van Deursen, J. M. Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J. Cell Biol. 188, 83–100 (2010). · DOI
  8. Ricke, R. M., Jeganathan, K. B. & van Deursen, J. M. Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J. Cell Biol. 193, 1049–1064 (2011). · DOI
  9. Serrano, M. et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27–37 (1996). · DOI · Paper page
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  12. Baker, D. J., Jin, F., Jeganathan, K. B. & van Deursen, J. M. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16, 475–486 (2009). · DOI
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  14. Sudakin, V., Chan, G. K. & Yen, T. J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154, 925–936 (2001). · DOI
  15. Babu, J. R. et al. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J. Cell Biol. 160, 341–353 (2003). · DOI
  16. Lukas, C. et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat. Cell Biol. 13, 243–253 (2011). · DOI
  17. Janssen, A., van der Burg, M., Szuhai, K., Kops, G. J. & Medema, R. H. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science 333, 1895–1898 (2011). · DOI
  18. Holland, A. J. & Cleveland, D. W. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 13, 501–514 (2012). · DOI
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  23. Miyamoto, T. et al. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Hum. Mol. Genet. 20, 2058–2070 (2011). · DOI
  24. Malureanu, L. et al. Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J. Cell Biol. 191, 313–329 (2010). · DOI
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  36. Liu, X. K. et al. Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Diabetes 53 (Suppl. 3), S165–S168 (2004). · DOI
  37. Oh, H. et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl Acad. Sci. USA 100, 12313–12318 (2003). · DOI
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Metadata

Authors
Baker, D. J., Dawlaty, M. M., Wijshake, T., Jeganathan, K. B., Malureanu, L., van Ree, J. H., Crespo-Diaz, R., Reyes, S., Seaburg, L., Shapiro, V., Behfar, A., Terzic, A., van de Sluis, B., & van Deursen, J. M.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2012-12-16
Volume
15
Issue
1
Pages
96-102
ISSN
  • 1465-7392
  • 1476-4679
DOI
10.1038/ncb2643
PMC
PMC3707109
Cited by
246
References
14
Language
en
Licence
www.springer.com/tdm (tdm)

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