The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
A two-step mechanism for epigenetic specification of centromere identity and function
Open accessAbstract
The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is demonstrated to be the epigenetic mark that acts through a two-step mechanism to identify, maintain and propagate centromere function indefinitely. Initially, centromere position is replicated and maintained by chromatin assembled with the centromere-targeting domain (CATD) of CENP-A substituted into H3. Subsequently, nucleation of kinetochore assembly onto CATD-containing chromatin is shown to require either the amino- or carboxy-terminal tail of CENP-A for recruitment of inner kinetochore proteins, including stabilizing CENP-B binding to human centromeres or direct recruitment of CENP-C, respectively.
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The molecular basis for centromere identity and function
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A Molecular View of Kinetochore Assembly and Function
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Self-citationMechanisms generating cancer genome complexity from a single cell division error
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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
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Pogo-like Transposases Have Been Repeatedly Domesticated into CENP-B-Related Proteins
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Metadata
- Authors
- Fachinetti, D., Diego Folco, H., Nechemia-Arbely, Y., Valente, L. P., Nguyen, K., Wong, A. J., Zhu, Q., Holland, A. J., Desai, A., Jansen, L. E. T., & Cleveland, D. W.
- Venue
- Nature Cell Biology
- Published
- 2013-07-21
- Volume
- 15
- Issue
- 9
- Pages
- 1056-1066
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2042967115
- Cited by
- 255
- References
- 57
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- green
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