The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling
Open accessAbstract
Emerging evidence suggests that cancer is populated and maintained by tumour-initiating cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite recent advances, the molecular regulatory mechanisms that may be shared between normal and malignant stem cells remain poorly understood. Here we show that the ΔNp63 isoform of the Trp63 transcription factor promotes normal mammary stem cell (MaSC) activity by increasing the expression of the Wnt receptor Fzd7, thereby enhancing Wnt signalling. Importantly, Fzd7-dependent enhancement of Wnt signalling by ΔNp63 also governs tumour-initiating activity of the basal subtype of breast cancer. These findings establish ΔNp63 as a key regulator of stem cells in both normal and malignant mammary tissues and provide direct evidence that breast cancer TICs and normal MaSCs share common regulatory mechanisms.
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Cites
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Cited by
Predicting cell-to-cell communication networks using NATMI
Hou, R., Denisenko, E., Ong, H. T., Ramilowski, J. A., & Forrest, A. R. R. (2020) · Nature Communications · doi:10.1038/s41467-020-18873-z · Cited by 285
Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2018 · Cited by 267
Maintaining epithelial stemness with p63
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Metadata
- Authors
- Chakrabarti, R., Wei, Y., Hwang, J., Hang, X., Andres Blanco, M., Choudhury, A., Tiede, B., Romano, R.-A., DeCoste, C., Mercatali, L., Ibrahim, T., Amadori, D., Kannan, N., Eaves, C. J., Sinha, S., & Kang, Y.
- Venue
- Nature Cell Biology
- Published
- 2014-09-21
- Volume
- 16
- Issue
- 10
- Pages
- 1004-1015
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2066446030
- Cited by
- 207
- References
- 9
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Chakrabarti, R., Wei, Y., Hwang, J., Hang, X., Andres Blanco, M., Choudhury, A., Tiede, B., Romano, R.-A., DeCoste, C., Mercatali, L., Ibrahim, T., Amadori, D., Kannan, N., Eaves, C. J., Sinha, S., & Kang, Y. (2014). ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nature Cell Biology. https://doi.org/10.1038/ncb3040
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
