The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The spindle assembly checkpoint works like a rheostat rather than a toggle switch
Open accessAbstract
The spindle assembly checkpoint (SAC) is essential in mammalian mitosis to ensure the equal segregation of sister chromatids. The SAC generates a mitotic checkpoint complex (MCC) to prevent the anaphase-promoting complex/cyclosome (APC/C) from targeting key mitotic regulators for destruction until all of the chromosomes have attached to the mitotic apparatus. A single unattached kinetochore can delay anaphase for several hours, but how it is able to block the APC/C throughout the cell is not understood. Present concepts of the SAC posit that either it exhibits an all-or-nothing response or there is a minimum threshold sufficient to block the APC/C (ref. ). Here, we have used gene targeting to measure SAC activity, and find that it does not have an all-or-nothing response. Instead, the strength of the SAC depends on the amount of MAD2 recruited to kinetochores and on the amount of MCC formed. Furthermore, we show that different drugs activate the SAC to different extents, which may be relevant to their efficacy in chemotherapy.
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Cites
The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227
Gascoigne, K. E., & Taylor, S. S. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.002 · Cited by 832
Foley, E. A., Maldonado, M., & Kapoor, T. M. (2011) · Nature Cell Biology · doi:10.1038/ncb2327 · Cited by 267
Cited by
Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events
McCloy, R. A., Rogers, S., Caldon, C. E., Lorca, T., Castro, A., & Burgess, A. (2014) · Cell Cycle · doi:10.4161/cc.28401 · Cited by 853
The molecular biology of spindle assembly checkpoint signaling dynamics.
Musacchio, A. (2015) · Current Biology · doi:10.1016/j.cub.2015.08.051 · Cited by 778
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
Sivakumar, S., & Gorbsky, G. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3934 · Cited by 259
Müllers, E., Cascales, H. S., Jaiswal, H., Saurin, A. T., & Lindqvist, A. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945831 · Cited by 84
Metadata
- Authors
- Collin, P., Nashchekina, O., Walker, R., & Pines, J.
- Venue
- Nature Cell Biology
- Published
- 2013-10-06
- Volume
- 15
- Issue
- 11
- Pages
- 1378-1385
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2071110654
- Cited by
- 204
- References
- 3
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
