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Emerging regulation and functions of autophagy
Open accessAbstract
Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.
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“cancer cells can withstand long periods of nutrient deprivation via the self-catabolic process of macroautophagy”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Boya et al., 2013
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Metadata
- Authors
- Boya, P., Reggiori, F., & Codogno, P.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- University Medical Center Utrecht (NL)
- Inserm (FR)
- Corresponding author
- Boya, Patricia
- Reggiori, Fulvio
- Codogno, Patrice
- Venue
- Nature Cell Biology
- Published
- 2013-07
- Volume
- 15
- Issue
- 7
- Pages
- 713-720
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC7097732
- OpenAlex
- W2089230333
- Cited by
- 1,216
- References
- 95
- Citations by year
- 2026: 22 · 2025: 58 · 2024: 87 · 2023: 89 · 2022: 96 · 2021: 118 · 2020: 124 · 2019: 110 · 2018: 97 · 2017: 98 · 2016: 107 · 2015: 102 · 2014: 98 · 2013: 10
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-08-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (DN82‐303)
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- ZonMw (821.02.017, 016.130.606, 700.59.003, 822.02.014)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (DN82-303, 016.130.606)
- Institut National Du Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, autophagy-related proteins, post-translational regulation, metabolic regulation, membrane transport, host defense, cellular homeostasis, cell type-specific gene regulation
- MeSH terms
- Animals, Autophagy, Biological Transport, Humans, Host-Pathogen Interactions
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