The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
An Actin-Based Wave Generator Organizes Cell Motility
Open accessAbstract
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the spatial dynamics of a key actin regulator--the Scar/WAVE complex--which plays an important role in regulating cell shape in both metazoans and plants. We have recently discovered that the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile immune cell, the human neutrophil. Actin is both an output and input to the Scar/WAVE complex: the complex stimulates actin assembly, and actin polymer is also required to remove the complex from the membrane. These reciprocal interactions appear to generate propagated waves of actin nucleation that exhibit many of the properties of morphogenesis in motile cells, such as the ability of cells to flow around barriers and the intricate spatial organization of protrusion at the leading edge. We propose that cell motility results from the collective behavior of multiple self-organizing waves.
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Cites
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835
Self-citationScar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
Machesky, L. M., Mullins, R. D., Higgs, H. N., Kaiser, D. A., Blanchoin, L., May, R. C., Hall, M. E., & Pollard, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3739 · Cited by 773
Kunda, P., Craig, G., Dominguez, V., & Baum, B. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.005 · Cited by 341
Rakeman, A. S., & Anderson, K. V. (2006) · Development · doi:10.1242/dev.02473 · Cited by 107
Cited by
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa-Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,457
Unusual biophysics of intrinsically disordered proteins
Uversky, V. N. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.12.008 · Cited by 566
An Adhesion-Dependent Switch between Mechanisms That Determine Motile Cell Shape
Barnhart, E. L., Lee, K.-C., Keren, K., Mogilner, A., & Theriot, J. A. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001059 · Cited by 310
Arp2/3 complex interactions and actin network turnover in lamellipodia
Lai, F. P., Szczodrak, M., Block, J., Faix, J., Breitsprecher, D., Mannherz, H. G., Stradal, T. E., Dunn, G. A., Small, J. V., & Rottner, K. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.34 · Cited by 300
Bement, W. M., Leda, M., Moe, A. M., Kita, A. M., Larson, M. E., Golding, A. E., Pfeuti, C., Su, K.-C., Miller, A. L., Goryachev, A. B., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3251 · Cited by 299
Metadata
- Authors
- Weiner, O. D., Marganski, W. A., Wu, L. F., Altschuler, S. J., & Kirschner, M. W.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-08-14
- Volume
- 5
- Issue
- 9
- Pages
- e221
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2101679999
- Cited by
- 400
- References
- 4
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Weiner, O. D., Marganski, W. A., Wu, L. F., Altschuler, S. J., & Kirschner, M. W. (2007). An Actin-Based Wave Generator Organizes Cell Motility. PLoS Biology. https://doi.org/10.1371/journal.pbio.0050221
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
