Emerging regulation and functions of autophagy

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057

The Role of Atg Proteins in Autophagosome Formation

Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600

Eaten alive: a history of macroautophagy

Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,155

The emerging hallmarks of cancer metabolism

Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926

Current knowledge on exosome biogenesis and release

Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362

Molecular definitions of autophagy and related processes

Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Dunn, J. D., Álvarez, L., Zhang, X., & Soldati, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.005 · Cited by 1,233

Autophagy in malignant transformation and cancer progression

Galluzzi, L., Pietrocola, F., Bravo‐San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490784 · Cited by 1,182

Apoptosis, autophagy, necroptosis, and cancer metastasis

Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0321-5 · Cited by 1,066

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,007

Targeting the progression of chronic kidney disease

Ruiz-Ortega, M., Rayego-Mateos, S., Lamas, S., Ortiz, A., & Rodrigues-Diez, R. R. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0248-y · Cited by 979

The Roles of Autophagy in Cancer

Yun, C. W., & Lee, S. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113466 · Cited by 965

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

Skotland, T., Hessvik, N. P., Sandvig, K., & Llorente, A. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r084343 · Cited by 730

Copper metabolism in cell death and autophagy

Xue, Q., Kang, R., Klionsky, D. J., Tang, D., Liu, J., & Chen, X. (2023) · Autophagy · doi:10.1080/15548627.2023.2200554 · Cited by 731

Autophagy and multidrug resistance in cancer

Li, Y., Lei, Y., Yao, N., Wang, C., Hu, N., Ye, W., Zhang, D., & Chen, Z. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0219-2 · Cited by 678

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

Masucci, M. T., Minopoli, M., & Carriero, M. V. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01146 · Cited by 671

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

Michel, P. P., Hirsch, É. C., & Hunot, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.038 · Cited by 622

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 595

Adherent-invasive Escherichia coli in inflammatory bowel disease

Palmela, C., Chevarin, C., Xu, Z., Torres, J., Sevrin, G., Hirten, R. P., Barnich, N., Ng, S. C., & Colombel, J. (2017) · Gut · doi:10.1136/gutjnl-2017-314903 · Cited by 570

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Ronan, B., Flamand, O., Vescovi, L., Dureuil, C., Durand, L., Fassy, F., Bachelot, M.-F., Lamberton, A., Mathieu, M., Bertrand, T., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1681 · Cited by 500

Mitochondrial biogenesis and clearance: a balancing act

Ploumi, C., Daskalaki, I., & Tavernarakis, N. (2016) · FEBS Journal · doi:10.1111/febs.13820 · Cited by 479

Autophagy and cellular immune responses

Ma, Y., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.017 · Cited by 447

How autophagy controls the intestinal epithelial barrier

Foerster, E. G., Mukherjee, T., Cabral-Fernandes, L., da Rocha, J. D. B., Girardin, S. E., & Philpott, D. J. (2021) · Autophagy · doi:10.1080/15548627.2021.1909406 · Cited by 427

Roles of Autophagy in Oxidative Stress

Yun, H. R., Jo, Y. H., Kim, J., Shin, Y., Kim, S. S., & Choi, T. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093289 · Cited by 413

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

Chun, Y., & Kim, J. (2018) · Cells · doi:10.3390/cells7120278 · Cited by 396

Autophagy in liver diseases: Time for translation?

Allaire, M., Rautou, P.-E., Codogno, P., & Lotersztajn, S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.026 · Cited by 378

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Petherick, K. J., Conway, O. J. L., Mpamhanga, C., Osborne, S. A., Kamal, A. M., SAXTY, B. A., & Ganley, I. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.c114.627778 · Cited by 378

Development of autophagy inducers in clinical medicine

Levine, B., Packer, M., & Codogno, P. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73938 · Cited by 351

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

Esteban‐Martínez, L., Sierra‐Filardi, E., McGreal, R., Salazar‐Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D. P., Graña‐Castro, O., Malumbres, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695916 · Cited by 344

The Role of Autophagy and Mitophagy in Bone Metabolic Disorders

Wang, S., Deng, Z., Ma, Y., Jin, J., Qi, F., Li, S., Liu, C., Lyu, F., & Zheng, Q. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.46627 · Cited by 333

Autophagy inhibitors

Pasquier, B. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2104-y · Cited by 329

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

Feng, Y., Yao, Z., & Klionsky, D. J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.02.002 · Cited by 296

Posttranslational modification of autophagy-related proteins in macroautophagy

Xie, Y., Kang, R., Sun, X., Zhong, M., Huang, J., Klionsky, D. J., & Tang, D. (2015) · Autophagy · doi:10.4161/15548627.2014.984267 · Cited by 302

Ageing and Osteoarthritis

Sacitharan, P. K. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_6 · Cited by 316

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders

Zhang, S., Peng, X., Yang, S., Li, X., Huang, M., Wei, S., Liu, J., He, G., Zheng, H., Yang, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04593-3 · Cited by 335

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

Lenoir, O., Jasiek, M., Hénique, C., Guyonnet, L., Hartleben, B., Bork, T., Chipont, A., Flosseau, K., Bensaada, I., Schmitt, A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1049799 · Cited by 296

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

Catalano, M., D’Alessandro, G., Lepore, F., Corazzari, M., Caldarola, S., Valacca, C., Faienza, F., Esposito, V., Limatola, C., Cecconi, F., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.016 · Cited by 302

Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders

Yang, Z., & Ming, X.-F. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00533 · Cited by 290

Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles

Hafrén, A., Macia, J.-L., Love, A. J., Milner, J. J., Drucker, M., & Hofius, D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610687114 · Cited by 278

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

Minakaki, G., Menges, S., Kittel, A., Emmanouilidou, E., Schaeffner, I., Barkovits, K., Bergmann, A., Rockenstein, E., Adame, A., Marxreiter, F., et al. (2018) · Autophagy · doi:10.1080/15548627.2017.1395992 · Cited by 272

PIKfyve inhibition increases exosome release and induces secretory autophagy

Hessvik, N. P., Øverbye, A., Brech, A., Torgersen, M. L., Jakobsen, I. S., Sandvig, K., & Llorente, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2309-8 · Cited by 269

An overview of macroautophagy in yeast

Wen, X., & Klionsky, D. J. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.02.021 · Cited by 261

Hallmarks of Aging: An Autophagic Perspective

Barbosa, M. C., Grosso, R. A., & Fader, C. M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00790 · Cited by 275

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

Glatigny, M., Moriceau, S., Rivagorda, M., Ramos-Brossier, M., Nascimbeni, A. C., Lante, F., Shanley, M. R., Boudarene, N., Rousseaud, A., Friedman, A. K., et al. (2019) · Current Biology · doi:10.1016/j.cub.2018.12.021 · Cited by 257

PI(5)P Regulates Autophagosome Biogenesis

Vicinanza, M., Korolchuk, V. I., Ashkenazi, A., Puri, C., Menzies, F. M., Clarke, J. H., & Rubinsztein, D. C. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.007 · Cited by 256

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

Wu, H., Che, X., Zheng, Q., Wu, A., Pan, K., Shao, A., Wu, Q., Zhang, J., & Hong, Y. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9719 · Cited by 259

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Dou, Q., Chen, H., Wang, K., Yuan, K., Lei, Y., Li, K., Lan, J., Chen, Y., Huang, Z., Xie, N., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2887 · Cited by 260

Targeting autophagy-related protein kinases for potential therapeutic purpose

Xiang, H., Zhang, J., Lin, C., Zhang, L., Liu, B., & Ouyang, L. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.003 · Cited by 258

Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics

Nascimbeni, A. C., Codogno, P., & Morel, É. (2016) · FEBS Journal · doi:10.1111/febs.13987 · Cited by 255

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Song, L., Tang, S. H., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09720-x · Cited by 249

Loss of Mitochondrial Function Impairs Lysosomes

Demers-Lamarche, J., Guillebaud, G., Tlili, M., Todkar, K. J., Bélanger, N., Grondin, M., Nguyen, A., Michel, J. J. C., & Germain, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.695825 · Cited by 242

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.

Ferrington, D. A., Sinha, D., & Kaarniranta, K. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.09.002 · Cited by 241

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

Nah, J., Yuan, J., & Jung, Y. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0034 · Cited by 234

Autophagy in the eye: Development, degeneration, and aging

Boya, P., Esteban‐Martínez, L., Serrano‐Puebla, A., Gómez‐Sintes, R., & Villarejo‐Zori, B. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.08.001 · Cited by 236

Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons

Zhang, X., Wei, M., Fan, J., Yan, W., Zha, X., Song, H., Wan, R., Yin, Y., & Wang, W. (2020) · Autophagy · doi:10.1080/15548627.2020.1840796 · Cited by 230

Programmed cell death in atherosclerosis and vascular calcification

Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 243

Regulation of Tumor Progression by Programmed Necrosis

Lee, S. Y., Ju, M. K., Jeon, H. M., Jeong, E. K., Lee, Y. J., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3537471 · Cited by 238

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation

Chang, J., Lee, S., & Blackstone, C. D. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77598 · Cited by 224

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

Hu, W., Liu, C., Bi, Z., Zhou, Q. Y., Zhang, H., Li, L., Zhang, J., Zhu, W., Song, Y., Zhang, F., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01199-1 · Cited by 215

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Bakula, D., Müller, A. J., Zuleger, T., Takács, Z., Franz‐Wachtel, M., Thost, A.-K., Brigger, D., Tschan, M. P., Frickey, T., Robenek, H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15637 · Cited by 216

AMPK and autophagy in glucose/glycogen metabolism

Ha, J., Guan, K., & Kim, J. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.08.002 · Cited by 219

Functional characterization of SOX2 as an anticancer target

Zhang, S., Xiong, X., & Sun, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00242-3 · Cited by 215

Autophagy in the physiology and pathology of the central nervous system

Nikoletopoulou, V., Papandreou, M. E., & Tavernarakis, N. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.204 · Cited by 206

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

Serrano‐Puebla, A., & Boya, P. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12966 · Cited by 204

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

Nilsson, P., & Saido, T. C. (2014) · BioEssays · doi:10.1002/bies.201400002 · Cited by 206

ER–plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis

Nascimbeni, A. C., Giordano, F., Dupont, N., Grasso, D., Vaccaro, M. I., Codogno, P., & Morel, É. (2017) · The EMBO Journal · doi:10.15252/embj.201797006 · Cited by 211

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

Boya, P., Codogno, P., & Rodriguez-Muela, N. (2018) · Development · doi:10.1242/dev.146506 · Cited by 197

Turnip Mosaic Virus Counteracts Selective Autophagy of the Viral Silencing Suppressor HCpro

Hafrén, A., Üstün, Ş., Hochmuth, A., Svenning, S., Johansen, T., & Hofius, D. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.01198 · Cited by 200

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis

Devereaux, K., Dall’Armi, C., Alcazar-Roman, A., Ogasawara, Y., Zhou, X., Wang, F., Yamamoto, A., De Camilli, P., & Di Paolo, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076405 · Cited by 182

Mechanisms of MAVS Regulation at the Mitochondrial Membrane

Jacobs, J. L., & Coyne, C. B. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.10.007 · Cited by 203

Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer

Gugnoni, M., Sancisi, V., Manzotti, G., Gandolfi, G., & Ciarrocchi, A. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.415 · Cited by 205

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

Stürner, E., & Behl, C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00177 · Cited by 202

Atomistic Autophagy: The Structures of Cellular Self-Digestion

Hurley, J. H., & Schulman, B. A. (2014) · Cell · doi:10.1016/j.cell.2014.01.070 · Cited by 197

Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma

Chen, Y., Chen, H., Wang, K., Zhang, L., Huang, Z., Liu, J., Zhang, Z., Luo, M., Lei, Y., Peng, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.022 · Cited by 192

Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase

Li, F., Zhang, C., Li, Y., Wu, G., Hou, X., Zhou, X., & Wang, A. (2018) · Nature Communications · doi:10.1038/s41467-018-03658-2 · Cited by 194

Autophagy and proinflammatory cytokines: Interactions and clinical implications

Ge, Y., Huang, M., & Yao, Y.-M. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.07.001 · Cited by 191

Proton channels and exchangers in cancer

Spugnini, E. P., Sonveaux, P., Stock, C. M., Pérez‐Sayáns, M., Milito, A. D., Avnet, S., Garcı́a, A. G., Harguindey, S., & Fais, S. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.10.015 · Cited by 186

Skeletal muscle autophagy and its role in sarcopenia and organismal aging

Jiao, J., & Demontis, F. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.03.009 · Cited by 184

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

Maycotte, P., Jones, K. L., Goodall, M. L., Thorburn, J., & Thorburn, A. M. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0487 · Cited by 188

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

Gabandé‐Rodríguez, E., Boya, P., Labrador-Cantarero, V., Dotti, C. G., & Ledesma, M. D. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.4 · Cited by 177

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

Kadota, T., Fujita, Y., Yoshioka, Y., Araya, J., Kuwano, K., & Ochiya, T. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.005 · Cited by 179

Dysregulation of autophagy as a common mechanism in lysosomal storage diseases

Seranova, E., Connolly, K. J., Zatyka, M., Rosenstock, T. R., Barrett, T. G., Tuxworth, R. I., & Sarkar, S. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170055 · Cited by 183

Mitochondrial quality control: from molecule to organelle

Roca-Portoles, A., & Tait, S. W. G. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03775-0 · Cited by 178

Getting ready for building: signaling and autophagosome biogenesis

Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 178

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

Hyttinen, J. M. T., Amadio, M., Viiri, J., Pascale, A., Salminen, A., & Kaarniranta, K. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.002 · Cited by 172

Autophagy: A Druggable Process

Morel, É., Mehrpour, M., Botti, J., Dupont, N., Hamaï, A., Nascimbeni, A. C., & Codogno, P. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104936 · Cited by 174

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

Kaarniranta, K., Tokarz, P., Koskela, A. K. J., Paterno, J. J., & Błasiak, J. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9371-8 · Cited by 176

HIV-1–Associated Atherosclerosis

Kearns, A. C., Gordon, J., Burdo, T. H., & Qin, X. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.012 · Cited by 169

Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells

Marchand, B., Arsenault, D., Raymond-Fleury, A., Boisvert, F., & Boucher, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616714 · Cited by 172

Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

Ma, T., Li, J., Xu, Y., Chen, Y., Xu, T., Wang, H., Liu, K., Cao, N., Nie, B., Zhu, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3256 · Cited by 168

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Hernández‐Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, Í. J., Casas, J., Montes, L. R., Antón, Z., García-Taboada, E., Salazar‐Roa, M., Lorente, M., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1213927 · Cited by 168

GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy

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Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases

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Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids

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Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics

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Autophagy: roles in intestinal mucosal homeostasis and inflammation

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Autophagy, a key mechanism of oncogenesis and resistance in leukemia

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The role of autophagy in hepatocellular carcinoma: friend or foe

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The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain

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Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms

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Osteocyte apoptosis: the roles and key molecular mechanisms in resorption-related bone diseases

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Autophagy in kidney disease and aging: lessons from rodent models

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Autophagy: machinery and regulation

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Autophagy in cells of the blood

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The nonautophagic functions of autophagy-related proteins

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Autophagy at the crossroads of metabolism and cellular defense

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