The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
Open accessAbstract
Cardiac development arises from two sources of mesoderm progenitors, the first heart field (FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive multipotent cardiac progenitors common for both heart fields. Here, using clonal analysis of the earliest prospective cardiovascular progenitors in a temporally controlled manner during early gastrulation, we found that Mesp1 progenitors consist of two temporally distinct pools of progenitors restricted to either the FHF or the SHF. FHF progenitors were unipotent, whereas SHF progenitors were either unipotent or bipotent. Microarray and single-cell PCR with reverse transcription analysis of Mesp1 progenitors revealed the existence of molecularly distinct populations of Mesp1 progenitors, consistent with their lineage and regional contribution. Together, these results provide evidence that heart development arises from distinct populations of unipotent and bipotent cardiac progenitors that independently express Mesp1 at different time points during their specification, revealing that the regional segregation and lineage restriction of cardiac progenitors occur very early during gastrulation.
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Cites
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
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Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
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Capturing Cardiogenesis in Gastruloids
Rossi, G., Broguiere, N., Miyamoto, M., Boni, A., Guiet, R., Girgin, M., Kelly, R. G., Kwon, C., & Lutolf, M. P. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2020.10.013 · Cited by 306
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Precardiac organoids form two heart fields via Bmp/Wnt signaling
Andersen, P., Tampakakis, E., Jimenez, D. V., Kannan, S., Miyamoto, M., Shin, H. K., Saberi, A., Murphy, S., Sulistio, E., Chelko, S. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05604-8 · Cited by 132
SCL/TAL1: a multifaceted regulator from blood development to disease
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Metadata
- Authors
- Lescroart, F., Chabab, S., Lin, X., Rulands, S., Paulissen, C., Rodolosse, A., Auer, H., Achouri, Y., Dubois, C., Bondue, A., Simons, B. D., & Blanpain, C.
- Venue
- Nature Cell Biology
- Published
- 2014-08-24
- Volume
- 16
- Issue
- 9
- Pages
- 829-840
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2006028524
- Cited by
- 331
- References
- 5
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- green
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