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Pogo-like Transposases Have Been Repeatedly Domesticated into CENP-B-Related Proteins

Mateo, Lidia, González, Josefa·2014·Genome Biology and Evolution
DOI 10.1093/gbe/evu153PMC PMC4231638
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Fig. 1.— Domain structure of pogo transposase and CR proteins. (A) Human CENP-B (hCENP-B), D. melanogaster pogo transposase (pogoR11), D. melanogaster CAG (CAG), yeast CENP-B homologs (Abp1, Cbh1, Cbh2), and Spodoptera frugiperda CENP-B homolog (SfCENP-B). CENP-B_N domain is shown in red, d1iufa1 in yellow, HTH_Tnp_Tc5 in green, DDE_1 in light blue, DIM in pink, and PCNA in dark blue. Domains predicted by hmmscan are shown as black-lined boxes, the other domains were inferred from experimental evidence. The discontinuous line indicates the deleted region. (B) 3D structure prediction of D. melanogaster CAG DBD using human CENP-B as a template. Z-score = −6.66 and −6.7 for CENP-B and CAG, respectively.
Fig. 1.— Domain structure of pogo transposase and CR proteins. (A) Human CENP-B (hCENP-B), D. melanogaster pogo transposase (pogoR11), D. melanogaster CAG (CAG), yeast CENP-B homologs (Abp1, Cbh1, Cbh2), and Spodoptera frugiperda CENP-B homolog (SfCENP-B). CENP-B_N domain is shown in red, d1iufa1 in yellow, HTH_Tnp_Tc5 in green, DDE_1 in light blue, DIM in pink, and PCNA in dark blue. Domains predicted by hmmscan are shown as black-lined boxes, the other domains were inferred from experimental evidence. The discontinuous line indicates the deleted region. (B) 3D structure prediction of D. melanogaster CAG DBD using human CENP-B as a template. Z-score = −6.66 and −6.7 for CENP-B and CAG, respectively.CC BY-NC · PubMed Central
Fig. 2.— Biological processes overrepresented in the CAG 2-neighbourhood PPI. Hierarchical representation of the 72 biological process GO terms enriched in the neighbourhood-2 of CAG PPI network. Node colors indicate the level of significance. The overrepresented GO terms were categorized into four groups related to the neigbourhood-1 genes of CAG PPI: Cell cycle and spindle organization, response to stimulus and regulation of metabolic process, nucleic acids metabolism, and protein metabolism. GO terms enriched also in the neighborhood-2 of human CENP-B are represented inside gray boxes.
Fig. 2.— Biological processes overrepresented in the CAG 2-neighbourhood PPI. Hierarchical representation of the 72 biological process GO terms enriched in the neighbourhood-2 of CAG PPI network. Node colors indicate the level of significance. The overrepresented GO terms were categorized into four groups related to the neigbourhood-1 genes of CAG PPI: Cell cycle and spindle organization, response to stimulus and regulation of metabolic process, nucleic acids metabolism, and protein metabolism. GO terms enriched also in the neighborhood-2 of human CENP-B are represented inside gray boxes.CC BY-NC · PubMed Central
Fig. 3.— Phylogenetic distribution of pogo-related transposases and transposase-derived genes in metazoans. JR and CR indicate that the sequences belong to the JR clade and the CR clades, respectively. Filled-boxes depict pogo-related transposases and empty boxes depict transposase-derived genes. Numbers in the nodes show posterior probabilities (black) and bootstrap values (red). Shaded branches correspond to new CR proteins identified in this work and in d'Alençon et al 2011 (table 1) that have been incorporated to the previously published phylogeny (Casola et al 2008). Dotted lines represent branches not drawn to scale. Trees including nonmetazoans pogo-related transposases and transposase-derived genes are depicted in supplementary figures S2 and S3, Supplementary Material online.
Fig. 3.— Phylogenetic distribution of pogo-related transposases and transposase-derived genes in metazoans. JR and CR indicate that the sequences belong to the JR clade and the CR clades, respectively. Filled-boxes depict pogo-related transposases and empty boxes depict transposase-derived genes. Numbers in the nodes show posterior probabilities (black) and bootstrap values (red). Shaded branches correspond to new CR proteins identified in this work and in d'Alençon et al 2011 (table 1) that have been incorporated to the previously published phylogeny (Casola et al 2008). Dotted lines represent branches not drawn to scale. Trees including nonmetazoans pogo-related transposases and transposase-derived genes are depicted in supplementary figures S2 and S3, Supplementary Material online.CC BY-NC · PubMed Central

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Metadata

Authors
Mateo, L., & González, J.
Venue
Genome Biology and Evolution
Publisher
Oxford University Press (OUP)
Published
2014-07-24
Volume
6
Issue
8
Pages
2008-2016
ISSN
1759-6653
DOI
10.1093/gbe/evu153
PMC
PMC4231638
Cited by
44
References
0
Language
en

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Mateo, L., & González, J. (2014). Pogo-like Transposases Have Been Repeatedly Domesticated into CENP-B-Related Proteins. Genome Biology and Evolution. https://doi.org/10.1093/gbe/evu153