The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium
Open accessAbstract
Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after anaphase onset oocytes and embryonic cells of frogs and echinoderms exhibit cortical waves of Rho activity and F-actin polymerization. The waves are modulated by cyclin-dependent kinase 1 (Cdk1) activity and require the Rho GEF (guanine nucleotide exchange factor), Ect2. Surprisingly, during wave propagation, although Rho activity elicits F-actin assembly, F-actin subsequently inactivates Rho. Experimental and modelling results show that waves represent excitable dynamics of a reaction–diffusion system with Rho as the activator and F-actin the inhibitor. We propose that cortical excitability explains fundamental features of cytokinesis including its cell cycle regulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lifeact: a versatile marker to visualize F-actin
Riedl, J., Crevenna, A. H., Kessenbrock, K., Yu, J. H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T. A., Werb, Z., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1220 · Cited by 2,189
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science · doi:10.1126/science.1081412 · Cited by 1,412
Cyclin synthesis drives the early embryonic cell cycle
Murray, A. W., & Kirschner, M. W. (1989) · Nature · doi:10.1038/339275a0 · Cited by 1,191
Spiral Calcium Wave Propagation and Annihilation in Xenopus laevis Oocytes
Lechleiter, J., Girard, S., Peralta, E., & Clapham, D. (1991) · Science · doi:10.1126/science.2011747 · Cited by 730
Reassembly of contractile actin cortex in cell blebs
Charras, G. T., Hu, C.-K., Coughlin, M., & Mitchison, T. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602085 · Cited by 619
Green, R. A., Paluch, E., & Oegema, K. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155718 · Cited by 569
Versatile fluorescent probes for actin filaments based on the actin‐binding domain of utrophin
Burkel, B. M., von Dassow, G., & Bement, W. M. (2007) · Cell Motility · doi:10.1002/cm.20226 · Cited by 461
Self-citationElectrical Turbulence in Three-Dimensional Heart Muscle
Winfree, A. T. (1994) · Science · doi:10.1126/science.7973648 · Cited by 448
An Actin-Based Wave Generator Organizes Cell Motility
Weiner, O. D., Marganski, W. A., Wu, L. F., Altschuler, S. J., & Kirschner, M. W. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050221 · Cited by 400
Rappaport, R. (1990) · Biomechanics of Active Movement and Deformation of Cells · doi:10.1007/978-3-642-83631-2_1 · Cited by 361
Cited by
A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4
Michaud, A., Leda, M., Swider, Z. T., Kim, S., He, J., Landino, J., Valley, J. R., Huisken, J., Goryachev, A. B., von Dassow, G., et al. (2022) · Journal of Cell Biology · doi:10.1083/jcb.202203017 · Cited by 59
Self-citationRhoA regulation in space and time
de Seze, J., Gatin, J., & Coppey, M. (2023) · FEBS Letters · doi:10.1002/1873-3468.14578 · Cited by 42
Marshall-Burghardt, S., Migueles-Ramírez, R. A., Lin, Q., El Baba, N., Saada, R., Umar, M., Mavalwala, K., & Hayer, A. (2024) · Science Advances · doi:10.1126/sciadv.adn6858 · Cited by 23
Metadata
- Authors
- Bement, W. M., Leda, M., Moe, A. M., Kita, A. M., Larson, M. E., Golding, A. E., Pfeuti, C., Su, K.-C., Miller, A. L., Goryachev, A. B., & von Dassow, G.
- Venue
- Nature Cell Biology
- Published
- 2015-10-19
- Volume
- 17
- Issue
- 11
- Pages
- 1471-1483
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2160375286
- Cited by
- 299
- References
- 36
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium. https://app.cochat.ai/papers/10.1038/ncb3251
- The paper
- Bement, W. M., Leda, M., Moe, A. M., Kita, A. M., Larson, M. E., Golding, A. E., Pfeuti, C., Su, K.-C., Miller, A. L., Goryachev, A. B., & von Dassow, G. (2015). Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium. Nature Cell Biology. https://doi.org/10.1038/ncb3251
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
