Cited by 1,216Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCalcium signaling and nucleotide metabolism

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Emerging regulation and functions of autophagy

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Boya, Patricia, Reggiori, Fulvio, Codogno, Patrice·2013·Nature Cell Biology

DOI 10.1038/ncb2788PMC PMC7097732

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Abstract

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

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RETRACTED: Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
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Retracted
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Autophagy fights disease through cellular self-digestion
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
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RETRACTED ARTICLE: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice
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Authors: Boya, P., Reggiori, F., & Codogno, P.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
University Medical Center Utrecht (NL)
Inserm (FR)
Corresponding author: Boya, Patricia
Reggiori, Fulvio
Codogno, Patrice
ORCID: Boya, Patricia
Reggiori, Fulvio
Codogno, Patrice
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2013-07
Volume: 15
Issue: 7
Pages: 713-720
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2788
PMC: PMC7097732
OpenAlex: W2089230333
Cited by: 1,216
References: 95
Citations by year: 2026: 22 · 2025: 58 · 2024: 87 · 2023: 89 · 2022: 96 · 2021: 118 · 2020: 124 · 2019: 110 · 2018: 97 · 2017: 98 · 2016: 107 · 2015: 102 · 2014: 98 · 2013: 10
FWCI: 12.52
Type: journal article
Language: en
Update notices: erratum (2013-08-01)
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Cell Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (DN82‐303)
Agence Nationale de la Recherche
Institut National de la Santé et de la Recherche Médicale
ZonMw (821.02.017, 016.130.606, 700.59.003, 822.02.014)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (DN82-303, 016.130.606)
Institut National Du Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, autophagy-related proteins, post-translational regulation, metabolic regulation, membrane transport, host defense, cellular homeostasis, cell type-specific gene regulation
MeSH terms: Animals, Autophagy, Biological Transport, Humans, Host-Pathogen Interactions

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